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1. 发明申请

WO2012122391A1 HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS 审中-公开
标题翻译：脂质合成的杂环调节剂
公开(公告)号：WO2012122391A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028309
申请日：2012-03-08
申请人： 3-V BIOSCIENCES, INC. , OSLOB, Johan D. , McDOWELL, Robert S. , JOHNSON, Russell , YANG, Hanbiao , EVANCHIK, Marc , ZAHARIA, Cristiana A. , CAI, Haiying , HU, Lily W.
发明人： OSLOB, Johan D. , McDOWELL, Robert S. , JOHNSON, Russell , YANG, Hanbiao , EVANCHIK, Marc , ZAHARIA, Cristiana A. , CAI, Haiying , HU, Lily W.
IPC分类号： A01N43/58
CPC分类号： C07D471/04 , A61K31/4525 , A61K31/454 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/14 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/10 , C07D491/107 , C07D513/04 , Y02A50/385 , Y02A50/387 , Y02A50/465 , A61K2300/00
摘要： Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatits C infection, cancer and metabolic disorders.
摘要翻译：提供了脂肪酸合成调节剂的化合物。该化合物可用于治疗以调节功能和/或脂肪酸合成酶途径为特征的脂肪酸合酶功能失调的病症。提供了用于治疗诸如肝脏C感染，癌症和代谢紊乱等病毒感染的疾病的方法。

2. 发明申请

WO2003087054A2 METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE ENZYMATIC ACTIVITY 审中-公开
标题翻译：用于鉴定调节酶活性的化合物的方法
公开(公告)号：WO2003087054A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/006217
申请日：2003-02-26
申请人： SUNESIS PHARMACEUTICALS, INC. , ERLANSON, Daniel, A. , MCDOWELL, Robert, S. , HANSEN, Stig
发明人： ERLANSON, Daniel, A. , MCDOWELL, Robert, S. , HANSEN, Stig
IPC分类号： C07D
CPC分类号： G01N33/573 , C07K1/1072 , G01N2333/916 , G01N2500/02
摘要： The present invention relates to the use of “tethering” to identify compounds that modulate enzymatic activity.
摘要翻译：本发明涉及“系链”用于鉴定调节酶活性的化合物的用途。

3. 发明申请

WO0242773B1 AN EXTENDED TETHERING APPROACH FOR RAPID IDENTIFICATION OF LIGANDS 审中-公开
标题翻译：用于快速鉴定配体的扩展方法
公开(公告)号：WO0242773B1
公开(公告)日：2002-12-12
申请号：PCT/US0144036
申请日：2001-11-20
申请人： SUNESIS PHARMACEUTICALS INC , ERLANSON DANIEL A , BRAISTED ANDREW , MCDOWELL ROBERT , PRESCOTT JOHN
发明人： ERLANSON DANIEL A , BRAISTED ANDREW , MCDOWELL ROBERT , PRESCOTT JOHN
IPC分类号： G01N33/50 , C07B61/00 , C40B30/04 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C40B30/04 , B01J2219/0072 , C07B2200/11 , C40B40/04 , C40B50/14 , G01N33/6845 , G01N2500/04 , Y02P20/55
摘要： The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.
摘要翻译：本发明涉及用于靶分子的结合配偶体的快速鉴定和表征以及提供具有改善的结合亲和力的结合配偶体的方法。更具体地说，本发明涉及用于快速鉴定至少两个彼此靠近结合靶分子的结合配偶体的改进的系链方法。

4. 发明申请

WO0242773A3 AN EXTENDED TETHERING APPROACH FOR RAPID IDENTIFICATION OF LIGANDS 审中-公开
公开(公告)号：WO0242773A3
公开(公告)日：2002-11-14
申请号：PCT/US0144036
申请日：2001-11-20
申请人： SUNESIS PHARMACEUTICALS INC , ERLANSON DANIEL A , BRAISTED ANDREW , MCDOWELL ROBERT , PRESCOTT JOHN
发明人： ERLANSON DANIEL A , BRAISTED ANDREW , MCDOWELL ROBERT , PRESCOTT JOHN
IPC分类号： G01N33/50 , C07B61/00 , C40B30/04 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C40B30/04 , B01J2219/0072 , C07B2200/11 , C40B40/04 , C40B50/14 , G01N33/6845 , G01N2500/04 , Y02P20/55
摘要： The invention concerns a method for rapid identification and characterization of binding partners for a target molecule, and for providing binding partners with improved binding affinity. More specifically, the invention concerns an improved tethering method for the rapid identification of at least two binding partners that bind near one another to a target molecule.

