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1. 发明授权

US08658695B2 Disodium salts, monohydrates, and ethanol solvates for delivering active agents 有权
标题翻译：用于递送活性剂的二钠盐，一水合物和乙醇溶剂化物
公开(公告)号：US08658695B2
公开(公告)日：2014-02-25
申请号：US13481310
申请日：2012-05-25
申请人： William Elliott Bay , Rajesh K. Agarwal , Kiran Chaudhary , Shingai Majuru , Michael M. Goldberg , JoAnne P. Corvino , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph Zielinski
发明人： William Elliott Bay , Rajesh K. Agarwal , Kiran Chaudhary , Shingai Majuru , Michael M. Goldberg , JoAnne P. Corvino , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph Zielinski
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07C231/00 , A61K9/2013 , A61K47/183 , C07C235/60 , C07D265/26 , C07C235/58
摘要： The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
摘要翻译：发明人已经发现，某些递送剂的二钠盐比相应的单钠盐具有惊人的更大的递送活性剂的功效。此外，本发明人已经发现，这些递送剂的二钠盐与乙醇形成溶剂合物并与水合。优选的递送剂包括但不限于N-（5-氯水杨酰基）-8-氨基辛酸（5-CNAC），N-（10- [2-羟基苯甲酰基]氨基）癸酸（SNAD）和N - （8- [2-羟基苯甲酰基]氨基）辛酸酯（SNAC）。本发明还提供了制备二钠盐，乙醇溶剂合物和水合物的方法以及含有二钠盐，乙醇溶剂化物和/或水合物的组合物。

2. 发明授权

US07049283B2 Pharmaceutical compositions for the oral delivery of pharmacologically active agents 有权
公开(公告)号：US07049283B2
公开(公告)日：2006-05-23
申请号：US10006311
申请日：2001-12-04
申请人： Joseph M. Ault , Moise Azria , Simon David Bateman , Joseph Sikora , Gregory Sparta , Rebecca Fai-ying Yang , Jie Xiao
发明人： Joseph M. Ault , Moise Azria , Simon David Bateman , Joseph Sikora , Gregory Sparta , Rebecca Fai-ying Yang , Jie Xiao
IPC分类号： A01N37/18
CPC分类号： A61K9/2027 , A61K9/2013 , A61K9/2054 , A61K47/183
摘要： Solid pharmaceutical compositions suitable for the oral delivery of pharmacologically active agents, e.g. peptides, comprising a therapeutically-effective amount of a pharmacologically active agent; a crospovidone or povidone; and a delivery agent for said pharmacologically active agent are disclosed. The compositions provide excellent oral bioavailability of pharmacologically active agents, particularly calcitonin.

3. 发明申请

US20060071123A1 Automatic control systems for aircraft auxiliary power units, and associated methods 有权
标题翻译：飞机辅助动力装置自动控制系统及相关方法
公开(公告)号：US20060071123A1
公开(公告)日：2006-04-06
申请号：US10951185
申请日：2004-09-27
申请人： Phuong Nguyen , Joseph Sikora , Thomas Campbell
发明人： Phuong Nguyen , Joseph Sikora , Thomas Campbell
IPC分类号： B64C13/16
CPC分类号： B64D41/00 , B64D2041/002 , B64D2221/00
摘要： Systems and methods for operating aircraft power systems are disclosed. A power system in accordance with one embodiment of the invention includes an aircraft auxiliary power unit and a controller coupled to the aircraft auxiliary power unit, with the controller being configured to automatically stop the auxiliary power unit while the auxiliary power unit is functioning normally. The controller can also be configured to automatically start the auxiliary power unit in-flight when power supplied or expected to be supplied to a subsystem of the aircraft has a non-zero value at or below a threshold value. The controller may also be configured to start the auxiliary power unit when a load or expected load on the subsystem meets or exceeds a threshold value.
摘要翻译：公开了用于操作飞机动力系统的系统和方法。根据本发明的一个实施例的电力系统包括飞行器辅助动力单元和耦合到飞行器辅助动力单元的控制器，其中控制器被配置为在辅助动力单元正常运行时自动停止辅助动力单元。控制器还可以被配置为在供电或期望提供给飞行器的子系统的电源具有等于或小于阈值的非零值时，在飞行中自动启动辅助电源单元。控制器还可以被配置为在子系统上的负载或预期负载满足或超过阈值时启动辅助电源单元。

