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1. 发明授权

US08168179B2 Treatment method using anti-PD-L1 antibody 有权
标题翻译：使用抗PD-L1抗体的治疗方法
公开(公告)号：US08168179B2
公开(公告)日：2012-05-01
申请号：US12538698
申请日：2009-08-10
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译：通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。

2. 发明授权

US08728474B2 Immunopotentiative composition 有权
标题翻译：免疫组成
公开(公告)号：US08728474B2
公开(公告)日：2014-05-20
申请号：US12959307
申请日：2010-12-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译：通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。

3. 发明授权

US07595048B2 Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 有权
标题翻译：通过抑制PD-1诱导的免疫抑制信号治疗癌症的方法
公开(公告)号：US07595048B2
公开(公告)日：2009-09-29
申请号：US10519925
申请日：2003-07-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibit the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译：通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症的底物的筛选方法或通过免疫增强感染治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。抑制PD-1，PD-L1或PD-L2功能的本发明的组合物可用于治疗癌症或感染。

4. 发明申请

US20090297518A1 IMMUNOPOTENTIATIVE COMPOSITION 有权
标题翻译：免疫组化
公开(公告)号：US20090297518A1
公开(公告)日：2009-12-03
申请号：US12538698
申请日：2009-08-10
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , A61P31/18 , A61P31/12
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译：通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。

5. 发明授权

US6010809A Silver halide light-sensitive color photographic material 失效
标题翻译：卤化银感光彩色感光材料
公开(公告)号：US6010809A
公开(公告)日：2000-01-04
申请号：US166943
申请日：1998-06-10
申请人： Fumio Ishii , Shinichi Daiba , Tomohiro Oshiyama , Shigeto Hirabayashi , Yoshiko Iwai
发明人： Fumio Ishii , Shinichi Daiba , Tomohiro Oshiyama , Shigeto Hirabayashi , Yoshiko Iwai
IPC分类号： G03C7/30 , G03C7/32 , G03C7/34 , G03C7/38 , G03C7/392 , G03C1/04 , G03C1/06
CPC分类号： G03C7/39208 , G03C7/3825 , G03C7/3006 , G03C7/301 , G03C7/3225 , G03C7/344
摘要： A silver halide light-sensitive color photographic material is disclosed. The material comprises thermotropic low molecular crystal. The material is improved in light fastness of a dye image and dye-forming efficiency.
摘要翻译：公开了一种卤化银感光彩色照相材料。该材料包括热致低分子晶体。该材料改善了染料图像的耐光性和染料形成效率。

6. 发明申请

US20060110383A1 Immunopotentiative composition 有权
公开(公告)号：US20060110383A1
公开(公告)日：2006-05-25
申请号：US10519925
申请日：2003-07-02
申请人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku Honjo , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , A61K38/17 , A61K48/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that selects the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for cancer or infection treatment.

7. 发明授权

US06808871B2 Silver halide photographic emulsion 失效
标题翻译：卤化银照相乳剂
公开(公告)号：US06808871B2
公开(公告)日：2004-10-26
申请号：US10266482
申请日：2002-10-08
申请人： Katsuhiko Suzuki , Yoshiko Iwai
发明人： Katsuhiko Suzuki , Yoshiko Iwai
IPC分类号： G03C1005
CPC分类号： G03C7/3022 , G03C1/0051 , G03C1/035 , G03C7/22 , G03C7/39208 , G03C2001/03558
摘要： A silver halide emulsion is disclosed, comprising silver halide grains, wherein at least 50% of total grain projected area is accounted for by tabular grains having an aspect ratio of 10 to 100 and at least 50% by number of total grains is accounted for by tabular grains having at least 30 dislocation lines per grain in the fringe portion of the grain, and the emulsion contains a compound having a function of permitting injection of at least two electrons into silver halide via photoexcitation by a single photon.
摘要翻译：公开了一种卤化银乳剂，其包含卤化银颗粒，其中总颗粒投影面积的至少50％由具有10至100的纵横比的片状颗粒占据，并且至少50％的总颗粒数由片状颗粒在颗粒的边缘部分中每颗粒具有至少30个位错线，并且乳液含有具有通过单个光子通过光激发将至少两个电子注入卤化银的功能的化合物。