5. 发明申请

WO2009039246A3 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
标题翻译：治疗弗氏病家族病毒感染的方法，用于治疗弗氏病家族病毒感染的组合物和用于鉴定用于治疗弗氏病家族病毒感染的组合物的筛选测定
公开(公告)号：WO2009039246A3
公开(公告)日：2009-06-11
申请号：PCT/US2008076804
申请日：2008-09-18
申请人： UNIV STANFORD , QUAKE STEPHEN R , EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN , GERBER DORON , DVORY-SOBOL HADAS
发明人： QUAKE STEPHEN R , EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN , GERBER DORON , DVORY-SOBOL HADAS
IPC分类号： A61K31/7056 , A61K31/675 , A61K39/29 , C12Q1/70
CPC分类号： A61K31/4184 , A61K31/67 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D235/08 , C07D235/12 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2500/02 , A61K2300/00
摘要： Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of identifying a candidate agent for the treatment of hepatitis C virus (HCV) infection, and the like.
摘要翻译：简要描述，本公开的实施方案包括组合物，药物组合物，治疗感染来自病毒的病毒的宿主的方法，鉴定用于治疗丙型肝炎病毒（HCV）感染的候选药物等的方法。

6. 发明申请

WO2008036762A1 METHOD AND APPARATUS FOR CONTINUOUS CATALYST SYNTHESIS 审中-公开
标题翻译：连续催化合成的方法和装置
公开(公告)号：WO2008036762A1
公开(公告)日：2008-03-27
申请号：PCT/US2007/078929
申请日：2007-09-19
申请人： NANOSTELLAR, INC. , SHARMA, Ramesh K. , FUJDALA, Kyle L. , TRUEX, Timothy J. , MCDOWELL, Robert , JIA, Jifei
发明人： SHARMA, Ramesh K. , FUJDALA, Kyle L. , TRUEX, Timothy J. , MCDOWELL, Robert , JIA, Jifei
IPC分类号： B01J37/02
CPC分类号： B01J37/16 , B01J23/40 , B01J23/52 , B01J35/04 , B01J37/0211 , B01J37/031 , B01J37/038
摘要： A method for preparing a catalyst that involves continuously supplying a first stream containing a solvent, one or more metal precursors, and one or more support materials, and a second stream containing at least one reducing agent and/or precipitating agent. The first and second streams are combined to form a combined stream. In one embodiment, the combined stream may be fed to a mixing vessel. In another embodiment, the streams are combined in a mixing vessel. After the streams are combined, one or more metal precursors is reduced or precipitated within the pores of the one or more support materials. Thereafter, solids are separated from the combined stream and processed to produce the supported metal, mixed-metal, metal oxide, or mixed-metal oxide catalyst. In another embodiment, ceramic or metallic monoliths may be coated with the catalytic material after the stream combination and before or after the solid separation and subsequent processing.
摘要翻译：一种制备催化剂的方法，所述催化剂包括连续供应含有溶剂的第一物流，一种或多种金属前体和一种或多种载体材料，以及含有至少一种还原剂和/或沉淀剂的第二物流。第一和第二流被组合以形成组合流。在一个实施例中，组合的流可以被供给到混合容器。在另一个实施方案中，将流合并在混合容器中。在流合并后，一种或多种金属前体在一种或多种载体材料的孔隙内还原或沉淀。此后，将固体与合并的流分离并加工以产生负载的金属，混合金属，金属氧化物或混合金属氧化物催化剂。在另一个实施方案中，陶瓷或金属整料可以在流组合之后和在固体分离和后续处理之前或之后用催化材料涂覆。

