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1. 发明申请

WO2008066627A2 ADENOSINE SIGNALING IN DIAGNOSIS, TREATMENT AND PREVENTION OF PRIAPISM AND ERECTILE DYSFUNCTION 审中-公开
标题翻译：腺苷信号转导在诊断，治疗和预防预防和排除功能障碍中的作用
公开(公告)号：WO2008066627A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/022520
申请日：2007-10-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , YANG, Xia , KELLEMS, Rodney , BLACKBURN, Michael
发明人： YANG, Xia , KELLEMS, Rodney , BLACKBURN, Michael
IPC分类号： A61K31/522
CPC分类号： A61K31/522 , A61K49/0004
摘要： We disclose a method of treating priapism in a mammal by administering to the mammal a composition containing an effective amount of an inhibitor of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the inhibitor of adenosine signaling has at least one activity selected from the group consisting of decreasing adenosine levels in the mammal, inhibiting adenosine receptor activity in the mammal, and inhibiting signaling pathways downstream of an adenosine receptor in the mammal. We also disclose a method of treating erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal. In addition, we disclose a method of diagnosing erectile dysfunction in a mammal by administering to the mammal a composition containing an effective amount of an activator of adenosine signaling and a pharmaceutically-acceptable carrier, wherein the activator of adenosine signaling has at least one activity selected from the group consisting of increasing adenosine levels in the mammal, increasing adenosine receptor activity in the mammal, and increasing activity in signaling pathways downstream of an adenosine receptor in the mammal, and observing blood flow in the mammal's penis.
摘要翻译：我们公开了一种通过给哺乳动物施用含有有效量的腺苷信号传导抑制剂和药学上可接受的载体的组合物治疗哺乳动物中的特应性皮炎的方法，其中腺苷信号传导抑制剂在选自降低哺乳动物腺苷水平，抑制哺乳动物腺苷受体活性和抑制哺乳动物腺苷受体下游信号传导途径的组中的至少一种活性。我们还公开了一种治疗哺乳动物勃起功能障碍的方法，通过给哺乳动物施用含有有效量的腺苷信号传导活化剂和药学上可接受的载体的组合物，其中腺苷信号传导活化剂具有至少一种选自该组由增加哺乳动物中的腺苷水平，增加哺乳动物中的腺苷受体活性以及增加哺乳动物中腺苷受体下游的信号通路中的活性组成。此外，我们公开了一种诊断哺乳动物勃起功能障碍的方法，通过给哺乳动物施用含有有效量的腺苷信号传导活化剂和药学上可接受的载体的组合物，其中腺苷信号传导活化剂具有至少一种选择的活性从由增加哺乳动物中的腺苷水平，增加哺乳动物中的腺苷受体活性和增加哺乳动物中腺苷受体下游的信号传导途径中的活性以及观察哺乳动物阴茎中的血流组成的组中。

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