4. 发明授权

US06993043B1 End-to-end prioritized data delivery on networks using IP over frame relay 失效
标题翻译：使用IP over帧中继的网络端到端优先数据传输
公开(公告)号：US06993043B1
公开(公告)日：2006-01-31
申请号：US09711549
申请日：2000-11-13
申请人： Hrair Aldermeshian , Arvind S Chakravarti , Richard Hellstern , Raymond L. Kimber , Ali Mohammad Kujoory , Yonatan Aharon Levy , John Babu Medamana , John Joseph Sikora
发明人： Hrair Aldermeshian , Arvind S Chakravarti , Richard Hellstern , Raymond L. Kimber , Ali Mohammad Kujoory , Yonatan Aharon Levy , John Babu Medamana , John Joseph Sikora
IPC分类号： H04L12/66
CPC分类号： H04L47/2491 , H04L12/2854 , H04L12/4633 , H04L45/04 , H04L45/28 , H04L47/16 , H04L49/205 , H04L2012/5667 , H04L2212/00 , H04Q11/0478
摘要： The invention provides methods and systems for providing priority processing to critical data as the data is transmitted across a network. A plurality of Internet protocol (IP) packets, each of which contains data and priority information, are received at a first router. The data contained in the IP packets is then encapsulated into frame relay frames containing the priority information. The frame relay frames are transmitted from the first router to a frame relay network in a manner determined by the priority information included in the frame relay frames. The frame relay frames are then transmitted across a frame relay network to a second router in a manner determined by the priority information included in the frame relay frames.
摘要翻译：本发明提供了当通过网络传输数据时，为关键数据提供优先处理的方法和系统。在第一路由器处接收多个互联网协议（IP）分组，每个分组包含数据和优先级信息。然后将包含在IP包中的数据封装到包含优先级信息的帧中继帧中。帧中继帧以由帧中继帧中包含的优先级信息确定的方式从第一路由器发送到帧中继网络。然后，帧中继帧以由帧中继帧中包括的优先级信息确定的方式通过帧中继网络传输到第二路由器。

5. 发明授权

US07659311B2 Disodium salts, monohydrates, and ethanol solvates for delivering active agents 有权
标题翻译：用于递送活性剂的二钠盐，一水合物和乙醇溶剂化物
公开(公告)号：US07659311B2
公开(公告)日：2010-02-09
申请号：US12111750
申请日：2008-04-29
申请人： William Elliott Bay , Rajesh K. Agarwal , Kiran Chaudhary , Shingai Majuru , Michael M. Goldberg , JoAnne P. Corvino , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph L. Zielinski
发明人： William Elliott Bay , Rajesh K. Agarwal , Kiran Chaudhary , Shingai Majuru , Michael M. Goldberg , JoAnne P. Corvino , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph L. Zielinski
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07C231/00 , A61K9/2013 , A61K47/183 , C07C235/60 , C07D265/26 , C07C235/58
摘要： The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16 alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above. The invention also provides a hydrate of a disodium salt of a delivery agent of the formula above. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
摘要翻译：发明人已经发现，某些递送剂的二钠盐比相应的单钠盐具有惊人的更大的递送活性剂的功效。此外，本发明人已经发现，这些递送剂的二钠盐与乙醇形成溶剂合物并与水合。递送剂具有下式：其中R 1，R 2，R 3和R 4独立地是氢，卤素，C 1 -C 4烷基或C 1 -C 4烷氧基; 取代或未取代的C 2 -C 16亚烯基，取代或未取代的C 1 -C 12烷基（亚芳基）或取代或未取代的芳基（C 1 -C 12亚烷基）。本发明的水合物和溶剂合物对于递送活性剂（例如肝素和降钙素）比其相应的单钠盐和游离酸具有惊人的更大的功效。本发明提供了一种醇溶剂合物，例如乙醇溶剂化物，其具有上式的递送剂的二钠盐。本发明还提供了上式的递送剂的二钠盐的水合物。优选的递送剂包括但不限于N-（5-氯水杨酰基）-8-氨基辛酸（5-CNAC），N-（10- [2-羟基苯甲酰基]氨基）癸酸（SNAD）和N - （8- [2-羟基苯甲酰基]氨基）辛酸酯（SNAC）。本发明还提供了制备二钠盐，乙醇溶剂合物和水合物的方法以及含有二钠盐，乙醇溶剂合物和/或水合物的组合物。

