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1. 发明申请

US20080268063A1 Coated Controlled Release Polymer Particles as Efficient Oral Delivery Vehicles for Biopharmaceuticals 有权
标题翻译：涂层控释聚合物颗粒作为生物制药的高效口服输送载体
公开(公告)号：US20080268063A1
公开(公告)日：2008-10-30
申请号：US11666908
申请日：2005-11-04
申请人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
发明人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
IPC分类号： A61K9/14 , A61K31/7088 , A61K38/28 , A61K38/02 , A61K39/00
CPC分类号： A61K9/5138 , A61K9/0043 , A61K9/0065 , A61K9/5036 , A61K9/5153 , A61K9/5192 , A61K38/28
摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
摘要翻译：用于将活性剂递送至患者的组合物。该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。

2. 发明申请

US20070292387A1 TRANSMUCOSAL DELIVERY OF PHARMACEUTICAL ACTIVE SUBSTANCES 审中-公开
标题翻译：药物活性物质的转运
公开(公告)号：US20070292387A1
公开(公告)日：2007-12-20
申请号：US11847237
申请日：2007-08-29
申请人： Sangyong JON , Eunhye LEE , Jin Ju LEE , In-Hyun LEE
发明人： Sangyong JON , Eunhye LEE , Jin Ju LEE , In-Hyun LEE
IPC分类号： A61K38/21 , A61K38/20 , A61K38/22 , A61K38/19 , A61K38/28 , A61K38/26 , A61K31/722 , C07K9/00 , C07K14/52 , C07K14/54 , C07K14/56 , C08B37/08
CPC分类号： A61K47/61 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/0053 , A61K9/006 , C07K14/62
摘要： Provided is a conjugate including a pharmacologically active substance covalently bound to chitosan or its derivative and a method for transmucosal delivery of a pharmacologically active substance using the same. Specifically, a conjugate includes a pharmacologically active substance covalently bound via a linker to chitosan; and a pharmaceutical composition for transmucosal administration of a drug includes the aforementioned conjugate and a pharmaceutically acceptable carrier. Further provided is a method for in vivo delivery of a pharmacologically active substance via a transmucosal route, by covalent binding of the active substance with chitosan or its derivative via a linker. The conjugate in accordance with the present invention exhibits excellent absorption rate and biocompatibility in biological mucous membranes, particularly mucous membranes of the alimentary canal (especially the gastrointestinal tract), in vivo degradability, and superior bioavailability even with oral administration, thus enabling treatment of diseases via oral administration of a drug.
摘要翻译：提供了包含与壳聚糖或其衍生物共价结合的药理活性物质的缀合物和使用其的药理活性物质的经粘膜递送的方法。具体地，缀合物包括通过连接体与壳聚糖共价结合的药理活性物质; 并且用于药物的经粘膜给药的药物组合物包括上述缀合物和药学上可接受的载体。进一步提供了通过经粘膜途径体内递送药理活性物质的方法，通过活性物质与壳聚糖或其衍生物通过接头共价结合。根据本发明的缀合物在生物粘膜，特别是消化道粘膜（特别是胃肠道）中表现出优异的吸收速率和生物相容性，体内降解性和即使口服给药也具有优异的生物利用度，因此能够治疗疾病通过口服给药。

