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1. 发明授权

EP1140158B1 MULTI-COMPONENT VACCINE COMPRISING AT LEAST TWO ANTIGENS FROM HAEMOPHILUS INFLUENZAE 有权
标题翻译： MULTIKOMPONENTIMPFSTOFF与至少两个流感嗜血杆菌抗原
公开(公告)号：EP1140158B1
公开(公告)日：2006-09-13
申请号：EP99957822.2
申请日：1999-12-15
申请人： Sanofi Pasteur Limited , Loosmore, Sheena M. , Yang, Yan-Ping , Klein, Michel H.
发明人： LOOSMORE, Sheena, M. , YANG, Yan-Ping , KLEIN, Michel, H.
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

2. 发明公开

EP1140158A2 MULTI-COMPONENT VACCINE COMPRISING AT LEAST TWO ANTIGENS FROM HAEMOPHILUS INFLUENZAE 有权
标题翻译： MULTIKOMPONENTIMPFSTOFF与至少两个流感嗜血杆菌抗原
公开(公告)号：EP1140158A2
公开(公告)日：2001-10-10
申请号：EP99957822.2
申请日：1999-12-15
申请人： Aventis Pasteur Limited , Loosmore, Sheena M. , Yang, Yan-Ping , Klein, Michel H.
发明人： LOOSMORE, Sheena, M. , YANG, Yan-Ping , KLEIN, Michel, H.
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

3. 发明专利

DE69933237D1 未知
公开(公告)号：DE69933237D1
公开(公告)日：2006-10-26
申请号：DE69933237
申请日：1999-12-15
申请人： SANOFI PASTEUR LTD , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE M , YANG YAN-PING , KLEIN H
IPC分类号： A61K39/102 , C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/116 , A61K39/13 , A61K39/295 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

4. 发明专利

AU1543900A Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease 未知
公开(公告)号：AU1543900A
公开(公告)日：2000-07-03
申请号：AU1543900
申请日：1999-12-15
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

5. 发明专利

AT339221T 未知
公开(公告)号：AT339221T
公开(公告)日：2006-10-15
申请号：AT99957822
申请日：1999-12-15
申请人： SANOFI PASTEUR LTD , LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/295
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.

6. 发明申请

WO0051633A2 MULTI-COMPONENT VACCINE COMPRISING AT LEAST THREE ANTIGENS TO PROTECT AGAINST DISEASE CAUSED BY HAEMOPHILUS INFLUENZAE 审中-公开
标题翻译：包含至少三种抗原的多组分疫苗可以防治HAEMOPHILUS INFLUENZAE引起的疾病
公开(公告)号：WO0051633A2
公开(公告)日：2000-09-08
申请号：PCT/CA0000207
申请日：2000-02-29
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： A61K39/102 , A61K39/116 , A61K39/295 , A61P31/04 , A61P31/16
CPC分类号： A61K39/102 , A61K2039/55505
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least three different antigens of Haemophilus influenzae, two of which are adhesins. High molecular weight (HMW) proteins and Haemophilus influenzae adhesin (Hia) proteins of non-typeable Haemophilus influenzae comprise the adhesin components while the other antigen is a non-proteolytic analog of Hin47 protein. Each component does not impair the immunogenicity of the others. The Haemophilus vaccine may be combined with DTP component vaccines, which may contain inactivated poliovirus, including type 1, type 2 and/or type 3, and/or a conjugate of a capsular polysaccharide of Haemophilus influenzae and tetanus or diphtheria toxoid, including PRP-T, to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
摘要翻译：多组分免疫原性组合物赋予免疫宿主免受流感嗜血杆菌引起的感染的保护。这种组合物包含流感嗜血杆菌的至少三种不同的抗原，其中两种是粘附素。不可分型流感嗜血杆菌的高分子量（HMW）蛋白和流感嗜血杆菌粘附素（Hia）蛋白包含粘附素组分，而另一种抗原是Hin47蛋白的非蛋白水解类似物。每个成分不影响其他成分的免疫原性。嗜血杆菌疫苗可以与DTP组分疫苗组合，其可以含有灭活的脊髓灰质炎病毒，包括1型，2型和/或3型，和/或流感嗜血杆菌和破伤风或白喉类毒素的荚膜多糖的缀合物，包括PRP- T，以提供多价成分疫苗，而不损害其他抗原的免疫原性。

