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1. 发明授权

US09572660B2 Prosthetic heart valves 有权
标题翻译：假心脏瓣膜
公开(公告)号：US09572660B2
公开(公告)日：2017-02-21
申请号：US12451678
申请日：2008-06-04
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/82 , A61F2/24 , A61L27/36 , A61L27/54
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

2. 发明申请

US20100168839A1 PROSTHETIC HEART VALVES 有权
标题翻译：先天性心脏瓣膜
公开(公告)号：US20100168839A1
公开(公告)日：2010-07-01
申请号：US12451678
申请日：2008-06-04
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/008 , A61L27/3604 , A61L27/54
摘要： A prosthetic heart valve (10) (e.g., a prosthetic aortic valve) is designed to be somewhat circumferentially collapsible and then re-expandable. The collapsed condition may be used for less invasive delivery of the valve into a patient. When the valve reaches the implant site in the patient, it re-expands to normal operating size, and also to engage surrounding tissue of the patient. The valve includes a stent portion (200) and a ring portion (100) that is substantially concentric with the stent portion but downstream from the stent portion in the direction of blood flow through the implanted valve. When the valve is implanted, the stent portion engages the patient's tissue at or near the native valve annulus, while the ring portion engages tissue downstream from the native valve site (e.g., the aorta).
摘要翻译：假体心脏瓣膜（10）（例如，假体主动脉瓣）被设计成有些周向可折叠并且然后再膨胀。折叠状态可以用于将瓣膜侵入性较差的患者。当阀门到达病人的植入部位时，它会重新扩大到正常的操作大小，并且还可以接合病人的周围组织。所述阀包括支架部分（200）和环状部分（100），所述支架部分（100）与所述支架部分基本上同心，但在所述支架部分的下游沿着通过所述植入瓣膜的血流方向。当植入瓣膜时，支架部分在天然瓣膜环处或附近接合患者组织，而环部分接合自然瓣膜部位（例如，主动脉）下游的组织。

3. 发明申请

US20100161040A1 CARDIOVASCULAR VALVE AND VALVE HOUSING APPARATUSES AND SYSTEMS 有权
标题翻译：心脏瓣膜和阀门壳体设备和系统
公开(公告)号：US20100161040A1
公开(公告)日：2010-06-24
申请号：US12340189
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/24
CPC分类号： A61B17/11 , A61B5/1076 , A61B17/00234 , A61B17/1152 , A61B17/32002 , A61B17/32053 , A61B2017/00252 , A61B2017/00349 , A61B2017/00778 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061 , A61F2/06 , A61F2/064 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/30714 , A61F2250/0089 , A61M1/10 , A61M1/1008 , A61M1/1096 , A61M1/12 , A61M27/006
摘要： A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed.
摘要翻译：公开了一种心血管瓣膜组件，其包括壳体组件，壳体组件包括可拆卸地附接到第一部分的第一部分和第二部分。阀可以定位在壳体组件内。可以构造阀，其可以是机械阀，生物组织阀或聚合物阀，以允许流体沿单个方向流过壳体组件。在某些实施例中，阀组件还可以包括设置在第二部分上的至少一个联接结构和限定在第一部分中的至少一个孔，其中孔被构造成接收联接结构以将第一部分耦合到第二部分。还公开了包含心血管阀组件的相应系统。

