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1. 发明公开

EP3810285A1 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 审中-实审
公开(公告)号：EP3810285A1
公开(公告)日：2021-04-28
申请号：EP18924932.9
申请日：2018-12-21
申请人： Enzo Biochem, Inc. , Elazar, Rabbani , Donegan, James J. , Diamond, Paul
发明人： RABBANI, Elazar , DONEGAN, James J. , DIAMOND, Paul
IPC分类号： A61P35/02 , A61K31/4245 , C07C215/28 , C07D271/06

2. 发明公开

EP1855534A4 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES 审中-公开
标题翻译：器官和组织的改进细胞重建
公开(公告)号：EP1855534A4
公开(公告)日：2008-12-17
申请号：EP05855792
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： A01K67/027 , A01N63/00 , A01N65/00
CPC分类号： A01K67/0271 , A01K2217/30 , A01K2267/025
摘要： One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non-human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or at least substantially all cell types of a solid organ or tissue; methods for cellularly reconstituting solid organs and tissues with replacement cells, such as human cells, with respect to selected cell types and/or at least substantially all cell types of an organ or tissue; modified non-human mammals for cellularly reconstituting solid organs and tissues with replacement cells; and the cellularly reconstituted solid organs and tissues. The production of human organs and tissues according to the invention overcomes the limitations associated with xenotransplantation of animal organs and tissues to humans.

3. 发明公开

EP1855534A2 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES 审中-公开
标题翻译：器官和组织的改进细胞重建
公开(公告)号：EP1855534A2
公开(公告)日：2007-11-21
申请号：EP05855792.7
申请日：2005-12-29
申请人： Diamond, Paul
发明人： Diamond, Paul
IPC分类号： A01N63/00 , A01N65/00
CPC分类号： A01K67/0271 , A01K2217/30 , A01K2267/025
摘要： One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non-human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or at least substantially all cell types of a solid organ or tissue; methods for cellularly reconstituting solid organs and tissues with replacement cells, such as human cells, with respect to selected cell types and/or at least substantially all cell types of an organ or tissue; modified non-human mammals for cellularly reconstituting solid organs and tissues with replacement cells; and the cellularly reconstituted solid organs and tissues. The production of human organs and tissues according to the invention overcomes the limitations associated with xenotransplantation of animal organs and tissues to humans.

4. 发明申请

WO2020005313A1 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 审中-公开
公开(公告)号：WO2020005313A1
公开(公告)日：2020-01-02
申请号：PCT/US2018/067131
申请日：2018-12-21
申请人： ENZO BIOCHEM, INC. , RABBANI, Elazar , DONEGAN, James J. , DIAMOND, Paul
发明人： RABBANI, Elazar , DONEGAN, James J. , DIAMOND, Paul
IPC分类号： A61P35/02 , A61K31/4245 , C07C215/28 , C07D271/06
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.

5. 发明申请

WO2006074012A2 FACILITATED CELLULAR RECONSTITUTION OF ORGANS AND TISSUES 审中-公开
标题翻译：机构和组织的辅助细胞重建
公开(公告)号：WO2006074012A2
公开(公告)日：2006-07-13
申请号：PCT/US2005/047291
申请日：2005-12-29
申请人： DIAMOND, Paul
发明人： DIAMOND, Paul
IPC分类号： C12N5/08
CPC分类号： A01K67/0271 , A01K2217/30 , A01K2267/025
摘要： One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non-human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or at least substantially all cell types of a solid organ or tissue; methods for cellularly reconstituting solid organs and tissues with replacement cells, such as human cells, with respect to selected cell types and/or at least substantially all cell types of an organ or tissue; modified non-human mammals for cellularly reconstituting solid organs and tissues with replacement cells; and the cellularly reconstituted solid organs and tissues. The production of human organs and tissues according to the invention overcomes the limitations associated with xenotransplantation of animal organs and tissues to humans.
摘要翻译：本发明的一个方面提供用于在非人哺乳动物宿主中生产至少基本上细胞的人类固体器官和固体组织的改进方法。本发明的相关方面提供：关于选择的细胞类型和/或至少基本上所有细胞类型的固体器官或组织获得器官和/或组织特异性基因表达和/或表型的基于移植的方法; 相对于选择的细胞类型和/或至少基本上所有细胞类型的器官或组织，用替代细胞例如人细胞细胞重建固体器官和组织的方法; 修饰的非人哺乳动物用于用置换细胞细胞重构固体器官和组织; 和细胞重构的固体器官和组织。根据本发明的人体器官和组织的产生克服了与人类的动物器官和组织的异种移植有关的限制。

6. 发明申请

WO2005019428A3 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
公开(公告)号：WO2005019428A3
公开(公告)日：2005-03-03
申请号：PCT/US2004/027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND, Paul
发明人： DIAMOND, Paul
IPC分类号： C12H21/00
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.