7. 发明申请

WO0020609A3 PROTECTIVE RECOMBINANT HAEMOPHILUS INFLUENZAE HIGH MOLECULAR WEIGHT PROTEINS 审中-公开
标题翻译：保护性重组蛋白流感嗜血杆菌高分子量蛋白
公开(公告)号：WO0020609A3
公开(公告)日：2000-08-03
申请号：PCT/CA9900938
申请日：1999-10-07
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , YANG YAN PING , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , YANG YAN-PING , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K9/127 , A61K9/14 , A61K9/48 , A61K39/00 , A61K39/102 , A61P31/04 , C07K14/195 , C07K14/285 , C12N1/12 , C12N1/13 , C12N1/21 , C12N15/31 , C12N15/70 , C12P21/02 , C12R1/93 , A61K31/70 , A61K38/16
CPC分类号： C07K14/285 , A61K39/00 , C12N15/70
摘要： Protective high molecular weight (HMW) proteins are produced recombinantly by expression from E. coli by using a promoter effective in E. coli and a nucleic acid molecule which contains a modified operon of a non-typeable strain of Haemophilus. The modified operon contains the portion only of the A region which encodes the mature HMW protein and the complete B and C regions of the operon. Enhanced levels of expression of the HMW proteins can be achieved by including the E. coli cer gene, a further copy of the portion of the A region of the operon encoding the mature protein or both, in the expression vector. Nucleotide and deduced amino acid sequences of the hmw1 and hmw2 genes and HMW1 and HMW2 proteins, respectively, of several non-typeable Haemophilus influenzae strain have been identified.
摘要翻译：通过使用在大肠杆菌中有效的启动子和含有嗜血杆菌不可分型菌株的修饰操纵子的核酸分子，通过大肠杆菌表达重组产生保护性高分子量（HMW）蛋白质。修饰的操纵子仅含有编码成熟HMW蛋白的A区和操纵子的完整B区和C区的部分。通过在表达载体中包含大肠杆菌cer基因，编码成熟蛋白或两者的操纵子的A区的部分的进一步拷贝，可以实现HMW蛋白表达水平的提高。已鉴定出几种不可分型的流感嗜血杆菌菌株的hmw1和hmw2基因以及HMW1和HMW2蛋白的核苷酸和推导的氨基酸序列。

8. 发明申请

WO9640929A3 TRANSFERRIN RECEPTOR GENES 审中-公开
标题翻译：转铁蛋白受体基因
公开(公告)号：WO9640929A3
公开(公告)日：1997-03-06
申请号：PCT/CA9600399
申请日：1996-06-07
申请人： CONNAUGHT LAB , LOOSMORE SHEENA M , HARKNESS ROBIN E , SCHRYVERS ANTHONY B , CHONG PELE , GRAY OWEN SCOTT , YANG YAN PING , MURDIN ANDREW D , KLEIN MICHEL H
发明人： LOOSMORE SHEENA M , HARKNESS ROBIN E , SCHRYVERS ANTHONY B , CHONG PELE , GRAY-OWEN SCOTT , YANG YAN-PING , MURDIN ANDREW D , KLEIN MICHEL H
IPC分类号： C12N15/09 , A61K39/00 , A61K39/102 , A61K48/00 , A61P31/00 , A61P31/04 , C07K14/285 , C12N1/21 , C12N5/10 , C12N15/31 , C12P21/02 , C12N15/70 , C12N15/86
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.

9. 发明申请

WO1994012641A1 HAEMOPHILUS OUTER MEMBRANE PROTEIN 审中-公开
标题翻译： HAEMOPHILUS外膜蛋白
公开(公告)号：WO1994012641A1
公开(公告)日：1994-06-09
申请号：PCT/CA1993000501
申请日：1993-11-23
申请人： CONNAUGHT LABORATORIES LIMITED , CHONG, Pele , THOMAS, Wayne , YANG, Yan-Ping , LOOSMORE, Sheena , SIA, Dwo, Yuan, Charles , KLEIN, Michel
发明人： CONNAUGHT LABORATORIES LIMITED
IPC分类号： C12N15/31
CPC分类号： C07K14/285 , A61K39/00 , C07K16/1242 , C07K2317/34
摘要： Purified and isolated nucleic acid from specific strains of Haemophilus influenzae is provided which encodes at least a portion of the D15 outer membrane protein of Haemophilus. The nucleic acid is used to produce peptides, polypeptides and proteins free of contaminant associated with Haemophilus for purposes of diagnosis and medical treatment. Furthermore, the nucleic acid may be used in the diagnosis of Haemophilus infection. Antisera obtained following immunization with the nucleic acid D15 outer membrane protein or peptides also may be used for the purpose of diagnosis and medical treatment.
摘要翻译：提供了来自流感嗜血杆菌的特异性菌株的纯化和分离的核酸，其编码嗜血杆菌D15外膜蛋白的至少一部分。核酸用于产生与嗜血杆菌相关的污染物的肽，多肽和蛋白质，用于诊断和治疗。此外，核酸可用于诊断嗜血杆菌感染。用核酸D15外膜蛋白或肽免疫后获得的抗血清也可用于诊断和治疗的目的。

10. 发明申请

WO0190383A3 CO-EXPRESSION OF RECOMBINANT PROTEINS 审中-公开
标题翻译：共表达重组蛋白
公开(公告)号：WO0190383A3
公开(公告)日：2002-08-08
申请号：PCT/CA0100611
申请日：2001-05-03
申请人： AVENTIS PASTEUR , LOOSMORE SHEENA M , YANG YAN-PING
发明人： LOOSMORE SHEENA M , YANG YAN-PING
IPC分类号： C07K14/285 , C12N15/63 , C12N15/70 , C07K14/315
CPC分类号： C07K14/285 , C07K2319/00 , C12N15/63 , C12N15/70
摘要： Expression vectors are described which permit the recombinant expression of proteins which essentially contain, in addition to nucleic acid encoding the recombinant protein, nucleic acid encoding a non-proteolytic analog of Haemophilus Hin47 protein, with or without leader sequence, or nucleic acid encoding high molecular weight proteins of non-typeable Haemophilus , which are hmwB , hmwC or hmwBC .
摘要翻译：描述了允许重组表达蛋白质的重组表达，除了编码重组蛋白的核酸之外，还包含编码嗜血杆菌Hin47蛋白的非蛋白水解类似物的核酸，具有或不具有前导序列，或编码高分子量的核酸不可分泌型嗜血杆菌的重量蛋白，其为hmwB，hmwC或hmwBC。

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