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1. 发明授权

US09021674B2 System for loading a collapsible heart valve 有权
标题翻译：用于装载可折叠心脏瓣膜的系统
公开(公告)号：US09021674B2
公开(公告)日：2015-05-05
申请号：US13364501
申请日：2012-02-02
申请人： Brett Allen Hillukka , Huisun Wang , Valerie J. Glazier , Yousef F. Alkhatib , Jacob John Daly , Ralph Joseph Thomas
发明人： Brett Allen Hillukka , Huisun Wang , Valerie J. Glazier , Yousef F. Alkhatib , Jacob John Daly , Ralph Joseph Thomas
IPC分类号： B25B31/00 , B23P11/00 , A61F2/24 , A61F2/00 , A61F2/97 , A61F2/95
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/2412 , A61F2/2436 , A61F2/97 , A61F2002/9522 , A61F2250/0039 , Y10T29/49826 , Y10T29/53909 , Y10T29/53943
摘要： An assembly for collapsing a self-expanding prosthetic heart valve includes a compression member, a support member and a constricting member. The compression member has a tapered wall between its first open end and its second open end, the tapered wall defining an open space adapted to receive the valve. The support member has a base and a recess adapted to receive an end of the valve. The support member and the compression member are movable toward one another to compress the valve and push it through a relatively small aperture in the second open end of the compression member. The second end of the constricting member is sized to receive the compressed valve from the second open end of the compression member for loading into a delivery device.
摘要翻译：用于塌缩自膨胀假体心脏瓣膜的组件包括压缩构件，支撑构件和收缩构件。压缩构件在其第一开口端和其第二开口端之间具有锥形壁，锥形壁限定适于接收阀的开放空间。支撑构件具有适于容纳阀的端部的基部和凹部。支撑构件和压缩构件可彼此移动以压缩阀并将其推压通过压缩构件的第二开口端中的相对小的孔。收缩构件的第二端的尺寸被设计成从压缩构件的第二开口端接收压缩的阀，用于装载到输送装置中。

2. 发明授权

US08728154B2 Prosthetic aortic heart valves 有权
标题翻译：假体主动脉瓣膜
公开(公告)号：US08728154B2
公开(公告)日：2014-05-20
申请号：US12733344
申请日：2008-08-21
申请人： Yousef F. Alkhatib
发明人： Yousef F. Alkhatib
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2445 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076
摘要： A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve. The connecting struts are designed to bulge out into the valsalva sinus to help anchor the prosthetic valve in place. The valve is circumferentially collapsible to a relatively small diameter for less-invasive delivery into the patient. The valve circumferentially expands to a larger operational diameter when deployed at the implant site.
摘要翻译：假体主动脉瓣包括环形环形流入部分，其被设计为驻留在患者的天然主动脉瓣膜环内或附近，以及环形主动脉流出部分，其被设计为驻留在患者主动脉中的至少一部分 valsalva窦。环形流入部分和主动脉流出部分通过多个连接支柱彼此连接，所述多个连接支柱被限制在靠近病人天然主动脉瓣的连合处的区域。连接支柱被设计成凸出到瓦尔萨瓦窦中，以帮助将假肢瓣锚定到位。瓣膜周向可折叠到相对较小的直径，用于较少侵入性地输送到患者体内。当部署在植入部位时，阀周向地膨胀到更大的操作直径。

3. 发明授权

US08512398B2 Apparatus and method for implanting collapsible/expandable prosthetic heart valves 有权
标题翻译：用于植入可折叠/可扩张的假体心脏瓣膜的装置和方法
公开(公告)号：US08512398B2
公开(公告)日：2013-08-20
申请号：US12452128
申请日：2008-06-26
申请人： Yousef F. Alkhatib
发明人： Yousef F. Alkhatib
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/013 , A61F2/24 , A61F2/2418 , A61F2/2439 , A61F2002/016 , A61F2002/018 , A61F2002/9517 , A61F2230/0071 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for delivering a prosthetic heart valve into a patient by means that are less invasive than conventional open-chest, open-heart surgery. The prosthetic valve may be collapsed while in a delivery device. When the valve reaches the desired implant site in the patient, the valve can be released from the delivery device, which allows the valve to re-expand to the configuration in which it can function as a heart valve. For example, the delivery device may be constructed to facilitate delivery of the prosthetic valve into the patient via the apex of the patient's heart.
摘要翻译：用于将假体心脏瓣膜输送到患者体内的装置，其方式是比传统的胸腔开放心脏手术侵入性较差。假体瓣膜可能在输送装置中折叠。当阀门到达病人所需的植入部位时，阀门可以从输送装置中释放出来，这样可以使阀门重新膨胀到其可用作心脏瓣膜的结构。例如，输送装置可以构造成便于经由患者心脏的顶点将假体瓣膜输送到患者体内。