7. 发明申请

WO2005019428A2 REGULATION OF POLYNUCLEIC ACID ACTIVITY AND EXPRESSION 审中-公开
公开(公告)号：WO2005019428A2
公开(公告)日：2005-03-03
申请号：PCT/US2004027149
申请日：2004-08-20
申请人： XIRNARA PROPERTIES LLC , DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N15/113 , C12N
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2330/30
摘要： The invention provides methods and systems for controlling the expression and, In general, the cellular activity of preselected polynucleic acid molecules. The invention also provides methods and systems for genetically modifying cells and multi-cellular organism to inpart resistance to viruses. The invention further provides methods and systems for genetically modifying cells and multi-cellular organisms so that they diagnostically report viral infection. One aspect of the invention involves rendering target polynucleic nucleic acid molecules as functional templates for at least one template-directed polynucleic acid polymerase so that the utilization of the polynucleic acid molecule as a template by the polymerase modulates the activity of the targeted polynucleic acid molecule. Other aspects of the invention of the invention involve rendering selected polynucleic nucleic acid molecules as targets for RNA silencing, whether or not the silencing is polymerase-mediated.

8. 发明申请

WO2010008929A1 WORK-PIECE TRANSFER SYSTEMS AND METHODS 审中-公开
标题翻译：工作转移系统和方法
公开(公告)号：WO2010008929A1
公开(公告)日：2010-01-21
申请号：PCT/US2009/049189
申请日：2009-06-30
申请人： ULVAC, INC. , DIAMOND, Paul
发明人： DIAMOND, Paul
IPC分类号： H01L21/677
CPC分类号： H01L21/67754 , H01L21/67742 , H01L21/67745
摘要： A dual-robot transfer system including: a transfer module for transferring work-pieces into and out of a process module; a physical interface between the transfer module and a supply- and-accept system; a first robot located substantially in the transfer module for transferring work-pieces to and from the process module and a buffer station located in the transfer module, the first robot including a first top arm and a first bottom arm, the first top arm and first bottom arm substantially having a first range of motion; and a second robot located substantially in the transfer module for transferring work-pieces to and from the process module, the buffer station, and the physical interface, the second robot including a second top arm and a second bottom arm, the second top arm and second bottom arm substantially having a second range of motion which overlaps in part with the first range of motion.
摘要翻译：一种双机器人传送系统，包括：传送模块，用于将工件传入和传出处理模块; 传输模块与供应和接受系统之间的物理接口; 基本上位于传送模块中的用于将工件传送到处理模块和从处理模块传送工件的第一机器人和位于传送模块中的缓冲站，第一机器人包括第一顶臂和第一底臂，第一顶臂和第一底臂基本上具有第一运动范围; 以及基本上位于传送模块中的用于将工件传送到处理模块，缓冲站和物理接口的第二机器人，第二机器人包括第二顶臂和第二底臂，第二顶臂和第二底部臂基本上具有与第一运动范围重叠的第二运动范围。

9. 发明申请

WO2018237379A2 SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS 审中-公开
公开(公告)号：WO2018237379A2
公开(公告)日：2018-12-27
申请号：PCT/US2018/039263
申请日：2018-06-25
申请人： ENZO BIOCHEM, INC. , ELAZAR, Rabbani , DONEGAN, James, J. , DIAMOND, Paul
发明人： ELAZAR, Rabbani , DONEGAN, James, J. , DIAMOND, Paul
IPC分类号： A61K31/135 , A61K31/4245 , A61K45/06 , A61P35/00 , A61P35/02
摘要： The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine- 1 -phosphate receptor agonists, such as ozanimod.

10. 发明申请

WO2006072018A3 METHODS FOR SUPPORTING AND PRODUCING HUMAN CELLS AND TISSUES IN NON-HUMAN MAMMAL HOSTS 审中-公开
标题翻译：支持和生产非人类雄性HOSTS中的人类细胞和组织的方法
公开(公告)号：WO2006072018A3
公开(公告)日：2007-08-09
申请号：PCT/US2005047510
申请日：2005-12-29
申请人： DIAMOND PAUL
发明人： DIAMOND PAUL
IPC分类号： C12N5/00
CPC分类号： A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2267/02
摘要： Provided are methods for culturing and producing human cell containing compositions, such as organs and blood, in non-human mammal hosts and for the preparation of animalhosted human cell containing compositions for transplantation to human subjects. In one aspect, non-human hosts genetically modified or treated to reduce the expression of xenoantigens, such as alpha-galactosyl epitopes, are used to reduce the transfer of xenoantigens to the hosted human cells. In another aspect, non-human hosts genetically modified to express or over-express molecules that promote immunological tolerance to a graft, such as hDAF, are used so that the molecules are transferred to the hosted human cells. These aspects facilitate the immunological acceptance of the human cell containing compositions upon transplantation to a human subject. Still another aspect provides conditioning treatments that facilitate the immunological acceptance of human cell containing compositions that have been supported in non-human hosts upon their transplantation to a human subject.
摘要翻译：提供了在非人哺乳动物宿主中培养和产生含有人细胞的组合物如器官和血液的方法，以及用于制备用于移植给人类受试者的含有动物的人细胞的组合物。在一个方面，被遗传修饰或治疗以减少异种抗原表达（例如α-半乳糖基表位）的非人宿主用于减少异种抗原向托管人细胞的转移。在另一方面，使用遗传修饰以表达或过度表达促进对移植物（例如hDAF）的免疫耐受性的分子的非人宿主，使得分子被转移到宿主的人细胞。这些方面促进了人体细胞含有组合物移植到人类受试者时的免疫学接受。另一方面提供了调理治疗，其促进了在非人类宿主移植到人类受试者时已被支持的含有人细胞的组合物的免疫学接受。

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