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1. 发明授权

US08858497B2 Device and method for removing material from a hollow anatomical structure 有权
标题翻译：从中空解剖结构中去除材料的装置和方法
公开(公告)号：US08858497B2
公开(公告)日：2014-10-14
申请号：US13274163
申请日：2011-10-14
申请人： Giorgio Di Palma , William A. Cartier , William Appling , William C. Hamilton, Jr.
发明人： Giorgio Di Palma , William A. Cartier , William Appling , William C. Hamilton, Jr.
IPC分类号： A61M29/00 , A61B17/221 , A61M25/00 , A61B17/22
CPC分类号： A61B17/221 , A61B2017/22082 , A61B2017/2212 , A61B2017/2215 , A61M25/0069 , A61M25/007 , A61M25/0071
摘要： A medical device for removing a material from a hollow anatomical structure is provided. The device includes a radially expandable capture member. The device includes a treatment segment that is positioned distally of the capture member in use and having at least one exit port adapted for delivering a fluid agent to the material. The device includes an embolic capture device that is positioned distally of the treatment segment in use and including a radially expandable filter for capturing a part of the material which travels downstream of the treatment segment. Additionally, a method is provided herein for infusing, injecting, distributing, or releasing an intended fluid into a hollow anatomical structure.
摘要翻译：提供了用于从中空解剖结构中去除材料的医疗装置。该装置包括可径向扩张的捕获构件。该装置包括在使用中位于捕获构件的远端处的处理段，并且具有适于将流体试剂输送到材料的至少一个出口。该装置包括栓塞捕获装置，其在使用中位于治疗区段的远侧，并且包括径向可扩张的过滤器，用于捕获在治疗区段下游行进的材料的一部分。此外，本文提供了一种用于将预期流体输注，注入，分配或释放到中空解剖结构中的方法。

2. 发明申请

US20120316546A1 Device and Method for Endovascular Treatment for Causing Closure of a Blood Vessel 有权
标题翻译：血管闭塞的血管内治疗装置及方法
公开(公告)号：US20120316546A1
公开(公告)日：2012-12-13
申请号：US13566502
申请日：2012-08-03
申请人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, JR. , Joe D. Brown
发明人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, JR. , Joe D. Brown
IPC分类号： A61B18/20
CPC分类号： A61B18/24 , A61B90/39 , A61B90/94 , A61B2017/00526 , A61B2017/22068 , A61B2018/00101 , A61B2018/00404 , A61B2018/0063 , A61B2018/2205 , A61B2018/2244 , A61B2090/3925 , G02B6/262
摘要： An endovascular treatment method for causing closure of a blood vessel is provided. The method includes inserting into a blood vessel an optical fiber having a core through which a laser light travels and a spacer sleeve arranged around a distal portion of the core. A distal end of the core defines an enlarged light emitting face, which advantageously provides substantially lower power density while providing the same amount of total energy during a treatment session. After the insertion, laser light is applied through the light emitting face while the inserted optical fiber and spacer sleeve are longitudinally moved. The spacer sleeve positions the light emitting face away from an inner wall of the blood vessel and application of the laser light causes closure of the blood vessel.
摘要翻译：提供了用于引起血管闭合的血管内治疗方法。该方法包括向血管插入具有激光通过的芯的光纤和围绕芯的远端部分布置的间隔套筒。芯的远端限定放大的发光面，其有利地提供显着更低的功率密度，同时在治疗期间提供相同量的总能量。插入后，插入的光纤和间隔套筒纵向移动时，通过发光面施加激光。间隔套筒将发光面朝远离血管的内壁定位，并且施加激光导致血管闭合。

3. 发明申请

US20120059356A1 DEVICE AND METHOD FOR REMOVING MATERIAL FROM A HOLLOW ANATOMICAL STRUCTURE 有权
标题翻译：从中空解剖结构中去除材料的装置和方法
公开(公告)号：US20120059356A1
公开(公告)日：2012-03-08
申请号：US13274163
申请日：2011-10-14
申请人： Giorgio di Palma , William A. Cartier , William Appling , William C. Hamilton, JR.
发明人： Giorgio di Palma , William A. Cartier , William Appling , William C. Hamilton, JR.
IPC分类号： A61M37/00 , A61B17/22
CPC分类号： A61B17/221 , A61B2017/22082 , A61B2017/2212 , A61B2017/2215 , A61M25/0069 , A61M25/007 , A61M25/0071
摘要： A medical device for removing a material from a hollow anatomical structure is provided. The device includes a radially expandable capture member. The device includes a treatment segment that is positioned distally of the capture member in use and having at least one exit port adapted for delivering a fluid agent to the material. The device includes an embolic capture device that is positioned distally of the treatment segment in use and including a radially expandable filter for capturing a part of the material which travels downstream of the treatment segment. Additionally, a method is provided herein for infusing, injecting, distributing, or releasing an intended fluid into a hollow anatomical structure.
摘要翻译：提供了用于从中空解剖结构中去除材料的医疗装置。该装置包括可径向扩张的捕获构件。该装置包括在使用中位于捕获构件的远端处的处理段，并且具有适于将流体试剂输送到材料的至少一个出口。该装置包括栓塞捕获装置，其在使用中位于治疗区段的远侧，并且包括径向可扩张的过滤器，用于捕获在治疗区段下游行进的材料的一部分。此外，本文提供了一种用于将预期流体输注，注入，分配或释放到中空解剖结构中的方法。

