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1. 发明授权

US4177056A Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides 失效
标题翻译：用作药物和农药载体的水不溶性亲水性共聚物
公开(公告)号：US4177056A
公开(公告)日：1979-12-04
申请号：US872191
申请日：1978-01-25
申请人： Karl F. Mueller , William R. Good
发明人： Karl F. Mueller , William R. Good
IPC分类号： A01N25/10 , A61L9/04 , B01D71/44 , B01D71/80 , C08F290/06 , C08F299/06 , C08G18/67 , A01N9/22 , A61K31/78
CPC分类号： A01N25/10 , A61L9/048 , B01D71/44 , B01D71/80 , C08F290/062 , C08F299/06 , C08G18/671 , B01D2325/48 , C08G2210/00
摘要： A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different water-soluble mono-olefinic monomers, or (b) copolymer of said water-soluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000.
摘要翻译：一种水不溶性亲水凝胶，其包含：（A）约30至约90％的相同或不同水溶性单烯烃单体的亲水性（a）聚合物，或（b）所述水溶性单体与1至 70％的水不溶性，相同或不同的单烯烃单体，该聚合物或共聚物与（B）约10至约70％的分子量为约400至约8000的末端二烯烃疏水性大分子单体交联。

2. 发明授权

US4873086A Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof 失效
标题翻译：具有增加的有机溶剂可溶活性剂负载能力的水凝胶，其制备及其用途
公开(公告)号：US4873086A
公开(公告)日：1989-10-10
申请号：US229189
申请日：1988-08-08
申请人： William R. Good , John Mikes , Joseph Sikora
发明人： William R. Good , John Mikes , Joseph Sikora
IPC分类号： A01N25/10 , A61K9/20 , A61K47/32 , C08F290/06
CPC分类号： C08F290/062 , A01N25/10 , A61K47/32 , A61K9/2027 , Y10S514/944 , Y10S514/95 , Y10S528/904
摘要： An organic solvent soluble active agent containing water-insoluble hydrophilic hydrogel comprising a copolymer of (A) a water-soluble monoolefinic monomer or a mixture thereof optimally containing up to 50% thereof of one or more water-insoluble mono-olefinic monomers and (B) a terminally diolefinic hydrophobic macromer containing polypropylene oxide or polytetramethylene oxide units prepared in the presence of an effective macromer expanding amount of a macromer soluble compound of the formulaR'--R"--O.sub.n R"'where R', R", R"' and n are as defined in the claims, hydrogels useful in the loading of such active agents, their preparation, and use are disclosed.
摘要翻译：一种含有水不溶性亲水性水凝胶的有机溶剂可溶性活性剂，其包含（A）水溶性单烯烃单体或其最佳含有至多50％的一种或多种水不溶性单烯烃单体和（B ）含有聚环氧丙烷或聚四亚甲基氧单元的末端二烯烃疏水性大分子单体，其在有效大分子单体扩增量的式R'-R“-ORR”'的大分子单体可溶性化合物存在下制备，其中R'，R“ R“和n如权利要求中所定义，公开了可用于负载这种活性剂的水凝胶，它们的制备和用途。

3. 发明授权

US6024935A Lower-energy hydrogen methods and structures 失效
公开(公告)号：US6024935A
公开(公告)日：2000-02-15
申请号：US822170
申请日：1997-03-21
申请人： Randell L. Mills , William R. Good , Jonathan Phillips , Arthur I. Popov
发明人： Randell L. Mills , William R. Good , Jonathan Phillips , Arthur I. Popov
IPC分类号： F02G1/043 , G21B3/00 , C01B3/02
CPC分类号： G21B3/00 , F02G1/043 , F02G2243/52 , Y02E30/18
摘要： Methods and apparatus for releasing energy from hydrogen atoms (molecules) by stimulating their electrons to relax to quantized lower energy levels and smaller radii (smaller semimajor and semiminor axes) than the "ground state" by providing energy sinks or means to remove energy resonant with the hydrogen energy released to stimulate these transitions. An energy sink, energy hole, can be provided by the transfer of at least one electron between participating species including atoms, ions, molecules, and ionic and molecular compounds. In one embodiment, the energy hole comprises the transfer of t electrons from one or more donating species to one or more accepting species whereby the sum of the ionization energies and/or electron affinities of the electron donating species minus the sum of the ionization energies and/or electron affinities of the electron accepting species equals approximately mX27.21 eV (mX48.6 eV) for atomic (molecular) hydrogen below "ground state" transitions where m and t are integers. The present invention further comprises a hydrogen spillover catalyst, a multifunctionality material having a functionality which dissociates molecular hydrogen to provide free hydrogen atoms which spill over to a functionality which supports mobile free hydrogen atoms and a functionality which can be a source of the energy holes. The energy reactor includes one of an electrolytic cell, a pressurized hydrogen gas cell, and a hydrogen gas discharge cell. A preferred pressurized hydrogen gas energy reactor comprises a vessel; a source of hydrogen; a means to control the pressure and flow of hydrogen into the vessel; a material to dissociate the molecular hydrogen into atomic hydrogen, and a material which can be a source of energy holes in the gas phase. The gaseous source of energy holes includes those that sublime, boil, and/or are volatile at the elevated operating temperature of the gas energy reactor wherein the exothermic reaction of electronic transitions of hydrogen to lower energy states occurs in the gas phase.

