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2. 发明专利

IL282594D0 Bcl xl inhibitory compounds having low cell permeability and antibody drug conjugates including the same 未知
公开(公告)号：IL282594D0
公开(公告)日：2021-06-30
申请号：IL28259421
申请日：2021-04-22
申请人： ABBVIE INC , TAO ZHI FU , DOHERTY GEORGE , WANG XILU , SONG XIAOHONG , SULLIVAN GERARD M , KUNZER AARON , WENDT MICHAEL , MARIN VIOLETA L , FREY ROBIN R , CULLEN STEVE C , WELCH DENNIE S , SHEN XIAOQIANG , BENNETT DAVID JONATHAN , HAIGHT ANTHONY R , ACKLER SCOTT L , BOGHAERT ERWIN R , SOUERS ANDREW J , JUDD ANDREW S
发明人： TAO ZHI-FU , DOHERTY GEORGE , WANG XILU , SONG XIAOHONG , SULLIVAN GERARD M , KUNZER AARON , WENDT MICHAEL , MARIN VIOLETA L , FREY ROBIN R , CULLEN STEVE C , WELCH DENNIE S , SHEN XIAOQIANG , BENNETT DAVID JONATHAN , HAIGHT ANTHONY R , ACKLER SCOTT L , BOGHAERT ERWIN R , SOUERS ANDREW J , JUDD ANDREW S
IPC分类号： A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/4985 , A61K31/538 , A61K45/06 , A61K47/68 , A61P35/00 , A61P35/02 , A61P43/00
摘要： The present disclosure concerns Bcl-xL inhibitors having low cell permeability, antibody drug conjugates (ADCs) comprising the inhibitors, synthons useful for synthesizing the ADCs, compositions comprising the inhibitors or ADCs, and various methods of using the inhibitors and ADCs.

3. 发明专利

DE3212097A1 未知
公开(公告)号：DE3212097A1
公开(公告)日：1983-10-13
申请号：DE3212097
申请日：1982-04-01
申请人： FREITAG LUTZ , WENDT MICHAEL DR
发明人： WENDT MICHAEL DR , FREITAG LUTZ , DANKWART FRANZ JOSEPH DIPL PHY
IPC分类号： A61M16/00
摘要： A method of and apparatus for producing a controlled pressure level in a respirator for human patients which is equipped with a tracheal tube 3 connected to the respirator and connectable to the trachea, comprises producing an oscillatory gas stream by means of two opposite gas jets in an attachment tube 4 which has two end openings. By controlling the pressure and/or frequency of the gas jets, a varying pressure level propagating into the tracheal tube is modulated onto the gas stream. The respirator for carrying out the method comprises two gas jet pipes 20, 21 having nozzle tips 24, 25 of which one discharges or points within the attachment tube 4 substantially in the direction of the tracheal tube 3 and the other substantially in the opposite direction.

4. 发明专利

IL272681D0 Macrocyclic mcl-1 inhibitors and methods of use 未知
公开(公告)号：IL272681D0
公开(公告)日：2020-03-31
申请号：IL27268120
申请日：2020-02-14
申请人： ABBVIE DEUTSCHLAND , BRAJE WILFRIED , ABBVIE INC , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
IPC分类号： C07D20060101
摘要： The present disclosure provides for compounds of formula (I)wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

5. 发明专利

SG11202001182QA MACROCYCLIC MCL-1 INHIBITORS AND METHODS OF USE 未知
公开(公告)号：SG11202001182QA
公开(公告)日：2020-03-30
申请号：SG11202001182Q
申请日：2018-08-15
申请人： ABBVIE INC , ABBVIE DEUTSCHLAND , BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
发明人： BRAJE WILFRIED , DOHERTY GEORGE , JANTOS KATJA , JI CHENG , JUDD ANDREW , KUNZER AARON , MASTRACCHIO ANTHONY , SONG XIAOHONG , SOUERS ANDREW , SULLIVAN GERARD , TAO ZHI-FU , TESKE JESSE , WANG XILU , WENDT MICHAEL , PENNING THOMAS , LAI CHUNQUI , KLING ANDREAS , POHLKI FRAUKE
IPC分类号： A61K31/395 , A61P35/00 , C07D515/22
摘要： The present disclosure provides for compounds of formula (I)wherein A 2 , A 3 , A 4 , A 6 , A 7 , A 8 , A 15 , R A , R 5 , R 9 , R 10A , R 10B , R 11 , R 12 , R 13 , R 14 , R 16 , W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).

