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1. 发明申请

WO2004084724A1 DIAGNOSIS OF DISEASE BY DETERMINATION OF ELECTRICAL NETWORK PROPERTIES OF A BODY PART 审中-公开
标题翻译：通过确定身体部位的电气网络特性来诊断疾病
公开(公告)号：WO2004084724A1
公开(公告)日：2004-10-07
申请号：PCT/CA2004/000458
申请日：2004-03-26
申请人： Z-TECH (CANADA) INC. , SEMLYEN, Adam , GRAOVAC, Milan
发明人： SEMLYEN, Adam , GRAOVAC, Milan
IPC分类号： A61B5/053
CPC分类号： A61B5/0536
摘要： A system and method for detecting and diagnosing disease states in a body part is described. The method is based on a set of electrical impedance measurements taken on the surface of a body part and a representation of the body part in the form of a network of impedances that would result in the same surface measurements as the actual body part. The system includes an electrical data unit for measuring electrical data of the body part, the electrical data unit having a plurality of N e electrodes. The system also includes a network module for representing the body part by a network, the network having external nodes and internal nodes connected by current pathways. The system further includes an electrical properties module for determining electrical properties of the pathways using the measured electrical data, and a diagnosis module for utilizing the electrical properties to diagnose the possibility of disease in the body part. It is well known, for example, that tissue electrical impedance changes with malignancy.
摘要翻译：描述用于检测和诊断身体部位中的疾病状态的系统和方法。该方法基于在身体部分的表面上进行的一组电阻抗测量，以及以导致与实际身体部分相同的表面测量的阻抗网络形式的身体部位的表示。该系统包括用于测量身体部位的电气数据的电子数据单元，该电子数据单元具有多个Ne电极。该系统还包括用于通过网络表示身体部位的网络模块，该网络具有通过当前路径连接的外部节点和内部节点。该系统还包括用于使用所测量的电气数据确定通路的电气特性的电气特性模块，以及用于利用电气特性来诊断身体部位疾病可能性的诊断模块。众所周知，例如，组织电阻抗随恶性变化而变化。

2. 发明申请

WO2006056074A1 WEIGHTED GRADIENT METHOD AND SYSTEM FOR DIAGNOSING DISEASE 审中-公开
标题翻译：用于诊断疾病的加权梯度方法和系统
公开(公告)号：WO2006056074A1
公开(公告)日：2006-06-01
申请号：PCT/CA2005/001800
申请日：2005-11-28
申请人： Z-TECH (CANADA) INC. , GRAOVAC, Milan , MARTENS, James , PAVLOVIC, Zoran , IRONSTONE, Joel
发明人： GRAOVAC, Milan , MARTENS, James , PAVLOVIC, Zoran , IRONSTONE, Joel
IPC分类号： A61B5/05 , A61B5/053
CPC分类号： A61B5/0536 , A61B5/055
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating the effect of the electrical property of each finite element on the voltage between two electrodes when a known current flows between corresponding electrodes through the body part. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算当已知电流通过身体部分在相应的电极之间流动时，每个有限元的电性质对两个电极之间的电压的影响。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

3. 发明申请

WO2004049936A3 IMPROVED BREAST ELECTRODE ARRAY AND METHOD OF ANALYSIS FOR DETECTING AND DIAGNOSING DISEASES 审中-公开
标题翻译：改进的乳腺电极阵列及检测和诊断疾病的分析方法
公开(公告)号：WO2004049936A3
公开(公告)日：2004-08-19
申请号：PCT/CA0301833
申请日：2003-12-01
申请人： Z TECH CANADA INC , ORGAN LESLIE W , SAFAEE-RAD REZA , GRAOVAC MILAN , SMITH KENNETH CARLESS , IRONSTONE JOEL STEVEN
发明人： ORGAN LESLIE W , SAFAEE-RAD REZA , GRAOVAC MILAN , SMITH KENNETH CARLESS , IRONSTONE JOEL STEVEN
IPC分类号： A61B5/053
CPC分类号： A61B5/4312 , A61B5/053 , A61B5/061 , A61B2562/0209 , A61B2562/046
摘要： This invention provides for an improved breast electrode array and method of analysis for detecting and diagnosing diseases, particularly using the improved electrode array of this invention. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. In one aspect of the invention, at least one of the outer electrodes is spaced from the body greater than the other outer electrodes. In a further aspect of the invention, at least one of the inner electrodes is spaced from the body greater than the other inner electrodes, and the at least one inner electrode is provided on the flexible arm having the at least one outer electrode. A number of diagnostic methods based on homologous electrical difference analysis are also disclosed utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
摘要翻译：本发明提供了改进的用于检测和诊断疾病的乳房电极阵列和分析方法，特别是使用本发明的改进的电极阵列。特别地，电极阵列具有主体，从主体延伸的多个柔性臂以及由多个柔性臂提供的多个外部电极以及设置在至少一个柔性臂上的多个内部电极，以及位于主体和外部电极之间的中间，并且外部电极和内部电极被布置在臂上以获得各个电极之间的阻抗测量结果。在本发明的一个方面中，至少一个外电极与本体间隔开的距离大于其他外电极。在本发明的另一方面中，至少一个内电极与本体间隔开大于其它内电极，并且至少一个内电极设置在具有至少一个外电极的柔性臂上。当采取阻抗测量时，还利用由内电极和外电极产生的不同拓扑结构来公开基于同源电差分析的多种诊断方法。

