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1. 发明申请

WO2012061653A2 BIOFUEL AND CHEMICAL PRODUCTION BY RECOMBINANT MICROORGANISMS VIA FERMENTATION OF PROTEINACIOUS BIOMASS 审中-公开
标题翻译：重组微生物生物燃料和化学品生产通过发酵生物质蛋白
公开(公告)号：WO2012061653A2
公开(公告)日：2012-05-10
申请号：PCT/US2011059231
申请日：2011-11-03
申请人： UNIV CALIFORNIA , LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
发明人： LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N15/52 , C12N15/63 , C12P7/00 , C12P13/00
CPC分类号： C12N15/815 , C12N1/20 , C12N9/0016 , C12N9/1096 , C12N15/63 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/16 , C12P7/24 , C12P7/40 , C12P13/04 , Y02E50/10 , Y02E50/17 , Y02P20/582
摘要： Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM) from a suitable nitrogen rich biomass.
摘要翻译：本文提供了代谢性修饰的微生物，其特征在于与野生型生物体相比具有增加的酮酸流量并且包含至少一种编码酶的多核苷酸，所述酶在表达时导致产生更大量的化学产物野生型生物体。重组微生物可用于从各种含氮生物质组合物和其他碳源生产大量化学组合物。更具体地说，本文提供了生产醇，乙醛，乙酸，异丁醛，异丁酸，正丁醛，正丁酸，2-甲基-1-丁醛，2-甲基-1-丁酸，3-甲基-1-丁醇， 1-丁醛，3-甲基-1-丁酸，氨，铵，氨基酸，2,3-丁二醇，1,4-丁二醇，2-甲基-1,4-丁二醇，2-甲基-1,4-丁二醇，丁二胺，异丁烯，衣康酸，乙偶姻，丙酮，异丁烯，1,5-二氨基戊烷，L-乳酸，D-乳酸，莽草酸，甲羟戊酸，聚羟基丁酸酯（PHB），类异戊二烯，脂肪酸，高丙氨酸，4-氨基丁酸 GABA），琥珀酸，苹果酸，柠檬酸，己二酸，对羟基肉桂酸，四氢呋喃，3-甲基四氢呋喃，γ-丁内酯，吡咯烷酮，n-甲基吡咯烷酮，天冬氨酸，赖氨酸，cadeverine，2-酮己二酸酸和/或S-腺苷甲硫氨酸（SAM）。

2. 发明申请

WO2011137192A1 PRODUCTION OF 1,4-BUTANEDIOL BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物生产1,4-丁二醇
公开(公告)号：WO2011137192A1
公开(公告)日：2011-11-03
申请号：PCT/US2011/034198
申请日：2011-04-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , YAN, Yajun
发明人： LIAO, James, C. , YAN, Yajun
IPC分类号： C12P7/16 , C12P7/18
CPC分类号： C12N15/70 , C12N15/52 , C12P7/16 , C12P7/18 , Y02E50/10
摘要： Provided herein are metabolically-modified microorganisms useful for producing 1,4-butanediol.
摘要翻译：本文提供了可用于生产1,4-丁二醇的代谢改性微生物。

3. 发明申请

WO2006010117A2 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：重组微生物生产黄酮类化合物
公开(公告)号：WO2006010117A2
公开(公告)日：2006-01-26
申请号：PCT/US2005/024525
申请日：2005-07-11
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , KOFFAS, Mattheos , LEONARD, Effendi , YAN, Yajun , CHEMLER, Joseph
发明人： KOFFAS, Mattheos , LEONARD, Effendi , YAN, Yajun , CHEMLER, Joseph
IPC分类号： C12P17/06
CPC分类号： C12Y203/01074 , C12N9/0006 , C12N9/1037 , C12N9/90 , C12P17/06 , C12Y101/01219 , C12Y505/01006
摘要： Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids.
摘要翻译：提供了用于在微生物宿主中生产类黄酮的方法和组合物。所述组合物包含一组编码参与生物合成途径中的一个或多个步骤的酶的基因，所述生物合成途径用于将苯丙素类转化成各种类黄酮。该方法包括以下步骤：将该组基因导入异源宿主细胞中，允许细胞在合适的培养基中生长，使得基因的表达导致酶的产生。当向转化的细胞提供特定的底物时，酶作用于底物以产生所需的类黄酮。

