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1. 发明申请

WO2009020236A2 NOVEL VIRAL VECTOR 审中-公开
标题翻译：新的VIRAL VECTOR
公开(公告)号：WO2009020236A2
公开(公告)日：2009-02-12
申请号：PCT/JP2008/064503
申请日：2008-08-06
申请人： EDUCATIONAL FOUNDATION JICHI MEDICAL UNIVERSITY , OTSUKA PHARMACEUTICAL CO., LTD. , YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
发明人： YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
IPC分类号： C12N15/866 , A61K39/145 , A61K39/015
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
摘要翻译：本发明提供新型转移载体和重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为活性成分的药物，其可用作疟疾和流感等感染性疾病的预防或治疗药物。更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为有效成分的药物。

2. 发明申请

WO1989009081A1 TEMPORARY PACING CATHETER 审中-公开
标题翻译：临时管道
公开(公告)号：WO1989009081A1
公开(公告)日：1989-10-05
申请号：PCT/JP1989000328
申请日：1989-03-29
申请人： NIPPON ZEON CO., LTD. , MIYATA, Shinichi , KAWABATA, Takashi , TAKAGI, Kiyoshi , MIYAHARA, Masaru , TSUJI, Takashi , YOSHIDA, Shigeto , HORIKAWA, Masayuki , IWAI, Fumiharu
发明人： NIPPON ZEON CO., LTD.
IPC分类号： A61N01/362
CPC分类号： A61N1/0565 , A61N1/3625 , A61N1/365
摘要： A temporary pacing catheter integrally provided with a temporary pacemaking function is disclosed. The temporary pacemaker integrally incorporated in the temporary pacing catheter is remarkably small-sized and can be fixedly mounted on a body of a patient, so that the patient can be advantageously transferred. Since a manual work, which has been required for the connection of the pacemaker with the catheter and the like, can be omitted, the temporary pacing catheter packed under the sterilized condition is suitable for an emergency treatment. In addition, if the temporary pacing catheter is provided with a balloon so as to envelop a distally-positioned electrode when it is expanded, the catheter can safely and speedily float within a heart and blood vessels.

3. 发明申请

WO1997024370A1 NOVEL ANTIGENIC PROTEINS OF MYCOPLASMATA, GENES THEREOF, AND RECOMBINANT VECTOR AND USE OF THE SAME 审中-公开
标题翻译： MYCOPLASMATA的新型抗原蛋白，其基因及其重组载体及其用途
公开(公告)号：WO1997024370A1
公开(公告)日：1997-07-10
申请号：PCT/JP1996003863
申请日：1996-12-27
申请人： NIPPON ZEON CO., LTD. , FUJISAWA, Ayumi , YOSHIDA, Shigeto
发明人： NIPPON ZEON CO., LTD.
IPC分类号： C07K14/30
CPC分类号： C07K16/1253 , A61K38/00 , C07K14/30
摘要： An antigenic protein that has an epitope recognizable by a monoclonal antibody 35A6 having the activity of inhibiting the metabolim of mycoplasmata infecting birds and that originate in Mycoplasma gallisepticum or antigenic proteins having an activity equivalent thereto.
摘要翻译：具有可被单克隆抗体35A6识别的表位的抗原性蛋白质具有抑制感染鸟的支原体代谢物的活性，并且起源于加利福里菌支原体或具有相当活性的抗原蛋白质。

