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1. 发明申请

WO2008024754A9 NUCLEIC ACID ARRAY WITH RELEASABLE NUCLEIC ACID PROBES 审中-公开
公开(公告)号：WO2008024754A9
公开(公告)日：2008-02-28
申请号：PCT/US2007/076391
申请日：2007-08-21
申请人： CNVGENES, INC. , ZAINIEV, Gafur , ZAINIEV, Inlik
发明人： ZAINIEV, Gafur , ZAINIEV, Inlik
IPC分类号： C12M1/34 , G01N33/00 , C07H21/04 , B01D59/42 , G01N21/00 , G01N11/00

2. 发明申请

WO2008024754A2 NUCLEIC ACID ARRAY WITH RELEASABLE NUCLEIC ACID PROBES 审中-公开
标题翻译：核酸序列与可释放的核酸探针
公开(公告)号：WO2008024754A2
公开(公告)日：2008-02-28
申请号：PCT/US2007076391
申请日：2007-08-21
申请人： CNVGENES INC , ZAINIEV GAFUR , ZAINIEV INLIK
发明人： ZAINIEV GAFUR , ZAINIEV INLIK
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , B01J2219/00358 , B01J2219/00644 , B01J2219/00653 , B01J2219/00722 , B01L3/5027 , C12Q2565/125 , C12Q2547/107 , C12Q2537/149
摘要： A process is provided for identifying a complementary target nucleic acid. The process includes the hybridization of a nucleic acid probe to a carrier to form a nucleic acid probe- carrier complex. The complex is placed in a compartment bounded by a media permeable to the nucleic acid probe and exclusive of both the carrier and the complex. The complex is then denatured, with the nucleic acid probe transported through the media and into contact with the target nucleic acid. The nucleic acid probe hybridizes to the complementary target nucleic acid to yield a probe-target double stranded complex. A non-complementary nucleic acid probe, independent probe-target complex is returned to the compartment and given an opportunity to rehybridize to the carrier. A determination as to whether at least one of the complementary target nucleic acid or the carrier is present as a complex provides information as to probe sequences complementary to the target nucleic acid.
摘要翻译：提供了用于鉴定互补靶核酸的方法。该方法包括将核酸探针与载体杂交以形成核酸探针 - 载体复合物。将复合物置于由可渗透核酸探针的介质限定的区域中，并且不包括载体和复合物两者。然后将复合物变性，核酸探针通过培养基传输并与靶核酸接触。核酸探针与互补靶核酸杂交以产生探针 - 靶双链复合物。将非互补核酸探针，独立的探针 - 靶复合物返回到隔室，给予再载体载体的机会。作为复合物存在至少一种互补靶核酸或载体的确定提供了与靶核酸互补的探针序列的信息。

3. 发明申请

WO2008097349A3 NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES 审中-公开
标题翻译：具有固定核酸抗体和互补游离核酸探针的核酸阵列
公开(公告)号：WO2008097349A3
公开(公告)日：2008-10-09
申请号：PCT/US2007076382
申请日：2007-08-21
申请人： CNVGENES INC , ZAINIEV GAFUR , ZAINIEV INLIK
发明人： ZAINIEV GAFUR , ZAINIEV INLIK
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00
CPC分类号： C12Q1/6837 , C12Q2537/161
摘要： A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.
摘要翻译：用于鉴定与靶核酸互补的核酸探针的方法涉及形成点阵列，其中阵列的每个点具有与核酸探针杂交的固定化核酸抗探针。抗探针 - 探针复合物阵列变性。然后将核酸探针移入包含靶核酸的靶室中。建立杂交条件以在目标核酸具有互补序列的情况下在目标核酸与核酸探针之间形成双链复合。允许与靶核酸不互补的核酸探针与抗探针重新杂交。确定暴露于与靶核酸不互补的核酸探针的抗探针点是否在暴露于非互补核酸探针后是单链提供关于靶核酸序列的信息。

4. 发明申请

WO2008097349A2 NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES 审中-公开
标题翻译：具有固定核酸抗原探针和完全免费的核酸探针的核酸阵列
公开(公告)号：WO2008097349A2
公开(公告)日：2008-08-14
申请号：PCT/US2007/076382
申请日：2007-08-21
申请人： CNVGENES, INC. , ZAINIEV, Gafur , ZAINIEV, Inlik
发明人： ZAINIEV, Gafur , ZAINIEV, Inlik
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6837 , C12Q2537/161
摘要： A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.
摘要翻译：用于鉴定靶核酸的互补核酸探针的方法包括形成阵列阵列，其中阵列的每个点具有与核酸探针杂交的固定的核酸抗探针。抗探针 - 探针复合物的阵列变性。然后将核酸探针移动到包括靶核酸的靶室中。建立杂交条件以在目标核酸具有序列互补性的情况下在靶核酸和核酸探针之间形成双链复合。允许与靶核酸不互补的核酸探针用抗探针重新杂化。确定在暴露于非互补核酸探针之后，暴露于与靶核酸不互补的核酸探针的抗探针点是单链提供关于靶核酸序列的信息。

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