3. 发明授权

US09492400B2 Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals 有权
标题翻译：涂覆的控释聚合物颗粒作为用于生物药物的高效口服递送载体
公开(公告)号：US09492400B2
公开(公告)日：2016-11-15
申请号：US11666908
申请日：2005-11-04
申请人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
发明人： Sangyong Jon , Omid C. Farokhazd , Robert S. Langer , Jianjun Cheng
IPC分类号： A61K9/16 , A61K9/50 , A61K9/51 , A61K9/00
CPC分类号： A61K9/5138 , A61K9/0043 , A61K9/0065 , A61K9/5036 , A61K9/5153 , A61K9/5192 , A61K38/28
摘要： A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle through the intestinal mucosa. A molecular weight and cross-link density of the polymer may be selected such that the polymer core will decompose in a predetermined time interval. The fraction of the dose of the drug entering the system at circulation during the predetermined time interval may be between about 0.25% and about 25%. The composition may be formulated as a plurality of nanoparticles or microparticles that are combined with a pharmaceutically acceptable carrier to produce an edible or inhalable drug product.
摘要翻译：用于将活性剂递送至患者的组合物。该组合物包括包封活性剂的聚合物芯和围绕该芯设置的粘膜粘附性涂层。聚合物可以包括共价连接的聚（乙二醇）链，并且可以选择粘膜粘附性涂层以促进颗粒通过肠粘膜的转移。可以选择聚合物的分子量和交联密度，使得聚合物芯将以预定的时间间隔分解。在预定时间间隔期间进入系统的药物剂量的分数可以在约0.25％至约25％之间。组合物可以配制成与药学上可接受的载体组合以产生可食用或可吸入的药物产品的多个纳米颗粒或微粒。

4. 发明授权

US07550441B2 Controlled release polymer nanoparticle containing bound nucleic acid ligand for targeting 有权
标题翻译：含有结合核酸配体的控制释放聚合物纳米粒子用于靶向
公开(公告)号：US07550441B2
公开(公告)日：2009-06-23
申请号：US10860918
申请日：2004-06-04
申请人： Omid C. Farokhzad , Sangyong Jon , Robert S. Langer
发明人： Omid C. Farokhzad , Sangyong Jon , Robert S. Langer
IPC分类号： A61K31/7088 , A61K31/713 , A61K9/14 , C12Q1/00 , C12N11/00
CPC分类号： C12N15/87 , A61K9/1647 , A61K47/59 , A61K47/593 , A61K47/60 , A61K48/0041 , A61K48/0083 , Y10S530/817
摘要： The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
摘要翻译：本发明涉及包含与受控释放聚合物体系结合的核酸配体的缀合物，含有缀合物的药物组合物和使用该缀合物的治疗方法。控释聚合物体系包括诸如治疗，诊断，预后或预防剂的试剂。与受控释放聚合物体系结合的核酸配体选择性地结合到靶，例如细胞表面抗原，从而将受控释放的聚合物体系递送到靶。

5. 发明申请

US20060237080A1 Patterned surfaces and polymeric microstructures within robust microfluidic channels 审中-公开
标题翻译：鲁棒的微流体通道内的图形表面和聚合物微结构
公开(公告)号：US20060237080A1
公开(公告)日：2006-10-26
申请号：US11350221
申请日：2006-02-08
申请人： Sangyong Jon , Alireza Khademhosseini , Robert Langer , Kahp Suh
发明人： Sangyong Jon , Alireza Khademhosseini , Robert Langer , Kahp Suh
IPC分类号： F16K11/22
CPC分类号： B01L3/502707 , B01L2200/0668 , B01L2200/12 , B01L2300/0816 , B01L2300/0877 , B81B2201/058 , B81C1/00071 , B81C2201/019 , Y10T137/87877
摘要： Microfluidic channel. The channel includes a microfluidic mold defining a channel and a substrate including patterned regions. The microfluidic mold is in conformal contact with the substrate to form an irreversible seal. The patterned regions are adapted to immobilize cells.
摘要翻译：微流通道。通道包括限定通道的微流体模具和包括图案化区域的衬底。微流体模具与衬底保形接触以形成不可逆的密封。图案化区域适于固定细胞。