4. 发明授权

US09566146B2 Cardiovascular valve and valve housing apparatuses and systems 有权
标题翻译：心血管阀和阀门外壳设备和系统
公开(公告)号：US09566146B2
公开(公告)日：2017-02-14
申请号：US12340189
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61F2/24 , A61F2/06 , A61B17/11 , A61B17/115 , A61B17/3205 , A61M1/10 , A61B17/32 , A61B17/00 , A61F2/30
CPC分类号： A61B17/11 , A61B5/1076 , A61B17/00234 , A61B17/1152 , A61B17/32002 , A61B17/32053 , A61B2017/00252 , A61B2017/00349 , A61B2017/00778 , A61B2017/1107 , A61B2017/1132 , A61B2017/1135 , A61B2090/061 , A61F2/06 , A61F2/064 , A61F2/24 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/30714 , A61F2250/0089 , A61M1/10 , A61M1/1008 , A61M1/1096 , A61M1/12 , A61M27/006
摘要： A cardiovascular valve assembly is disclosed including a housing assembly comprising a first portion and a second portion removably attached to the first portion. A valve may be positioned within the housing assembly. The valve, which may be a mechanical valve, a biological tissue valve, or a polymeric valve, may be structured to allow fluid to flow through the housing assembly in a single direction. In certain embodiments, the valve assembly may further include at least one coupling structure provided on the second portion and at least one aperture defined in the first portion, with the aperture structured to receive the coupling structure to couple the first portion to the second portion. Corresponding systems incorporating cardiovascular valve assemblies are also disclosed.
摘要翻译：公开了一种心血管瓣膜组件，其包括壳体组件，壳体组件包括可拆卸地附接到第一部分的第一部分和第二部分。阀可以定位在壳体组件内。可以构造阀，其可以是机械阀，生物组织阀或聚合物阀，以允许流体沿单个方向流过壳体组件。在某些实施例中，阀组件还可以包括设置在第二部分上的至少一个联接结构和限定在第一部分中的至少一个孔，其中孔被构造成接收联接结构以将第一部分耦合到第二部分。还公开了包含心血管阀组件的相应系统。

5. 发明申请

US20120078347A1 STENT FEATURES FOR COLLAPSIBLE PROSTHETIC HEART VALVES 有权
标题翻译：可靠的前置心脏瓣膜的特点
公开(公告)号：US20120078347A1
公开(公告)日：2012-03-29
申请号：US13203627
申请日：2010-02-25
申请人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
发明人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/915 , A61F2002/91575 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
摘要翻译：假体心脏瓣膜包括具有扩张状态和折叠状态的支架。支架包括多个远端细胞，多个近端细胞，将近端细胞耦合到远端细胞的多个支撑支柱以及连接到多个近端细胞的至少一个支撑柱。近端细胞与远端细胞纵向间隔开。支柱结构和连接到近端细胞和近端细胞到支撑柱的各种支柱构型和连接可改善支架的灵活性并减少瓣膜小叶中的压力。

6. 发明授权

US08905961B2 Systems, apparatuses, and methods for cardiovascular conduits and connectors 有权
标题翻译：用于心血管导管和连接器的系统，装置和方法
公开(公告)号：US08905961B2
公开(公告)日：2014-12-09
申请号：US12340280
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61M5/00 , A61F2/86 , A61F2/90 , A61F2/04 , A61F2/06 , A61F2/89 , A61F2/848 , A61F2/88 , A61B17/11 , A61F2/07 , A61B17/00 , A61F2/24 , A61F2/92
CPC分类号： A61F2/064 , A61B17/11 , A61B2017/00252 , A61B2017/00867 , A61B2017/1135 , A61F2/06 , A61F2/07 , A61F2/24 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2/89 , A61F2/92 , A61F2002/072
摘要： A cardiovascular conduit system may comprise a connector. The connector may comprise a proximal end adapted to attach to a cardiovascular organ. The proximal end may comprise a first plurality of expandable members, and each member in the first plurality of expandable members may be deployable from a delivery position to a deployed position. The first plurality of expandable members may be dimensioned to deploy inside the cardiovascular organ to secure the connector to the cardiovascular organ. The connector may comprise a distal end adapted to attach to a conduit and an opening extending through the connector. Connectors for cardiovascular conduit systems may also include expandable stents. Connectors may be rotatably secured to a conduit, and the conduit may be reinforced. Methods for forming and using cardiovascular conduit systems are also disclosed.
摘要翻译：心血管导管系统可以包括连接器。连接器可以包括适于附接到心血管器官的近端。近端可以包括第一多个可扩张构件，并且第一多个可扩张构件中的每个构件可以从输送位置展开到展开位置。可以将第一组多个可扩张构件的尺寸设计成部署在心血管器官内部以将连接器固定到心血管器官。连接器可以包括适于附接到导管的远端和延伸穿过连接器的开口。用于心血管导管系统的连接器还可以包括可扩张支架。连接器可以可旋转地固定到导管，并且导管可以被加强。还公开了形成和使用心血管导管系统的方法。

