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1. 发明专利

JP2008237929A Improved electrical impedance method and apparatus for detecting and diagnosing diseases 审中-公开
标题翻译：改进的电气阻抗方法和装置，用于检测和诊断疾病
公开(公告)号：JP2008237929A
公开(公告)日：2008-10-09
申请号：JP2008136378
申请日：2008-05-26
申请人： Z-Tech (Canada) Inc , ズィー−テック (カナダ) インコーポレイテッドZ−Tech (Canada) Inc.
发明人： ORGAN LESLIE W , SMITH KENNETH C , SAFAEE-RAD REZA , GRAOVAC MILAN , DARMOS GEORGE P , GAVRILOV ILYA
IPC分类号： A61B5/05 , A61B5/0408 , A61B5/0478 , A61B5/0492 , A61B5/053
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/0209 , A61B2562/046
摘要： PROBLEM TO BE SOLVED: To provide an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. SOLUTION: The diagnosing method is provided for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于通过使用多个电阻抗测量来检测和诊断活生物体中的疾病状态的改进的方法和装置。解决方案：提供诊断方法用于诊断人乳腺中疾病状态的改进的电极阵列，并且公开了将阵列应用于乳房的方法，其确保从第一身体部分尽可能精确地和可重复地对应于从另一个同源的第二身体部分获得的多个阻抗测量。公开了基于同源电差分析的许多诊断方法，包括通过与预先建立的阈值比较来计算用于指示疾病状态的多个度量，以及用于指示位置的多个图形显示器的构造疾病到身体部位。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2004520108A Improved electrical impedance method and apparatus for detecting and diagnosing a disease 审中-公开
公开(公告)号：JP2004520108A
公开(公告)日：2004-07-08
申请号：JP2002553983
申请日：2001-12-14
申请人：ズィー−テック (カナダ) インコーポレイテッドZ−Tech (Canada) Inc.
发明人：ダブリュオーガン，レスリー , ガヴリロフ，イルヤ , グラオヴァク，ミラン , サファイー−ラド，レザ , シースミス，ケネス , ピーダーモス，ジョージ
IPC分类号： A61B5/05 , A61B5/0408 , A61B5/0478 , A61B5/053
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/0209 , A61B2562/046
摘要：発明は、複数の電気インピーダンス測定値を用いることにより生体の疾患状態を検出及び診断するための改善された方法及び装置に関し、特に、人間の乳房における疾患状態の存在を診断するための改善された電極アレイを提供し、第１の身体部位から得られる多数のインピーダンス値が、別の、相同の、第２の身体部位から得られる多数のインピーダンス測定値に可能な限り正確に、高い再現性をもって、対応することを確実にする、乳房へのアレイの貼付方法を開示する。あらかじめ確立された閾値との比較により疾患状態を表示するために用いられる多くの計量の計算及び身体部位の扇形セクターに疾患の位置を示すための多くのグラフィック表示の構成を含む、相同電気的差解析に基づく、多くの診断方法が開示される。

3. 发明专利

JP2010523067A Protection circuit for the compensation level variable control to reduce the load of the resistance signal and capacitive signal 有权
公开(公告)号：JP2010523067A
公开(公告)日：2010-07-08
申请号：JP2010501336
申请日：2008-03-31
申请人：ズィー−テック (カナダ) インコーポレイテッドZ−Tech (Canada) Inc.
发明人：アイアンストーン、ジョエル , アルトメイド、モリー , カーレススミス、ケニス , チャン、フランク , シンファン、チャン , ワン、デイビッド
IPC分类号： H03H11/28
CPC分类号： H03F1/56 , H03F1/14
摘要：種々の実施形態において、本開示は、寄生インピーダンスによって分路される信号伝送チャネルにおける寄生インピーダンス信号の負荷を低減するための動作保護回路および方法に関する。信号伝送チャネルに発生する電気信号によって、リーク電流が寄生インピーダンスを介して流れる。種々の実施形態において、動作保護回路は増幅器およびインピーダンスを備え、インピーダンスの一端は信号伝送チャネルに連結される。増幅器の入力は信号伝送チャネルに連結され、増幅器の出力はインピーダンスの他端に連結されてインピーダンスに補償電流を流す。増幅器のゲインおよびインピーダンスの値は、補償電流が、リーク電流量に実質的に等しい量を有するように選択される。

