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1. 发明授权

US09547058B2 Automated MRI detection of tissue macromolecular T2/T2* characteristics using Z-spectra 有权
标题翻译：使用Z光谱自动MRI检测组织大分子T2 / T2 *特征
公开(公告)号：US09547058B2
公开(公告)日：2017-01-17
申请号：US13601723
申请日：2012-08-31
申请人： Mitsue Miyazaki , Cheng Ouyang , Xiangzhi Zhou
发明人： Mitsue Miyazaki , Cheng Ouyang , Xiangzhi Zhou
IPC分类号： G01R33/50 , G01R33/54 , G01R33/48 , G01R33/56
CPC分类号： G01R33/50 , G01R33/4816 , G01R33/54 , G01R33/543 , G01R33/5605
摘要： A magnetic resonance imaging (MRI) system and method (a) acquires k-space data for a patient ROI over a predetermined band of RF frequencies using RF excitation pulses having respectively corresponding RF frequencies incrementally offset from a nuclear magnetic resonant (NMR) Larmor frequency for free nuclei thus causing chemical exchange saturation transfer (CEST) effects and to process such acquired data into Z-spectra data for voxels in the ROI; (b) analyzes the acquired Z-spectra data to provide spectral peak width data corresponding to T2/T2* tissue values in the ROI for macromolecules participating in magnetization transfer contrast (MTC) effects producing said Z-spectra data; and (c) stores and/or displays data representative of T2/T2* tissue values of the ROI which values are different for different tissues.
摘要翻译：磁共振成像（MRI）系统和方法（a）使用具有逐渐偏离核磁共振（NMR）拉莫尔频率的分别对应的RF频率的RF激励脉冲获取在RF频率的预定频带上的患者ROI的k空间数据对于自由核，从而导致化学交换饱和转移（CEST）效应，并将这些获取的数据处理成ROI中的体素的Z谱数据; （b）分析所获得的Z光谱数据，以提供对应于参与产生所述Z光谱数据的磁化转移对比（MTC）效应的大分子的ROI中的T2 / T2 *组织值的光谱峰宽数据; 和（c）存储和/或显示表示不同组织的值不同的ROI的T2 / T2 *组织值的数据。

2. 发明申请

US20140081125A1 NON-CONTRAST DYNAMIC MRI MYOCARDIAL PERFUSION ANALYSIS AND VISUALIZATION 审中-公开
标题翻译：非对照动态MRI心肌灌注分析和可视化
公开(公告)号：US20140081125A1
公开(公告)日：2014-03-20
申请号：US13618001
申请日：2012-09-14
申请人： Xiangzhi ZHOU , Mitsue MIYAZAKI , Tsutomu HOSHINO
发明人： Xiangzhi ZHOU , Mitsue MIYAZAKI , Tsutomu HOSHINO
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/0044 , A61B5/0263 , A61B5/742 , G01R33/385 , G01R33/4833 , G01R33/5608 , G01R33/56366
摘要： Black blood time to inversion (BBTI) tag-on and tag-off images acquired by magnetic resonance imaging (MRI) are analyzed to produce difference magnitude 3D images as a function of time (BBTI values) representing blood perfusion in a region of interest (ROI). Perfusion data of the ROI having values which are different for normal and abnormal myocardial tissues are displayed for plural slices of a 3D image and for plural BBTI values in a single display panel.
摘要翻译：分析通过磁共振成像（MRI）获得的黑血时间反转（BBTI）标记和标记图像，以产生表示感兴趣区域中血液灌注的时间（BBTI值）的函数的差值3D图像（投资回报率）。针对正常和异常心肌组织不同的值的ROI的灌注数据被显示用于3D图像的多个切片，并且在单个显示面板中显示多个BBTI值。

3. 发明授权

US09818515B2 Modified Nd—Fe—B permanent magnet with high corrosion resistance 有权
公开(公告)号：US09818515B2
公开(公告)日：2017-11-14
申请号：US13132266
申请日：2008-12-01
申请人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
发明人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
IPC分类号： H01F7/02 , H01F1/057 , H01F41/02
CPC分类号： H01F1/0577 , H01F41/0266
摘要： A type of sintered Nd—Fe—B permanent magnet with high corrosion resistance is produced by dual alloy method. The method comprises the following steps: preparing the powders of master phase alloy and intergranular phase alloy respectively, mixing the powders, compacting the powders in magnetic field, sintering the compacted body at 1050˜1125° C., and annealing at 920-1020° C. and 500-650° C. successively.

4. 发明授权

US09545206B2 Non-contrast MRI with differentiation of ischemic, infarct and normal tissue 有权
公开(公告)号：US09545206B2
公开(公告)日：2017-01-17
申请号：US13587294
申请日：2012-08-16
申请人： Mitsue Miyazaki , Xiangzhi Zhou , Tsutomu Hoshino
发明人： Mitsue Miyazaki , Xiangzhi Zhou , Tsutomu Hoshino
IPC分类号： A61B5/026 , A61B5/055 , G01R33/563 , A61B5/00
CPC分类号： A61B5/0263 , A61B5/055 , A61B5/7289 , A61B2576/023 , G01R33/56366 , G06T7/0016 , G06T2207/30048 , G06T2207/30104
摘要： Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.