7. 发明申请

WO1994026723A2 PREPARATION OF N-CYANODITHIOIMINO-CARBONATES AND 3-MERCAPTO-5-AMINO-1H-1,2,4-TRIAZOLE 审中-公开
标题翻译： N-氰基亚氨基二碳酸酯和3-巯基-5-氨基-1H-1,2,4-三唑的制备
公开(公告)号：WO1994026723A2
公开(公告)日：1994-11-24
申请号：PCT/US1994005157
申请日：1994-05-10
申请人： GENENTECH, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , MARSTERS, James, C., Jr. , BROWN, Michael, S. , CROWLEY, Craig, W. , GOLDSTEIN, Joseph, L. , JAMES, Guy, L. , McDOWELL, Robert, S. , OARE, David , RAWSON, Thomas, E. , REYNOLDS, Mark , SOMERS, Todd, G.
发明人： GENENTECH, INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
IPC分类号： C07D243/14
CPC分类号： C07D223/16 , A61K38/00 , C07D243/10 , C07D243/24 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D409/14 , C07D487/04 , C07D513/04 , C07K5/0207 , C07K5/0606 , C07K5/06139 , C07K5/06191 , C07K5/081 , C07K5/0821 , C07K5/0827 , C07K5/1013 , C07K5/1024 , C07K5/1027
摘要： Benzodiazepine derivatives are disclosed that act as potent inhibitors of ras farnesyl:protein transferase. Pharmaceutical compositions containing these benzodiazepines are provided for treatment of diseases for which inhibition of the ras farnesyl:protein transferase is indicated.
摘要翻译：公开了苯并二氮杂衍生物，其作为法西尼酯：蛋白转移酶的有效抑制剂。提供含有这些苯二氮卓类药物的药物组合物，用于治疗对法拉第法：蛋白转移酶的抑制作用的疾病的治疗。

8. 发明申请

WO2009039248A3 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
公开(公告)号：WO2009039248A3
公开(公告)日：2009-09-24
申请号：PCT/US2008076806
申请日：2008-09-18
申请人： UNIV STANFORD , EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN , DVORY-SOBOL HADAS
发明人： EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN , DVORY-SOBOL HADAS
IPC分类号： A61K31/4184 , A61P1/16 , A61P31/12
CPC分类号： A61K31/4184 , A61K31/67 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D235/08 , C07D235/12 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2500/02 , A61K2300/00
摘要： Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.

9. 发明申请

WO2009039248A2 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION AND COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
标题翻译：治疗黄病毒科家族病毒感染的组合物和治疗黄病毒科家族病毒感染的组合物
公开(公告)号：WO2009039248A2
公开(公告)日：2009-03-26
申请号：PCT/US2008076806
申请日：2008-09-18
申请人： UNIV STANFORD , EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN
发明人： EINAV SHIRIT , GLENN JEFFREY S , MCDOWELL ROBERT , YANG WENJIN
CPC分类号： A61K31/4184 , A61K31/67 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D235/08 , C07D235/12 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2500/02 , A61K2300/00
摘要： Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of treating HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3'UTR of HCV negative strand RNA in a host, methods of treating liver fibrosis in a host, and the like.
摘要翻译：简而言之，本公开的实施方案包括组合物，药物组合物，治疗感染黄病毒科病毒的病毒的宿主的方法，治疗宿主中HCV复制的方法，抑制NS4B多肽与3' 在宿主中的HCV负链RNA的UTR，治疗宿主中的肝纤维化的方法等。

10. 发明申请

WO2009039246A2 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
标题翻译：治疗黄病毒科家族病毒感染的方法，治疗黄病毒科家族病毒感染的组合物和筛选鉴定治疗黄病毒科家族病毒感染的组合物的试验
公开(公告)号：WO2009039246A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/076804
申请日：2008-09-18
申请人： STANFORD UNIVERSITY , QUAKE, Stephen, R. , EINAV, Shirit , GLENN, Jeffrey, S. , MCDOWELL, Robert , YANG, Wenjin , GERBER, Doron , DVORY-SOBOL, Hadas
发明人： QUAKE, Stephen, R. , EINAV, Shirit , GLENN, Jeffrey, S. , MCDOWELL, Robert , YANG, Wenjin , GERBER, Doron , DVORY-SOBOL, Hadas
IPC分类号： A61K31/7056 , A61K31/67 , A61K39/29 , C12Q1/70
CPC分类号： A61K31/4184 , A61K31/67 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D235/08 , C07D235/12 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2500/02 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395 , A61K2300/00
摘要： Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of identifying a candidate agent for the treatment of hepatitis C virus (HCV) infection, and the like.
摘要翻译：简言之，本公开的实施方案包括组合物，药物组合物，治疗感染黄病毒科病毒的病毒的宿主的方法，鉴定候选药物的方法用于治疗丙型肝炎病毒（HCV）感染等。

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