4. 发明授权

US4853227A Transdermal administration of a systemic active agent to a premature neonatal infant 失效
标题翻译：将全身活性剂透皮给药给早产新生儿
公开(公告)号：US4853227A
公开(公告)日：1989-08-01
申请号：US112917
申请日：1987-10-23
申请人： Tamie Kurihara-Bergstrom , William R. Good , Charles D. Ebert
发明人： Tamie Kurihara-Bergstrom , William R. Good , Charles D. Ebert
IPC分类号： A61K9/70 , A61M35/00
CPC分类号： A61M35/00 , A61K9/7023
摘要： A method of treating a premature neonatal infant of a gestational age between about 24 and about 35 weeks with a pharmaceutically acceptable, systemically active, substantially skin compatible, water-soluble neonatal therapeutic agent having a molecular weight below about 5000, and which agent is substantially non-transmissable through normal mature intact human skin, comprising:(a) applying to the intact neonatal skin of said infant a transdermal device comprising (i) a backing member, (ii) a substantially shape retaining hydrogel reservoir having a water content of between about 5 percent and about 95 percent preferably between 10 percent and 80 percent by weight of said reservoir and containing an effective amount of said agent, (iii) a skin contacting surface of predetermined area, and (iv) means for maintaining said reservoir in material transmitting relationship to said skin;(b) maintaining said skin contacting surface of said device in material transmitting relationship to said intact neonatal skin of the infant for an extended period of time; and(c) delivering said agent through the intact neonatal skin in a controlled continuous manner such that the blood plasma level of said agent is substantially within the therapeutic index of said agent for a majority of said extended period of time.
摘要翻译：一种在约24至约35周之间用具有分子量低于约5000的药学上可接受的，系统活性的，基本上与皮肤相容的水溶性新生儿治疗剂来治疗胎龄较早的新生儿婴儿的方法，包括：（a）向所述婴儿的完整的新生儿皮肤施用透皮装置，其包括（i）背衬构件，（ii）基本上保持形状的水凝胶储存器，其水含量介于约5％至约95％，优选10％至80％，并含有有效量的所述试剂，（iii）预定面积的皮肤接触表面，和（iv）用于将所述储存器保持在材料中的装置传递与所述皮肤的关系; （b）将所述装置的所述皮肤接触表面与所述婴儿的所述完整的新生儿皮肤的材料传播关系延长一段时间; 和（c）以受控的连续方式将所述药剂输送穿过完整的新生儿皮肤，使得所述药剂的血浆水平基本上在所述药剂的治疗指数中大部分所述延长的一段时间。

5. 发明授权

US4305034A Magnetic field intensity measuring device with frequency change indication 失效
标题翻译：具有频率变化指示的磁场强度测量装置
公开(公告)号：US4305034A
公开(公告)日：1981-12-08
申请号：US27970
申请日：1979-04-09
申请人： James C. Long , Monroe J. Willner , William R. Good
发明人： James C. Long , Monroe J. Willner , William R. Good
IPC分类号： G01R33/02
CPC分类号： G01R33/02
摘要： A device powered by a DC source produces an output signal the frequency of which changes as a function of changes in external magnetic fields sensed by such device. A pair of non-linear amplifiers are interconnected so that the output of one amplifier is the input of the other amplifier. An inductive sensor is connected between the outputs of the amplifiers. The inductive sensor has an elongated magnetic core and a coil is wound on the core. The voltages at the outputs of the amplifiers, across the inductive sensor, switch between zero and the full voltage of the DC source.
摘要翻译：由DC源供电的装置产生一个输出信号，其频率随着这种装置感测到的外部磁场的变化而变化。一对非线性放大器互连，使得一个放大器的输出是另一个放大器的输入。电感式传感器连接在放大器的输出端之间。感应传感器具有细长的磁芯，线圈缠绕在芯上。放大器的输出端，电感传感器两端的电压在零和直流电源的全电压之间切换。

6. 发明授权

US4192827A Water-insoluble hydrophilic copolymers 失效
标题翻译：水不溶性亲水共聚物
公开(公告)号：US4192827A
公开(公告)日：1980-03-11
申请号：US883022
申请日：1978-03-03
申请人： Karl F. Mueller , William R. Good
发明人： Karl F. Mueller , William R. Good
IPC分类号： C08F299/06 , C08G18/67 , C08L75/00 , C08G73/12
CPC分类号： C08F299/06 , C08G18/671 , C08G2210/00
摘要： A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different water-soluble mono-olefinic monomers, or (b) copolymer of said water-soluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000.
摘要翻译：一种水不溶性亲水凝胶，其包含：（A）约30至约90％的相同或不同水溶性单烯烃单体的亲水性（a）聚合物，或（b）所述水溶性单体与1至 70％的水不溶性，相同或不同的单烯烃单体，该聚合物或共聚物与（B）约10至约70％的分子量为约400至约8000的末端二烯烃疏水性大分子单体交联。

