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1. 发明申请

US20060054876A1 Crash cushion 有权
标题翻译：碰撞垫
公开(公告)号：US20060054876A1
公开(公告)日：2006-03-16
申请号：US11223471
申请日：2005-09-08
申请人： John LaTurner , Michael Oberth , Douglas Wilkinson
发明人： John LaTurner , Michael Oberth , Douglas Wilkinson
IPC分类号： E01F15/00
CPC分类号： E01F15/146
摘要： A vehicle crash cushion for decelerating a vehicle includes front and rear anchors spaced along a longitudinal direction and at least one deformable attenuator member extending in the longitudinal direction and having a first end coupled to the front anchor and a second end coupled to the rear anchor. A support member is positioned adjacent the attenuator member and is moveable in the longitudinal direction relative thereto between at least an initial position and an impact position toward the rear anchor and away from the front anchor. At least one deforming member is mounted on the support member and is engaged with at least a portion of the attenuator member. In another aspect, a vehicle crash cushion includes first and second side panels each having at least one longitudinally extending ridge and at least one longitudinally extending valley. The first side panel is moveable relative to the second side panel in response to an axial force being applied to the elongated frame. A connector includes at least one first strap portion disposed in the valley of and connected to the first side panel and at least one second strap portion disposed adjacent to and connected to at least one ridge of the second side panel.
摘要翻译：用于减速车辆的车辆碰撞缓冲器包括沿着纵向方向间隔开的前锚固件和后锚定件以及沿纵向方向延伸的至少一个可变形的衰减器构件，并且具有联接到前锚固件的第一端和联接到后锚杆的第二端。支撑构件邻近衰减器构件定位，并且可以在至少初始位置和朝向后锚固件的远离前锚的冲击位置之间沿纵向相对于其移动。至少一个变形构件安装在支撑构件上并与衰减器构件的至少一部分接合。在另一方面，一种车辆撞击缓冲垫包括第一和第二侧板，每个侧板具有至少一个纵向延伸的脊和至少一个纵向延伸的谷部。响应于施加到细长框架的轴向力，第一侧板可相对于第二侧板移动。连接器包括设置在第一侧板的谷部并连接到第一侧板的至少一个第一带部分和与第二侧板的至少一个脊相邻并连接到第二侧板的至少一个脊部的至少一个第二带部分。

2. 发明申请

US20080085153A1 CRASH CUSHION 有权
公开(公告)号：US20080085153A1
公开(公告)日：2008-04-10
申请号：US11950066
申请日：2007-12-04
申请人： John LaTurner , Michael Oberth , Douglas Wilkinson
发明人： John LaTurner , Michael Oberth , Douglas Wilkinson
IPC分类号： E01F15/00
CPC分类号： E01F15/146
摘要： A vehicle crash cushion for decelerating a vehicle includes first, second and third bays. The first bay is positioned forwardly of the second bay and the second bay is positioned forwardly of the third bay. The first, second and third bays each have energy absorbing structures with first, second and third impact strengths respectively. The first impact strength is greater than the third impact strength, which is greater than the second impact strength. In another aspect, a deformable tube is at least partially filled with a secondary component, which filled portion has a greater deformation strength than unfilled portions of the tube. In another aspect, a vehicle crash cushion includes first and second side panels. A connector includes a first strap portion disposed in a valley of and connected to the first side panel and a second strap portion disposed adjacent to and connected to a ridge of the second side panel.
摘要翻译：用于减速车辆的车辆碰撞缓冲器包括第一，第二和第三舱。第一个海湾位于第二个海湾的前方，第二个海湾位于第三个海湾的前方。第一，第二和第三托架各自具有分别具有第一，第二和第三冲击强度的能量吸收结构。第一冲击强度大于第三冲击强度，其大于第二冲击强度。在另一方面，可变形管至少部分地填充有次级部件，该填充部分具有比管的未填充部分更大的变形强度。另一方面，一种车辆撞击缓冲垫包括第一和第二侧板。连接器包括设置在第一侧面板的谷部并连接到第一侧面板的第一带部分和邻近并连接到第二侧板的脊部的第二带部分。

3. 发明申请

US20050070719A1 Inhibitors of dipeptidyl peptidase iv 审中-公开
标题翻译：二肽基肽酶抑制剂
公开(公告)号：US20050070719A1
公开(公告)日：2005-03-31
申请号：US10499675
申请日：2002-12-26
申请人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
发明人： Sergei Belyakov , Gregory Hamilton , David Hurst , Vincent Kalish , Weixing Li , Eric Wang , Douglas Wilkinson , Yong-Qian Wu , Weizheng Xu
IPC分类号： C07D295/18 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4453 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K38/00 , A61K45/00 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P15/00 , A61P15/16 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/06 , A61P39/02 , A61P41/00 , A61P43/00 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/18 , C07D209/42 , C07D209/46 , C07D209/48 , C07D217/14 , C07D217/16 , C07D217/22 , C07D217/26 , C07D233/60 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/078 , C07K5/097
CPC分类号： C07D209/48 , A61K38/00 , C04B35/632 , C07D205/04 , C07D207/04 , C07D207/16 , C07D207/20 , C07D207/22 , C07D209/42 , C07D209/46 , C07D217/14 , C07D217/16 , C07D217/26 , C07D263/06 , C07D277/04 , C07D277/06 , C07D295/125 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D409/06 , C07D417/06 , C07K5/06156 , C07K5/0821
摘要： Novel inhibitors of dipeptidyl peptidase IV (DPP IV), pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, and of such other enumerated conditions as can be treated with inhibitors of DPP IV.
摘要翻译：提供了二肽基肽酶IV（DPP IV）的新型抑制剂，包含治疗有效量的新型DPP IV抑制剂的药物组合物，以及治疗医学病症的新方法。本文描述的DPP IV的新型抑制剂可用于治疗神经障碍，糖尿病，炎症性疾病如关节炎，肥胖症，骨质疏松症以及可用DPP IV抑制剂治疗的其他列举的病症。

4. 发明授权

US06656971B2 Trisubstituted carbocyclic cyclophilin binding compounds and their use 失效
公开(公告)号：US06656971B2
公开(公告)日：2003-12-02
申请号：US10057203
申请日：2002-01-25
申请人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
发明人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
IPC分类号： A61K31166
CPC分类号： C07D209/48 , A61K31/325 , C07C233/29 , C07C233/66 , C07C233/75 , C07C233/76 , C07C235/42 , C07C235/56 , C07C243/38 , C07C255/54 , C07C275/42 , C07C311/46 , C07C311/48 , C07C335/18 , C07C335/36 , C07C337/06 , C07C2602/10 , C07D213/56 , C07D213/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/135 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/422 , Y02A50/423
摘要： The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.

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