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1. 发明专利

IL225406A Therapeutic applications of smad7 未知
公开(公告)号：IL225406A
公开(公告)日：2019-09-26
申请号：IL22540613
申请日：2013-03-21
申请人： UNIV COLORADO REGENTS , XIAO JING WANG , YOSEF REFAELI , QINGHONG ZHANG
发明人： XIAO-JING WANG , YOSEF REFAELI , QINGHONG ZHANG
IPC分类号： A61K38/17 , A61K38/16
摘要： The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.

2. 发明专利

IL225406D0 Therapeutic applications of smad7 未知
公开(公告)号：IL225406D0
公开(公告)日：2013-06-27
申请号：IL22540613
申请日：2013-03-21
申请人： UNIV COLORADO REGENTS , XIAO JING WANG , YOSEF REFAELI , QINGHONG ZHANG
IPC分类号： A61K20060101 , A61K38/16
摘要： The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.

3. 发明授权

US09150831B2 Conditionally immortalized long-term stem cells and methods of making and using such cells 有权
标题翻译：有条件永生化的长期干细胞以及制造和使用这些细胞的方法
公开(公告)号：US09150831B2
公开(公告)日：2015-10-06
申请号：US12701383
申请日：2010-02-05
申请人： John C. Cambier , Yosef Refaeli , Sara Ann Johnson , Brian Curtis Turner
发明人： John C. Cambier , Yosef Refaeli , Sara Ann Johnson , Brian Curtis Turner
IPC分类号： C12N5/0789 , C07K14/47 , C12N15/62 , C12N5/0735
CPC分类号： C12N5/0647 , C07K14/005 , C07K14/4738 , C07K14/4747 , C07K14/82 , C07K2319/10 , C07K2319/50 , C12N5/0635 , C12N5/0636 , C12N5/0646 , C12N15/62 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/48 , C12N2501/606 , C12N2510/04 , C12N2740/16322
摘要： Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
摘要翻译：公开了用于有条件永生化干细胞的方法，包括成体和胚胎干细胞，通过这些方法产生的细胞，使用这种细胞的治疗和实验室或研究方法，以及鉴定与细胞分化和发育相关的化合物或治疗疾病的方法，使用这样的细胞。还描述了急性骨髓性白血病（AML）的小鼠模型和与这种小鼠模型相关的细胞和方法。

4. 发明授权

US06838236B1 VPR function and activity 失效
标题翻译： VPR功能和活动
公开(公告)号：US06838236B1
公开(公告)日：2005-01-04
申请号：US08167608
申请日：1993-12-15
申请人： David B. Weiner , David Nathan Levy , Yosef Refaeli
发明人： David B. Weiner , David Nathan Levy , Yosef Refaeli
IPC分类号： A61K38/00 , A61K47/48 , C07K14/16 , G01N33/569 , C12Q1/70
CPC分类号： C07K14/005 , A61K38/00 , A61K47/62 , C12N2740/16322 , G01N33/56988
摘要： Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized by hyperproliferating undifferentiated cells such as cancer by administering such compositions. Methods of identifying compounds which have anti-HIV activity are disclosed, in particular, methods of identifying compounds which modulate the activity of vpr and of identifying compounds which inhibit vpr binding to the HIV protein gag.
摘要翻译：公开了包含HIV蛋白质vpr或编码vpr的核酸分子的药物组合物。还公开了通过施用这样的组合物治疗患有特征在于通过过度增殖未分化细胞例如癌症的患者的方法。公开了鉴定具有抗HIV活性的化合物的方法，特别是鉴定调节vpr活性的化合物和鉴定抑制vpr与HIV蛋白质凝胶结合的化合物的方法。

