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1. 发明申请

WO2003066870A2 METHOD FOR DETECTING POLYMORPHISMS IN NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸中多态性的方法
公开(公告)号：WO2003066870A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003654
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12P
CPC分类号： C12Q1/6858 , C12Q2525/313 , C12Q2525/161
摘要： The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acid is compared to a reference nucleic acid having a known genotype. The nucleic acids can be of any length, even less than 100 base pairs. In the methods, one or more extra mismatches are introduced into the nucleic acids at or near the site of the polymorphism. The nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex that can be detected to indicate that the nucleic acids differ in genotype.
摘要翻译：本发明提供了确定多态性位点处核酸基因型的方法。该方法实现足够大的灵敏度以检测核酸之间的任何差异，甚至单核苷酸多态性的存在。在该方法中，将核酸与具有已知基因型的参照核酸进行比较。核酸可以是任何长度，甚至小于100个碱基对。在该方法中，在多态性位点处或附近的核酸中引入一个或多个额外的错配。核酸在能够形成稳定的四向复合物的条件下接触，其可被检测以表明核酸在基因型上不同。

2. 发明申请

WO2003066827A2 METHODS AND COMPOSITIONS FOR DETECTING DIFFERENCES BETWEEN NUCLEIC ACIDS 审中-公开
标题翻译：用于检测核酸之间差异的方法和组合物
公开(公告)号：WO2003066827A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003679
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12N
CPC分类号： C12Q1/6827 , C12Q1/6839 , C12Q2537/119 , C12Q2521/514
摘要： The present invention provides methods for detecting the presence or absence of a difference between two related nucleic acid sequences. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex if the nucleic acids differ in sequence. The presence of the four way complex is determined with a detection molecule and a labeled four-stranded tracer molecule.
摘要翻译：本发明提供了检测两个相关核酸序列之间差异的存在或不存在的方法。该方法实现足够大的灵敏度以检测核酸之间的任何差异，甚至单核苷酸多态性的存在。在所述方法中，如果核酸序列不同，则核酸在能够形成稳定的四元复合物的条件下接触。用检测分子和标记的四链示踪剂分子确定四方复合物的存在。

3. 发明申请

WO2010033716A3 METHOD FOR OPTIMIZING WELL PRODUCTION IN RESERVOIRS HAVING FLOW BARRIERS 审中-公开
标题翻译：优化具有流动障碍的储层的井产量的方法
公开(公告)号：WO2010033716A3
公开(公告)日：2010-07-01
申请号：PCT/US2009057337
申请日：2009-09-17
申请人： CHEVRON USA INC , LIU SONG , TIAN LIXIN , WEN XIAN-HUAN , ZHAO CHUNMING , YANG QINGHONG , ZHANG PENG , ZHOU DENGEN , LI BO , LAN LICHUAN , GE LIZHEN , LIAO XINWU , ZHANG FENGLI , WEI MICHAEL S
发明人： LIU SONG , TIAN LIXIN , WEN XIAN-HUAN , ZHAO CHUNMING , YANG QINGHONG , ZHANG PENG , ZHOU DENGEN , LI BO , LAN LICHUAN , GE LIZHEN , LIAO XINWU , ZHANG FENGLI , WEI MICHAEL S
IPC分类号： E21B43/00 , G01V1/30
CPC分类号： E21B43/00
摘要： Computer-implemented systems and methods are provided for optimizing hydrocarbon recovery from subsurface formations, including subsurface formations having bottom water or edgewater. A system and method can be configured to receive data indicative of by-pass oil areas in the subsurface formation from reservoir simulation, identify flow barriers in the subsurface formation based on the by-pass oil areas identified by the reservoir simulation, and predict the lateral extension of the identified flow barriers in the subsurface formation. Infill horizontal wells can be placed at areas of the subsurface formation relative to the flow barriers such that production from a horizontal well in the subsurface formation optimizes hydrocarbon recovery.
摘要翻译：提供计算机实施的系统和方法用于优化来自地下地层的烃采收，包括具有底水或边水的地下地层。系统和方法可以被配置为从储层模拟接收指示地下地层中的旁路油区的数据，基于由储层模拟识别的旁路油区来识别地下地层中的流动障碍，并且预测侧向在地下地层中确定流动屏障的延伸。可以将填充水平井放置在相对于流动屏障的地下地层区域中，使得地下地层中水平井的产量优化烃采收率。

4. 发明申请

WO2010033716A2 METHOD FOR OPTIMIZING WELL PRODUCTION IN RESERVOIRS HAVING FLOW BARRIERS 审中-公开
标题翻译：在流动障碍物储层中优化生产的方法
公开(公告)号：WO2010033716A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057337
申请日：2009-09-17
申请人： CHEVRON U.S.A. INC. , LIU, Song , TIAN, Lixin , WEN, Xian-Huan , ZHAO, Chunming , YANG, Qinghong , ZHANG, Peng , ZHOU, Dengen , LI, Bo , LAN, Lichuan , GE, Lizhen , LIAO, Xinwu , ZHANG, Fengli , WEI, Michael S.
发明人： LIU, Song , TIAN, Lixin , WEN, Xian-Huan , ZHAO, Chunming , YANG, Qinghong , ZHANG, Peng , ZHOU, Dengen , LI, Bo , LAN, Lichuan , GE, Lizhen , LIAO, Xinwu , ZHANG, Fengli , WEI, Michael S.
IPC分类号： E21B43/00 , G01V1/30
CPC分类号： E21B43/00
摘要： Computer-implemented systems and methods are provided for optimizing hydrocarbon recovery from subsurface formations, including subsurface formations having bottom water or edgewater. A system and method can be configured to receive data indicative of by-pass oil areas in the subsurface formation from reservoir simulation, identify flow barriers in the subsurface formation based on the by-pass oil areas identified by the reservoir simulation, and predict the lateral extension of the identified flow barriers in the subsurface formation. Infill horizontal wells can be placed at areas of the subsurface formation relative to the flow barriers such that production from a horizontal well in the subsurface formation optimizes hydrocarbon recovery.
摘要翻译：提供计算机实现的系统和方法，用于优化地下构造的烃回收，包括具有底部水或污水的地下地层。一种系统和方法可以被配置为接收指示来自储层模拟的地下地层旁路油区的数据，基于由油藏模拟识别的旁路油区，识别地下地层中的流动障碍，并预测横向在地下地层中识别的流动障碍的扩展。填充水平井可以放置在相对于流动屏障的地下地层的区域，使得地下地层中的水平井的生产优化了烃回收。

5. 发明申请

WO2003066870A3 METHOD FOR DETECTING POLYMORPHISMS IN NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2003066870A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003654
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12Q1/68
摘要： The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acid is compared to a reference nucleic acid having a known genotype. The nucleic acids can be of any length, even less than 100 base pairs. In the methods, one or more extra mismatches are introduced into the nucleic acids at or near the site of the polymorphism. The nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex that can be detected to indicate that the nucleic acids differ in genotype.

6. 发明申请

WO2003066827A3 METHODS AND COMPOSITIONS FOR DETECTING DIFFERENCES BETWEEN NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2003066827A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003679
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12Q1/68
摘要： The present invention provides methods for detecting the presence or absence of a difference between two related nucleic acid sequences. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex if the nucleic acids differ in sequence. The presence of the four way complex is determined with a detection molecule and a labeled four-stranded tracer molecule.

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