6. 发明申请

US20110052697A1 Aptamer-Directed Drug Delivery 审中-公开
标题翻译：适配体定向药物递送
公开(公告)号：US20110052697A1
公开(公告)日：2011-03-03
申请号：US12301225
申请日：2007-05-17
申请人： Omid C. Farokhzad , Sangyong Jon , Vaishali Bagalkot , Liangfang Zhang , Benjamin Teply , Etgar Levy-Nissenbaum , Robert S. Langer
发明人： Omid C. Farokhzad , Sangyong Jon , Vaishali Bagalkot , Liangfang Zhang , Benjamin Teply , Etgar Levy-Nissenbaum , Robert S. Langer
IPC分类号： A61K9/14 , C07H21/04 , A61K31/7088 , A61P35/00
CPC分类号： A61K31/704 , A61K31/337 , A61K47/549 , A61K47/6935 , A61K47/6937 , A61K48/00 , A61K49/0019 , A61K49/0021 , A61K49/0054 , A61K49/0067 , B82Y5/00
摘要： The present invention provides systems, methods, and compositions for targeted delivery of a therapeutic agent organs, tissues, cells, extracellular matrix components, and intracellular compartments. The present invention provides a complex comprising a therapeutic or diagnostic agent and a nucleic acid targeting moiety, wherein the agent non-covalently associates with base pairs of the nucleic acid targeting moiety. The invention provides targeted particles comprising a particle and an inventive complex. The present invention provides methods of designing, manufacturing, and using inventive complexes and targeted particles.
摘要翻译：本发明提供用于靶向递送治疗剂器官，组织，细胞，细胞外基质组分和细胞内区室的系统，方法和组合物。本发明提供了包含治疗剂或诊断剂和核酸靶向部分的复合物，其中所述药剂与核酸靶向部分的碱基对非共价缔合。本发明提供了包含颗粒和本发明复合物的目标颗粒。本发明提供了设计，制造和使用本发明复合物和靶向颗粒的方法。

7. 发明申请

US20050037075A1 Targeted delivery of controlled release polymer systems 有权
标题翻译：靶向递送控释聚合物体系
公开(公告)号：US20050037075A1
公开(公告)日：2005-02-17
申请号：US10860918
申请日：2004-06-04
申请人： Omid Farokhzad , Sangyong Jon , Robert Langer
发明人： Omid Farokhzad , Sangyong Jon , Robert Langer
IPC分类号： A61K20060101 , A61K9/127 , A61K9/14 , A61K9/16 , A61K9/22 , A61K9/51 , A61K47/48 , A61K48/00 , C12N15/87
CPC分类号： C12N15/87 , A61K9/1647 , A61K47/59 , A61K47/593 , A61K47/60 , A61K48/0041 , A61K48/0083 , Y10S530/817
摘要： The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
摘要翻译：本发明涉及包含与受控释放聚合物体系结合的核酸配体的缀合物，含有缀合物的药物组合物和使用该缀合物的治疗方法。控释聚合物体系包括诸如治疗，诊断，预后或预防剂的试剂。与受控释放聚合物体系结合的核酸配体选择性地结合到靶，例如细胞表面抗原，从而将受控释放的聚合物体系递送到靶。

8. 发明申请

US20090041673A1 Thermally Crosslinked Contrast Agents 审中-公开
标题翻译：热交联对比剂
公开(公告)号：US20090041673A1
公开(公告)日：2009-02-12
申请号：US11833873
申请日：2007-08-03
申请人： Sangyong Jon , Yong Yeon Jeong , Haerim Lee , Mi Kyung Yu , Sangjin Park , Jae II Kim
发明人： Sangyong Jon , Yong Yeon Jeong , Haerim Lee , Mi Kyung Yu , Sangjin Park , Jae II Kim
IPC分类号： A61K49/18 , A61K49/04
CPC分类号： A61K49/0054 , A61K49/0002 , A61K49/0032 , A61K49/0093 , A61K49/1863 , B82Y5/00
摘要： The present invention relates to a contrast agent comprising a plurality of nanoparticles, wherein each of the nanoparticles comprises: (a) a signal generating core; and (b) a polymeric shell coated on the signal generating core, wherein the polymeric shell comprises a water soluble hydoxysilyl- or alkoxysilyl-functionalized polymer and wherein the polymer shell is thermally crosslinked through hydroxysilyl or alkoxysilyl groups of the polymer.
摘要翻译：本发明涉及包含多个纳米颗粒的造影剂，其中每个纳米颗粒包括：（a）信号产生芯; 和（b）涂覆在所述信号产生芯上的聚合物壳，其中所述聚合物壳包含水溶性羟基甲硅烷基或烷氧基甲硅烷基官能化聚合物，并且其中所述聚合物壳通过所述聚合物的羟基甲硅烷基或烷氧基甲硅烷基进行热交联。

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