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1. 发明申请

WO2005072822A1 CONTROL OF ATRIAL DEFIBRILLATION THERAPY BASED ON HEMODYNAMIC SENSOR FEEDBACK 审中-公开
标题翻译：基于HEMODYNAMIC传感器反馈的ATRIAL DEFIBRILLATION治疗控制
公开(公告)号：WO2005072822A1
公开(公告)日：2005-08-11
申请号：PCT/US2005/001065
申请日：2005-01-12
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
发明人： HETTRICK, Douglas, A. , EULER, David, E. , WARMAN, Eduardo, N. , UJHELYI, Michael, R. , MEHRA, Rahul , ZIEGLER, Paul, D. , MUSLEY, Shailesh, K., V. , DISTAD, Charles, E. , RITSCHER, David, E.
IPC分类号： A61N1/37
CPC分类号： A61N1/3702 , A61N1/3621 , A61N1/365 , A61N1/36564 , A61N1/395 , A61N1/3962
摘要： Control of defibrillation therapy delivered by implantable medical devices (IMDs) using hemodynamic sensor feedback is disclosed. The hemodynamic sensor feedback allows for increased control over application of atrial defibrillation therapy. Specifically, the therapy is delivered when a fibrillation episode results in a discrete loss of hemodynamic function. Defibrillation therapy is thus withheld for hemodynamically benign arrhythmias.
摘要翻译：公开了使用血液动力学传感器反馈控制由可植入医疗装置（IMD）递送的除颤疗法。血液动力学传感器反馈允许增加对心房除颤治疗的应用的控制。具体来说，当纤维性颤动发作导致血液动力学功能的离散损失时，进行治疗。因此，对于血液动力学良性心律失常，禁止使用除颤疗法。

2. 发明申请

WO2012154985A2 AV NODAL STIMULATION DURING ATRIAL TACHYARRHYTHMIA TO PREVENT INAPPROPRIATE THERAPY DELIVERY 审中-公开
标题翻译：急性心肌梗塞期间的AV NODAL刺激，以防止不准确的治疗方案
公开(公告)号：WO2012154985A2
公开(公告)日：2012-11-15
申请号：PCT/US2012/037371
申请日：2012-05-10
申请人： MEDTRONIC, INC. , WARMAN, Eduardo N. , BURNES, John E. , MICHELS, Koen J. , ZIEGLER, Paul D. , KORNET, Lilian
发明人： WARMAN, Eduardo N. , BURNES, John E. , MICHELS, Koen J. , ZIEGLER, Paul D. , KORNET, Lilian
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/3622 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3624
摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.
摘要翻译：本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。在室性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者递送不适当的治疗。

3. 发明申请

WO2007059383A2 PACING DEVICE FOR MINIMIZING VENTRICULAR PAUSES AFTER DELIVERY OF ATRIAL ANTI-TACHYCARDIA PACING THERAPY 审中-公开
标题翻译：输送ATRA抗感染药物治疗后最小化静脉血栓的装置
公开(公告)号：WO2007059383A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/060513
申请日：2006-11-03
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , KRAUSE, Paul, G. , ANDERSON, Katherine, H.
发明人： ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , KRAUSE, Paul, G. , ANDERSON, Katherine, H.
CPC分类号： A61N1/3622 , A61N1/3624
摘要： A pacing control is used in a multiple-chamber cardiac pacing system, which, upon detecting an atrial arrhythmia, automatically switches to a special therapy mode and administers a selected anti-tachycardia pacing (ATP) therapy in the atrium, and which switches to a standard pacing mode following delivery of the ATP therapy. The pacing control adjusts the timing of pacing pulses to be delivered to the atrium and/or the ventricle to minimize any potential ventricular pauses that may result from the switch from the therapy mode to the standard pacing mode.
摘要翻译：起搏控制用于多室心脏起搏系统，其在检测到心房心律失常时自动切换到特殊治疗模式，并在心房中进行选择的抗心动过速起搏（ATP）治疗，并且切换到 ATP疗法运送后的标准起搏模式。起搏控制调节将被输送到心房和/或心室的起搏脉冲的定时，以最小化从治疗模式切换到标准起搏模式可能导致的任何潜在心室停搏。