4. 发明授权

US09173704B2 Device and method for the ablation of fibrin sheath formation on a venous catheter 有权
标题翻译：在静脉导管上消融纤维蛋白鞘形成的装置和方法
公开(公告)号：US09173704B2
公开(公告)日：2015-11-03
申请号：US12488070
申请日：2009-06-19
申请人： Eamonn P. Hobbs , William C. Hamilton, Jr.
发明人： Eamonn P. Hobbs , William C. Hamilton, Jr.
IPC分类号： A61B18/12 , A61B18/14 , A61N1/32 , A61B18/00
CPC分类号： A61M25/0043 , A61B18/1492 , A61B2018/00357 , A61B2018/00386 , A61B2018/00613 , A61B2018/00839 , A61B2018/0097 , A61M2025/0019 , A61M2205/054 , A61N1/327
摘要： An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.
摘要翻译：提供了能够破坏不期望的细胞生长的留置静脉导管和方法。导管包括具有至少一个内腔并适于放置在静脉内以长期使用的轴。多个电极位于轴的远端部分附近，并且适于从电压发生器接收足够数量的多个电脉冲以使细胞在轴上生长的不期望的细胞生长中破坏。在本发明的一个方面，探针构造成可移除地插入到至少一个内腔中，并且电极位于探针的远端部分附近。

5. 发明授权

US08864754B2 Device and method for endovascular treatment for causing closure of a blood vessel 有权
标题翻译：用于引起血管闭塞的血管内治疗的装置和方法
公开(公告)号：US08864754B2
公开(公告)日：2014-10-21
申请号：US12100309
申请日：2008-04-09
申请人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, Jr. , Joe D. Brown
发明人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, Jr. , Joe D. Brown
IPC分类号： A61B18/20 , A61B18/24 , A61B19/00 , A61B18/00 , A61B17/22
CPC分类号： A61B18/24 , A61B90/39 , A61B90/94 , A61B2017/00526 , A61B2017/22068 , A61B2018/00101 , A61B2018/00404 , A61B2018/0063 , A61B2018/2205 , A61B2018/2244 , A61B2090/3925 , G02B6/262
摘要： An endovascular laser treatment device for causing closure of a blood vessel uses an optical fiber adapted to be inserted into a blood vessel. An inner sleeve is arranged around a distal portion of the optical fiber core such that both distal ends of the inner sleeve and the optical fiber core form an enlarged light emitting face. The enlarged emitting face provides substantially lower power density while providing the same amount of total energy during a treatment session. An outer sleeve arranged around the inner sleeve acts as a spacer to position the light emitting face away from an inner wall of the blood vessel. The enlarged light emitting face and the outer sleeve acting as a spacer reduces the possibility of thermal run-away and device damage, and reduce the possibility of vessel perforations, leading to less bruising, post-operative pain and other clinical complications.
摘要翻译：用于引起血管闭合的血管内激光治疗装置使用适于插入血管的光纤。内套筒围绕光纤芯的远端部分布置，使得内套管的远端和光纤芯形成放大的发光面。放大的发射面提供显着更低的功率密度，同时在治疗期间提供相同量的总能量。布置在内套筒周围的外套管用作间隔件，以将发光面定位成离开血管的内壁。放大的发光面和作为间隔物的外套筒减少了热损失和器件损坏的可能性，并减少了血管穿孔的可能性，导致较少的瘀伤，手术后疼痛和其他临床并发症。

6. 外观设计

USD631154S1 Probe handle tip 有权
标题翻译：探头手柄提示
公开(公告)号：USD631154S1
公开(公告)日：2011-01-18
申请号：US29338393
申请日：2009-06-10
申请人： William C. Hamilton, Jr.
设计人： William C. Hamilton, Jr.
CPC分类号： A61B18/1477 , A61B17/3417 , A61B18/1492 , A61B2017/3456 , A61B2018/00053 , A61B2018/00613

7. 外观设计

USD630321S1 Probe handle 有权
标题翻译：探头手柄
公开(公告)号：USD630321S1
公开(公告)日：2011-01-04
申请号：US29338391
申请日：2009-06-10
申请人： William C. Hamilton, Jr.
设计人： William C. Hamilton, Jr.