4. 发明申请

US20040243019A1 Weighted gradient method and system for diagnosing disease 审中-公开
标题翻译：加权梯度法和诊断疾病系统
公开(公告)号：US20040243019A1
公开(公告)日：2004-12-02
申请号：US10806186
申请日：2004-03-23
申请人： Z-Tech (Canada) Inc.
发明人： Milan Graovac , Zoran Pavlovic
IPC分类号： A61B005/05
CPC分类号： A61B5/0531
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating the effect of the electrical property of each finite element at any one of a plurality of electrodes on the periphery of the body part as a function of the position of the finite element within the grid. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算在身体部位的周边上的多个电极中的任一个上的每个有限元的电性质的影响作为一个功能的网格内有限元的位置。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

5. 发明申请

US20040243018A1 Apparatus and method for determining adequacy of electrode-to-skin contact and electrode quality for bioelectrical measurements 审中-公开
标题翻译：用于确定电极对皮肤接触的充分性和用于生物电测量的电极质量的装置和方法
公开(公告)号：US20040243018A1
公开(公告)日：2004-12-02
申请号：US10724458
申请日：2003-11-28
申请人： Z-Tech (Canada) Inc.
发明人： Leslie William Organ , Kenneth Carless Smith , Joel Steven Ironstone
IPC分类号： A61B005/05
CPC分类号： A61B5/4312 , A61B5/04085 , A61B5/0424 , A61B5/053 , A61B5/0531 , A61B5/6843 , A61B10/0041 , A61B2017/00026 , A61B2018/0016 , A61B2090/065 , A61B2562/0219
摘要： A system and method for diagnosing the possibility of disease in a body part is described. The system includes an electrode array containing a plurality of electrodes capable of being electrically coupled to the body part. A first measurement unit makes an electrode assessment measurement with the electrode array. An electrode assessment module determines whether the plurality of electrodes are suitably coupled to the body part based on the electrode assessment measurement. If there is suitable coupling, a second measurement unit makes a diagnosis measurement with the electrode array. An electrical property module obtains an electrical property of the body part, such as impedance, based on the diagnosis measurement. A diagnosis module diagnoses the possibility of disease based on the measured electrical property.
摘要翻译：描述了用于诊断身体部位中疾病可能性的系统和方法。该系统包括电极阵列，其包含能够电耦合到身体部分的多个电极。第一测量单元用电极阵列进行电极评估测量。电极评估模块基于电极评估测量来确定多个电极是否适当地耦合到身体部位。如果有合适的耦合，则第二测量单元用电极阵列进行诊断测量。电气性能模块基于诊断测量获得身体部位的电气特性，例如阻抗。诊断模块基于测量的电气特性来诊断疾病的可能性。

6. 发明申请

US20040210157A1 Electrical impedance method and apparatus for detecting and diagnosing diseases 审中-公开
标题翻译：用于检测和诊断疾病的电阻抗方法和装置
公开(公告)号：US20040210157A1
公开(公告)日：2004-10-21
申请号：US10841552
申请日：2004-05-10
申请人： Z-TECH (CANADA) INC.
发明人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
IPC分类号： A61B005/05
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.
摘要翻译：本发明涉及通过使用多个电阻抗测量来检测和诊断活体中疾病状态的改进方法和装置。特别地，本发明提供了用于诊断人乳房中疾病状态的改善的电极阵列，并且公开了将阵列应用于乳房的方法，其确保从第一身体部位获得的多个阻抗测量值尽可能精确地和可重复地对应于从另一个同源的第二身体部分获得的多个阻抗测量。公开了基于同源电差分析的许多诊断方法，包括通过与预先建立的阈值比较来计算用于指示疾病状态的多个度量，以及用于指示位置的多个图形显示器的构造疾病到身体部位。