6. 发明申请

US20080287543A1 Pharmaceutical composition comprising 5-methyl-2 (2'-chloro-6'-fluoroanillino) phen ylacetic acid 审中-公开
标题翻译：包含5-甲基-2（2'-氯-6'-氟苯胺基）苯基乙酸的药物组合物
公开(公告)号：US20080287543A1
公开(公告)日：2008-11-20
申请号：US12220060
申请日：2008-07-21
申请人： Rose-Marie Dannenfelser , Vivia Christine Georgousis , Maha Y. Khaled , Tarun S. Patel , Joseph Sikora , Barbara Wang
发明人： Rose-Marie Dannenfelser , Vivia Christine Georgousis , Maha Y. Khaled , Tarun S. Patel , Joseph Sikora , Barbara Wang
IPC分类号： A61K31/195 , A61P29/00
CPC分类号： A61K31/135 , A61K9/0019 , A61K31/196 , A61K47/10 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/44
摘要： The invention relates to a composition for the treatment of a cyclooxygenase-2-mediated disorder or condition comprising 5-methyl-2-(2′-chloro-6′-fluoroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof suitable for parenteral administration, and to a method for the treatment of a cyclooxygenase-2-mediated disorder or condition in a human or animal in need of such treatment by parenteral administration of 5-methyl-2-(2′-chloro-6′-fluroanilino)phenylacetic acid or a pharmaceutically acceptable salt, preferably the potassium salt, thereof.
摘要翻译：本发明涉及用于治疗环氧合酶-2介导的病症或病症的组合物，其包含5-甲基-2-（2'-氯-6'-氟苯胺基）苯乙酸或其药学上可接受的盐，优选钾盐，以及用于治疗需要这种治疗的人或动物中环氧合酶-2介导的病症或病症的方法，通过肠胃外给药5-甲基-2-（2'-氯-6 芴丙基）苯乙酸或其药学上可接受的盐，优选其钾盐。

7. 发明申请

US20060220914A1 METHODS AND SYSTEMS FOR DISPLAYING AIRCRAFT ENGINE CHARACTERISTICS 有权
标题翻译：用于显示飞机发动机特性的方法和系统
公开(公告)号：US20060220914A1
公开(公告)日：2006-10-05
申请号：US10860760
申请日：2004-06-03
申请人： Joseph Sikora , John Wiedemann
发明人： Joseph Sikora , John Wiedemann
IPC分类号： G08B21/00
CPC分类号： G01D7/08
摘要： A method and system for displaying aircraft engine information. In one embodiment, the method includes directing the display of an icon that represents an overall operational state of an aircraft engine, with the overall operational state including one of a started state and an unstarted state. The method can further include directing a change in a displayed characteristic of the icon when the overall operational state of the aircraft engine changes from the one of the started state and the unstarted state to the other of the started state and the unstarted state. In a further embodiment, the method can further include repeatedly directing changes in the display of the icon as the aircraft changes from the unstarted state to the started state.
摘要翻译：一种用于显示飞机发动机信息的方法和系统。在一个实施例中，该方法包括引导表示飞机发动机的总体操作状态的图标的显示，其中总体操作状态包括起动状态和未启动状态之一。该方法可以进一步包括当飞行器引擎的总体操作状态从启动状态和未启动状态中的一个改变为启动状态和未启动状态中的另一个时引导图标的显示特性的改变。在另一个实施例中，该方法还可以包括当飞机从未启动状态改变到开始状态时重复地指示图标的显示中的改变。

8. 发明申请

US20060191150A1 Template device and method of using same 审中-公开
标题翻译：模板设备及其使用方法
公开(公告)号：US20060191150A1
公开(公告)日：2006-08-31
申请号：US11368977
申请日：2006-03-06
申请人： Joseph Sikora , Raymond Mancison
发明人： Joseph Sikora , Raymond Mancison
IPC分类号： B43L7/00
CPC分类号： B25H7/00 , H02G1/00 , H02G2200/30
摘要： A template device and method of using same, the template device includes: a substantially planar member defining a plurality of channels therein; wherein, the channels at least partially define a plurality of concentric shapes each corresponding to a known electrical box configuration, respectively. The device may include at least one leveling indicator such as a leveling bubble container. The device may include a stud finding device, or means for attaching to a stud finding device. The device may be integrated with, or include means for attaching to, a sheet rock square.
摘要翻译：模板装置及其使用方法，模板装置包括：在其中限定多个通道的基本上平面的构件; 其中，通道至少部分地限定多个同心形状，分别对应于已知的电气箱配置。该装置可以包括至少一个流平指示器，例如调平气泡容器。该装置可以包括螺柱查找装置或用于附接到螺柱发现装置的装置。该装置可以与片状岩石广场一体化或包括附接到片状岩石方块的装置。

