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1. 发明申请

WO2005112587A2 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译： WOUND HEALING POLYMER组合物及其使用方法
公开(公告)号：WO2005112587A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/016678
申请日：2005-05-12
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, G. , GOPALAN, Sindhu, M.
IPC分类号： A61K35/44
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可用于外部伤口敷料中，作为用于将伤口愈合剂递送至内部身体部位的聚合物植入物，或作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的可生物降解聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物和环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比在5:95至95:5范围内形成的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

2. 发明申请

WO2005112587A3 WOUND HEALING POLYMER COMPOSITIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：创伤治疗聚合物组合物及其使用方法
公开(公告)号：WO2005112587A3
公开(公告)日：2009-04-09
申请号：PCT/US2005016678
申请日：2005-05-12
申请人： MEDIVAS LLC , CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
发明人： CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM G , GOPALAN SINDHU M , KATSARAVA RAMAZ
IPC分类号： A61K47/00
CPC分类号： A61K35/44 , A61K9/0024 , A61K38/00 , A61K47/34 , A61K47/59 , A61K47/593 , A61K47/595 , A61L15/26 , A61L15/44 , A61L15/60 , A61L15/64 , A61L26/0019 , A61L26/0066 , A61L31/10 , A61L31/148 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/416 , A61L2300/604 , A61L2300/64 , C08L77/12 , C08L79/02
摘要： The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and/or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyratevalerate copolymers, and copolymers of the cyclic diester monomer, 3(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and e-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
摘要翻译：本发明提供生物活性聚合物组合物，其可配制成通过调节组合物的各种组分以受控的速率释放伤口愈合剂。组合物可以用作外部伤口敷料，作为用于将伤口愈合剂递送到内部身体部位的聚合物植入物，或者作为可植入手术装置的表面上的涂层，以递送共价连接到生物相容的，可生物降解的聚合物和/或嵌入在水凝胶内。还提供了使用本发明生物活性聚合物组合物促进伤口，特别是慢性伤口的自然愈合的方法。可用于形成血液相容的亲水层或涂层的可生物降解的共聚物聚酯的实例包括共聚酯酰胺，共聚酯氨基甲酸酯，乙交酯 - 丙交酯共聚物，乙交酯 - 己内酯共聚物，聚-3-羟基丁酸戊酯共聚物，以及环状二酯单体的共聚物， 3（S）[（烷氧基羰基）甲基] -1,4-二恶烷-2,5-二酮与L-丙交酯。乙交酯 - 丙交酯共聚物包括使用乙醇酸与L-乳酸的单体摩尔比为5:95至95:5的聚（乙交酯-L-丙交酯）共聚物，优选乙醇酸与L-乳酸的单体摩尔比，乳酸范围为45:65至95:5。乙交酯 - 己内酯共聚物包括乙交酯和ε-己内酯嵌段共聚物，例如Monocryl或Poliglecaprone。

3. 发明申请

WO2004075781A3 BIOACTIVE STENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：生物手术及其使用方法
公开(公告)号：WO2004075781A3
公开(公告)日：2006-08-03
申请号：PCT/US2004005940
申请日：2004-02-26
申请人： MEDIVAS LLC , CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM GORDON , GOPALAN SINDHU M
发明人： CARPENTER KENNETH W , ZHANG HUASHI , MCCARTHY BRENDAN J , SZINAI ISTVAN , TURNELL WILLIAM GORDON , GOPALAN SINDHU M
IPC分类号： A61F2/00 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/148 , A61L2300/25 , A61L2300/604 , A61L2300/80
摘要： The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.
摘要翻译：本发明基于以下发现：支架可以涂覆有促进支架植入部位的内源性愈合过程的可生物降解的生物活性聚合物。聚合物随时间生物降解，释放在动脉中建立或重建自然愈合过程的药剂。优选地，在动脉损伤时植入支架，例如在血管成形术时，为了保护损伤的动脉免受引起平滑肌细胞增殖的有害的血液传导因素的侵害。

4. 发明申请

WO2004075781A2 BIOACTIVE STENTS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：生物手术及其使用方法
公开(公告)号：WO2004075781A2
公开(公告)日：2004-09-10
申请号：PCT/US2004/005940
申请日：2004-02-26
申请人： MEDIVAS, LLC , CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, Gordon , GOPALAN, Sindhu, M.
发明人： CARPENTER, Kenneth, W. , ZHANG, Huashi , McCARTHY, Brendan, J. , SZINAI, Istvan , TURNELL, William, Gordon , GOPALAN, Sindhu, M.
IPC分类号： A61F
CPC分类号： A61L31/16 , A61K31/685 , A61K31/7048 , A61L31/10 , A61L31/148 , A61L2300/25 , A61L2300/604 , A61L2300/80
摘要： The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.
摘要翻译：本发明基于以下发现：支架可以涂覆有促进支架植入部位的内源性愈合过程的可生物降解的生物活性聚合物。聚合物随时间生物降解，释放在动脉中建立或重建自然愈合过程的药剂。优选地，在动脉损伤时植入支架，例如在血管成形术时，为了保护损伤的动脉免受引起平滑肌细胞增殖的有害的血液传导因素的侵害。

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