4. 发明申请

WO2015175793A1 MICROBIAL APPROACH FOR THE PRODUCTION OF 5-HYDROXYTRYPTOPHAN 审中-公开
标题翻译：用于生产5-羟基吡啶的微生物方法
公开(公告)号：WO2015175793A1
公开(公告)日：2015-11-19
申请号：PCT/US2015/030811
申请日：2015-05-14
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , YAN, Yajun , LIN, Yuheng
发明人： YAN, Yajun , LIN, Yuheng
IPC分类号： C12P13/22
CPC分类号： C12P13/227 , A23K20/10 , A23L2/52 , C12N9/0028 , C12N9/0071 , C12N9/88 , C12Y105/01034 , C12Y114/16001 , C12Y402/01096
摘要： 5-hydroxytryptophan (5-HTP), a precursor of serotonin, is produced in a microbial host cell. A modified bacterial phenylalanine 4-hydroxylase (P4H) catalyzes the tryptophan 5 -hydroxylation reaction. Optionally the host cell includes a cofactor regeneration mechanism, allowing continuous production of 5-HTP without supplementation of exogenous cofactors.
摘要翻译：在微生物宿主细胞中产生5-羟色胺（5-HTP），5-羟色胺的前体。改良的细菌苯丙氨酸4-羟化酶（P4H）催化色氨酸5-羟化反应。任选地，宿主细胞包括辅因子再生机制，允许在不补充外源辅因子的情况下连续生产5-HTP。

5. 发明申请

WO2012061653A9 BIOFUEL AND CHEMICAL PRODUCTION BY RECOMBINANT MICROORGANISMS VIA FERMENTATION OF PROTEINACIOUS BIOMASS 审中-公开
标题翻译：通过发酵蛋白质生物量的重组微生物的生物化学和化学生产
公开(公告)号：WO2012061653A9
公开(公告)日：2012-07-19
申请号：PCT/US2011059231
申请日：2011-11-03
申请人： UNIV CALIFORNIA , LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
发明人： LIAO JAMES C , CHO KWANG MYUNG , YAN YAJUN , HUO YIXIN
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N15/52 , C12N15/63 , C12P7/00 , C12P13/00
CPC分类号： C12N15/815 , C12N1/20 , C12N9/0016 , C12N9/1096 , C12N15/63 , C12N15/75 , C12N15/77 , C12N15/78 , C12N15/80 , C12N15/81 , C12P7/04 , C12P7/16 , C12P7/24 , C12P7/40 , C12P13/04 , Y02E50/10 , Y02E50/17 , Y02P20/582
摘要： Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM) from a suitable nitrogen rich biomass.
摘要翻译：本文提供了代谢修饰的微生物，其特征在于与野生型生物体相比具有增加的酮酸通量，并且包含至少一种编码酶的多核苷酸，当表达导致产生更大量的化学产品时，与野生型生物体。重组微生物可用于从各种含氮生物质组合物和其它碳源生产大量化学成分。更具体地，本文提供了生产醇，乙醛，乙酸酯，异丁醛，异丁酸，正丁醛，正丁酸，2-甲基-1-丁醛，2-甲基-1-丁酸，3-甲基-1-丁酸， 1-丁醇，3-甲基-1-丁酸，氨，铵，氨基酸，2,3-丁二醇，1,4-丁二醇，2-甲基-1,4-丁二醇，2-甲基-1,4-丁二醇，丁二胺，异丁烯，衣康酸酯，乙偶姻，丙酮，异丁烯，1,5-二氨基戊烷，L-乳酸，D-乳酸，莽草酸，甲羟戊酸，聚羟基丁酸（PHB），类异戊二烯，脂肪酸，高丙氨酸，4-氨基丁酸 GABA），琥珀酸，苹果酸，柠檬酸，己二酸，对羟基肉桂酸，四氢呋喃，3-甲基 - 四氢呋喃，γ-丁内酯，吡咯烷酮，正 - 甲基吡咯烷酮，天冬氨酸，赖氨酸，仙茅素，2-酮己二酸酸和/或S-腺苷 - 甲硫氨酸（SAM）。