6. 发明专利

IL287315D0 Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases 未知
公开(公告)号：IL287315D0
公开(公告)日：2021-12-01
申请号：IL28731521
申请日：2021-10-17
申请人： ABBVIE INC , TAO ZHI FU , WANG XILU , WENDT MICHAEL , SOUERS ANDREW J , JUDD ANDREW S , KUNZER AARON , SULLIVAN GERARD
发明人： TAO ZHI-FU , WANG XILU , WENDT MICHAEL , SOUERS ANDREW J , JUDD ANDREW S , KUNZER AARON , SULLIVAN GERARD
IPC分类号： A61K31/496 , A61K31/5377 , A61K45/06 , A61P35/00 , A61P37/00
摘要： Disclosed herein are compounds that inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.

7. 发明专利

DE202016004191U1 Neuartiges erotisches Spielzeug - ein Multi-Masturbator 未知
公开(公告)号：DE202016004191U1
公开(公告)日：2016-09-21
申请号：DE202016004191
申请日：2016-07-06
申请人： WENDT MICHAEL
IPC分类号： A61H19/00
摘要： Der Multi-Masturbator ist dadurch gekennzeichnet, dass er multible Seiten hat, wobei jede Seite einen eigenen Masturbator für sich darstellt.

8. 发明专利

DE3323482C1 Auxiliary instrument for the introduction of tracheal tubes 未知
公开(公告)号：DE3323482C1
公开(公告)日：1984-06-28
申请号：DE3323482
申请日：1983-06-30
申请人： REINHOLD PAUL DR , HANSEN JOCHEN DR , WENDT MICHAEL DR
发明人： REINHOLD PAUL DR , HANSEN JOCHEN DR , WENDT MICHAEL DR
IPC分类号： A61M16/04 , A61M16/00
摘要： The risks associated with the nasal introduction of tracheal tubes can be reduced by use of an auxiliary instrument which comprises a traction member (1) and a tubular sheath (2) which is closed on one side, is fastened on the end of the member and consists of a thin-walled, flexible material, especially a rubber or plastic balloon open on one side, which sheath is longer than the tracheal tube section extending from the introduction end beyond the fixing balloon and the diameter of which is larger than the diameter of this section including the uninflated fixing balloon. The auxiliary instrument is joined to the tracheal tube, before introduction of the latter, by pushing the sheath over the introduction end of the tracheal tube and pushing the traction member through the tracheal tube. During insertion of the tracheal tube through the nasal space, both the balloon of the tracheal tube and the patient are protected by the sheath. The auxiliary instrument can be pulled through the tracheal tube and removed by the traction member by folding the sheath over.

9. 发明专利

CA1311341C APPARATUS AND PROCESS FOR THERMOFORMING PLASTIC MATERIALS 未知
公开(公告)号：CA1311341C
公开(公告)日：1992-12-15
申请号：CA585058
申请日：1988-12-06
申请人： WENDT MICHAEL L
发明人： WENDT MICHAEL L
IPC分类号： B29C51/04 , B29C51/42 , B29C51/10
摘要： An apparatus and method for thermoforming articles out of a sheet plastic material utilizes a female mold having one or more cavities and a male mold including corresponding plug assists. Each cavity of the female mold communicates with a first passageway connected to a switched vacuum source. Each plug assist is provided with at least one inlet extending through the plug assist and at least one second passageway, each of which communicate with a respective cavity when the mold is closed. A switched first heated air source communicates with the inlet supplies heated air through the inlet into the cavity under pressure. A second switched heated air source communicates with each second passageway supplies air through the second passageways into a cavity when the mold is in the closed position. third switched air source communicates with the inlet supplies air through the inlet into the cavity at a third pressure and temperature. Pressure of the first air source is suitably adjusted to create a cushion between the plug assist and the production sheet to prevent contact as the mold is closing. Pressures, temperatures and flows are controlled to enhance rapid, uniform crystallization of a plastic substrate being molded.

10. 发明专利

DD139304A1 未知
公开(公告)号：DD139304A1
公开(公告)日：1979-12-19
申请号：DD20833878
申请日：1978-10-09
申请人： WENDT MICHAEL
发明人： WENDT MICHAEL
IPC分类号： G01N23/223 , G01N23/225

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