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1. 发明专利

AU2003219719A1 METHODS AND COMPOSITIONS FOR DETECTING DIFFERENCES BETWEEN NUCLEIC ACIDS 未知
公开(公告)号：AU2003219719A1
公开(公告)日：2003-09-02
申请号：AU2003219719
申请日：2003-02-07
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68

2. 发明专利

AU9468701A Detection of dna variation 未知
公开(公告)号：AU9468701A
公开(公告)日：2002-04-02
申请号：AU9468701
申请日：2001-09-24
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68 , C12Q1/6827 , C12Q1/6858 , C12P19/34

3. 发明专利

AU2003215086A8 Method for detecting polymorphisms in nucleic acids 未知
公开(公告)号：AU2003215086A8
公开(公告)日：2003-09-02
申请号：AU2003215086
申请日：2003-02-07
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68 , C07H21/04 , C07H21/02 , C12P19/34
摘要： The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acid is compared to a reference nucleic acid having a known genotype. The nucleic acids can be of any length, even less than 100 base pairs. In methods, one or more extra mismatches are introduced into the nucleic acids at or near the site of the polymorphism. The nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex that can be detected to indicate that the nucleic acids differ in genotype.

4. 发明专利

AU3136202A Methods for detection of differences in nucleic acids 未知
公开(公告)号：AU3136202A
公开(公告)日：2002-05-06
申请号：AU3136202
申请日：2001-10-23
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68 , C12Q1/6827
摘要： The present invention provides methods for determining the genotype of a target nucleic acid. In the methods, a target nucleic acid is contacted with a probe polynucleotide and a reference nucleic acid under conditions in which they are capable of forming a four-way nucleic acid complex with a branch structure that is capable of migration. Detection of resolution of the four-way complex under the appropriate conditions indicates the genotype of the target nucleic acid.

5. 发明申请

WO0234937A3 METHODS FOR DETECTION OF DIFFERENCES IN NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸差异的方法
公开(公告)号：WO0234937A3
公开(公告)日：2002-08-08
申请号：PCT/US0151104
申请日：2001-10-23
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6827 , C12Q2525/313
摘要： The present invention provides methods for determining the genotypes of a target nucleic acid. In the methods, a target nucleic acid is contacted with a probe polynucleotide and a reference nucleic acid under conditions in which they are capable of forming a four-way nucleic acid complex with a branch structure that is capable of migration. Detection of resolution of the four-way complex under the appropriate conditions indicates the genotype of the target nucleic acid.
摘要翻译：本发明提供了用于确定靶核酸的基因型的方法。在所述方法中，使靶核酸与探针多核苷酸和参照核酸在能够形成具有能够迁移的分支结构的四向核酸复合物的条件下接触。在合适的条件下检测四路复合物的分辨率表明目标核酸的基因型。

6. 发明专利

AU2003219719A8 Methods and compositions for detecting differences between nucleic acids 未知
公开(公告)号：AU2003219719A8
公开(公告)日：2003-09-02
申请号：AU2003219719
申请日：2003-02-07
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68

7. 发明专利

AU2003215086A1 METHOD FOR DETECTING POLYMORPHISMS IN NUCLEIC ACIDS 未知
公开(公告)号：AU2003215086A1
公开(公告)日：2003-09-02
申请号：AU2003215086
申请日：2003-02-07
申请人： FRESHGENE INC
发明人： YANG QINGHONG
IPC分类号： C12Q1/68
摘要： The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acid is compared to a reference nucleic acid having a known genotype. The nucleic acids can be of any length, even less than 100 base pairs. In methods, one or more extra mismatches are introduced into the nucleic acids at or near the site of the polymorphism. The nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex that can be detected to indicate that the nucleic acids differ in genotype.

8. 发明专利

AU4563401A Methods for detection of differences in nucleic acids 未知
公开(公告)号：AU4563401A
公开(公告)日：2001-09-24
申请号：AU4563401
申请日：2001-03-12
申请人： FRESHGENE INC
发明人： YANG QINGHONG , YANG WENDY , LISHANSKI ALLA
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/34 , C12Q1/68 , G01N33/566

9. 发明申请

WO2003066870A2 METHOD FOR DETECTING POLYMORPHISMS IN NUCLEIC ACIDS 审中-公开
标题翻译：检测核酸中多态性的方法
公开(公告)号：WO2003066870A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003654
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12P
CPC分类号： C12Q1/6858 , C12Q2525/313 , C12Q2525/161
摘要： The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acid is compared to a reference nucleic acid having a known genotype. The nucleic acids can be of any length, even less than 100 base pairs. In the methods, one or more extra mismatches are introduced into the nucleic acids at or near the site of the polymorphism. The nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex that can be detected to indicate that the nucleic acids differ in genotype.
摘要翻译：本发明提供了确定多态性位点处核酸基因型的方法。该方法实现足够大的灵敏度以检测核酸之间的任何差异，甚至单核苷酸多态性的存在。在该方法中，将核酸与具有已知基因型的参照核酸进行比较。核酸可以是任何长度，甚至小于100个碱基对。在该方法中，在多态性位点处或附近的核酸中引入一个或多个额外的错配。核酸在能够形成稳定的四向复合物的条件下接触，其可被检测以表明核酸在基因型上不同。

10. 发明申请

WO2003066827A2 METHODS AND COMPOSITIONS FOR DETECTING DIFFERENCES BETWEEN NUCLEIC ACIDS 审中-公开
标题翻译：用于检测核酸之间差异的方法和组合物
公开(公告)号：WO2003066827A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003679
申请日：2003-02-07
申请人： FRESHGENE, INC. , YANG, Qinghong
发明人： YANG, Qinghong
IPC分类号： C12N
CPC分类号： C12Q1/6827 , C12Q1/6839 , C12Q2537/119 , C12Q2521/514
摘要： The present invention provides methods for detecting the presence or absence of a difference between two related nucleic acid sequences. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphisms. In the methods, the nucleic acids are contacted under conditions in which they are capable of forming a stable four-way complex if the nucleic acids differ in sequence. The presence of the four way complex is determined with a detection molecule and a labeled four-stranded tracer molecule.
摘要翻译：本发明提供了检测两个相关核酸序列之间差异的存在或不存在的方法。该方法实现足够大的灵敏度以检测核酸之间的任何差异，甚至单核苷酸多态性的存在。在所述方法中，如果核酸序列不同，则核酸在能够形成稳定的四元复合物的条件下接触。用检测分子和标记的四链示踪剂分子确定四方复合物的存在。

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