8. 发明授权

US06756191B2 Silver halide photographic light-sensitive emulsion and silver halide photographic light-sensitive material using thereof 失效
标题翻译：卤化银照相感光乳剂和使用其的卤化银照相感光材料
公开(公告)号：US06756191B2
公开(公告)日：2004-06-29
申请号：US10199166
申请日：2002-07-19
申请人： Tatsuo Tanaka , Nobuaki Kagawa , Yoshiko Iwai , Tomohiro Oshiyama
发明人： Tatsuo Tanaka , Nobuaki Kagawa , Yoshiko Iwai , Tomohiro Oshiyama
IPC分类号： G03C108
CPC分类号： G03C7/3924 , G03C1/09 , G03C1/127 , G03C1/16 , G03C1/18 , G03C1/20 , G03C1/22 , G03C1/346
摘要： A silver halide photographic light-sensitive emulsion comprising a silver halide and a compound represented by the following Formula (I): wherein each X3 and X4 represents independently N, P, S, Se or Te; each Y1 and Y2 represents independently a group of carbon atoms necessary to complete a 6 to 12 membered heterocyclic ring with X3 and X4.
摘要翻译：包含卤化银和由下式（I）表示的化合物的卤化银照相感光乳剂：其中每个X 3和X 4独立地表示N，P，S，Se或Te; 每个Y 1和Y 2独立地表示完成具有X 3和X 4的6至12元杂环所必需的碳原子团。

9. 发明申请

US20110081341A1 IMMUNOPOTENTIATIVE COMPOSITION 有权
标题翻译：免疫组化
公开(公告)号：US20110081341A1
公开(公告)日：2011-04-07
申请号：US12959307
申请日：2010-12-02
申请人： Tasuku HONJO , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
发明人： Tasuku HONJO , Nagahiro Minato , Yoshiko Iwai , Shiro Shibayama
IPC分类号： A61K39/395 , A61P31/00 , A61P35/00
CPC分类号： C07K16/2818 , A61K9/0019 , A61K31/7088 , A61K38/1774 , A61K38/212 , A61K39/3955 , A61K45/06 , A61K47/02 , A61K47/26 , A61K2039/505 , A61K2039/507 , C07K14/70521 , C07K16/18 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/73 , C07K2317/76 , C07K2319/30 , C12Q1/025 , G01N33/5011 , G01N33/574 , G01N2500/00 , Y02A50/39 , Y02A50/394 , Y02A50/463 , Y02A50/466
摘要： Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibits the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
摘要翻译：通过由PD-1，PD-L1或PD-L2诱导的免疫抑制信号的抑制和使用它们的疗法，包括作为活性成分的免疫增强底物，用于癌症或感染的底物的筛选方法由免疫增强引起的癌症或感染治疗的组合物治疗，用于筛选方法的细胞系，选择用于癌症治疗的底物的评价方法和用于评价方法的癌细胞移植的哺乳动物。抑制PD-1，PD-L1或PD-L2的功能的本发明的组合物可用于治疗癌症或感染。

10. 发明授权

US06376161B1 Image information recording method 失效
标题翻译：图像信息记录方法
公开(公告)号：US06376161B1
公开(公告)日：2002-04-23
申请号：US09799673
申请日：2001-03-07
申请人： Yoshiko Iwai , Shigeto Hirabayashi
发明人： Yoshiko Iwai , Shigeto Hirabayashi
IPC分类号： G03C730
CPC分类号： H04N1/00262 , G03C1/49827 , G03C7/39208 , G03C7/407 , G03C2001/0476 , H04N1/00249
摘要： An image information recording method is disclosed. The method comprises the steps of imagewise exposed to light a silver halide photographic light-sensitive material comprising a support having thereon a light-sensitive layer comprising light-sensitive silver halide and a coupler, color developing the image wise exposed silver halide photographic light-sensitive material, converting the image information formed on the silver halide photographic light-sensitive material to electric information while the light-sensitive material is wetted without a drying and at least a part of developed silver is remained in the light-sensitive material, and recording the image information on another recording medium according as electric image information.
摘要翻译：公开了一种图像信息记录方法。该方法包括以下步骤：将含有感光性卤化银和成色剂的感光层的支持体的卤化银照相感光材料成像曝光，对彩色曝光的卤化银照相感光材料进行彩色显影将形成在卤化银摄影感光材料上的图像信息转换成电信息，同时感光材料被润湿而不干燥，并且至少部分显影的银留在感光材料中，并记录图像信息根据电图像信息在另一记录介质上。

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