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1. 发明授权

US08058275B2 Diazabenzo[de] anthracen-3-one compounds and methods for inhibiting PARP 有权
标题翻译：二氮杂苯并[de]蒽-3-酮化合物和抑制PARP的方法
公开(公告)号：US08058275B2
公开(公告)日：2011-11-15
申请号：US12910448
申请日：2010-10-22
申请人： Weizheng Xu , Greg Delahanty , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Jie Zhang
IPC分类号： C07D487/06 , A61K31/5025
CPC分类号： C07D491/06 , A61K31/495 , A61K31/5025
摘要： The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（“PARP”）的二氮杂苯并[de]蒽-3-酮化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述条件的效果。

2. 发明授权

US07750008B2 Compounds, methods and pharmaceutical compositions for inhibiting PARP 有权
标题翻译：用于抑制PARP的化合物，方法和药物组合物
公开(公告)号：US07750008B2
公开(公告)日：2010-07-06
申请号：US12540776
申请日：2009-08-13
申请人： Vincent Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy D. Xing , Qun Liu
发明人： Vincent Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy D. Xing , Qun Liu
IPC分类号： C07D487/06 , A61K31/5025
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供了抑制聚（ADP-核糖）聚合酶（“PARP”），含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述病症的作用的方法的化合物。

3. 发明申请

US20090028815A1 Diazabenzo[De]anthracen-3-one Compounds and Methods for Inhibiting Parp 有权
标题翻译：二氮杂苯并[d]蒽-3-酮抑制碱的化合物和方法
公开(公告)号：US20090028815A1
公开(公告)日：2009-01-29
申请号：US11814238
申请日：2006-01-19
申请人： Weizheng Xu , Greg Delahanty , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Jie Zhang
IPC分类号： A61K38/20 , C07D237/26 , C07D237/06 , C07D413/14 , A61K31/4025 , A61K31/5025 , A61P35/00
CPC分类号： C07D491/06 , A61K31/495 , A61K31/5025
摘要： The present invention relates to diazabenzo[de]anthracen-3-one compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（“PARP”）的二氮杂苯并[de]蒽-3-酮化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述条件的效果。

4. 发明申请

US20050070719A1 Inhibitors of dipeptidyl peptidase iv 审中-公开
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US20050070719A1
公开(公告)日：2005-03-31
申请号：US10499675
申请日：2002-12-26
申请人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
发明人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
IPC分类号： C07D295/18 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K38/00 , A61K45/00 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P15/00 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P39/02 , A61P41/00 , A61P43/00 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/46 , C07D209/48 , C07D217/14 , C07D217/16 , C07D217/22 , C07D217/26 , C07D233/60 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/078 , C07K5/097
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了二肽基肽酶IV（DPP IV）的新型抑制剂，包含治疗有效量的新型DPP IV抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP IV的新型抑制剂可用于治疗神经障碍，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其他列举的病症。

5. 发明授权

US06635786B2 Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use 失效
公开(公告)号：US06635786B2
公开(公告)日：2003-10-21
申请号：US09829827
申请日：2001-04-10
申请人： Jia-He Li , Dana Victor Ferraris , Paul W. Kletzly , Weixing Li , Eric Yanjun Wang , Amy D. Xing , Weizheng Xu , Jie Zhang
发明人： Jia-He Li , Dana Victor Ferraris , Paul W. Kletzly , Weixing Li , Eric Yanjun Wang , Amy D. Xing , Weizheng Xu , Jie Zhang
IPC分类号： C07C23300
CPC分类号： C07D207/325 , C07C69/76 , C07C225/16 , C07C233/65 , C07C233/66 , C07C233/69 , C07C233/73 , C07C255/46 , C07C311/46 , C07C2601/14 , C07C2603/18 , C07C2603/40 , C07D213/30 , C07D213/40 , C07D295/13 , C07D295/192 , C07D311/82 , C07D311/86 , C07D327/08 , C07D411/12
摘要： Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.

6. 发明申请

US20120309717A1 COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 审中-公开
标题翻译：化合物，方法和用于抑制PARP的药物组合物
公开(公告)号：US20120309717A1
公开(公告)日：2012-12-06
申请号：US13364063
申请日：2012-02-01
申请人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
发明人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
IPC分类号： A61K31/675 , A61P35/02 , A61K31/655 , A61P35/00 , A61K31/5025 , A61K31/5377
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供抑制聚（ADP-核糖）聚合酶（PARP）的化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述病症的作用的方法。

7. 发明授权

US08236802B2 PARP inhibitor compounds, compositions and methods of use 有权
标题翻译： PARP抑制剂化合物，组合物和使用方法
公开(公告)号：US08236802B2
公开(公告)日：2012-08-07
申请号：US12244399
申请日：2008-10-02
申请人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
发明人： Weizheng Xu , Greg Delahanty , Ling Wei , Jie Zhang
IPC分类号： A01N43/58 , A61K31/50 , C07D491/00
CPC分类号： A61K31/519 , A61K31/53 , C07D487/06 , C07D519/00
摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.
摘要翻译：本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射进行放射增敏的用途。本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

8. 发明申请

US20100256095A1 COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 有权
标题翻译：化合物，方法和用于抑制PARP的药物组合物
公开(公告)号：US20100256095A1
公开(公告)日：2010-10-07
申请号：US12818879
申请日：2010-06-18
申请人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
发明人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
IPC分类号： A61K31/675 , A61K31/655 , A61K31/5377 , A61K31/5025 , A61P1/00 , A61P35/02 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P19/02
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供抑制聚（ADP-核糖）聚合酶（“PARP”）的化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述病症的作用的方法。

9. 发明申请

US20090088407A1 COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 失效
标题翻译：化合物，方法和用于抑制PARP的药物组合物
公开(公告)号：US20090088407A1
公开(公告)日：2009-04-02
申请号：US12254356
申请日：2008-10-20
申请人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
发明人： Vincent J. Kalish , Jie Zhang , Weizheng Xu , Jia-He Li , Amy Dongxia Xing , Qun Liu
IPC分类号： A61K31/5025 , A61K31/675 , A61P35/00
CPC分类号： C07D487/06 , C07D471/06 , C07D491/06 , C07D491/08
摘要： The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein.
摘要翻译：本发明提供抑制聚（ADP-核糖）聚合酶（“PARP”）的化合物，含有这些化合物的组合物和使用这些PARP抑制剂治疗，预防和/或改善本文所述病症的作用的方法。

10. 发明授权

US07247641B2 Compounds, derivatives, compositions, preparation and uses 失效
标题翻译：化合物，衍生物，组合物，制备和用途
公开(公告)号：US07247641B2
公开(公告)日：2007-07-24
申请号：US10486239
申请日：2002-08-06
申请人： Weizheng Xu , Dana V. Ferraris , Jia-He Li , Vincent J. Kalish
发明人： Weizheng Xu , Dana V. Ferraris , Jia-He Li , Vincent J. Kalish
IPC分类号： C07D471/04 , A61K31/4745 , A61P25/28
CPC分类号： A61K49/0008 , C07D471/04 , C07D471/06 , C07D513/06
摘要： This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.
摘要翻译：本发明涉及化合物，药物组合物和使用所公开的化合物抑制PARP的方法。

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