4. 发明申请

WO2006105394A1 SYSTEM AND METHODS FOR IMPROVING PACING PARAMETERS USING ACUTE HEMODYNAMIC FEEDBACK DURING DEVICE IMPLANT 审中-公开
标题翻译：用于在设备植入期间使用急性HEMODYMM反馈改善PAC参数的系统和方法
公开(公告)号：WO2006105394A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/011897
申请日：2006-03-30
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D.
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D.
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36528
摘要： The efficacy of cardiac resynchronization therapy applied to a patient's heart by an implantable device are improved by obtaining acute hemodynamic feedback during implantation of a pacing device. A first and a second ultrasound transducer are temporarily placed proximate to a portion of the patient's heart during device implant, and a distance between the ultrasound transducers is monitored as the therapy is applied. A parameter (e.g. lead location, biventricular pacing, pacing rate, or the like) of the cardiac therapy is adjusted in response to the distance between the ultrasound transducers until a desired result is obtained, after which the first and second ultrasound transducers can be removed from the patient.
摘要翻译：通过在植入装置期间获得急性血流动力学反馈来改善通过可植入装置应用于患者心脏的心脏再同步治疗的功效。在装置植入期间，第一和第二超声换能器临时放置在患者心脏的一部分附近，并且当应用治疗时，监测超声换能器之间的距离。响应于超声换能器之间的距离来调整心脏疗法的参数（例如引导位置，双心室起搏，起搏速率等），直到获得期望的结果，然后可以去除第一和第二超声换能器来自病人。

5. 发明申请

WO2006104844A2 SYSTEM FOR CHARACTERIZING CHRONIC PHYSIOLOGICAL DATA 审中-公开
标题翻译：系统表征慢性生理数据
公开(公告)号：WO2006104844A2
公开(公告)日：2006-10-05
申请号：PCT/US2006010589
申请日：2006-03-23
申请人： MEDTRONIC INC , ZIEGLER PAUL D , HETTRICK DOUGLAS A , SARKAR SHANTANU
发明人： ZIEGLER PAUL D , HETTRICK DOUGLAS A , SARKAR SHANTANU
IPC分类号： A61B5/0464
CPC分类号： A61B5/0031 , A61B5/7257
摘要： An implantable medical device (IMD) senses physiological episodes and stores data associated with the physiological episodes in the IMD. The data is then processed based on a pattern of recurrence of the physiological episodes.
摘要翻译：可植入医疗设备（IMD）感测生理事件并在IMD中存储与生理事件相关的数据。然后基于生理事件的复发模式处理数据。

6. 发明申请

WO2012154985A3 AV NODAL STIMULATION DURING ATRIAL TACHYARRHYTHMIA TO PREVENT INAPPROPRIATE THERAPY DELIVERY 审中-公开
标题翻译：急性心肌梗塞期间的AV NODAL刺激，以防止不准确的治疗方案
公开(公告)号：WO2012154985A3
公开(公告)日：2013-04-11
申请号：PCT/US2012037371
申请日：2012-05-10
申请人： MEDTRONIC INC , WARMAN EDUARDO N , BURNES JOHN E , MICHELS KOEN J , ZIEGLER PAUL D , KORNET LILIAN
发明人： WARMAN EDUARDO N , BURNES JOHN E , MICHELS KOEN J , ZIEGLER PAUL D , KORNET LILIAN
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/3622 , A61N1/36053 , A61N1/36114 , A61N1/3621 , A61N1/3624
摘要： The disclosure describes techniques for delivering electrical stimulation to decrease the ventricular rate response during an atrial tachyarrhythmia, such as atrial fibrillation. AV nodal stimulation is employed during an atrial tachyarrhythmia episode with rapid ventricular conduction to distinguish ventricular tachyarrhythmia from supraventricular tachycardia and thereby prevent delivering inappropriate therapy to a patient.
摘要翻译：本公开描述了用于递送电刺激以降低心房速发性心律失常（例如心房颤动）期间的心室率反应的技术。在室性快速性心律失常发作期间采用AV淋巴结刺激，其具有快速的心室传导以区分室上性快速性心律失常与室上性心动过速，从而阻止对患者递送不适当的治疗。

7. 发明申请

WO2011053386A1 STROKE RISK MONITORING SYSTEM INCLUDING IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：涉及风险监测系统，包括可植入医疗设备
公开(公告)号：WO2011053386A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/033912
申请日：2010-05-06
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D.
发明人： ZIEGLER, Paul, D.
IPC分类号： A61N1/362 , A61B5/0205 , G06F19/00
CPC分类号： A61N1/3621 , A61B5/0031 , A61B5/0205 , A61B5/0535 , A61B5/0809 , A61B5/7275 , A61N1/36585 , G06F19/00
摘要： One or more example techniques for monitoring the stroke risk of a patient via a system including an implantable medical device. In some examples, a method including monitoring at least one physiological parameter of a patient via an implantable medical device; determining whether each of a plurality stroke risk factors are present based at least in part on the at least one physiological parameters monitored via the implantable medical device; and generating a stroke risk score based on the stroke risk factors determined to be present, wherein the stroke risk score is reflective of the patient's risk of stroke.
摘要翻译：一种或多种用于通过包括可植入医疗装置的系统监测患者的行程风险的示例性技术。在一些示例中，包括通过可植入医疗装置监测患者的至少一个生理参数的方法; 至少部分地基于经由所述可植入医疗装置监测的所述至少一个生理参数，确定是否存在多个中风危险因素中的每一个; 以及基于确定存在的中风危险因素产生中风风险评分，其中所述卒中风险评分反映所述患者的卒中风险。