8. 发明申请

US20100256630A1 IRREVERSIBLE ELECTROPORATION (IRE) FOR ESOPHAGEAL DISEASE 审中-公开
标题翻译：不可逆电气（IRE）用于食管疾病
公开(公告)号：US20100256630A1
公开(公告)日：2010-10-07
申请号：US12755517
申请日：2010-04-07
申请人： William C. Hamilton, JR. , Mark Ortiz
发明人： William C. Hamilton, JR. , Mark Ortiz
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00488 , A61B2018/00613 , A61B2018/1465
摘要： A method for treating Barrett's esophagus and esophageal cancer by using non-thermal electroporation energy to ablate diseased portions of the esophagus which, in effect, prevents stomach acids and other fluids from entering the esophagus thereby alleviating continued deterioration of the esophagus and allows the columnar cells in the lining of the esophagus to assume their normal physical characteristics and functions and.
摘要翻译：一种通过使用非热电穿孔能来消融食道的病变部分来治疗巴雷特食管和食管癌的方法，其实际上防止胃酸和其它流体进入食道，从而减轻食管的持续恶化，并允许柱状细胞在食管的衬里中承担其正常的身体特征和功能。

9. 发明授权

US08864755B2 Device and method for endovascular treatment for causing closure of a blood vessel 有权
标题翻译：用于引起血管闭塞的血管内治疗的装置和方法
公开(公告)号：US08864755B2
公开(公告)日：2014-10-21
申请号：US13566502
申请日：2012-08-03
申请人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, Jr. , Joe D. Brown
发明人： William M. Appling , Ralph A. Meyer , Theodore J. Beyer , William C. Hamilton, Jr. , Joe D. Brown
IPC分类号： A61B18/20 , A61B18/24 , A61B19/00 , A61B18/00 , A61B17/22
CPC分类号： A61B18/24 , A61B90/39 , A61B90/94 , A61B2017/00526 , A61B2017/22068 , A61B2018/00101 , A61B2018/00404 , A61B2018/0063 , A61B2018/2205 , A61B2018/2244 , A61B2090/3925 , G02B6/262
摘要： An endovascular treatment method for causing closure of a blood vessel is provided. The method includes inserting into a blood vessel an optical fiber having a core through which a laser light travels and a spacer sleeve arranged around a distal portion of the core. A distal end of the core defines an enlarged light emitting face, which advantageously provides substantially lower power density while providing the same amount of total energy during a treatment session. After the insertion, laser light is applied through the light emitting face while the inserted optical fiber and spacer sleeve are longitudinally moved. The spacer sleeve positions the light emitting face away from an inner wall of the blood vessel and application of the laser light causes closure of the blood vessel.
摘要翻译：提供了用于引起血管闭合的血管内治疗方法。该方法包括向血管插入具有激光通过的芯的光纤和围绕芯的远端部分布置的间隔套筒。芯的远端限定放大的发光面，其有利地提供显着更低的功率密度，同时在治疗期间提供相同量的总能量。插入后，插入的光纤和间隔套筒纵向移动时，通过发光面施加激光。间隔套筒将发光面朝远离血管的内壁定位，并且施加激光导致血管闭合。

10. 发明授权

US08663116B2 Methods, assemblies, and devices for positioning a catheter tip using an ultrasonic imaging system 有权
标题翻译：用于使用超声成像系统定位导管尖端的方法，组件和装置
公开(公告)号：US08663116B2
公开(公告)日：2014-03-04
申请号：US13347786
申请日：2012-01-11
申请人： William C. Hamilton, Jr.
发明人： William C. Hamilton, Jr.
IPC分类号： A61B8/14
CPC分类号： A61B8/0841 , A61B8/12 , A61B2034/2063 , A61B2090/3929 , A61M25/0102 , A61M25/0108 , A61M25/09 , A61M2025/0008 , A61M2210/12
摘要： A catheter assembly includes an elongated member having an ultrasonic beacon disposed adjacent to a distal end portion of the elongated member, a power supply releasably attachable adjacent to the proximal end of the elongated member, and a catheter. The distal end portion of the elongated member with the ultrasonic transmitter is inserted into an anatomical structure of the human body, and the ultrasonic transmitter is powered by the power supply. Using conventional medical ultrasonography equipment, a technician is able to observe and/or track on a display an image of the internal structure of the human body and an image such as an illuminated bright spot representing the energized ultrasonic beacon. After locating the elongated member, the power supply is removed, and the catheter is slid onto the elongated member to locate the catheter tip. Thereafter, the elongated member is removed.
摘要翻译：导管组件包括具有邻近细长构件的远端部分设置的超声波信标的细长构件，可细长地附接到细长构件的近端的电源和导管。具有超声波发射器的细长构件的远端部插入到人体的解剖结构中，超声波发射器由电源供电。使用传统的医学超声波设备，技术人员能够在显示器上观察和/或跟踪人体的内部结构的图像和诸如表示通电的超声波信标的照明亮点的图像。在定位细长构件之后，去除电源，并且将导管滑动到细长构件上以定位导管尖端。此后，移除细长构件。

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