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1. 发明申请

WO2011088126A2 TREATMENT OF VIRAL INFECTION WITH PRENYLTRANSFERASE INHIBITORS 审中-公开
标题翻译：用预处理酶抑制剂治疗病毒感染
公开(公告)号：WO2011088126A2
公开(公告)日：2011-07-21
申请号：PCT/US2011020998
申请日：2011-01-12
申请人： EIGER BIOPHARMACEUTICALS INC , CORY DAVID , CHOONG INGRID , MURPHY BRIAN , YANG WENJIN , GLENN JEFFREY S
发明人： CORY DAVID , CHOONG INGRID , MURPHY BRIAN , YANG WENJIN , GLENN JEFFREY S
CPC分类号： A61K31/197 , A61K31/40 , A61K31/435 , A61K31/4439 , A61K31/675 , A61K31/7068 , A61K2300/00
摘要： Inhibitors of prenylation such as farnesyl transferase inhibitors can be used to treat HDV infection.
摘要翻译：异戊烯基化抑制剂如法呢基转移酶抑制剂可用于治疗HDV感染。

2. 发明申请

WO2010107739A3 METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
公开(公告)号：WO2010107739A3
公开(公告)日：2010-09-23
申请号：PCT/US2010/027400
申请日：2010-03-16
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , CHOONG, Ingrid, C. , CORY, David , GLENN, Jeffrey, S. , YANG, Wenjin , EIGER BIOPHARMACEUTICALS, INC.
发明人： CHOONG, Ingrid, C. , CORY, David , GLENN, Jeffrey, S. , YANG, Wenjin
IPC分类号： A61K31/4184 , A61K31/437 , A61K31/4178 , A61K31/337 , A61K31/4965 , A61P31/12
摘要： Clemizole and clemizole analog compounds, and pharmaceutical compositions of the same, are useful in methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, and methods of treating liver fibrosis in a host.

3. 发明申请

WO2010039195A3 SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION 审中-公开
标题翻译：筛选HCV双价体螺旋（AH）功能抑制剂
公开(公告)号：WO2010039195A3
公开(公告)日：2010-05-27
申请号：PCT/US2009005306
申请日：2009-09-23
申请人： UNIV LELAND STANFORD JUNIOR , GLENN JEFFREY S , CHO NAM-JOON , YANG WENJIN
发明人： GLENN JEFFREY S , CHO NAM-JOON , YANG WENJIN
IPC分类号： G01N33/68 , G01N33/92
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent.
摘要翻译：筛选方法用于鉴定HCV两亲性螺旋（AH）功能的药理学抑制剂，该抑制剂可用于预防和治疗HCV感染。还提供了用于抑制病毒复制的化合物。本发明的方法基于意想不到的发现，即AH的存在，例如， HCV多肽的AH引起囊泡表观直径的增加。本发明的方法例如以高通量形式向脂质囊泡中添加AH肽; 该添加可以在不存在或存在候选药剂的情况下进行。测量表观囊泡大小的变化，并与对照样品比较。囊泡大小或聚集的增加表明存在AH功能; 并且缺乏增加表明AH功能不存在或已被测试药剂抑制。

4. 发明申请

WO2010039195A2 SCREENING FOR INHIBITORS OF HCV AMPHIPATHIC HELIX (AH) FUNCTION 审中-公开
标题翻译：筛选HCV雄性HELIX（AH）功能的抑制剂
公开(公告)号：WO2010039195A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/005306
申请日：2009-09-23
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , GLENN, Jeffrey S. , CHO, Nam-Joon , YANG, Wenjin
发明人： GLENN, Jeffrey S. , CHO, Nam-Joon , YANG, Wenjin
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Screening methods are provided for identifying pharmacologic inhibitors of HCV amphipathic helix (AH) function, which inhibitors are useful in the prevention and treatment of HCV infection. Also provided are compounds useful in the inhibition of viral replication. The methods of the invention are based on the unexpected discovery that the presence of an AH, e.g. an AH of an HCV polypeptide, causes an increase in the apparent diameter of the vesicles. The methods of the invention provide for addition of AH peptides to lipid vesicles, for example in a high-throughput format; which addition may be performed in the absence or presence of a candidate pharmacologic agent. The change in apparent vesicle size is measured, and compared to control samples. An increase in vesicle size or aggregation is indicative of AH function being present; and a lack of increase is indicative that the AH function is absent or has been inhibited by a test agent.
摘要翻译：提供筛选方法用于鉴定HCV两亲性螺旋（AH）功能的药理学抑制剂，该抑制剂可用于预防和治疗HCV感染。还提供了可用于抑制病毒复制的化合物。本发明的方法基于意想不到的发现，即AH的存在，例如， HCV多肽的AH引起囊泡表观直径的增加。本发明的方法提供了将AH肽添加到脂质囊泡中，例如以高通量形式加入; 该添加可以在不存在或存在候选药理剂的情况下进行。测量明显囊泡大小的变化，并与对照样品进行比较。囊泡大小或聚集的增加表明存在AH功能; 并且缺乏增加表明AH功能不存在或已被测试者抑制。

5. 发明申请

WO2009039248A8 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
公开(公告)号：WO2009039248A8
公开(公告)日：2009-03-26
申请号：PCT/US2008/076806
申请日：2008-09-18
申请人： STANFORD UNIVERSITY , EINAV, Shirit , GLENN, Jeffrey, S. , MCDOWELL, Robert , YANG, Wenjin , DVORY-SOBOL, Hadas
发明人： EINAV, Shirit , GLENN, Jeffrey, S. , MCDOWELL, Robert , YANG, Wenjin , DVORY-SOBOL, Hadas
摘要： Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