8. 发明申请

WO2006104844A3 SYSTEM FOR CHARACTERIZING CHRONIC PHYSIOLOGICAL DATA 审中-公开
公开(公告)号：WO2006104844A3
公开(公告)日：2006-10-05
申请号：PCT/US2006/010589
申请日：2006-03-23
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , SARKAR, Shantanu
发明人： ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , SARKAR, Shantanu
IPC分类号： A61B5/00
摘要： An implantable medical device (IMD) senses physiological episodes and stores data associated with the physiological episodes in the IMD. The data is then processed based on a pattern of recurrence of the physiological episodes.

9. 发明申请

WO2005105206A1 AUTOMATIC OPTIMIZATION OF LOWR CARDIAC PACING RATE 审中-公开
标题翻译：自动优化LOWR CARDIAC PACING RATE
公开(公告)号：WO2005105206A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/011853
申请日：2005-04-08
申请人： MEDTRONIC, INC. , ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , MEHRA, Rahul
发明人： ZIEGLER, Paul, D. , HETTRICK, Douglas, A. , MEHRA, Rahul
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3622
摘要： A method and device for determining an optimal lower rate (100) and adjusting the programmed lower pacing rate to the optimal rate (145) that includes monitoring a parameter (116) in response to therapy delivered (115) at a first rate during a first time period to generate first parameter data (120), and determining whether the therapy was delivered for a predetermined portion of the first time period (117). The parameter is monitored (116) in response to the therapy delivered (115) at a next rate (110) during a next time period (115) to generate next parameter data (116), and a determination is made as to whether the therapy was delivered for a predetermined portion of the next time period (117). A metric corresponding to the first parameter data is determined to generate a first parameter metric (135), and corresponding to the next parameter data to generate a next parameter metric (135) used for determining an optimal therapy delivery rate (140).
摘要翻译：一种用于确定最佳较低速率（100）并且将编程的较低起搏速率调整到最佳速率（145）的方法和装置，其包括响应于在第一次速率期间以第一速率传送（115）的治疗来监视参数（116）产生第一参数数据（120）的时间段，以及确定治疗是否在第一时间段（117）的预定部分被递送。响应于在下一个时间段（115）期间以下一个速率（110）递送的治疗（115）来响应参数（116）以产生下一个参数数据（116），并且确定治疗被递送下一个时间段（117）的预定部分。确定对应于第一参数数据的度量以产生第一参数度量（135），并且对应于下一参数数据以生成用于确定最佳治疗传送率（140）的下一个参数度量（135）。

10. 发明申请

WO2005105205A1 METHOD AND APPARATUS FOR CONTROLLING DELIVERY OF PACING PULSES IN RESPONSE TO INCREASED ECTOPIC FREQUENCY 审中-公开
标题翻译：控制输送脉冲的方法和装置对增加的频率频率的响应
公开(公告)号：WO2005105205A1
公开(公告)日：2005-11-10
申请号：PCT/US2005/012143
申请日：2005-04-08
申请人： MEDTRONIC, INC. , HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , MITTELSTADT, Jacqueline , MEHRA, Rahul
发明人： HETTRICK, Douglas, A. , ZIEGLER, Paul, D. , MITTELSTADT, Jacqueline , MEHRA, Rahul
IPC分类号： A61N1/362
CPC分类号： A61N1/3621
摘要： A method and device for controlling delivery of therapy in an implantable device that includes sensing a plurality of events, detecting whether there is an increase in the frequency of first events of the plurality of events corresponding to onset of a second event of the plurality of sensed events, adjusting parameters associated with delivery of the therapy in response to the detected increased frequency of first sensed events, and delivering the therapy using the adjusted parameters.
摘要翻译：一种用于控制可植入装置中治疗传递的方法和装置，包括感测多个事件，检测是否存在与多个感测的第二事件的开始对应的多个事件的第一事件的频率的增加事件，响应于检测到的第一感测事件的增加的频率调整与治疗的递送相关联的参数，以及使用调整的参数递送治疗。

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