9. 发明授权

US4873086A Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof 失效
标题翻译：具有增加的有机溶剂可溶活性剂负载能力的水凝胶，其制备及其用途
公开(公告)号：US4873086A
公开(公告)日：1989-10-10
申请号：US229189
申请日：1988-08-08
申请人： William R. Good , John Mikes , Joseph Sikora
发明人： William R. Good , John Mikes , Joseph Sikora
IPC分类号： A01N25/10 , A61K9/20 , A61K47/32 , C08F290/06
CPC分类号： C08F290/062 , A01N25/10 , A61K47/32 , A61K9/2027 , Y10S514/944 , Y10S514/95 , Y10S528/904
摘要： An organic solvent soluble active agent containing water-insoluble hydrophilic hydrogel comprising a copolymer of (A) a water-soluble monoolefinic monomer or a mixture thereof optimally containing up to 50% thereof of one or more water-insoluble mono-olefinic monomers and (B) a terminally diolefinic hydrophobic macromer containing polypropylene oxide or polytetramethylene oxide units prepared in the presence of an effective macromer expanding amount of a macromer soluble compound of the formulaR'--R"--O.sub.n R"'where R', R", R"' and n are as defined in the claims, hydrogels useful in the loading of such active agents, their preparation, and use are disclosed.
摘要翻译：一种含有水不溶性亲水性水凝胶的有机溶剂可溶性活性剂，其包含（A）水溶性单烯烃单体或其最佳含有至多50％的一种或多种水不溶性单烯烃单体和（B ）含有聚环氧丙烷或聚四亚甲基氧单元的末端二烯烃疏水性大分子单体，其在有效大分子单体扩增量的式R'-R“-ORR”'的大分子单体可溶性化合物存在下制备，其中R'，R“ R“和n如权利要求中所定义，公开了可用于负载这种活性剂的水凝胶，它们的制备和用途。

10. 发明授权

US08207227B2 Disodium salts, monohydrates, and ethanol solvates for delivering active agents 有权
标题翻译：用于递送活性剂的二钠盐，一水合物和乙醇溶剂化物
公开(公告)号：US08207227B2
公开(公告)日：2012-06-26
申请号：US13053641
申请日：2011-03-22
申请人： William E. Bay , Rajesh K. Agarwal , Kiran Chaudhary , Michael M. Goldberg , Joanne P. Corvino , Shingai Majuru , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph Zielinski
发明人： William E. Bay , Rajesh K. Agarwal , Kiran Chaudhary , Michael M. Goldberg , Joanne P. Corvino , Shingai Majuru , Moise Azria , Joseph Ault , Simon D. Bateman , Subash Patel , Joseph Sikora , Rebecca F. Yang , Joseph Zielinski
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07C231/00 , A61K9/2013 , A61K47/183 , C07C235/60 , C07D265/26 , C07C235/58
摘要： The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these delivery agents form solvates with ethanol and hydrates with water. The delivery agents have the formula wherein R1, R2, R3, and R4 are independently hydrogen, halogen, C1-C4 alkyl, or C1-C4 alkoxy; and R5 is a substituted or unsubstituted C2-C16alkylene, substituted or unsubstituted C2-C16 alkenylene, substituted or unsubstituted C1-C12 alkyl(arylene), or substituted or unsubstituted aryl(C1-C12 alkylene). The hydrates and solvates of present invention also have surprisingly greater efficacy for delivering active agents, such as heparin and calcitonin, than their corresponding monosodium salts and free acids. The present invention provides an alcohol solvate, such as ethanol solvate, of a disodium salt of a delivery agent of the formula above. The invention also provides a hydrate of a disodium salt of a delivery agent of the formula above. Preferred delivery agents include, but are not limited to, N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC), N-(10-[2-hydroxybenzoyl]amino)decanoic acid (SNAD), and sodium N-(8-[2-hydroxybenzoyl]amino)caprylate (SNAC). The invention also provides methods of preparing the disodium salt, ethanol solvate, and hydrate and compositions containing the disodium salt, ethanol solvate, and/or hydrate.
摘要翻译：发明人已经发现，某些递送剂的二钠盐比相应的单钠盐具有惊人的更大的递送活性剂的功效。此外，本发明人已经发现，这些递送剂的二钠盐与乙醇形成溶剂合物并与水合。递送剂具有下式：其中R 1，R 2，R 3和R 4独立地是氢，卤素，C 1 -C 4烷基或C 1 -C 4烷氧基; 取代或未取代的C 2 -C 16亚烷基，取代或未取代的C 1 -C 12烷基（亚芳基）或取代或未取代的芳基（C 1 -C 12亚烷基）。本发明的水合物和溶剂合物对于递送活性剂（例如肝素和降钙素）比其相应的单钠盐和游离酸具有惊人的更大的功效。本发明提供了一种醇溶剂合物，例如乙醇溶剂化物，其具有上式的递送剂的二钠盐。本发明还提供了上式的递送剂的二钠盐的水合物。优选的递送剂包括但不限于N-（5-氯水杨酰基）-8-氨基辛酸（5-CNAC），N-（10- [2-羟基苯甲酰基]氨基）癸酸（SNAD）和N - （8- [2-羟基苯甲酰基]氨基）辛酸酯（SNAC）。本发明还提供了制备二钠盐，乙醇溶剂合物和水合物的方法以及含有二钠盐，乙醇溶剂化物和/或水合物的组合物。

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