4. 外观设计

USD660967S1 Surgical stent 有权
标题翻译：手术支架
公开(公告)号：USD660967S1
公开(公告)日：2012-05-29
申请号：US29375253
申请日：2010-09-20
申请人： Peter Nicholas Braido , Thomas Mark Benson , Aaron J. Chalekian , Yousef F. Alkhatib
设计人： Peter Nicholas Braido , Thomas Mark Benson , Aaron J. Chalekian , Yousef F. Alkhatib
CPC分类号： A61F2/91 , A61F2230/005 , A61F2230/0054 , A61F2230/008

5. 发明申请

US20100191326A1 APPARATUS AND METHOD FOR IMPLANTING COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES 有权
标题翻译：用于植入可膨胀/可扩展的前置心脏瓣膜的装置和方法
公开(公告)号：US20100191326A1
公开(公告)日：2010-07-29
申请号：US12452128
申请日：2008-06-26
申请人： Yousef F. Alkhatib
发明人： Yousef F. Alkhatib
IPC分类号： A61F2/24 , A61F2/01
CPC分类号： A61F2/2436 , A61F2/013 , A61F2/24 , A61F2/2418 , A61F2/2439 , A61F2002/016 , A61F2002/018 , A61F2002/9517 , A61F2230/0071 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for delivering a prosthetic heart valve into a patient by means that are less invasive than conventional open-chest, open-heart surgery. The prosthetic valve may be collapsed while in a delivery device. When the valve reaches the desired implant site in the patient, the valve can be released from the delivery device, which allows the valve to re-expand to the configuration in which it can function as a heart valve. For example, the delivery device may be constructed to facilitate delivery of the prosthetic valve into the patient via the apex of the patient's heart.
摘要翻译：用于将假体心脏瓣膜输送到患者体内的装置，其方式是比传统的胸腔开放心脏手术侵入性较差。假体瓣膜可能在输送装置中折叠。当阀门到达病人所需的植入部位时，阀门可以从输送装置中释放出来，这样可以使阀门重新膨胀到其可用作心脏瓣膜的结构。例如，输送装置可以构造成便于经由患者心脏的顶点将假体瓣膜输送到患者体内。

6. 发明申请

US20080228223A1 Heart valve chordae replacement methods and apparatus 有权
标题翻译：心脏瓣膜切除方法及装置
公开(公告)号：US20080228223A1
公开(公告)日：2008-09-18
申请号：US12074586
申请日：2008-03-04
申请人： Yousef F. Alkhatib
发明人： Yousef F. Alkhatib
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61F2/2427 , A61B17/0401 , A61B17/064 , A61B17/08 , A61B2017/00247 , A61B2017/00867 , A61B2017/0417 , A61B2017/06052 , A61B2017/0649 , A61B2018/00392 , A61B2090/036 , A61F2/2442 , A61F2/2457
摘要： Apparatus for attaching a prosthetic tether between a leaflet of a patient's heart valve and another portion of the patient's heart to help prevent prolapse of the leaflet and/or to otherwise improve leaflet function. The apparatus can be used with relatively low invasiveness of the patient's body. The apparatus releasably clamps the leaflet during attachment of the tether to the leaflet. The apparatus may include an integrated display for indicating how extensively the leaflet is being clamped. The apparatus may include structure for stabilizing the leaflet for better clamping. The apparatus may enter the heart through an aperture in the wall of the heart, and may include structure for helping to reduce blood leakage from that aperture. The apparatus may be able to enter the heart by following a guide wire. The apparatus may include various means for attaching the tether to the leaflet.
摘要翻译：用于将患者心脏瓣膜的小叶与患者心脏的另一部分之间的假肢系绳连接以有助于防止小叶脱垂和/或另外改善小叶功能的装置。该装置可以以相对低的患者身体的侵入性使用。该装置在将系绳附接到小叶时可释放地夹紧小叶。所述装置可以包括用于指示所述传单被广泛地夹紧的集成显示器。该装置可以包括用于稳定小叶以更好地夹紧的结构。该装置可以通过心脏壁中的孔进入心脏，并且可以包括用于帮助减少该孔的血液渗漏的结构。该装置可能能够通过跟随导丝进入心脏。该装置可以包括用于将系绳附接到传单的各种装置。

