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1. 发明申请

US20090071560A1 HERMETIC COMPRESSOR 审中-公开
标题翻译： HERMETIC压缩机
公开(公告)号：US20090071560A1
公开(公告)日：2009-03-19
申请号：US12164170
申请日：2008-06-30
申请人： Yong Yeon Jeong
发明人： Yong Yeon Jeong
IPC分类号： F16K15/16 , F04B39/10
CPC分类号： A47L9/327 , Y10T137/7892
摘要： A hermetic compressor having an improved discharge valve assembly to efficiently limit deformation of a stopper caused by a reed valve while achieving efficient opening operation of the reed valve. The hermetic compressor includes a compression chamber and a discharge valve assembly. The discharge valve assembly includes a valve plate, a reed valve provided at one surface of the valve plate to open or close a discharge hole formed in the valve plate allowing communication with the compression chamber, the reed valve having a fixed end fastened to the valve plate and a moveable end adapted to cover the discharge hole of the valve plate, a stopper for covering the reed valve to limit the opening movement of the reed valve, the stopper including a fixed portion coupled to the valve plate and the fixed end of the reed valve, and an extension extending away from the fixed portion adapted to cover the moveable end of the reed valve, and a keeper for covering the stopper to limit deformation of the stopper caused by the reed valve. The extension of the stopper includes a first extension extending obliquely from the fixed end of the reed valve toward the keeper, and a second extension extending obliquely from the first extension toward the reed valve so as not to come into contact, at a distal end thereof, with the valve plate or the keeper when no external force is applied thereto.
摘要翻译：一种封闭式压缩机，其具有改进的排放阀组件，以有效地限制由簧片阀引起的止动件的变形，同时实现簧片阀的高效打开操作。封闭式压缩机包括压缩室和排出阀组件。排出阀组件包括阀板，设置在阀板的一个表面处的簧片阀，以打开或关闭形成在阀板中的排出孔，允许与压缩室连通，簧片阀具有紧固到阀的固定端板和适于覆盖阀板的排出孔的可动端，用于覆盖簧片阀以限制簧片阀的打开运动的止动件，止动器包括联接到阀板的固定部分和联接到阀板的固定端簧片阀和延伸远离固定部分的延伸部分，该延伸部分适于覆盖簧片阀的可移动端部，以及保持器，用于覆盖止动件以限制由簧片阀引起的止动件变形。止动件的延伸部包括从簧片阀的固定端朝向保持器倾斜延伸的第一延伸部，以及从第一延伸部朝向簧片阀倾斜延伸的第二延伸部，以在其远端不接触，当没有外力施加到阀板或保持器时。

2. 发明申请

US20090041673A1 Thermally Crosslinked Contrast Agents 审中-公开
标题翻译：热交联对比剂
公开(公告)号：US20090041673A1
公开(公告)日：2009-02-12
申请号：US11833873
申请日：2007-08-03
申请人： Sangyong Jon , Yong Yeon Jeong , Haerim Lee , Mi Kyung Yu , Sangjin Park , Jae II Kim
发明人： Sangyong Jon , Yong Yeon Jeong , Haerim Lee , Mi Kyung Yu , Sangjin Park , Jae II Kim
IPC分类号： A61K49/18 , A61K49/04
CPC分类号： A61K49/0054 , A61K49/0002 , A61K49/0032 , A61K49/0093 , A61K49/1863 , B82Y5/00
摘要： The present invention relates to a contrast agent comprising a plurality of nanoparticles, wherein each of the nanoparticles comprises: (a) a signal generating core; and (b) a polymeric shell coated on the signal generating core, wherein the polymeric shell comprises a water soluble hydoxysilyl- or alkoxysilyl-functionalized polymer and wherein the polymer shell is thermally crosslinked through hydroxysilyl or alkoxysilyl groups of the polymer.
摘要翻译：本发明涉及包含多个纳米颗粒的造影剂，其中每个纳米颗粒包括：（a）信号产生芯; 和（b）涂覆在所述信号产生芯上的聚合物壳，其中所述聚合物壳包含水溶性羟基甲硅烷基或烷氧基甲硅烷基官能化聚合物，并且其中所述聚合物壳通过所述聚合物的羟基甲硅烷基或烷氧基甲硅烷基进行热交联。

3. 发明申请

US20120230919A1 MRI CONTRAST AGENT COATED WITH CARBOXYLATED MANNAN AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：用对羧基苯甲酰胺涂覆的MRI对比剂及其生产方法
公开(公告)号：US20120230919A1
公开(公告)日：2012-09-13
申请号：US13087816
申请日：2011-04-15
申请人： Seong Jun YOON , Soo Youn JUN , An Sung KWON , Sang Hyeon KANG , Yong Yeon JEONG , In Kyu PARK , Chong Su CHO , You Kyoung KIM , Won Jong KIM , Ran NAMGUNG
发明人： Seong Jun YOON , Soo Youn JUN , An Sung KWON , Sang Hyeon KANG , Yong Yeon JEONG , In Kyu PARK , Chong Su CHO , You Kyoung KIM , Won Jong KIM , Ran NAMGUNG
IPC分类号： A61K49/06 , B82Y40/00 , B82Y5/00
CPC分类号： A61K49/1863 , B82Y15/00 , B82Y40/00 , Y10S977/773 , Y10S977/89 , Y10S977/93
摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
摘要翻译：本发明涉及涂覆有羧化甘露聚糖，特别是特异性靶向抗原呈递细胞并且具有优异的体内稳定性的羧化甘露聚糖包被的超顺磁性MRI造影剂的磁共振成像（MRI）造影剂及其制备方法。用本发明的羧化甘露聚糖涂覆的MRI造影剂可以由于其高表面负电荷而提供优异的体内稳定性和生物相容性，并且由于甘露聚糖的甘露糖可以特异性地引入抗原呈递细胞中，从而使抗原呈递细胞和含有抗原呈递细胞的组织。

4. 发明授权

US08961935B2 MRI contrast agent coated with carboxylated mannan and method for producing the same 有权
标题翻译：涂有羧化甘露聚糖的MRI造影剂及其制备方法
公开(公告)号：US08961935B2
公开(公告)日：2015-02-24
申请号：US13087816
申请日：2011-04-15
申请人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Sang Hyeon Kang , Yong Yeon Jeong , In Kyu Park , Chong Su Cho , You Kyoung Kim , Won Jong Kim , Ran Namgung
发明人： Seong Jun Yoon , Soo Youn Jun , An Sung Kwon , Sang Hyeon Kang , Yong Yeon Jeong , In Kyu Park , Chong Su Cho , You Kyoung Kim , Won Jong Kim , Ran Namgung
IPC分类号： A61K49/06 , B82Y40/00 , B82Y5/00 , A61K49/18 , B82Y15/00
CPC分类号： A61K49/1863 , B82Y15/00 , B82Y40/00 , Y10S977/773 , Y10S977/89 , Y10S977/93
摘要： The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.
摘要翻译：本发明涉及涂覆有羧化甘露聚糖，特别是特异性靶向抗原呈递细胞并且具有优异的体内稳定性的羧化甘露聚糖包被的超顺磁性MRI造影剂的磁共振成像（MRI）造影剂及其制备方法。用本发明的羧化甘露聚糖涂覆的MRI造影剂可以由于其高表面负电荷而提供优异的体内稳定性和生物相容性，并且由于甘露聚糖的甘露糖可以特异性地引入抗原呈递细胞中，从而使抗原呈递细胞和含有抗原呈递细胞的组织。

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