6. 发明申请

WO2006010117A3 PRODUCTION OF FLAVONOIDS BY RECOMBINANT MICROORGANISMS 审中-公开
标题翻译：通过重组微生物生产氟虫腈
公开(公告)号：WO2006010117A3
公开(公告)日：2006-06-22
申请号：PCT/US2005024525
申请日：2005-07-11
申请人： YORK THE RES FOUNDATION OF STA , KOFFAS MATTHEOS , LEONARD EFFENDI , YAN YAJUN , CHEMLER JOSEPH
发明人： KOFFAS MATTHEOS , LEONARD EFFENDI , YAN YAJUN , CHEMLER JOSEPH
IPC分类号： C12P1/00 , C12N15/82
CPC分类号： C12Y203/01074 , C12N9/0006 , C12N9/1037 , C12N9/90 , C12P17/06 , C12Y101/01219 , C12Y505/01006
摘要： Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flavonoids. The method comprises the steps of introducing the set of genes into a heterologous host cell, allowing growth of the cells in a suitable medium such that the expression of the genes results in production of enzymes. When specific substrate(s) is/are provided to the transformed cell, the enzymes act on the substrate(s) to produce the desired flavonoids.
摘要翻译：提供了用于在微生物宿主中生产黄酮的方法和组合物。组合物包含一组基因，其编码涉及用于将苯丙素转化为各种类黄酮的生物合成途径中的一个或多个步骤的酶。该方法包括以下步骤：将一组基因导入异源宿主细胞，允许细胞在合适的培养基中生长，使得基因的表达导致酶的产生。当向转化的细胞提供特异性底物时，酶作用于底物以产生所需的类黄酮。

7. 发明申请

WO2012061653A3 BIOFUEL AND CHEMICAL PRODUCTION BY RECOMBINANT MICROORGANISMS VIA FERMENTATION OF PROTEINACIOUS BIOMASS 审中-公开
公开(公告)号：WO2012061653A3
公开(公告)日：2012-05-10
申请号：PCT/US2011/059231
申请日：2011-11-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LIAO, James, C. , CHO, Kwang, Myung , YAN, Yajun , HUO, Yixin
发明人： LIAO, James, C. , CHO, Kwang, Myung , YAN, Yajun , HUO, Yixin
IPC分类号： C12N1/21 , C12N1/19 , C12N1/15 , C12N15/63 , C12N15/52 , C12P7/00 , C12P13/00
摘要： Provided herein are metabolically modified microorganisms characterized by having an increased keto-acid flux when compared with the wild-type organism and comprising at least one polynucleotide encoding an enzyme that when expressed results in the production of a greater quantity of a chemical product when compared with the wild-type organism. The recombinant microorganisms are useful for producing a large number of chemical compositions from various nitrogen containing biomass compositions and other carbon sources. More specifically, provided herein are methods of producing alcohols, acetaldehyde, acetate, isobutyraldehyde, isobutyric acid, n- butyraldehyde, n-butyric acid, 2-methyl-l-butyraldehyde, 2-methyl-l -butyric acid, 3- methyl-l-butyraldehyde, 3 -methyl- 1 -butyric acid, ammonia, ammonium, amino acids, 2,3-butanediol, 1,4-butanediol, 2-methyl-l, 4-butanediol, 2-methyl- 1,4-butanediamine, isobutene, itaconate, acetoin, acetone, isobutene, 1,5-diaminopentane, L-lactic acid, D- lactic acid, shikimic acid, mevalonate, polyhydroxybutyrate (PHB), isoprenoids, fatty acids, homoalanine, 4-aminobutyric acid (GABA), succinic acid, malic acid, citric acid, adipic acid, p-hydroxy-cinnamic acid, tetrahydrofuran, 3-methyl-tetrahydrofuran, gamma-butyrolactone, pyrrolidinone, n-methylpyrrolidone, aspartic acid, lysine, cadeverine, 2-ketoadipic acid, and/or S-adenosyl-methionine (SAM) from a suitable nitrogen rich biomass.

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