7. 发明授权

US08808366B2 Stent features for collapsible prosthetic heart valves 有权
标题翻译：支架功能可折叠假体心脏瓣膜
公开(公告)号：US08808366B2
公开(公告)日：2014-08-19
申请号：US13203627
申请日：2010-02-25
申请人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
发明人： Peter N. Braido , Yousef F. Alkhatib , Thomas M. Benson , Aaron J. Chalekian , Ott Khouengboua , Julia A. Neuman
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/915 , A61F2002/91575 , A61F2220/0075 , A61F2230/0054 , A61F2230/0067 , A61F2230/008
摘要： A prosthetic heart valve includes a stent having an expanded condition and a collapsed condition. The stent includes a plurality of distal cells, a plurality of proximal cells, a plurality of support struts coupling the proximal cells to the distal cells, and at least one support post connected to a plurality of proximal cells. The proximal cells are longitudinally spaced apart from the distal cells. Various strut configurations and connections of the struts to the proximal cells and of the proximal cells to the support post improve stent flexibility and reduce stress in the valve leaflets.
摘要翻译：假体心脏瓣膜包括具有扩张状态和折叠状态的支架。支架包括多个远端细胞，多个近端细胞，将近端细胞耦合到远端细胞的多个支撑支柱以及连接到多个近端细胞的至少一个支撑柱。近端细胞与远端细胞纵向间隔开。支柱结构和连接到近端细胞和近端细胞到支撑柱的各种支柱构型和连接可改善支架的灵活性并减少瓣膜小叶中的压力。

8. 发明申请

US20100160847A1 SYSTEMS, APPARATUSES, AND METHODS FOR CARDIOVASCULAR CONDUITS AND CONNECTORS 有权
标题翻译：心血管和连接器的系统，装置和方法
公开(公告)号：US20100160847A1
公开(公告)日：2010-06-24
申请号：US12340280
申请日：2008-12-19
申请人： Peter N. Braido , Yousef F. Alkhatib
发明人： Peter N. Braido , Yousef F. Alkhatib
IPC分类号： A61M5/00
CPC分类号： A61F2/064 , A61B17/11 , A61B2017/00252 , A61B2017/00867 , A61B2017/1135 , A61F2/06 , A61F2/07 , A61F2/24 , A61F2/848 , A61F2/86 , A61F2/88 , A61F2/89 , A61F2/92 , A61F2002/072
摘要： A cardiovascular conduit system may comprise a connector. The connector may comprise a proximal end adapted to attach to a cardiovascular organ. The proximal end may comprise a first plurality of expandable members, and each member in the first plurality of expandable members may be deployable from a delivery position to a deployed position. The first plurality of expandable members may be dimensioned to deploy inside the cardiovascular organ to secure the connector to the cardiovascular organ. The connector may comprise a distal end adapted to attach to a conduit and an opening extending through the connector. Connectors for cardiovascular conduit systems may also include expandable stents. Connectors may be rotateably secured to a conduit, and the conduit may be reinforced. Methods for forming and using cardiovascular conduit systems are also disclosed.
摘要翻译：心血管导管系统可包括连接器。连接器可以包括适于附接到心血管器官的近端。近端可以包括第一多个可扩张构件，并且第一多个可扩张构件中的每个构件可以从输送位置展开到展开位置。可以将第一组多个可扩张构件的尺寸设计成部署在心血管器官内部以将连接器固定到心血管器官。连接器可以包括适于附接到导管的远端和延伸穿过连接器的开口。用于心血管导管系统的连接器还可以包括可扩张支架。连接器可以可旋转地固定到导管，并且导管可以被加强。还公开了形成和使用心血管导管系统的方法。