5. 发明申请

US20140062476A1 MRI DETECTION OF TISSUE MACROMOLECULAR CHARACTERISTICS USING MTC EFFECTS 有权
标题翻译： MRI检测使用MTC效应的组织大分子特征
公开(公告)号：US20140062476A1
公开(公告)日：2014-03-06
申请号：US13705582
申请日：2012-12-05
申请人： Mitsue MIYAZAKI , Cheng Ouyang , Xiangzhi Zhou
发明人： Mitsue MIYAZAKI , Cheng Ouyang , Xiangzhi Zhou
IPC分类号： G01R33/54 , G01R33/341
CPC分类号： G01R33/54 , G01R33/341 , G01R33/50 , G01R33/5605
摘要： A magnetic resonance imaging (MRI) system and method (a) acquires k-space data for a patient ROI over a predetermined band of RF frequencies using RF excitation pulses having respectively corresponding RF frequencies incrementally offset from a nuclear magnetic resonant (NMR) Larmor frequency for free nuclei over a predetermined range of different offset frequencies in which target macromolecule responses are expected and to process such acquired data into spectral data for voxels in the ROI; (b) analyzes the acquired spectral data to provide spectral peak width data corresponding to tissue values in the ROI for macromolecules participating in magnetization transfer contrast (MTC) effects producing said spectral data; and (c) stores and/or displays data representative of tissue values of the ROI which values are different for different tissues.
摘要翻译：磁共振成像（MRI）系统和方法（a）使用具有逐渐偏离核磁共振（NMR）拉莫尔频率的分别对应的RF频率的RF激励脉冲获取在RF频率的预定频带上的患者ROI的k空间数据在预期目标大分子响应的不同偏移频率的预定范围内的自由核，并将这些获取的数据处理成ROI中的体素的光谱数据; （b）分析所获得的光谱数据，以提供对应于参与产生所述光谱数据的磁化转移对比（MTC）效应的大分子的ROI中的组织值的光谱峰宽数据; 和（c）存储和/或显示表示不同组织的值不同的ROI的组织值的数据。

6. 发明申请

US20140062473A1 AUTOMATED MRI DETECTION OF TISSUE MACROMOLECULAR T2/T2* CHARACTERISTICS USING Z-SPECTRA 有权
标题翻译：使用Z-SPECTRA自动检测组织大分子T2 / T2 *特征
公开(公告)号：US20140062473A1
公开(公告)日：2014-03-06
申请号：US13601723
申请日：2012-08-31
申请人： MITSUE MIYAZAKI , Cheng Ouyang , Xiangzhi Zhou
发明人： MITSUE MIYAZAKI , Cheng Ouyang , Xiangzhi Zhou
IPC分类号： G01R33/48 , G01R33/28
CPC分类号： G01R33/50 , G01R33/4816 , G01R33/54 , G01R33/543 , G01R33/5605
摘要： A magnetic resonance imaging (MRI) system and method (a) acquires k-space data for a patient ROI over a predetermined band of RF frequencies using RF excitation pulses having respectively corresponding RF frequencies incrementally offset from a nuclear magnetic resonant (NMR) Larmor frequency for free nuclei thus causing chemical exchange saturation transfer (CEST) effects and to process such acquired data into Z-spectra data for voxels in the ROI; (b) analyzes the acquired Z-spectra data to provide spectral peak width data corresponding to T2/T2* tissue values in the ROI for macromolecules participating in magnetization transfer contrast (MTC) effects producing said Z-spectra data; and (c) stores and/or displays data representative of T2/T2* tissue values of the ROI which values are different for different tissues.
摘要翻译：磁共振成像（MRI）系统和方法（a）使用具有逐渐偏离核磁共振（NMR）拉莫尔频率的分别对应的RF频率的RF激励脉冲获取在RF频率的预定频带上的患者ROI的k空间数据对于自由核，从而导致化学交换饱和转移（CEST）效应，并将这些获取的数据处理成ROI中的体素的Z谱数据; （b）分析获得的Z光谱数据，以提供对应于参与产生所述Z光谱数据的磁化转移对比（MTC）效应的大分子的ROI中的T2 / T2 *组织值的光谱峰宽数据; 和（c）存储和/或显示表示不同组织的值不同的ROI的T2 / T2 *组织值的数据。

7. 发明授权

US09700230B2 Enhanced fat saturation in myocardial infarction MRI 有权
公开(公告)号：US09700230B2
公开(公告)日：2017-07-11
申请号：US13598435
申请日：2012-08-29
申请人： Xiangzhi Zhou , Mitsue Miyazaki
发明人： Xiangzhi Zhou , Mitsue Miyazaki
IPC分类号： A61B5/055 , A61B5/00 , G01R33/56
CPC分类号： A61B5/055 , A61B5/0044 , G01R33/5607
摘要： MRI k-space data is acquired for a patient ROI during data acquisition sequences including a nuclear magnetic resonance (NMR) signal readout period using a late gadolinium enhanced (LGE) data acquisition sequence including at least one fat-specific RF NMR magnetization inversion pulse imposed (a) after a water-specific RF NMR magnetization inversion pulse timed to cause a substantial null in NMR magnetization of normal tissue protons near a center of the readout period and (b) before the readout period center, which fat-specific inversion pulse is also timed to cause a substantial null in NMR magnetization of fat tissue protons near the readout period center. The acquired MR image data is reconstructed into a contrast enhanced LGE image of tissues within the ROI but having substantially suppressed normal and fat components therein.

