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1. 发明申请

US20080208236A1 DERMAL MARKING FOR USE WITH A MEDICAL DEVICE 审中-公开
标题翻译：用于医疗设备的DMAAL标记
公开(公告)号：US20080208236A1
公开(公告)日：2008-08-28
申请号：US12039043
申请日：2008-02-28
申请人： Eamonn P. Hobbs , William M. Appling
发明人： Eamonn P. Hobbs , William M. Appling
IPC分类号： A61M37/00
CPC分类号： A61M39/0208 , A61B90/90 , A61B90/94 , A61B90/96 , A61B2090/395 , A61M37/0076 , A61M2039/0238 , A61M2205/6063
摘要： A dermal marking and a method of identifying the characteristics of an implanted medical device using the dermal marking. The method involves providing an implantable medical device, implanting a medical device in a patient, providing at least one dermal marking that contains information disclosing at least one characteristic of the implanted medical device, applying the at least one dermal marking to the skin of the patient, perceiving the dermal marking on the patient's skin, and identifying at least one characteristic of the implantable medical device based on the dermal marking.
摘要翻译：皮肤标记和使用真皮标记识别植入的医疗装置的特征的方法。该方法包括提供可植入医疗装置，将医疗装置植入患者体内，提供至少一个皮肤标记，其包含公开植入的医疗装置的至少一个特征的信息，将至少一个皮肤标记施加到患者的皮肤感知患者皮肤上的真皮标记，并且基于皮肤标记鉴定可植入医疗装置的至少一个特征。

2. 发明授权

US5439449A Flow visualization needle system 失效
标题翻译：流动可视化针系统
公开(公告)号：US5439449A
公开(公告)日：1995-08-08
申请号：US231276
申请日：1994-04-22
申请人： Harold C. Mapes , William M. Appling , Michael P. Cody , Eamonn P. Hobbs
发明人： Harold C. Mapes , William M. Appling , Michael P. Cody , Eamonn P. Hobbs
IPC分类号： A61M25/06 , A61M5/00
CPC分类号： A61M25/0693
摘要： A needle system which upon arterial entry provides a visual indication of pulsatile blood flow. The needle system includes an elongated needle with distal and proximal ends. There is a needle hub at the proximal end of the needle and a port position between the proximal needle end and proximal hub end. The visualization connector tube having two ends is provided. The tube is sufficiently clear to permit visualization of material held therein. The first end of the tube is in communication with the port. An elastomeric reservoir is provided. The reservoir is in free, direct, unrestricted two-way communication with a second tube end. The needle, needle hub, and tube all have predetermined volumes. The reservoir has an initial unexpanded state with a first pressure and a first volume and a second state expanded with a second pressure and a second volume. Air pressure in the needle system is increased upon arterial entry. The increase in air pressure compresses and displaces the air in the needle system allowing blood to migrate into a portion of the connector. This air compression and displacement results in a decrease of the volume of air in the system while the volume in the reservoir increases.
摘要翻译：在动脉进入时的针系统提供脉动血流的视觉指示。针系统包括具有远端和近端的细长针。在针的近端处有针座，并且在近端针端和近端毂端之间的端口位置。提供具有两端的可视化连接管。管足够透明以允许保持在其中的材料的可视化。管的第一端与端口连通。提供一个弹性储存器。水库与第二管端自由，直接，无限制的双向通信。针，针头和管都具有预定的体积。储存器具有初始未膨胀状态，其具有第一压力和第一容积，第二状态以第二压力和第二容积膨胀。动脉进入时，针系统中的空气压力增加。空气压力的增加压缩并移动针系统中的空气，从而允许血液迁移到连接器的一部分中。这种空气压缩和排量导致系统中的空气体积的减小，同时储存器中的体积增加。

