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1. 发明授权

US4447440A Sulphenamides-containing lipoxygenase inhibiting agents and their use in pharmaceutical compositions 失效
标题翻译：含有苯丙胺的脂氧合酶抑制剂及其在药物组合物中的应用
公开(公告)号：US4447440A
公开(公告)日：1984-05-08
申请号：US368193
申请日：1982-04-14
申请人： Wolf-Dieter Busse , Edmund Krauthausen , Mithat Mardin
发明人： Wolf-Dieter Busse , Edmund Krauthausen , Mithat Mardin
IPC分类号： A61K31/135 , A61K31/27 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/496 , A61K31/505 , A61K31/54 , A61P1/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C313/34 , C07D209/38 , C07D209/48 , C07D209/50 , C07D209/62 , C07D223/10 , C07D225/02 , C07D231/08 , C07D233/80 , C07D235/22 , C07D239/42 , C07D249/14 , C07D257/06 , C07D263/18 , C07D263/24 , C07D263/26 , C07D263/58 , C07D265/18 , C07D265/26 , C07D277/82 , C07D279/06 , C07D285/08 , C07D285/12 , C07D285/135 , C07D295/26 , C07D521/00
CPC分类号： C07D209/48 , C07C313/34 , C07D209/38 , C07D209/50 , C07D209/62 , C07D223/10 , C07D225/02 , C07D231/08 , C07D231/12 , C07D233/56 , C07D233/80 , C07D235/22 , C07D239/42 , C07D249/08 , C07D249/14 , C07D257/06 , C07D263/18 , C07D263/26 , C07D263/58 , C07D265/18 , C07D265/26 , C07D277/82 , C07D279/06 , C07D285/08 , C07D285/135 , C07D295/26
摘要： The invention relates to sulphenamide compounds of Formula (I) as defined herein and to methods for their preparation. Also included in the invention are compositions containing said sulphenamide compounds; and the use of said compounds and compositions as lipoxygenase inhibiting agent.
摘要翻译：本发明涉及本文定义的式（I）的苯丙胺化合物及其制备方法。本发明还包括含有所述苏必醇酰胺化合物的组合物; 以及所述化合物和组合物作为脂氧合酶抑制剂的用途。

2. 发明授权

US3996268A Cross-linking reagent for insulin synthesis 失效
标题翻译：用于胰岛素合成的交联剂
公开(公告)号：US3996268A
公开(公告)日：1976-12-07
申请号：US502425
申请日：1974-09-03
申请人： Frederick H. Carpenter , Wolf-Dieter Busse
发明人： Frederick H. Carpenter , Wolf-Dieter Busse
IPC分类号： C07C323/44 , C07K1/06 , C07K1/10 , C07K14/625 , C07C103/147 , C07C103/183 , C07C149/20
CPC分类号： C07K1/10 , C07C323/44 , C07K1/067 , C07K14/625 , Y10S930/26
摘要： Carbonyl-bis (L-methionine p-nitrophenyl ester) and its analogues are useful reagents for the intermolecular cross-linking of two chain peptide molecules such as occur in the hormone insulin. The cross-linking occurs across amino groups at preferred positions in the two peptide chains to fix the relative spacial position of the peptide chains and permit the oxidative formation of necessary disulfide bridges between the chains in high yields. The reagent is then removed from the linked chains to yield the insulin molecule. A method for preparation of the reagent is disclosed. Further, a procedure is disclosed by which the cross-linking reagent is used to specifically block certain amino groups on insulin to yield a cross-linked insulin which in turn is used to prepare isotopically labeled insulin and insulin analogues.
摘要翻译：羰基 - 双（L-甲硫氨酸对硝基苯酯）及其类似物是用于激素胰岛素中发生的两个链肽分子的分子间交联的有用试剂。交联发生在两个肽链中优选位置的氨基上，以固定肽链的相对空间位置，并允许以高产率在链之间氧化形成必需的二硫键。然后从连接的链中除去试剂以产生胰岛素分子。公开了一种制备试剂的方法。此外，公开了一种方法，通过该方法，交联剂用于特异性阻断胰岛素上的某些氨基，产生交联的胰岛素，其又用于制备同位素标记的胰岛素和胰岛素类似物。

3. 发明授权

US4760066A Method for treating human tumor cell metastasis 失效
标题翻译：治疗人肿瘤细胞转移的方法
公开(公告)号：US4760066A
公开(公告)日：1988-07-26
申请号：US928614
申请日：1986-11-04
申请人： Wolf-Dieter Busse , Kenneth V. Honn , Eike Moller , Friedel Seuter
发明人： Wolf-Dieter Busse , Kenneth V. Honn , Eike Moller , Friedel Seuter
IPC分类号： A61K31/415 , A61K31/52
CPC分类号： A61K31/415
摘要： A therapeutic method for reducing metastasis is disclosed. The method involves administering a therapeutically effective amount of 3-methyl-1-[2-(2-naphthyloxy)-ethyl]-2-pyrazolin-5-one or a pharmaceutically acceptable salt.
摘要翻译：公开了一种减少转移的治疗方法。该方法包括施用治疗有效量的3-甲基-1- [2-（2-萘氧基） - 乙基] -2-吡唑啉-5-酮或其药学上可接受的盐。

