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    • 5. 发明专利
    • Simple bad breath diagnostic kit
    • 简单的BAD BREATH DIAGNOSTIC KIT
    • JP2012251915A
    • 2012-12-20
    • JP2011125887
    • 2011-06-05
    • Wataru Sakamoto亘 坂本Asano Kozo浅野 行蔵Meguriya Yasuo廻谷 靖生
    • SAKAMOTO WATARUOSADA KAZUSANE
    • G01N33/50G01N1/12G01N21/78G01N33/48G01N33/52
    • PROBLEM TO BE SOLVED: To provide a simple inspection kit for performing bad breath diagnosis.SOLUTION: Bad breath (hydrogen sulfide) is simply determined by a visual inspection by using a methylene blue method and a principle of paper chromatography for color development at a solid phase for determination of the bad breath. Reaction impurities are removed to isolate methylene blue by using a chemical reaction product composed of a color developer N, N'-Dimethyl-p-phenylenediamine and ferric chloride 'fixing solution', auxiliary filter paper after capturing and fixing hydrogen sulfide in a specimen by using filter paper or a support obtained by containing zinc in a swab. Then, quantity of hydrogen sulfide is determined by a visual inspection or a photoelectric color difference meter. Since methylene blue is a stable coloring agent, highly sensitive and certain measurement is performed.
    • 要解决的问题:提供用于进行口臭诊断的简单检查套件。

      解决方案:通过使用亚甲基蓝法和目视检查方法,通过纸张色谱法在固相中进行色彩显色的原理来确定恶心(硫化氢),以测定口臭。 通过使用由显色剂N,N'-二甲基 - 对苯二胺和氯化铁固定液组成的化学反应产物,辅助滤纸在样品中捕获和固定硫化氢后,除去反应杂质以分离亚甲基蓝 使用滤纸或通过在棉签中含有锌获得的支持物。 然后,通过目视检查或光电色差计来确定硫化氢的量。 由于亚甲基蓝是稳定的着色剂,因此进行高灵敏度和一定的测量。 版权所有(C)2013,JPO&INPIT

    • 6. 发明专利
    • Xerostomia diagnostic kit for measuring stimulus saliva secretion amount
    • 用于测量刺激性SALIVA分泌量的XEROSTOMIA诊断试剂盒
    • JP2011099677A
    • 2011-05-19
    • JP2009252535
    • 2009-11-03
    • Kozo AsanoYasuo MeguriyaWataru Sakamoto亘 坂本靖生 廻谷行蔵 浅野
    • SAKAMOTO WATARUKANEHIRA TAKASHIMEGURIYA YASUOASANO KOZO
    • G01N33/50G01N21/78G01N33/483
    • PROBLEM TO BE SOLVED: To provide a simple inspection kit for xerostomia.
      SOLUTION: Determinate quantities of iodine and starch are spotted at specific positions of filter paper for paper chromatography, and a salivation stimulant, nicotine or capsaicin, is applied to an end of the filter paper to prepare filter paper for xerostomia diagnosis. The filter paper is put in the mouth of an examinee to cause the paper to absorb saliva. Thereafter, the amount of stimulus saliva secretion is measured from the position of a spot taking color with hydrogen peroxide solution. Or else, iron chloride (III) as a coloring agent is previously applied to the filter paper. The amount of stimulus secretion saliva is measured with capsaicin or nicotine applied to an end of test filter paper, the capsaicin or nicotine having a salivation stimulating action, allowing xerostomia to be diagnosed more surely. Further, determination is speeded and facilitated by using iron chloride (III) in place of hydrogen peroxide solution as a color-taking agent since coloration proceeds simultaneously with the absorption of saliva.
      COPYRIGHT: (C)2011,JPO&INPIT
    • 要解决的问题:为口腔干燥提供简单的检查套件。

      解决方案:确定纸张色谱法在滤纸特定位置处的碘和淀粉的数量,并将唾液激发剂,尼古丁或辣椒素施用于滤纸的末端以制备用于口腔干燥症诊断的滤纸。 将滤纸放入受试者的口中,使纸吸收唾液。 此后,从使用过氧化氢溶液的斑点的位置测量刺激性唾液分泌的量。 或者,作为着色剂的氯化铁(III)预先施加到滤纸上。 刺激分泌唾液的量是用辣椒素或尼古丁来测量的,该辣椒素或尼古丁应用于测试滤纸的末端,辣椒素或尼古丁具有唾液分泌刺激作用,可以更确切地诊断口腔干燥。 此外,通过使用氯化铁(III)代替过氧化氢溶液作为着色剂,加速和促进了测定,因为着色在与唾液的吸收同时进行。 版权所有(C)2011,JPO&INPIT

    • 7. 发明专利
    • New reagent composition for detecting peroxidase, and method for judging inflammatory disease or the like and method for measuring antioxidant activity by using the same
    • 用于检测过氧化物的新试剂组合物和用于判断炎症疾病的方法或类似方法以及使用其来测量抗氧化剂活性的方法
    • JP2008005838A
    • 2008-01-17
    • JP2007146291
    • 2007-05-31
    • Asano KozoHiroyuki IzumiWataru SakamotoSerotekku:Kk博之 和泉亘 坂本株式会社セロテック浅野 行蔵
    • SAKAMOTO WATARUMEGURIYA YASUOIZUMI HIROYUKI
    • C12Q1/28C12M1/34G01N21/77G01N21/78
    • PROBLEM TO BE SOLVED: To provide a new reagent composition by which peroxidase activities can be measured in high sensitivity, and a method for detecting the peroxidase activities; to provide a new retainer by which the peroxidase can easily be collected and measured; to judge the presence of inflammatory disease in an organism by the measurement of the peroxidase activities; and to measure antioxidant activities of a food or the like. SOLUTION: The reagent composition for detecting the peroxidase having excellent sensitivities contains DAB conventionally used in the detection of the peroxidase, and Guaiacol. The kit for detecting the peroxidase is also provided. The sample retainer capable of being directly used as a measuring device for readily and rapidly measuring the peroxidase activities, enabling the collection of saliva in the oral cavity, and easily applicable to food or the like containing a solid or viscous material is produced and used for judgement of dry mouth, periodontal disease, myocardial infarction, acute coronary arteriosclerosis, chronic nephritis, diabetes or the like, and measurement of the antioxidant activities. COPYRIGHT: (C)2008,JPO&INPIT
    • 待解决的问题:提供可以高灵敏度地测量过氧化物酶活性的新试剂组合物和检测过氧化物酶活性的方法; 提供新的保持器,通过其可以容易地收集和测量过氧化物酶; 通过测量过氧化物酶活性来判断生物体内炎症性疾病的存在; 并测量食品等的抗氧化活性。 解决方案:用于检测具有优异敏感性的过氧化物酶的试剂组合物含有常用于过氧化物酶检测的DAB和愈创木酚。 还提供了用于检测过氧化物酶的试剂盒。 可以直接用作测量装置的样品保持器,用于容易且快速地测量过氧化物酶活性,使得能够收集口腔中的唾液,并且容易适用于含有固体或粘性物质的食品等,并用于 口干,牙周病,心肌梗塞,急性冠状动脉硬化,慢性肾炎,糖尿病等的判断,抗氧化活性的测定。 版权所有(C)2008,JPO&INPIT