7. 发明申请

US20040167422A1 Breast electrode array and method of analysis for detecting and diagnosing diseases 审中-公开
标题翻译：乳房电极阵列及其分析方法，用于检测和诊断疾病
公开(公告)号：US20040167422A1
公开(公告)日：2004-08-26
申请号：US10724357
申请日：2003-12-01
申请人： Z-Tech (Canada) Inc.
发明人： Leslie W. Organ , Reza Safaee-Rad , Milan Graovac , Kenneth Carless Smith , Joel Steven Ironstone
IPC分类号： A61B005/053
CPC分类号： A61B5/4312 , A61B5/053 , A61B5/061 , A61B2562/046
摘要： A breast electrode array and method of analysis for detecting and diagnosing diseases. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. Diagnostic methods based on homologous electrical difference analysis are also provided, utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
摘要翻译：一种乳房电极阵列及其分析方法，用于检测和诊断疾病。特别地，电极阵列具有主体，从主体延伸的多个柔性臂以及由多个柔性臂设置的多个外部电极，以及多个内部电极，设置在至少一个柔性臂和位于主体和外部电极之间，并且外部电极和内部电极布置在臂上以获得各个电极之间的阻抗测量。还提供了基于同源电差分析的诊断方法，利用内外电极在进行阻抗测量时产生的不同拓扑结构。

8. 发明申请

US20040210158A1 Electrical impedance method and apparatus for detecting and diagnosing diseases 审中-公开
公开(公告)号：US20040210158A1
公开(公告)日：2004-10-21
申请号：US10841565
申请日：2004-05-10
申请人： Z-TECH (CANADA) INC.
发明人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
IPC分类号： A61B005/05
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.

9. 发明申请

US20040073131A1 Electrical impedance method and apparatus for detecting and diagnosing diseases 审中-公开
公开(公告)号：US20040073131A1
公开(公告)日：2004-04-15
申请号：US10705988
申请日：2003-11-13
申请人： Z-TECH (CANADA) INC.
发明人： Leslie W. Organ , Kenneth C. Smith , Reza Safaee-Rad , Milan Graovac , George P. Darmos , Ilya Gavrilov
IPC分类号： A61B005/05
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/046
摘要： The present invention relates to an improved method and apparatus for detecting and diagnosing disease states in a living organism by using a plurality of electrical impedance measurements. In particular, the invention provides for an improved electrode array for diagnosing the presence of a disease state in the human breast, and discloses a method of application of the array to the breast that ensures that the multiplicity of impedance measurements obtained from a first body part correspond as precisely and reproducibly as possible to the multiplicity of impedance measurements that are obtained from another, homologous, second body part. A number of diagnostic methods based on homologous electrical difference analysis are disclosed, including the calculation of a number of metrics used to indicate disease states by comparison with pre-established threshold values, and the construction of a number of graphical displays for indicating the location of disease to a body part sector.

10. 发明申请

WO2004084724A1 DIAGNOSIS OF DISEASE BY DETERMINATION OF ELECTRICAL NETWORK PROPERTIES OF A BODY PART 审中-公开
标题翻译：通过确定身体部位的电气网络特性来诊断疾病
公开(公告)号：WO2004084724A1
公开(公告)日：2004-10-07
申请号：PCT/CA2004/000458
申请日：2004-03-26
申请人： Z-TECH (CANADA) INC. , SEMLYEN, Adam , GRAOVAC, Milan
发明人： SEMLYEN, Adam , GRAOVAC, Milan
IPC分类号： A61B5/053
CPC分类号： A61B5/0536
摘要： A system and method for detecting and diagnosing disease states in a body part is described. The method is based on a set of electrical impedance measurements taken on the surface of a body part and a representation of the body part in the form of a network of impedances that would result in the same surface measurements as the actual body part. The system includes an electrical data unit for measuring electrical data of the body part, the electrical data unit having a plurality of N e electrodes. The system also includes a network module for representing the body part by a network, the network having external nodes and internal nodes connected by current pathways. The system further includes an electrical properties module for determining electrical properties of the pathways using the measured electrical data, and a diagnosis module for utilizing the electrical properties to diagnose the possibility of disease in the body part. It is well known, for example, that tissue electrical impedance changes with malignancy.
摘要翻译：描述用于检测和诊断身体部位中的疾病状态的系统和方法。该方法基于在身体部分的表面上进行的一组电阻抗测量，以及以导致与实际身体部分相同的表面测量的阻抗网络形式的身体部位的表示。该系统包括用于测量身体部位的电气数据的电子数据单元，该电子数据单元具有多个Ne电极。该系统还包括用于通过网络表示身体部位的网络模块，该网络具有通过当前路径连接的外部节点和内部节点。该系统还包括用于使用所测量的电气数据确定通路的电气特性的电气特性模块，以及用于利用电气特性来诊断身体部位疾病可能性的诊断模块。众所周知，例如，组织电阻抗随恶性变化而变化。

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