6. 发明申请

WO2007011810A1 SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的螺旋剂β-分泌酶抑制剂
公开(公告)号：WO2007011810A1
公开(公告)日：2007-01-25
申请号：PCT/US2006/027544
申请日：2006-07-14
申请人： MERCK & CO., INC. , SUNESIS PHARMACEUTICALS, INC. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
发明人： COBURN, Craig, A. , EGBERTSON, Melissa, S. , GRAHAM, Samuel, L. , MCGAUGHEY, Georgia, B. , STAUFFER, Shaun, R. , YANG, Wenjin , LU, Wanli , FAHR, Bruce
IPC分类号： C07D471/10 , A61K31/438 , A61P25/28
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the beta-secretase enzyme is involved.
摘要翻译：本发明涉及式（I）的螺哌啶化合物及其互变异构体，其是β-分泌酶的抑制剂，并且其可用于治疗涉及β-分泌酶的疾病，例如阿尔茨海默氏病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在治疗涉及β-分泌酶的疾病中的用途。

7. 发明申请

WO1996014314A3 THIEPANE COMPOUNDS INHIBITING AND DETECTING HIV PROTEASE 审中-公开
公开(公告)号：WO1996014314A3
公开(公告)日：1996-05-17
申请号：PCT/US1995014603
申请日：1995-11-03
申请人： GILEAD SCIENCES, INC. , BISCHOFBERGER, Norbert, W. , KIM, Choung, U. , KRAWCZYK, Steven, H. , MCGEE, Lawrence, R. , POSTICH, Michael, J. , YANG, Wenjin
发明人： GILEAD SCIENCES, INC.
IPC分类号： C07D337/00

8. 发明申请

WO9614314A2 THIEPANE COMPOUNDS INHIBITING AND DETECTING HIV PROTEASE 审中-公开
标题翻译：该化合物抑制和检测HIV病毒
公开(公告)号：WO9614314A2
公开(公告)日：1996-05-17
申请号：PCT/US9514603
申请日：1995-11-03
申请人： GILEAD SCIENCES INC , BISCHOFBERGER NORBERT W , KIM CHOUNG U , KRAWCZYK STEVEN H , MCGEE LAWRENCE R , POSTICH MICHAEL J , YANG WENJIN
发明人： BISCHOFBERGER NORBERT W , KIM CHOUNG U , KRAWCZYK STEVEN H , MCGEE LAWRENCE R , POSTICH MICHAEL J , YANG WENJIN
IPC分类号： A61K31/38 , A61K31/427 , A61K31/4436 , A61P31/18 , A61P43/00 , C07D337/04 , C07D409/12 , C07D417/12 , C07D495/04 , C07D495/12 , C07D337/00
CPC分类号： C07D495/04 , C07D337/04
摘要： Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositons are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.
摘要翻译：公开了用作免疫原，治疗学，诊断和用于其它工业目的的三取代和四取代的硫代吡喃组合物。组合物抑制病毒酶的蛋白水解活性，并且可用于抑制这些酶以及用于检测这些酶的测定。其中抗原性多肽与组合物结合的实施方案可用于产生针对硫替平半抗原或多肽的抗体。本发明的标记的thiepane可用作诊断试剂。

9. 发明申请

WO2021097190A1 MATRIX METALLOPROTEINASE (MMP) INHIBITORS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021097190A1
公开(公告)日：2021-05-20
申请号：PCT/US2020/060387
申请日：2020-11-13
申请人： FORESEE PHARMACEUTICALS CO., LTD. , YANG, Wenjin , CHANG, Kai-wei
发明人： YANG, Wenjin , CHANG, Kai-wei
IPC分类号： C07D239/70 , C07D405/12
摘要： Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

10. 发明申请

WO2011144061A3 CONGESTION DETECTION METHOD AND APPARATUS FOR CELL IN MOBILE NETWORK 审中-公开
标题翻译：移动网络小区检测方法和设备
公开(公告)号：WO2011144061A3
公开(公告)日：2012-04-19
申请号：PCT/CN2011074451
申请日：2011-05-20
申请人： HUAWEI TECH CO LTD , JIANG MING , YANG WENJIN
发明人： JIANG MING , YANG WENJIN
IPC分类号： H04W28/10
CPC分类号： H04W28/02
摘要： A congestion detection method and apparatus for cells in mobile network are provided, which relate to mobile communication technology field, and congestion detection and data distribution can be realized through core network element. The congestion detection method for cells in mobile network includes: acquiring a round trip time of a cell data message in real time; comparing the round trip time with a preset congestion round trip time threshold value, if the round trip time is longer than the congestion round trip time threshold value, determining the cell is overloaded and congestion, and if the round trip time is shorter than the congestion round trip time threshold value, determining the cell is not congestion.
摘要翻译：提供了一种移动网络中的小区拥塞检测方法和装置，涉及移动通信技术领域，通过核心网元可以实现拥塞检测和数据分发。移动网络中小区的拥塞检测方法包括：实时获取小区数据报文的往返时间; 将往返时间与预设的拥堵往返时间阈值进行比较，如果往返时间长于拥塞往返时间阈值，则确定小区过载和拥塞，并且如果往返时间短于拥塞往返时间阈值，确定小区没有拥塞。

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