7. 发明授权

US09572660B2 Prosthetic heart valves 有权
标题翻译：假心脏瓣膜
公开(公告)号：US09572660B2
公开(公告)日：2017-02-21
申请号：US12451678
申请日：2008-06-04
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/82 , A61F2/24 , A61L27/36 , A61L27/54
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

8. 发明授权

US09039759B2 Repositioning of prosthetic heart valve and deployment 有权
标题翻译：假性心脏瓣膜的重新定位和部署
公开(公告)号：US09039759B2
公开(公告)日：2015-05-26
申请号：US13215901
申请日：2011-08-23
申请人： Yousef F. Alkhatib , Peter Nicholas Braido
发明人： Yousef F. Alkhatib , Peter Nicholas Braido
IPC分类号： A61F2/24 , A61F2/95
CPC分类号： A61F2/2436 , A61F2/24 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2472 , A61F2002/9517 , A61F2002/9534 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0013 , A61F2230/0021 , A61F2230/0054 , A61F2230/008 , A61F2240/008 , A61F2250/0039
摘要： A collapsible prosthetic heart valve includes a stent and a valve assembly. The stent has an annulus section with a relatively small cross-section, and an aortic section with a relatively large cross-section. The valve assembly, including a cuff and a plurality of leaflets, is secured to the stent in the annulus section such that the valve assembly can be entirely deployed in the native valve annulus and function as intended while at least a portion of the aortic section is held by the delivery device in a manner that allows for resheathing. The configuration of the prosthetic valve is such that the valve leaflets can fully coapt and the valve can function properly even when the stent and/or valve assembly become distorted upon deployment or use.
摘要翻译：可折叠假体心脏瓣膜包括支架和阀组件。支架具有横截面相对较小的环形部分和具有相对较大横截面的主动脉部分。包括袖带和多个小叶的阀组件在环形部分中固定到支架，使得阀组件可以完全展开在天然瓣膜环中并按照预期的方式起作用，而主动脉部分的至少一部分是由输送装置以允许再感染的方式保持。假体瓣膜的构造使得即使当展开和/或瓣膜组件在展开或使用时变形时，瓣膜小叶片也可以完全适应并且阀门可正常工作。

9. 发明授权

US08936567B2 Balloon bifurcated lumen treatment 有权
标题翻译：气球分叉管腔治疗
公开(公告)号：US08936567B2
公开(公告)日：2015-01-20
申请号：US12479611
申请日：2009-06-05
申请人： Richard Noddin , Dan Quillin , Daniel J. Horn , Ying Xiong , Richard Goodin , The Thomas Trinh Tran , Yousef F. Alkhatib , Steve Hoff , Richard Dunn , Thomas Holman , Zach Tegels
发明人： Richard Noddin , Dan Quillin , Daniel J. Horn , Ying Xiong , Richard Goodin , The Thomas Trinh Tran , Yousef F. Alkhatib , Steve Hoff , Richard Dunn , Thomas Holman , Zach Tegels
IPC分类号： A61M31/00 , A61M37/00 , A61F2/954 , A61M25/10 , A61F2/958 , A61M29/00 , B29C39/02 , B29C43/02 , B29C45/00 , B29C47/00 , B29C49/00 , B29C49/08 , B29C67/00 , B29D22/00 , A61F2/856
CPC分类号： A61F2/954 , A61F2/856 , A61F2/958 , A61F2250/0036 , A61M25/1027
摘要： Balloon systems for treating bifurcated lumens include desirable burst and folding characteristics. In some cases, the balloon systems can be formed by varying the wall thickness of a balloon parison.
摘要翻译：用于治疗分叉腔的气球系统包括所需的爆裂和折叠特性。在一些情况下，球囊系统可以通过改变气球型坯的壁厚来形成。

10. 发明授权

US08784481B2 Collapsible/expandable prosthetic heart valves with native calcified leaflet retention features 有权
标题翻译：具有天然钙化小叶保留特征的可折叠/可扩张的假体心脏瓣膜
公开(公告)号：US08784481B2
公开(公告)日：2014-07-22
申请号：US12733763
申请日：2008-09-26
申请人： Yousef F. Alkhatib , Michael J. Girard
发明人： Yousef F. Alkhatib , Michael J. Girard
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.
摘要翻译：假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。瓣膜在病人的植入部位重新扩大到操作尺寸。阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

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