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    • 3. 发明申请
    • TRICYCLIC COMPOUND HAVING ANTIALLERGIC EFFECT
    • 具有抗真菌作用的三环化合物
    • WO1993022313A1
    • 1993-11-11
    • PCT/JP1993000549
    • 1993-04-27
    • MOCHIDA PHARMACEUTICAL CO., LTD.MOCHIZUKI, HidenoriKATO, KazuoYAMAMOTO, IchiroMIZUGUCHI, Kiyoshi
    • MOCHIDA PHARMACEUTICAL CO., LTD.
    • C07D471/06
    • C07D471/06
    • A nitrogenous tricyclic compound represented by general formula (I), a salt and a solvate thereof, and a solvate of a salt thereof, each inhibiting the production of an IgE antibody and being useful as a prophylactic and/or a therapeutic agent for allergic diseases, wherein R represents halogen, linear or branched C1-C10 alkyl which may be substituted by one or more halogen atoms, or phenyl or napthyl each of which may be substituted by 1 to 5 specified groups; Y represents hydrogen and Z represents hydrogen, hydroxy or a specified group, or alternatively Y and Z may be combined together to represent hydrazono or hydroximino each of which may be substituted by a specified group, or a specified group; and X -X SIMILAR C SIMILAR X represents CH-N-C=C or N-C=C-N, provided that when it is N-C=C-N, then Y and Z are neither hydroximino nor oxygen.
    • 由通式(I)表示的含氮三环化合物,其盐及其溶剂合物及其盐的溶剂合物,其各自抑制IgE抗体的产生,可用作过敏性疾病的预防和/或治疗剂 其中R表示卤素,可被一个或多个卤素原子取代的直链或支链C 1 -C 10烷基,或每个可被1至5个特定基团取代的苯基或萘基; Y表示氢,Z表示氢,羟基或特定基团,或者Y和Z可以组合在一起,表示可以被特定基团或特定基团取代的亚氨基或肟基; 并且X 1 -X 2类似C X表示CH-N-C = C或N-C = C-N,条件是当其为N-C = C-N时,则Y和Z既不是肟基也不是氧。