4. 发明授权

US4636497A Anti-thrombotic pharmaceutical compositions comprising tricyclo-4H-1,4-benzothiazine derivatives and method of use therefor 失效
标题翻译：包含三环-4H-1,4-苯并噻嗪衍生物的抗血栓形成药物组合物及其用途
公开(公告)号：US4636497A
公开(公告)日：1987-01-13
申请号：US770895
申请日：1985-08-29
申请人： Ekkehard Niemers , Rudi Grutzmann , Mithat Mardin , Wolf-Dieter Busse , Horst Meyer
发明人： Ekkehard Niemers , Rudi Grutzmann , Mithat Mardin , Wolf-Dieter Busse , Horst Meyer
IPC分类号： A61K31/54 , A61K31/5415 , A61P1/14 , A61P11/00 , A61P29/00 , A61P35/00 , A61P37/08 , C07D279/16 , C07D279/20 , C07D279/22 , C07D513/04 , A61K31/38 , C07D279/10
CPC分类号： C07D513/04 , C07D279/16 , C07D279/20
摘要： The present invention refers to novel anellated 4H-1,4-benzothiazines, several processes for the synthesis thereof, their use as pharmaceutical agents, in particular their use as lipoxygenase-inhibiting agents, pharmaceutical compositions containing the novel benzothiazines and a process for their manufacture.
摘要翻译：本发明涉及新型的有机化合的4H-1,4-苯并噻嗪，其合成方法，它们作为药物的用途，特别是其作为脂氧合酶抑制剂的用途，含有新的苯并噻嗪类的药物组合物及其制备方法。

5. 发明授权

US4540707A Nafazatrom as a lipoxygenase inhibitor 失效
公开(公告)号：US4540707A
公开(公告)日：1985-09-10
申请号：US486175
申请日：1983-04-18
申请人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
发明人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , Y10S514/821 , Y10S514/826
摘要： A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.

6. 发明授权

US4657924A Nafazatrom as a lipoxygenase inhibitor 失效
标题翻译： Nafazatrom作为脂氧合酶抑制剂
公开(公告)号：US4657924A
公开(公告)日：1987-04-14
申请号：US715438
申请日：1985-03-25
申请人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
发明人： Mithat Mardin , Wolf-Dieter Busse , Friedrich Hoffmeister , Friedel Seuter , Elisabeth Perzborn , Klaus Schlossmann , Dieter Mayer , Volker Fiedler
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , Y10S514/821 , Y10S514/826
摘要： A method of inhibiting lipoxygenase in a patient, for the prophylaxis and/or treatment of ischaemias and disorders in cardiac rhythm and of rheumatic, allergic and asthmatic diseases, oedemas, pulmonary embolisms, pulmonary hypertension, oxygen intoxications and ulcerations which comprises administering to such patient an effective amount of nafazatrom.
摘要翻译：一种抑制患者中脂质氧合酶的方法，用于预防和/或治疗心律和风湿性，过敏性和哮喘性疾病，oedemas，肺栓塞，肺动脉高压，氧中毒和溃疡中的局部缺血和疾病，其包括向该患者施用有效量的nafazatrom。

7. 发明授权

US4552874A Pyrazolooxazines, pyrazolothiazines, and pryazoloquinolines and their use as medicaments 失效
标题翻译：吡唑并恶嗪，吡唑并噻嗪和吡唑并喹啉及其作为药物的用途
公开(公告)号：US4552874A
公开(公告)日：1985-11-12
申请号：US462864
申请日：1983-02-01
申请人： Mithat Mardin , Rudolf Sundermann , Friedrich Hoffmeister , Wolf-Dieter Busse , Harald Horstmann , Siegfried Raddatz
发明人： Mithat Mardin , Rudolf Sundermann , Friedrich Hoffmeister , Wolf-Dieter Busse , Harald Horstmann , Siegfried Raddatz
IPC分类号： A61K31/435 , A61K31/535 , A61K31/54 , A61P1/04 , A61P7/02 , A61P9/10 , A61P29/00 , A61P43/00 , C07D265/36 , C07D471/04 , C07D498/04 , C07D498/14 , C07D513/04
CPC分类号： C07D471/04 , C07D265/36 , C07D513/04
摘要： The invention relates to pyrazolooxazines, pyrazolothiazines and pyrazoloquinolines defined herein by Formula I. The invention also includes compositions containing said Formula I compounds and methods for the use of said compounds and compositions for their lipoxygenase-inhibiting properties. Also included in the invention are methods for the manufacture of said compounds of Formula I.
摘要翻译：本发明涉及由式I定义的吡唑并恶嗪，吡唑并噻嗪和吡唑并喹啉。本发明还包括含有所述式I化合物的组合物和所述化合物和组合物用于其脂氧合酶抑制性质的方法。本发明还包括制备所述式I化合物的方法。

8. 发明授权

US4451475A Cyclic sulphenamide compounds, their production and their medicinal use 失效
标题翻译：环状苯磺酰胺化合物，其生产及其药用
公开(公告)号：US4451475A
公开(公告)日：1984-05-29
申请号：US368329
申请日：1982-04-14
申请人： Wolf-Dieter Busse , Edmund Krauthausen , Mithat Mardin
发明人： Wolf-Dieter Busse , Edmund Krauthausen , Mithat Mardin
IPC分类号： A61K31/42 , A61K31/421 , A61K31/423 , A61K31/425 , A61K31/426 , A61P29/00 , A61P37/08 , A61P43/00 , C07D263/26 , C07D263/58 , C07D277/14 , C07D277/26 , C07D277/34 , C07D263/22
CPC分类号： C07D263/58 , C07D263/26 , C07D277/14 , C07D277/34
摘要： The invention relates to cyclic sulphenamides of Formula I and methods for their manufacture. Also included in the invention are compositions containing said cyclic sulphenamides and methods for the use of said compounds and compositions as lipoxygenase inhibitors.
摘要翻译：本发明涉及式I的环状苯甲酰胺及其制备方法。本发明还包括含有所述环状苯甲酰胺的组合物和使用所述化合物和组合物作为脂氧合酶抑制剂的方法。

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