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1. 发明专利

JP2011182742A Composition having both dipeptidyl peptidase iv inhibitory activity in blood and secretion promotion activity of glucagon-like peptide-1 审中-公开
标题翻译：具有两种DIPEPTIDYP肽的组合物IV血液中的抑制活性和葡萄糖样肽-1的分泌促进活性
公开(公告)号：JP2011182742A
公开(公告)日：2011-09-22
申请号：JP2010053383
申请日：2010-03-10
申请人： Kozo Asano , Hiroshi Hara , Toru Hira , 博原 , 徹比良 , 行蔵浅野
发明人： HARA HIROSHI , HIRA TORU , ASANO KOZO
IPC分类号： A23L1/305 , A23L1/30 , A61K38/00 , A61P3/04 , A61P3/10 , A61P43/00 , C07K5/083 , C07K14/425
摘要： PROBLEM TO BE SOLVED: To provide a material effective for preventing and treating diabetes and obesity by increasing endogenous GLP-1. SOLUTION: Glucagon-like peptide-1 (GLP-1) being a digestive tract hormone is known to have an antidiabetic effect, however, only promotion of secretion of GLP-1 exhibits an insufficient effect, inhibition of decomposition as well as promotion of secretion is effective, concretely, a remarkable effect is obtained by inhibiting dipeptidyl peptidase-IV(DPP-IV) in blood. The preventive or therapeutic agent for diabetes or obesity comprises corn protein Zein hydrolyzate (ZeinH) having both secretion promotion action on GLP-1 and inhibitory action on DPP-IV or its amino acid sequence Leu-Pro-Phe as an active ingredient. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：通过增加内源性GLP-1来提供有效预防和治疗糖尿病和肥胖症的材料。解决方案：已知消化道激素的胰高血糖素样肽-1（GLP-1）具有抗糖尿病作用，但只有促进GLP-1的分泌才能发挥不足的作用，抑制分解以及促进分泌是有效的，具体来说，通过抑制血液中的二肽基肽酶-IV（DPP-IV）可以获得显着的效果。糖尿病或肥胖症的预防或治疗剂包括对GLP-1分泌促进作用和对DPP-IV或其氨基酸序列Leu-Pro-Phe作为活性成分具有抑制作用的玉米蛋白玉米素水解物（ZeinH）。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2010158226A MICROBIAL BIOASSAY OF tRNA-DEPENDENT AMIDOTRANSFERASE, AND METHOD FOR SCREENING ACTIVITY INHIBITOR UTILIZING THE SAME 审中-公开
标题翻译： tRNA依赖性氨基转移酶的微生物生物学及其使用活性抑制剂的方法
公开(公告)号：JP2010158226A
公开(公告)日：2010-07-22
申请号：JP2009004141
申请日：2009-01-10
申请人： Kozo Asano , 行蔵浅野
发明人： TANAKA MICHIKO , ASANO KOZO , TANAKA ISAO
IPC分类号： C12N15/09 , C12Q1/02 , C12Q1/25
摘要： PROBLEM TO BE SOLVED: To construct a screening method for search of a substance specifically inhibiting the activity of a tRNA-dependent amidotransferase (GatCAB), to simply measure the deterioration of the GatCAB activity in which the construction of an enzymic reaction system such as substrate preparation is difficult, and to efficiently screen an enzyme-specific inhibitor expected as a medicament.
SOLUTION: A coliform bacillus co-transformant of a plasmid starting transcription with a coliform bacillus RNA polymerase, and strictly controlling expression of a non-discriminating glutamyl-tRNA synthetase (ndGluRS) gene, and a plasmid permanently expressing GatCAB gene is constructed. The coliform bacillus is used as a test bacillus, and the deterioration of the GatCAB activity can readily be detected by measuring the growth of the coliform bacillus without preparing a substrate necessary for enzyme activity measurement and an enzyme protein. An inhibitor specific for the GatCAB can simply be searched for by screening a substance inhibiting the growth of the test bacillus without affecting a non-transformant.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为了构建用于搜索特异性抑制tRNA依赖性氨基转移酶（GatCAB）的活性的物质的筛选方法，简单地测量其中构建酶反应系统的GatCAB活性的劣化例如底物制备困难，并且有效地筛选预期作为药物的酶特异性抑制剂。解决方案：构建用大肠杆菌RNA聚合酶起始转录的质粒，严格控制非鉴别性谷氨酰-tRNA合成酶（ndGluRS）基因表达的大肠杆菌共转化体和永久表达GatCAB基因的质粒。大肠杆菌用作测试杆菌，并且通过测量大肠杆菌的生长而不需要制备酶活性测定所必需的底物和酶蛋白，可以容易地检测GatCAB活性的恶化。通过筛选抑制测试芽孢杆菌生长的物质，而不影响非转化体，可以简单地搜索特异于GatCAB的抑制剂。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2010063445A Mycoplasma fermentans gene, gene product, and method for producing glycoglycerophospholipid using enzymatic reaction thereof 审中-公开
标题翻译： MYCOPLASMA FERMENTANS基因，基因产物和使用其酶促反应产生甘露糖磷脂的方法
公开(公告)号：JP2010063445A
公开(公告)日：2010-03-25
申请号：JP2008235783
申请日：2008-09-13
申请人： A-Hitbio Inc , Kozo Asano , 有限会社A−HITBio , 行蔵浅野
发明人： ASANO KOZO , SONE TERUO , IKEDA JUNKO , MATSUDA KAZUHIRO , SATO SEIJI , SASAZAKI YOKO
IPC分类号： C12N15/09 , C12N9/10 , C12P19/44
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a glycoglycerophospholipid (GGPL) which is a membrane component of M. fermentans by reaction based on an enzyme expressed by Escherichia coli.
SOLUTION: Combination of codon is converted into Escherichia coli-type by selecting and cloning possible genes mf1 and mf3 from genomic information of M. fermentans. A glycoglycerophospholipid is successfully obtained by expressing these modified genes in E. coli, preparing cell fracture, and performing an enzymatic reaction after adding a substrate.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供通过基于由大肠杆菌表达的酶的反应的制备发酵甘草的膜组分的甘油聚磷脂（GGPL）的方法。解决方案：通过从发酵菌的基因组信息中选择和克隆可能的基因mf1和mf3，将密码子的组合转化为大肠杆菌型。通过在大肠杆菌中表达这些修饰的基因，制备细胞断裂并在添加底物后进行酶反应，成功获得了甘油磷脂。版权所有（C）2010，JPO＆INPIT