4. 发明申请

WO2005084539A1 SYSTEM AND METHOD FOR PREBALANCING ELECTRICAL PROPERTIES TO DIAGNOSE DISEASE 审中-公开
标题翻译：用于预测电学特性以诊断疾病的系统和方法
公开(公告)号：WO2005084539A1
公开(公告)日：2005-09-15
申请号：PCT/CA2005/000176
申请日：2005-02-11
申请人： Z-TECH (CANADA) INC. , PAVLOVIC, Zoran , GRAOVAC, Milan , IRONSTONE, Joel
发明人： PAVLOVIC, Zoran , GRAOVAC, Milan , IRONSTONE, Joel
IPC分类号： A61B5/05
CPC分类号： A61B5/053 , G06F19/00
摘要： A system and method for diagnosing the possibility of disease by making electrical measurements in one of a first body part and a second substantially similar body part are described. The present invention balances out differences between homologous body parts that are due to natural factors unrelated to disease, such as differences in size or symmetry between left and right breasts. Once data are prebalanced, statistical analyses can be performed on the data to diagnose disease. The system includes a normalizing module for obtaining a normalizing factors database from a screening population group to account for differences in spatial separation of impedance measurements. Once a set of normalizing factors is obtained, a prebalancing factor can be obtained that can further be used to adjust raw electrical measurements. Normalizing factors are applied to a smaller subset of measurements that are likely to better represent the body part as a whole. This set of measurements is reduced further by eliminating a set of the measurements that can be biased by a presence of a disease in a body part. The remaining measurements for each body part are then averaged to obtain an overall measure of a body part electrical property. The quotient between these measures is then used to adjust raw measurements. The adjusted measurements remove the imbalance that might exist due to natural differences between body parts. Adjusted measurements are then used as an input to other methods to obtain more accurate disease diagnostics.
摘要翻译：描述了通过在第一主体部分和第二基本上相似的身体部分中的一个中进行电测量来诊断疾病可能性的系统和方法。本发明平衡了归因于与疾病无关的自然因素的同源身体部位之间的差异，例如左乳房和右乳房之间的尺寸或对称性的差异。一旦数据进行前期平衡，就可以对数据进行统计分析以诊断疾病。该系统包括归一化模块，用于从筛选群体组获得归一化因子数据库以解决阻抗测量的空间分离的差异。一旦获得了一组归一化因子，就可以获得可以进一步用于调整原始电气测量的预平衡因子。归一化因子被应用于可能更好地代表身体整体的较小的测量子集。通过消除可以通过身体部位中的疾病的存在而偏移的一组测量来进一步减少该组测量。然后对每个身体部位的剩余测量值进行平均，以获得身体部位电气性质的总体度量。然后使用这些措施之间的商来调整原始测量。调整后的测量可以消除由于身体部位之间的自然差异而可能存在的不平衡。然后将调整后的测量值用作其他方法的输入，以获得更准确的疾病诊断。

5. 发明申请

WO02053028A8 ELECTRICAL IMPEDANCE METHOD AND APPARATUS FOR DETECTING AND DIAGNOSING DISEASES 审中-公开
标题翻译：用于检测和诊断疾病的电气阻抗方法和装置
公开(公告)号：WO02053028A8
公开(公告)日：2002-12-05
申请号：PCT/CA0101788
申请日：2001-12-14
申请人： Z TECH CANADA INC , ORGAN LESLIE W , SMITH KENNETH C , SAFAEE-RAD REZA , GRAOVAC MILAN , DARMOS GEORGE P , GAVRILOV ILYA
发明人： ORGAN LESLIE W , SMITH KENNETH C , SAFAEE-RAD REZA , GRAOVAC MILAN , DARMOS GEORGE P , GAVRILOV ILYA
IPC分类号： A61B5/05 , A61B5/0408 , A61B5/0478 , A61B5/053
CPC分类号： A61B5/0536 , A61B5/04085 , A61B2562/0209 , A61B2562/046