3. 发明授权

US09173704B2 Device and method for the ablation of fibrin sheath formation on a venous catheter 有权
标题翻译：在静脉导管上消融纤维蛋白鞘形成的装置和方法
公开(公告)号：US09173704B2
公开(公告)日：2015-11-03
申请号：US12488070
申请日：2009-06-19
申请人： Eamonn P. Hobbs , William C. Hamilton, Jr.
发明人： Eamonn P. Hobbs , William C. Hamilton, Jr.
IPC分类号： A61B18/12 , A61B18/14 , A61N1/32 , A61B18/00
CPC分类号： A61M25/0043 , A61B18/1492 , A61B2018/00357 , A61B2018/00386 , A61B2018/00613 , A61B2018/00839 , A61B2018/0097 , A61M2025/0019 , A61M2205/054 , A61N1/327
摘要： An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.
摘要翻译：提供了能够破坏不期望的细胞生长的留置静脉导管和方法。导管包括具有至少一个内腔并适于放置在静脉内以长期使用的轴。多个电极位于轴的远端部分附近，并且适于从电压发生器接收足够数量的多个电脉冲以使细胞在轴上生长的不期望的细胞生长中破坏。在本发明的一个方面，探针构造成可移除地插入到至少一个内腔中，并且电极位于探针的远端部分附近。

4. 发明授权

US08057460B2 Catheter retention 有权
标题翻译：导管保留
公开(公告)号：US08057460B2
公开(公告)日：2011-11-15
申请号：US11876280
申请日：2007-10-22
申请人： Eamonn P. Hobbs , William M. Appling , Angelo J. Tarricone , Theodore J. Beyer
发明人： Eamonn P. Hobbs , William M. Appling , Angelo J. Tarricone , Theodore J. Beyer
IPC分类号： A61M25/00
CPC分类号： A61M1/3653 , A61M1/3659 , A61M1/3661 , A61M2025/0031 , A61M2025/0034 , A61M2025/0037
摘要： A multiple tube catheter, such as a hemo-dialysis catheter, has first and second tubes which are attached to each other over a zone by one or more longitudinally extending wires which joins the two tubes over that zone. When a catheter is implanted in the patient, the attached zone is within the patient so that the catheter cannot be removed or advanced. When the catheter is to be removed, the longitudinally extending wire or wires are pulled proximally out of the tubes involved so that the two tubes can be separated and individually removed. A flexible separating prong within the patient and proximal of the zone holds the tubes apart to further assure that the catheter cannot be moved.
摘要翻译：诸如血液透析导管的多管导管具有第一和第二管，所述第一和第二管通过在该区域上连接两个管的一个或多个纵向延伸的线在区域上彼此连接。当将导管植入患者体内时，附着区域在患者体内，使得导管不能被移除或前进。当要取出导管时，纵向延伸的电线或电线从所涉及的管中向近侧拉出，使得两个管可以被分开并单独移除。患者内的柔性分离针头和区域的近端将管分开，以进一步确保导管不能移动。

5. 发明申请

US20100204638A1 IRREVERSIBLE ELECTROPORATION AND TISSUE REGENERATION 有权
标题翻译：不可逆转电泳和组织再生
公开(公告)号：US20100204638A1
公开(公告)日：2010-08-12
申请号：US12703355
申请日：2010-02-10
申请人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
发明人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
IPC分类号： A61M37/00 , A61B18/14
CPC分类号： A61N1/327 , A61B18/148 , A61N1/306
摘要： A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.
摘要翻译：本文描述了一种方法和装置，其使用耦合到电源并定位在治疗位置中的至少一个能量输送装置来治疗组织的靶区域，以便不可逆地电穿孔组织以消融靶区域，并将再生材料引入治疗区域。

6. 发明申请

US20120289888A1 Irreversible Electroporation and Tissue Regeneration 有权
标题翻译：不可逆电穿孔和组织再生
公开(公告)号：US20120289888A1
公开(公告)日：2012-11-15
申请号：US13556510
申请日：2012-07-24
申请人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
发明人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61B18/148 , A61N1/306
摘要： A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.
摘要翻译：本文描述了一种方法和装置，其使用耦合到电源并定位在治疗位置中的至少一个能量输送装置来治疗组织的靶区域，以便不可逆地电穿孔组织以消融靶区域，并将再生材料引入治疗区域。

7. 发明授权

US08231603B2 Irreversible electroporation and tissue regeneration 有权
标题翻译：不可逆电穿孔和组织再生
公开(公告)号：US08231603B2
公开(公告)日：2012-07-31
申请号：US12703355
申请日：2010-02-10
申请人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
发明人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61B18/148 , A61N1/306
摘要： A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.
摘要翻译：本文描述了一种方法和装置，其使用耦合到电源并定位在治疗位置中的至少一个能量输送装置来治疗组织的靶区域，以便不可逆地电穿孔组织以消融靶区域，并将再生材料引入治疗区域。