8. 发明授权

US09082538B2 Sintered Nd—Fe—B permanent magnet with high coercivity for high temperature applications 有权
标题翻译：用于高温应用的具有高矫顽力的烧结Nd-Fe-B永磁体
公开(公告)号：US09082538B2
公开(公告)日：2015-07-14
申请号：US13132222
申请日：2008-12-01
申请人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
发明人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
IPC分类号： H01F1/057 , H01F41/02
CPC分类号： H01F1/0577 , H01F41/0266
摘要： A type of sintered Nd—Fe—B permanent magnet with high intrinsic coercivity of about 30KOe or more is produced by dual alloy method. The method comprises the following steps: preparing the powders of master phase alloy and intergranular phase alloy respectively, mixing the powders, compacting the powders in magnetic field, sintering the compacted body at 1050˜1125° C. and annealing at 890-1000° C. and 500-650° C. successively. In the process of preparing the powder of intergranular phase alloy, the nano-powder additive selected from the group consisting of NiAl, TiC, SiC, AlN, TiN, ZrN and the combination thereof is used to modify the powder of intergranular phase alloy.
摘要翻译：通过双重合金法制造出具有约30KOe以上的高固有矫顽力的烧结Nd-Fe-B永磁体。该方法包括以下步骤：分别制备主相合金和晶间相合金粉末，混合粉末，在粉末中压实粉末，在1050〜1 125℃烧结压实体，在890-1000℃退火和500-650℃。在制备晶间相合金粉末的过程中，使用选自NiAl，TiC，SiC，AlN，TiN，ZrN的纳米粉末添加剂及其组合来改变晶间相合金粉末。

9. 发明申请

US20140050379A1 NON-CONTRAST MRI WITH DIFFERENTIATION OF ISCHEMIC, INFARCT AND NORMAL TISSUE 有权
标题翻译：非对照MRI与异位，无创和正常组织差异
公开(公告)号：US20140050379A1
公开(公告)日：2014-02-20
申请号：US13587294
申请日：2012-08-16
申请人： MITSUE MIYAZAKI , Xiangzhi Zhou , Tsutomu Hoshino
发明人： MITSUE MIYAZAKI , Xiangzhi Zhou , Tsutomu Hoshino
IPC分类号： G06K9/46 , G06K9/00
CPC分类号： A61B5/0263 , A61B5/055 , A61B5/7289 , A61B2576/023 , G01R33/56366 , G06T7/0016 , G06T2207/30048 , G06T2207/30104
摘要： Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.
摘要翻译：使用初始空间选择性RF标签脉冲（标签打开）和（b）不使用初始空间选择性NMR RF标签脉冲（标签关闭）将引发的MRI信号结合（a）处理成MR图像数据）分别对应的数据采集子序列。在不使用注入的造影剂的情况下，对多个时间 - 反转（TI）间隔中的每一个使用多维标记和标记数据采集子序列。对每个TI间隔减去获取的图像数据集，以产生差异值作为时间的函数，代表对正常，缺血和梗死组织进行区分的ROI的血液灌注。

10. 发明申请

US20110234350A1 MODIFIED ND-FE-B PERMANENT MAGNET WITH HIGH CORROSION RESISTANCE 有权
标题翻译：具有高耐腐蚀性的改性ND-FE-B永磁体
公开(公告)号：US20110234350A1
公开(公告)日：2011-09-29
申请号：US13132266
申请日：2008-12-01
申请人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
发明人： Mi Yan , Xiangzhi Zhou , Xiongfei Fan , Tianyu Ma , Wei Luo
IPC分类号： H01F7/02
CPC分类号： H01F1/0577 , H01F41/0266
摘要： A type of sintered Nd—Fe—B permanent magnet with high corrosion resistance is produced by dual alloy method. The method comprises the following steps: preparing the powders of master phase alloy and intergranular phase alloy respectively, mixing the powders, compacting the powders in magnetic field, sintering the compacted body at 1050˜1125° C., and annealing at 920-1020° C. and 500-650° C. successively
摘要翻译：通过双合金法制造出具有高耐腐蚀性的烧结Nd-Fe-B永磁体。该方法包括以下步骤：分别制备主相合金和晶间相合金粉末，混合粉末，在粉末中粉碎，在1050-1125℃烧结压实体，在920-1020°退火 C.和500-650℃

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