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    • 4. 发明申请
    • ADENOSINE SIGNALING IN DIAGNOSIS, TREATMENT AND PREVENTION OF PRIAPISM AND ERECTILE DYSFUNCTION
    • 腺苷信号转导在诊断,治疗和预防预防和排除功能障碍中的作用
    • WO2008066627A2
    • 2008-06-05
    • PCT/US2007/022520
    • 2007-10-24
    • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMYANG, XiaKELLEMS, RodneyBLACKBURN, Michael
    • YANG, XiaKELLEMS, RodneyBLACKBURN, Michael
    • A61K31/522
    • A61K31/522A61K49/0004
    • We disclose a method of treating priapism in a mammal by administering to the mammal a composition containing an effective amount of an inhibitor of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the inhibitor of adenosine signaling has at least one activity selected from the group consisting of decreasing adenosine levels in the mammal, inhibiting adenosine receptor activity in the mammal, and inhibiting signaling pathways downstream of an adenosine receptor in the mammal. We also disclose a method of treating erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal. In addition, we disclose a method of diagnosing erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal, and observing blood flow in the mammal's penis.
    • 我们公开了一种通过给哺乳动物施用含有有效量的腺苷信号传导抑制剂和药学上可接受的载体的组合物治疗哺乳动物中的特应性皮炎的方法,其中腺苷信号传导抑制剂在 选自降低哺乳动物腺苷水平,抑制哺乳动物腺苷受体活性和抑制哺乳动物腺苷受体下游信号传导途径的组中的至少一种活性。 我们还公开了一种治疗哺乳动物勃起功能障碍的方法,通过给哺乳动物施用含有有效量的腺苷信号传导活化剂和药学上可接受的载体的组合物,其中腺苷信号传导活化剂具有至少一种选自 该组由增加哺乳动物中的腺苷水平,增加哺乳动物中的腺苷受体活性以及增加哺乳动物中腺苷受体下游的信号通路中的活性组成。 此外,我们公开了一种诊断哺乳动物勃起功能障碍的方法,通过给哺乳动物施用含有有效量的腺苷信号传导活化剂和药学上可接受的载体的组合物,其中腺苷信号传导活化剂具有至少一种选择的活性 从由增加哺乳动物中的腺苷水平,增加哺乳动物中的腺苷受体活性和增加哺乳动物中腺苷受体下游的信号传导途径中的活性以及观察哺乳动物阴茎中的血流组成的组中。
    • 5. 发明申请
    • ADENOSINE SIGNALING IN DIAGNOSIS, TREATMENT AND PREVENTION OF PRIAPISM AND ERECTILE DYSFUNCTION
    • 腺苷信号在诊断,治疗和预防预防和治疗功能障碍
    • WO2008066627A3
    • 2008-12-11
    • PCT/US2007022520
    • 2007-10-24
    • UNIV TEXASYANG XIAKELLEMS RODNEYBLACKBURN MICHAEL
    • YANG XIAKELLEMS RODNEYBLACKBURN MICHAEL
    • A01K43/00
    • A61K31/522A61K49/0004
    • We disclose a method of treating priapism in a mammal by administering to the mammal a composition containing an effective amount of an inhibitor of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the inhibitor of adenosine signaling has at least one activity selected from the group consisting of decreasing adenosine levels in the mammal, inhibiting adenosine receptor activity in the mammal, and inhibiting signaling pathways downstream of an adenosine receptor in the mammal. We also disclose a method of treating erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal. In addition, we disclose a method of diagnosing erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal, and observing blood flow in the mammal's penis.
    • 我们公开了一种通过向哺乳动物施用含有有效量的腺苷信号传导抑制剂和药学上可接受的载体的组合物来治疗哺乳动物的阴茎勃起功能的方法,其中腺苷信号传导抑制剂具有至少一种选自以下的活性: 在哺乳动物中降低腺苷水平,抑制哺乳动物中的腺苷受体活性,以及​​抑制哺乳动物中腺苷受体下游的信号通路。 我们还公开了一种通过向哺乳动物施用含有有效量的腺苷信号传导激活剂和药学上可接受的载体的组合物来治疗哺乳动物的勃起功能障碍的方法,其中腺苷信号传导的激活剂具有至少一种选自 由哺乳动物中增加的腺苷水平组成的组,哺乳动物中腺苷受体活性的增加,以及增加哺乳动物腺苷受体下游信号通路的活性。 另外,我们公开了通过向哺乳动物施用含有有效量的腺苷信号传导激活剂和药学上可接受的载体的组合物来诊断哺乳动物勃起功能障碍的方法,其中腺苷信号传导的激活剂具有至少一种选择的活性 来自哺乳动物中增加的腺苷水平,增加哺乳动物中的腺苷受体活性,以及​​增加哺乳动物中腺苷受体下游的信号传导途径的活性,以及​​观察哺乳动物的阴茎中的血流。
    • 6. 发明授权
    • Live streaming video processing
    • 实时流视频处理
    • US08752112B2
    • 2014-06-10
    • US13445620
    • 2012-04-12
    • Charles Christian KrasicVijnan ShastriKrishna Kumar GadepalliYang XiaKrishnan EswaranWendy Tobagus
    • Charles Christian KrasicVijnan ShastriKrishna Kumar GadepalliYang XiaKrishnan EswaranWendy Tobagus
    • H04N21/234
    • H04N21/2187H04N21/234309H04N21/8456
    • Systems and methods for processing a live video stream are provided. An ingestion component receives segments of a live video stream in association with a request to process the live video stream. A control component generates an instruction graph for the live video stream based on predetermined criteria. The instruction graph defines a workflow for processing the live video stream, the workflow comprising a set of services for processing the segments. A transcoding component employs a subset of the services to process the segments based at least in part on the instruction graph and a distribution component then streams the segments to a device in response finishing process of the segments. With the live video processing system, segments of a video stream are processed and distributed as they are received. Thus segments of the video stream are processed and distributed prior to processing of the entire video stream.
    • 提供了用于处理直播视频流的系统和方法。 摄取组件与处理直播视频流的请求相关联地接收实况视频流的片段。 控制部件基于预定标准生成实时视频流的指令图。 指令图定义了用于处理直播视频流的工作流程,该工作流包括用于处理段的一组服务。 代码转换组件使用服务的子集来至少部分地基于指令图来处理段,然后分布组件在段的响应整理过程中将段流传送到设备。 使用实时视频处理系统,视频流的片段在被接收时被处理和分发。 因此,视频流的段在处理整个视频流之前被处理和分配。