5. 发明授权

US5763190A Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein 失效
标题翻译：用于鉴定能够诱导受体复合物的核易位的化合物的方法，所述受体复合物包含II型糖基血糖受体和病毒蛋白R相互作用蛋白
公开(公告)号：US5763190A
公开(公告)日：1998-06-09
申请号：US309644
申请日：1994-09-21
申请人： David B. Weiner , Yosef Refaeli
发明人： David B. Weiner , Yosef Refaeli
IPC分类号： A61K38/00 , A61K38/16 , A61K48/00 , C07K14/16 , G01N33/53 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K38/162 , A61K48/00 , C12N2710/14143 , C12N2740/16322
摘要： Human immunodeficiency virus (HIV)-1, HIV-2, and simian immunodeficiency virus contain, in addition to the canonical gag/pol/env genes, additional small open reading frames encoding gene products, including the 96-amino acid 15-kDa virion associated HIV-1 Vpr gene product. The conservation of the vpr open reading frame in primate lentiviruses suggests that vpr is critical to viral replication. A biologically active recombinant HIV-1 Vpr protein was employed as a ligand to identify its cellular targets. A novel 41-kDa cytosolic protein was identified and termed the viral protein R interacting protein, or Rip-1. Rip-1 displays a wide tissue distribution, including relevant targets of HIV infection. Vpr protein induced nuclear translocation of Rip-1, as did glucocorticoid receptor (GR)-II-stimulating steroids. Vpr and Rip-1 coimmunoprecipitated with the human GR as part of a receptor complex. The present invention discloses methods for the identification of compounds capable of inducing GR-II/Rip-1 receptor complex cytosolic to nuclear translocation.
摘要翻译：除了典型的gag / pol / env基因之外，人类免疫缺陷病毒（HIV）-1，HIV-2和猿猴免疫缺陷病毒还包含编码基因产物的其他小型开放阅读框，包括96-氨基酸15-kDa病毒粒子相关的HIV-1 Vpr基因产物。灵长类动物慢病毒的vpr开放阅读框的保护表明vpr对于病毒复制至关重要。使用生物活性的重组HIV-1 Vpr蛋白作为配体来鉴定其细胞靶标。鉴定了一种新型的41-kDa胞质蛋白，称为病毒蛋白R相互作用蛋白或Rip-1。 Rip-1显示广泛的组织分布，包括HIV感染的相关目标。 Vpr蛋白诱导Rip-1的核易位，糖皮质激素受体（GR）-II刺激类固醇也是如此。 Vpr和Rip-1与作为受体复合物的一部分的人GR共免疫沉淀。本发明公开了鉴定能够诱导细胞核移位的GR-II / Rip-1受体复合物的化合物的方法。

6. 发明授权

US5639598A Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions 失效
标题翻译：用于鉴定能够消除HIV Vpr-Rip-1结合相互作用的抗病毒剂的方法和试剂盒
公开(公告)号：US5639598A
公开(公告)日：1997-06-17
申请号：US246177
申请日：1994-05-19
申请人： David B. Weiner , Yosef Refaeli , David N. Levy
发明人： David B. Weiner , Yosef Refaeli , David N. Levy
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , G01N33/569 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , C07K16/1072 , G01N33/56988 , A61K38/00 , C12N2740/16322 , Y10S514/01
摘要： Human and simian immunodeficiency viruses (HIV/SIVs) contain, in addition to the canonical gag/pol/env genes, additional small open reading frames (ORFs) encoding gene products, including the 96-amino acid 15-kDa virion-associated HIV-1 Vpr gene product. Vpr functions as a regulator of cellular processes related to HIV replication. A biologically active recombinant HIV-1 Vpr protein was employed as a ligand to identify its cognate cellular target(s). A novel 41-kDa cytosolic viral protein R interacting protein, designated Rip-1, was identified using the recited assay. Rip-1 displays a wide-tissue distribution, including relevant targets of HIV infection. HIV-1 Vpr induced nuclear translocation of Rip-1. This invention provides novel biochemical reagents and methods that will facilitate the identification of antiviral agents.
摘要翻译：除了典型的gag / pol / env基因之外，人和猿免疫缺陷病毒（HIV / SIV）还包含编码基因产物的其他小型开放阅读框（ORF），包括96-氨基酸15-kDa病毒体相关的HIV- 1 Vpr基因产物。 Vpr作为与HIV复制有关的细胞过程的调节剂。使用生物活性的重组HIV-1 Vpr蛋白作为配体来鉴定其同源细胞靶标。使用所述测定法鉴定了一种名为Rip-1的新型41-kDa胞质病毒蛋白R相互作用蛋白。 Rip-1显示广泛的组织分布，包括艾滋病毒感染的相关目标。 HIV-1Vpr诱导Rip-1的核易位。本发明提供了促进抗病毒剂鉴定的新型生物化学试剂和方法。

7. 发明授权

US08883507B2 Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells 有权
标题翻译：有条件永生化的长期造血干细胞以及制造和使用这些细胞的方法
公开(公告)号：US08883507B2
公开(公告)日：2014-11-11
申请号：US11583970
申请日：2006-10-18
申请人： John C. Cambier , Yosef Refaeli , Sara Ann Johnson , Brian Curtis Turner
发明人： John C. Cambier , Yosef Refaeli , Sara Ann Johnson , Brian Curtis Turner
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： C12N5/0647 , C07K14/005 , C07K14/4738 , C07K14/4747 , C07K14/82 , C07K2319/10 , C07K2319/50 , C12N5/0635 , C12N5/0636 , C12N5/0646 , C12N15/62 , C12N2501/105 , C12N2501/113 , C12N2501/125 , C12N2501/145 , C12N2501/2303 , C12N2501/2306 , C12N2501/48 , C12N2501/606 , C12N2510/04 , C12N2740/16322
摘要： Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
摘要翻译：公开了用于有条件永生化干细胞的方法，包括成体和胚胎干细胞，通过这些方法产生的细胞，使用这种细胞的治疗和实验室或研究方法，以及鉴定与细胞分化和发育相关的化合物或治疗疾病的方法，使用这样的细胞。还描述了急性骨髓性白血病（AML）的小鼠模型和与这种小鼠模型相关的细胞和方法。