4. 发明申请

WO1997003187A2 MAREK'S DISEASE VIRUS GENES AND THEIR USE IN VACCINES FOR PROTECTION AGAINST MAREK'S DISEASE 审中-公开
标题翻译：马克病毒病毒基因及其在疫苗接种疫苗中的应用
公开(公告)号：WO1997003187A2
公开(公告)日：1997-01-30
申请号：PCT/US1996011360
申请日：1996-07-05
申请人： NIPPON ZEON CO., LTD. , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF AGRICULTURE , LEE, Lucy, F. , NAZERIAN, Keyvan , WITTER, Richard, L. , WU, Ping , YANAGIDA, Noboru , YOSHIDA, Shigeto
发明人： NIPPON ZEON CO., LTD. , THE UNITED STATES OF AMERICA, represented by THE SECRETARY OF AGRICULTURE
IPC分类号： C12N07/04
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2710/16322
摘要： A nucleotide sequence encoding the gp82 polypeptide of Marek's disease virus is disclosed. Also disclosed are recombinant viruses which are useful as vaccines for protecting agaisnt Marek's Disease, preferably containing two or more genes encoding Marek's Diesease Virus antigens such as glycoprotein B and glycoprotein gp82, under the control of a poxvirus promoter within a region of the DNA of fowlpox virus which is not essential for virus growth. Also provided is a vaccine exhibiting a synergistic immunoprotective effect, comprising a recombinant fowlpox virus expressing Marek's Disease Virus gB protein in combination with turkey herpesvirus. A method of immunizing poultry, comprising administering any of the disclosed vaccines, is also provided.
摘要翻译：公开了编码马立克氏病病毒的gp82多肽的核苷酸序列。还公开了可用于保护马立克氏病的疫苗的重组病毒，优选含有两种或更多种编码马立克氏Diesease病毒抗原如糖蛋白B和糖蛋白gp82的基因，在禽痘DNA的区域内的痘病毒启动子控制下病毒不是病毒生长所必需的。还提供了表现出协同免疫保护作用的疫苗，其包含与火鸡疱疹病毒组合的表达马立克氏病病毒gB蛋白的重组禽痘病毒。还提供了免疫家禽的方法，包括施用任何所公开的疫苗。

5. 发明申请

WO2007052841A1 PLATELET AGGREGATION INHIBITOR COMPOSITION 审中-公开
标题翻译： PLATELET聚合抑制剂组合物
公开(公告)号：WO2007052841A1
公开(公告)日：2007-05-10
申请号：PCT/JP2006/322417
申请日：2006-11-02
申请人： EDUCATIONAL FOUNDATION JICHI MEDICAL UNIVERSITY , OTSUKA PHARMACEUTICAL CO., LTD. , YOSHIDA, Shigeto , SUDO, Toshiki
发明人： YOSHIDA, Shigeto , SUDO, Toshiki
IPC分类号： C12N15/00 , A61K38/00 , A61P7/02 , C07K14/435 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C07K14/43563 , A61K38/17 , G01N33/5088
摘要： The invention provides a pharmaceutical composition comprising at least one polypeptide of the following (a) to (d): (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:1; (b) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (a) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity; (c) a polypeptide comprising the amino acid sequence of SEQ ID NO:3; and (d) a polypeptide comprising an amino acid sequence comprising one or more amino acid deletions, insertions, substitutions or additions in the amino acid sequence of the above (c) and having a platelet aggregation inhibitory activity and/or a platelet adhesion inhibitory activity, as an active component.
摘要翻译：本发明提供了包含至少一种以下（a）至（d）的多肽的药物组合物：（a）包含SEQ ID NO：1的氨基酸序列的多肽; （b）包含在上述（a）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽; （c）包含SEQ ID NO：3的氨基酸序列的多肽; 和（d）包含在上述（c）的氨基酸序列中包含一个或多个氨基酸缺失，插入，取代或添加并具有血小板聚集抑制活性和/或血小板粘附抑制活性的氨基酸序列的多肽，作为活性成分。

6. 发明申请

WO9703187A3 MAREK'S DISEASE VIRUS GENES AND THEIR USE IN VACCINES FOR PROTECTION AGAINST MAREK'S DISEASE 审中-公开
标题翻译：马克病毒病毒基因及其在疫苗接种疫苗中的应用
公开(公告)号：WO9703187A3
公开(公告)日：1997-03-20
申请号：PCT/US9611360
申请日：1996-07-05
申请人： NIPPON ZEON CO , US AGRICULTURE , LEE LUCY F , NAZERIAN KEYVAN , WITTER RICHARD L , WU PING , YANAGIDA NOBORU , YOSHIDA SHIGETO
发明人： LEE LUCY F , NAZERIAN KEYVAN , WITTER RICHARD L , WU PING , YANAGIDA NOBORU , YOSHIDA SHIGETO
IPC分类号： C12N15/09 , A61K39/00 , A61K39/255 , A61K48/00 , A61P31/12 , C07K14/055 , C12N7/00 , C12N7/04 , C12N15/86
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2710/16322
摘要： A nucleotide sequence encoding the gp82 polypeptide of Marek's disease virus is disclosed. Also disclosed are recombinant viruses which are useful as vaccines for protecting agaisnt Marek's Disease, preferably containing two or more genes encoding Marek's Diesease Virus antigens such as glycoprotein B and glycoprotein gp82, under the control of a poxvirus promoter within a region of the DNA of fowlpox virus which is not essential for virus growth. Also provided is a vaccine exhibiting a synergistic immunoprotective effect, comprising a recombinant fowlpox virus expressing Marek's Disease Virus gB protein in combination with turkey herpesvirus. A method of immunizing poultry, comprising administering any of the disclosed vaccines, is also provided.