4. 发明专利

JP2009264988A Simplified dry mouth diagnostic kit 审中-公开
标题翻译：简单干燥的牙科诊断包
公开(公告)号：JP2009264988A
公开(公告)日：2009-11-12
申请号：JP2008116506
申请日：2008-04-27
申请人： Kozo Asano , Wataru Sakamoto , 亘坂本 , 行蔵浅野
发明人： SAKAMOTO WATARU , KANEHIRA TAKASHI , MEGURIYA YASUO , ASANO KOZO
IPC分类号： G01N33/52 , A61B5/00 , G01N33/50
摘要： PROBLEM TO BE SOLVED: To provide an easy and reliable examination kit for dry mouth.
SOLUTION: A simple diagnostic filter in which the principle of paper chromatography that quantitatively causes subject's salivary to be soaked and develop into a filter of paper chromatography is combined with starch iodine reaction is formed, and dry mouth is diagnosed, based on the color reaction by dropping an official hydrogen peroxide solution or a novel coloring reagent thereto.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：为干口提供一个简单可靠的检测套件。解决方案：一种简单的诊断过滤器，其中将定量使受试者的唾液浸泡并发展成纸色谱过滤器的纸层析原理结合淀粉碘反应形成，并且基于通过将官方的过氧化氢溶液或新的着色剂滴下来进行着色反应。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2011099677A Xerostomia diagnostic kit for measuring stimulus saliva secretion amount 审中-公开
标题翻译：用于测量刺激性SALIVA分泌量的XEROSTOMIA诊断试剂盒
公开(公告)号：JP2011099677A
公开(公告)日：2011-05-19
申请号：JP2009252535
申请日：2009-11-03
申请人： Kozo Asano , Yasuo Meguriya , Wataru Sakamoto , 亘坂本 , 靖生廻谷 , 行蔵浅野
发明人： SAKAMOTO WATARU , KANEHIRA TAKASHI , MEGURIYA YASUO , ASANO KOZO
IPC分类号： G01N33/50 , G01N21/78 , G01N33/483
摘要： PROBLEM TO BE SOLVED: To provide a simple inspection kit for xerostomia.
SOLUTION: Determinate quantities of iodine and starch are spotted at specific positions of filter paper for paper chromatography, and a salivation stimulant, nicotine or capsaicin, is applied to an end of the filter paper to prepare filter paper for xerostomia diagnosis. The filter paper is put in the mouth of an examinee to cause the paper to absorb saliva. Thereafter, the amount of stimulus saliva secretion is measured from the position of a spot taking color with hydrogen peroxide solution. Or else, iron chloride (III) as a coloring agent is previously applied to the filter paper. The amount of stimulus secretion saliva is measured with capsaicin or nicotine applied to an end of test filter paper, the capsaicin or nicotine having a salivation stimulating action, allowing xerostomia to be diagnosed more surely. Further, determination is speeded and facilitated by using iron chloride (III) in place of hydrogen peroxide solution as a color-taking agent since coloration proceeds simultaneously with the absorption of saliva.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：为口腔干燥提供简单的检查套件。
解决方案：确定纸张色谱法在滤纸特定位置处的碘和淀粉的数量，并将唾液激发剂，尼古丁或辣椒素施用于滤纸的末端以制备用于口腔干燥症诊断的滤纸。将滤纸放入受试者的口中，使纸吸收唾液。此后，从使用过氧化氢溶液的斑点的位置测量刺激性唾液分泌的量。或者，作为着色剂的氯化铁（III）预先施加到滤纸上。刺激分泌唾液的量是用辣椒素或尼古丁来测量的，该辣椒素或尼古丁应用于测试滤纸的末端，辣椒素或尼古丁具有唾液分泌刺激作用，可以更确切地诊断口腔干燥。此外，通过使用氯化铁（III）代替过氧化氢溶液作为着色剂，加速和促进了测定，因为着色在与唾液的吸收同时进行。版权所有（C）2011，JPO＆INPIT

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