7. 发明授权

US5662925A Transdermal delivery system with adhesive overlay and peel seal disc 失效
标题翻译：透皮贴剂和剥离密封盘
公开(公告)号：US5662925A
公开(公告)日：1997-09-02
申请号：US638440
申请日：1996-04-26
申请人： Charles D. Ebert , Werner Heiber , William R. Good , Srinivasan Venkateshwaran
发明人： Charles D. Ebert , Werner Heiber , William R. Good , Srinivasan Venkateshwaran
IPC分类号： A61K9/70 , A61L25/00
CPC分类号： A61K9/703 , A61K9/7084
摘要： A device for administering an active agent to the skin or mucosa of an individual comprising a laminated composite of an adhesive overlay, a backing layer underlying the central portion of the adhesive overlay, an active agent-permeable membrane, the backing layer and membrane defining a reservoir that contains a formulation of the active agent, a peel seal disc underlying the active agent-permeable membrane, a heat seal about the periphery of the peel seal disc, the active agent-permeable membrane and the backing layer and a removable release liner underlying the exposed overlay and peel seal disc. The adhesive layer is above and peripheral to the path of the active agent to the skin or mucosa and is protected from degradation by the components of the reservoir by a multiplicity of heat seals. The peel seal disc protects against release of the active agent-containing reservoir and the release liner protects the adhesive from exposure to the environment prior to use.
摘要翻译：一种用于向个体的皮肤或粘膜施用活性剂的装置，其包括粘合剂覆盖物，粘合剂覆盖物的中心部分下方的背衬层，活性剂渗透膜，背衬层和膜的层压复合材料储存器，其包含活性剂的制剂，活性剂渗透膜下面的剥离密封盘，围绕剥离密封盘的周边的热密封，活性剂可渗透膜和背衬层以及可移除的释放衬垫暴露的覆盖层和剥离密封盘。粘合剂层位于活性剂到皮肤或粘膜的路径之上和周边，并通过多种热封保护储存器的部件免于降解。剥离密封盘防止含活性剂的储存器的释放，并且释放衬垫在使用之前保护粘合剂免于暴露于环境中。

8. 发明授权

US4304591A Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides 失效
标题翻译：用作药物和农药载体的水不溶性亲水性共聚物
公开(公告)号：US4304591A
公开(公告)日：1981-12-08
申请号：US46065
申请日：1979-06-06
申请人： Karl F. Mueller , William R. Good
发明人： Karl F. Mueller , William R. Good
IPC分类号： A01N25/10 , A61K9/20 , A61L9/04 , A61L27/54 , B01D71/44 , B01D71/80 , C08F290/06 , C08F299/06 , C08G18/67 , A01N43/48 , A01N43/64 , A61K31/78
CPC分类号： C08F290/062 , A01N25/10 , A61K9/2027 , A61L27/54 , A61L9/048 , B01D71/44 , B01D71/80 , C08F299/06 , C08G18/671 , A61L2300/602 , C08G2210/00
摘要： A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different watersoluble mono-olefinic monomers, or (b) copolymer of said watersoluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000 is disclosed. The gel is suitable for use as a carrier for medicaments and pesticides.
摘要翻译：一种水不溶性亲水性凝胶，其包含：（A）约30至约90％相同或不同水溶性单烯烃单体的亲水性（a）聚合物，或（b）所述水溶性单体与1至70％水的共聚物公开了不溶性，相同或不同的单烯烃单体，该聚合物或共聚物与（B）约10至约70％的分子量为约400至约8000的末端二烯烃疏水性大分子单体交联。该凝胶适用于药物和农药的载体。

9. 发明授权

US4277582A Water-insoluble hydrophilic copolymers 失效
标题翻译：水不溶性亲水共聚物
公开(公告)号：US4277582A
公开(公告)日：1981-07-07
申请号：US51337
申请日：1979-06-22
申请人： Karl F. Mueller , William R. Good
发明人： Karl F. Mueller , William R. Good
IPC分类号： C08G18/67 , C08G73/12 , C08L79/08
CPC分类号： C08G73/124 , C08G18/671 , C08L79/085 , C08G2210/00 , Y10S525/925
摘要： A water-insoluble hydrophilic gel comprising: (A) about 30 to about 90% of a hydrophilic (a) polymer of identical or different watersoluble mono-olefinic monomers, or (b) copolymer of said watersoluble monomers with 1 to 70% of water-insoluble, identical or different mono-olefinic monomers, which polymer or copolymer is cross-linked with (B) about 10 to about 70% of a terminal diolefinic hydrophobic macromer having a molecular weight from about 400 to about 8000.
摘要翻译：一种水不溶性亲水性凝胶，其包含：（A）约30至约90％相同或不同水溶性单烯烃单体的亲水性（a）聚合物，或（b）所述水溶性单体与1至70％水的共聚物不溶性，相同或不同的单烯烃单体，该聚合物或共聚物与（B）约10至约70％的分子量为约400至约8000的末端二烯烃疏水性大分子单体交联。

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