7. 发明申请

WO2009020236A3 BACULOVIRAL VECTORS WITH A DUAL VERTEBRATE AND BACULOVIRUS PROMOTER CONTROLLING AN IMMUNOGENIC FUSION GENE 审中-公开
标题翻译：具有双重VERTEBRATE和BACULVVUSUS PROMOTER控制免疫原性融合基因的BACULOVIRAL VECTORS
公开(公告)号：WO2009020236A3
公开(公告)日：2009-04-16
申请号：PCT/JP2008064503
申请日：2008-08-06
申请人： EDUCATIONAL FOUNDATION JICHI M , OTSUKA PHARMA CO LTD , YOSHIDA SHIGETO , KAWASAKI MASANORI , MATSUMOTO MAKOTO , OHBA YOSHIO , SAITO MASAHIRO , GOTO YOSHIHIRO , INAGAKI KATSUYA , MIZUKOSHI MASAMI , HARIGUCHI NORIMITSU , HIROTA KUNIKO
发明人： YOSHIDA SHIGETO , KAWASAKI MASANORI , MATSUMOTO MAKOTO , OHBA YOSHIO , SAITO MASAHIRO , GOTO YOSHIHIRO , INAGAKI KATSUYA , MIZUKOSHI MASAMI , HARIGUCHI NORIMITSU , HIROTA KUNIKO
IPC分类号： C12N15/866 , A61K39/015 , A61K39/145
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
摘要翻译：本发明提供新型转移载体和重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为活性成分的药物，其可用作疟疾和流感等感染性疾病的预防或治疗药物。更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为有效成分的药物。

8. 发明授权

US5276103A Uranium adsorbent 失效
标题翻译：铀吸附剂
公开(公告)号：US5276103A
公开(公告)日：1994-01-04
申请号：US776412
申请日：1991-11-25
申请人： Kobuke Yoshiaki , Yoshida Shigeto
发明人： Kobuke Yoshiaki , Yoshida Shigeto
IPC分类号： C01G43/00 , B01J20/26 , C02F1/28 , C22B60/02 , D01F6/18 , G21F9/12 , C08F8/32
CPC分类号： G21F9/12 , B01J20/26 , C02F1/285 , C22B60/0265 , C02F2101/006
摘要： A uranium adsorbent is prepared by reacting a polymer containing nitrile groups with hydroxylamine, wherein the amount of imidedioxime groups formed is relatively larger than that of amidoxime groups formed in terms of the integral values of areas of peaks respectively assigned to imidedioxime groups and amidoxime groups in the .sup.13 C-NMR spectrum chart of the adsorbent. The reaction may be effected: 1) in an organic solvent containing water under substantially neutral or weakly alkaline conditions, or 2) under acidic conditions. The uranium adsorptivity of the adsorbent is improved by hydrolyzing its residual nitrile groups under alkaline conditions.
摘要翻译： PCT No.PCT / SE90 / 00203 Sec。 371日期：1991年11月25日 102（e）日期1991年11月25日PCT 1990年3月29日PCT公布。公开号WO90 / 11826 日期：1990年10月18日。铀吸附剂通过使含有腈基团的聚合物与羟胺反应制备，其中形成的亚肟基基团的量相对于分别指定的峰面积的积分值形成的偕胺肟基团的量到吸附剂的13 C-NMR谱图中的亚肟基和偕胺肟基团。反应可以实现：1）在基本上中性或弱碱性条件下的含水的有机溶剂中，或2）在酸性条件下。通过在碱性条件下水解其残留的腈基来改善吸附剂的铀吸附性。

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