8. 发明授权

US08562588B2 Irreversible electroporation and tissue regeneration 有权
标题翻译：不可逆电穿孔和组织再生
公开(公告)号：US08562588B2
公开(公告)日：2013-10-22
申请号：US13556510
申请日：2012-07-24
申请人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
发明人： Eamonn P. Hobbs , James G. Lovewell , Robert M. Pearson
IPC分类号： A61M31/00
CPC分类号： A61N1/327 , A61B18/148 , A61N1/306
摘要： A method and device are herein described to treat a target region of tissue, using at least one energy delivery device coupled to a power source and positioned in a treatment position so as to irreversibly electroporate tissue to ablate a target region, and introduce regenerative materials into a treated region.
摘要翻译：本文描述了一种方法和装置，其使用耦合到电源并定位在治疗位置中的至少一个能量输送装置来治疗组织的靶区域，以便不可逆地电穿孔组织以消融靶区域，并将再生材料引入治疗区域。

9. 发明申请

US20100152725A1 METHOD AND SYSTEM FOR TISSUE TREATMENT UTILIZING IRREVERSIBLE ELECTROPORATION AND THERMAL TRACK COAGULATION 审中-公开
标题翻译：利用不可逆电气和热跟踪凝聚的组织治疗方法与系统
公开(公告)号：US20100152725A1
公开(公告)日：2010-06-17
申请号：US12627008
申请日：2009-11-30
申请人： Robert M. Pearson , Eamonn P. Hobbs , William M. Appling
发明人： Robert M. Pearson , Eamonn P. Hobbs , William M. Appling
IPC分类号： A61B18/14 , A61B18/18
CPC分类号： A61B18/18 , A61B18/12 , A61B18/1815 , A61B2018/00577 , A61B2018/00613 , A61B2018/2005 , A61N1/327 , A61N1/403
摘要： A system for selectively ablating tissue is provided herein that has at least one energy source that has a non-thermal energy source and a thermal energy source, at least one probe, means for selectively coupling the probe to one desired energy source of the at least one energy source, means for selectively energizing the non-thermal energy source of the at least one energy source to apply non-thermal energy to at least a portion of the desired region to ablate at least a portion of the desired region, and means for selectively energizing the thermal energy source of the at least one energy source during the withdrawal of the at least one probe to thermally ablate tissue substantially adjacent to a probe track.
摘要翻译：本文提供了一种用于选择性烧蚀组织的系统，其具有至少一个能量源，其具有非热能源和热能源，至少一个探针，用于选择性地将探针耦合到所述至少一个所需能量源的装置一个能量源，用于选择性地激励所述至少一个能量源的非热能源以将非热能施加到所述期望区域的至少一部分以便烧蚀所述期望区域的至少一部分的装置，以及用于在所述至少一个探针的抽出期间选择性地激励所述至少一个能量源的热能源，以热量消融基本上邻近探针轨道的组织。

10. 发明申请

US20090318849A1 Device and Method for the Ablation of Fibrin Sheath Formation on a Venous Catheter 有权
标题翻译：在静脉导管上消除纤维蛋白鞘形成的装置和方法
公开(公告)号：US20090318849A1
公开(公告)日：2009-12-24
申请号：US12488070
申请日：2009-06-19
申请人： Eamonn P. Hobbs , William C. Hamilton, JR.
发明人： Eamonn P. Hobbs , William C. Hamilton, JR.
IPC分类号： A61B18/18 , A61N1/30
CPC分类号： A61M25/0043 , A61B18/1492 , A61B2018/00357 , A61B2018/00386 , A61B2018/00613 , A61B2018/00839 , A61B2018/0097 , A61M2025/0019 , A61M2205/054 , A61N1/327
摘要： An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe.
摘要翻译：提供了能够破坏不期望的细胞生长的留置静脉导管和方法。导管包括具有至少一个内腔并适于放置在静脉内以长期使用的轴。多个电极位于轴的远端部分附近，并且适于从电压发生器接收足够数量的多个电脉冲以使细胞在轴上生长的不期望的细胞生长中破坏。在本发明的一个方面，探针构造成可移除地插入到至少一个内腔中，并且电极位于探针的远端部分附近。

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