6. 发明申请

WO2004084723A1 WEIGHTED GRADIENT METHOD AND SYSTEM FOR DIAGNOSING DISEASE 审中-公开
标题翻译：用于诊断疾病的加权梯度方法和系统
公开(公告)号：WO2004084723A1
公开(公告)日：2004-10-07
申请号：PCT/CA2004/000450
申请日：2004-03-25
申请人： Z-TECH (CANADA) INC. , GRAOVAC, Milan , PAVLOVIC, Zoran
发明人： GRAOVAC, Milan , PAVLOVIC, Zoran
IPC分类号： A61B5/053
CPC分类号： A61B5/0536 , A61B6/502 , A61B8/0825
摘要： A method for detecting and diagnosing disease states in a body part is described. The method starts with a preparatory step of modeling the body part as a grid of many finite elements, then calculating the effect of the electrical property of each finite element at any one of a plurality of electrodes on the periphery of the body part as a function of the position of the finite element within the grid. This is termed the weight (influence) of the element. With this baseline information, electrical impedance measurements made at the plurality of electrodes on the periphery of the body part can be used in a diagnostic module to calculate a Weighted Element Value (WEVal) for each element. In a preferred embodiment of invention, the difference in WEVal magnitude between corresponding elements of homologous body parts serves as an indicator of the presence of disease.
摘要翻译：描述了用于检测和诊断身体部位中的疾病状态的方法。该方法从将身体部分建模为许多有限元的网格的准备步骤开始，然后计算在身体部位的周边上的多个电极中的任一个上的每个有限元的电性质的影响作为一个功能的网格内有限元的位置。这被称为元件的重量（影响）。利用该基线信息，可以在诊断模块中使用在身体部位的周边上的多个电极处进行的电阻抗测量来计算每个元件的加权元素值（WEVal）。在本发明的优选实施方案中，同源体部分的相应元件之间的WEVal量值的差异用作疾病存在的指标。

7. 发明申请

WO2004049936A2 IMPROVED BREAST ELECTRODE ARRAY AND METHOD OF ANALYSIS FOR DETECTING AND DIAGNOSING DISEASES 审中-公开
标题翻译：改进的乳腺电极阵列和检测和诊断疾病分析方法
公开(公告)号：WO2004049936A2
公开(公告)日：2004-06-17
申请号：PCT/CA2003/001833
申请日：2003-12-01
申请人： Z-TECH (CANADA) INC. , ORGAN, Leslie, W. , SAFAEE-RAD, Reza , GRAOVAC, Milan , SMITH, Kenneth, Carless , IRONSTONE, Joel, Steven
发明人： ORGAN, Leslie, W. , SAFAEE-RAD, Reza , GRAOVAC, Milan , SMITH, Kenneth, Carless , IRONSTONE, Joel, Steven
IPC分类号： A61B5/053
CPC分类号： A61B5/4312 , A61B5/053 , A61B5/061 , A61B2562/0209 , A61B2562/046
摘要： This invention provides for an improved breast electrode array and method of analysis for detecting and diagnosing diseases, particularly using the improved electrode array of this invention. In particular, the electrode array has a body, a plurality of flexible arms extending from the body, and a plurality of outer electrodes provided by the plurality of flexible arms, and a plurality of inner electrodes provided on at least one of the flexible arms and positioned partway between the body and the outer electrodes, and the outer electrodes and the inner electrodes are arranged on the arms to obtain impedance measurements between respective electrodes. In one aspect of the invention, at least one of the outer electrodes is spaced from the body greater than the other outer electrodes. In a further aspect of the invention, at least one of the inner electrodes is spaced from the body greater than the other inner electrodes, and the at least one inner electrode is provided on the flexible arm having the at least one outer electrode. A number of diagnostic methods based on homologous electrical difference analysis are also disclosed utilizing the different topologies created by the inner and outer electrodes when taking impedance measurements.
摘要翻译：本发明提供了改进的乳房电极阵列和用于检测和诊断疾病的分析方法，特别是使用本发明的改进的电极阵列。特别地，电极阵列具有主体，从主体延伸的多个柔性臂和由多个柔性臂设置的多个外部电极，以及多个内部电极，设置在至少一个柔性臂和位于主体和外部电极之间，并且外部电极和内部电极布置在臂上以获得各个电极之间的阻抗测量。在本发明的一个方面，外电极中的至少一个与其它外电极间的距离比其他外电极大。在本发明的另一方面，至少一个内部电极与主体间隔开大于其它内部电极，并且至少一个内部电极设置在具有至少一个外部电极的柔性臂上。当采用阻抗测量时，利用由内外电极产生的不同拓扑结构，还公开了基于同源电差分析的许多诊断方法。

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