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    • 1. 发明申请
    • NUCLEIC ACID ARRAY WITH RELEASABLE NUCLEIC ACID PROBES
    • 核酸序列与可释放的核酸探针
    • WO2008024754A2
    • 2008-02-28
    • PCT/US2007076391
    • 2007-08-21
    • CNVGENES INCZAINIEV GAFURZAINIEV INLIK
    • ZAINIEV GAFURZAINIEV INLIK
    • C12Q1/68
    • C12Q1/6813B01J2219/00358B01J2219/00644B01J2219/00653B01J2219/00722B01L3/5027C12Q2565/125C12Q2547/107C12Q2537/149
    • A process is provided for identifying a complementary target nucleic acid. The process includes the hybridization of a nucleic acid probe to a carrier to form a nucleic acid probe- carrier complex. The complex is placed in a compartment bounded by a media permeable to the nucleic acid probe and exclusive of both the carrier and the complex. The complex is then denatured, with the nucleic acid probe transported through the media and into contact with the target nucleic acid. The nucleic acid probe hybridizes to the complementary target nucleic acid to yield a probe-target double stranded complex. A non-complementary nucleic acid probe, independent probe-target complex is returned to the compartment and given an opportunity to rehybridize to the carrier. A determination as to whether at least one of the complementary target nucleic acid or the carrier is present as a complex provides information as to probe sequences complementary to the target nucleic acid.
    • 提供了用于鉴定互补靶核酸的方法。 该方法包括将核酸探针与载体杂交以形成核酸探针 - 载体复合物。 将复合物置于由可渗透核酸探针的介质限定的区域中,并且不包括载体和复合物两者。 然后将复合物变性,核酸探针通过培养基传输并与靶核酸接触。 核酸探针与互补靶核酸杂交以产生探针 - 靶双链复合物。 将非互补核酸探针,独立的探针 - 靶复合物返回到隔室,给予再载体载体的机会。 作为复合物存在至少一种互补靶核酸或载体的确定提供了与靶核酸互补的探针序列的信息。
    • 2. 发明申请
    • NUCLEIC ACID ARRAY HAVING FIXED NUCLEIC ACID ANTI-PROBES AND COMPLEMENTARY FREE NUCLEIC ACID PROBES
    • 具有固定核酸抗体和互补游离核酸探针的核酸阵列
    • WO2008097349A3
    • 2008-10-09
    • PCT/US2007076382
    • 2007-08-21
    • CNVGENES INCZAINIEV GAFURZAINIEV INLIK
    • ZAINIEV GAFURZAINIEV INLIK
    • C12Q1/68C12M1/34C12M3/00
    • C12Q1/6837C12Q2537/161
    • A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic acid probes are then moved into a target chamber that includes a target nucleic acid. Hybridization conditions are established to form double-stranded complexation between the target nucleic acid and nucleic acid probes in instances where the target nucleic acid has a sequence complementary. The nucleic acid probes noncomplementary to the target nucleic acid are allowed to rehybridize with anti-probes. Determining whether the anti-probe spots exposed to nucleic acid probes noncomplementary to the target nucleic acid are single stranded after exposure to noncomplementary nucleic acid probes provides information as to target nucleic acid sequence.
    • 用于鉴定与靶核酸互补的核酸探针的方法涉及形成点阵列,其中阵列的每个点具有与核酸探针杂交的固定化核酸抗探针。 抗探针 - 探针复合物阵列变性。 然后将核酸探针移入包含靶核酸的靶室中。 建立杂交条件以在目标核酸具有互补序列的情况下在目标核酸与核酸探针之间形成双链复合。 允许与靶核酸不互补的核酸探针与抗探针重新杂交。 确定暴露于与靶核酸不互补的核酸探针的抗探针点是否在暴露于非互补核酸探针后是单链提供关于靶核酸序列的信息。
    • 4. 发明申请
    • DESIGN OF HIGH POWER PULSER FLASH LAMPS
    • 高功率脉冲闪光灯的设计
    • WO2007025208A3
    • 2008-01-03
    • PCT/US2006033355
    • 2006-08-25
    • LIGHTSTREAM TECHNOLOGIESLANTIS ROBERT MZLOTIN BORISULAN PETERPROSEANIC VLADIMIRZAINIEV GAFUR
    • LANTIS ROBERT MZLOTIN BORISULAN PETERPROSEANIC VLADIMIRZAINIEV GAFUR
    • H01J1/00
    • H01J61/80H01J5/48H01J61/073H01J61/30H01J61/33H01J61/34H01J61/50H01J61/52H01J61/90H01J61/95
    • Broadband output high power pulsed flash lamps are useful in many applications, and when specifically optimized, can become an excellent source of ultraviolet (UV) light, which is particularly useful for photo-chemically-induced materials processing applications. Multiple factors involved with the production of high-energy light pulses can in certain cases adversely affect the ultraviolet lamp operation, thereby resulting in the development of micro cracks in lamp envelopes and subsequent limitation in lamp lifetime. Similar factors can be responsible for an increased absorption of UV radiation by lamp components and degradation of lamp efficiency. This invention describes new pulsed flash lamp designs that enable a new generation of high power and performance as required by, for example, many large-scale photo-processing applications. This invention uniquely and advantageously mitigates the development of micro-cracks and failure, and produces dramatically improved electrical efficiency, stability of lamp optical characteristics, and service lifetime.
    • 宽带输出高功率脉冲闪光灯在许多应用中是有用的,当被特别优化时,可以成为紫外线(UV)光的优良来源,这对于光化学诱导的材料处理应用尤其有用。 与高能量光脉冲相关的多个因素在某些情况下可能对紫外线灯的操作产生不利影响,从而导致灯泡内的微裂纹的发展和灯寿命的限制。 类似的因素可能导致灯组件对UV辐射的吸收增加和灯效率的降低。 本发明描述了新的脉冲闪光灯设计,其能够实现例如许多大规模照相处理应用所要求的新一代高功率和性能。 本发明独特且有利地减轻微裂纹和破裂的发展,并且产生显着提高的电效率,灯的光学特性的稳定性和使用寿命。