9. 发明授权

US09021674B2 System for loading a collapsible heart valve 有权
标题翻译：用于装载可折叠心脏瓣膜的系统
公开(公告)号：US09021674B2
公开(公告)日：2015-05-05
申请号：US13364501
申请日：2012-02-02
申请人： Brett Allen Hillukka , Huisun Wang , Valerie J. Glazier , Yousef F. Alkhatib , Jacob John Daly , Ralph Joseph Thomas
发明人： Brett Allen Hillukka , Huisun Wang , Valerie J. Glazier , Yousef F. Alkhatib , Jacob John Daly , Ralph Joseph Thomas
IPC分类号： B25B31/00 , B23P11/00 , A61F2/24 , A61F2/00 , A61F2/97 , A61F2/95
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/2412 , A61F2/2436 , A61F2/97 , A61F2002/9522 , A61F2250/0039 , Y10T29/49826 , Y10T29/53909 , Y10T29/53943
摘要： An assembly for collapsing a self-expanding prosthetic heart valve includes a compression member, a support member and a constricting member. The compression member has a tapered wall between its first open end and its second open end, the tapered wall defining an open space adapted to receive the valve. The support member has a base and a recess adapted to receive an end of the valve. The support member and the compression member are movable toward one another to compress the valve and push it through a relatively small aperture in the second open end of the compression member. The second end of the constricting member is sized to receive the compressed valve from the second open end of the compression member for loading into a delivery device.
摘要翻译：用于塌缩自膨胀假体心脏瓣膜的组件包括压缩构件，支撑构件和收缩构件。压缩构件在其第一开口端和其第二开口端之间具有锥形壁，锥形壁限定适于接收阀的开放空间。支撑构件具有适于容纳阀的端部的基部和凹部。支撑构件和压缩构件可彼此移动以压缩阀并将其推压通过压缩构件的第二开口端中的相对小的孔。收缩构件的第二端的尺寸被设计成从压缩构件的第二开口端接收压缩的阀，用于装载到输送装置中。

10. 发明授权

US08728154B2 Prosthetic aortic heart valves 有权
标题翻译：假体主动脉瓣膜
公开(公告)号：US08728154B2
公开(公告)日：2014-05-20
申请号：US12733344
申请日：2008-08-21
申请人： Yousef F. Alkhatib
发明人： Yousef F. Alkhatib
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2445 , A61F2220/0016 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076
摘要： A prosthetic aortic valve includes an annular, annulus inflow portion that is designed to reside in or near the patient's native aortic valve annulus, and an annular, aortic outflow portion that is designed to reside in the patient's aorta downstream from at least a portion of the valsalva sinus. The annulus inflow portion and the aortic outflow portion are connected to one another by a plurality of connecting struts that are confined to regions near the commissures of the patient's native aortic valve. The connecting struts are designed to bulge out into the valsalva sinus to help anchor the prosthetic valve in place. The valve is circumferentially collapsible to a relatively small diameter for less-invasive delivery into the patient. The valve circumferentially expands to a larger operational diameter when deployed at the implant site.
摘要翻译：假体主动脉瓣包括环形环形流入部分，其被设计为驻留在患者的天然主动脉瓣膜环内或附近，以及环形主动脉流出部分，其被设计为驻留在患者主动脉中的至少一部分 valsalva窦。环形流入部分和主动脉流出部分通过多个连接支柱彼此连接，所述多个连接支柱被限制在靠近病人天然主动脉瓣的连合处的区域。连接支柱被设计成凸出到瓦尔萨瓦窦中，以帮助将假肢瓣锚定到位。瓣膜周向可折叠到相对较小的直径，用于较少侵入性地输送到患者体内。当部署在植入部位时，阀周向地膨胀到更大的操作直径。

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