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1. 发明申请

WO2005019428B1 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
标题翻译：多糖活性和表达的调控
公开(公告)号：WO2005019428B1
公开(公告)日：2005-09-29
申请号：PCT/US2004027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N15/113 , C12H21/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.
摘要翻译：本发明提供了用于控制表达的方法和系统，以及一般来说，预选的多核酸分子的细胞活性。本发明还提供用于遗传修饰细胞和多细胞生物体以抵抗病毒的方法和系统。本发明还提供用于遗传修饰细胞和多细胞生物体的方法和系统，使得它们诊断性地报告病毒感染。本发明的一个方面涉及将目标多核苷酸分子作为至少一个模板指导的聚核酸聚合酶的功能模板，使得通过聚合酶的多核酸分子作为模板的利用调节靶向的多核酸分子的活性。本发明的其它方面涉及将选择的多核核酸分子作为RNA沉默的靶标，无论沉默是否是聚合酶介导的。

2. 发明申请

WO2005019428A3 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
公开(公告)号：WO2005019428A3
公开(公告)日：2005-03-03
申请号：PCT/US2004/027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND, Paul
发明人： DIAMOND, Paul
IPC分类号： C12H21/00
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.

3. 发明申请

WO2005019428A2 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
公开(公告)号：WO2005019428A2
公开(公告)日：2005-03-03
申请号：PCT/US2004027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N15/113 , C12N
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.

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