8. 发明申请

US20110218210A1 COMPOUNDS FOR TREATING ABNORMAL CELLULAR PROLIFERATION 审中-公开
标题翻译：用于治疗异常细胞增殖的化合物
公开(公告)号：US20110218210A1
公开(公告)日：2011-09-08
申请号：US12809055
申请日：2008-11-03
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
IPC分类号： A61K31/519 , C12Q1/18 , C07D487/04 , C12N5/095 , C07D221/12 , C07D239/60 , A61K31/473 , A61K31/515 , A61P35/00
CPC分类号： C07D487/04
摘要： Provided herein are compounds, compositions and methods for treating disorders mediated by abnormal cellular proliferation and processes for identifying such compounds.
摘要翻译：本文提供了用于治疗由异常细胞增殖介导的病症的化合物，组合物和方法以及鉴定这些化合物的方法。

9. 发明授权

US5780220A Methods and compositions for inhibiting HIV replication 失效
标题翻译：用于抑制HIV复制的方法和组合物
公开(公告)号：US5780220A
公开(公告)日：1998-07-14
申请号：US382873
申请日：1995-02-03
申请人： David B. Weiner , Yosef Refaeli , David N. Levy
发明人： David B. Weiner , Yosef Refaeli , David N. Levy
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12P21/08 , G01N33/569 , C12Q1/70 , A01N43/04 , A61K31/56 , G01N33/53
CPC分类号： C07K14/005 , C07K16/1072 , G01N33/56988 , A61K38/00 , C12N2740/16322 , Y10S514/01
摘要： A method for treating an individual exposed to or infected with HIV is disclosed which comprises administering to said individual a therapeutically effective amount of one or more compounds which inhibit or prevent replication of said HIV by interfering with the replicative or other essential functions of Vpr expressed by said HIV, by interactively blocking the Vpr target in human cells, and thereby preventing translocation of the Vpr/target complex from the cytosol of said human cells to the nuclei of said cells, where Vpr carries on activities essential to replication of HIV. In preferred embodiments, the compound or compounds which interactively block the target are steroid hormone receptor antagonists, glucocorticoid receptor antagonists, or glucocorticoid receptor Type II antagonists, especially mifepristone (RU-486). Pharmaceutical compositions comprising these compounds, as well as a method for identifying them and a kit for use therein, are also disclosed.
摘要翻译：公开了一种用于治疗暴露于或感染HIV的个体的方法，其包括向所述个体施用治疗有效量的一种或多种化合物，所述一种或多种化合物通过干扰由Vpr表达的Vpr的复制或其它基本功能来抑制或阻止所述HIV的复制所述HIV通过交互阻断人细胞中的Vpr靶，从而防止Vpr /靶复合物从所述人细胞的胞质溶胶转移到所述细胞的细胞核，其中Vpr进行HIV复制必需的活性。在优选的实施方案中，交互地阻断靶标的化合物或类似物是类固醇激素受体拮抗剂，糖皮质激素受体拮抗剂或糖皮质激素受体II型拮抗剂，特别是米非司酮（RU-486）。还公开了包含这些化合物的药物组合物，以及用于鉴定它们的方法和用于其中的试剂盒。

10. 发明授权

US09169462B2 Methods for preparing mature erythrocytes from conditionally immortalized hematopoietic stem cells 有权
标题翻译：从条件永生化造血干细胞制备成熟红细胞的方法
公开(公告)号：US09169462B2
公开(公告)日：2015-10-27
申请号：US12506894
申请日：2009-07-21
申请人： Yosef Refaeli , Brian Curtis Turner
发明人： Yosef Refaeli , Brian Curtis Turner
IPC分类号： A61K35/12 , C12N5/00 , A61P43/00 , C12N5/078
CPC分类号： C12N5/0641 , C12N2510/04 , C12N2799/027 , C12N2800/30 , C12N2840/203
摘要： Provided herein are methods for preparing differentiated cells, and the cells prepared by such methods.
摘要翻译：本文提供了制备分化细胞的方法，以及通过这些方法制备的细胞。

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