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1. 发明申请

US20100241179A1 Techniques for Positioning Therapy Delivery Elements within a Spinal Cord or Brain 有权
标题翻译：在脊髓或脑内定位治疗传递元件的技术
公开(公告)号：US20100241179A1
公开(公告)日：2010-09-23
申请号：US12794363
申请日：2010-06-04
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/05 , A61N1/375 , A61M39/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

2. 发明申请

US20070255335A1 Controller for gastric constriction device with selectable electrode configurations 审中-公开
标题翻译：用于具有可选电极配置的胃收缩装置的控制器
公开(公告)号：US20070255335A1
公开(公告)日：2007-11-01
申请号：US11414502
申请日：2006-04-28
申请人： Timothy Herbert , Warren Starkebaum
发明人： Timothy Herbert , Warren Starkebaum
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61N1/05
摘要： This disclosure describes an implantable medical device that delivers electrical stimulation to a patient in combination with restriction ingestion of food by the patient to treaty obesity. The implantable medical device includes a gastric constriction device, such as a hydraulic or mechanical gastric band having a plurality of electrodes integrally formed thereon. A controller includes a control unit to control the degree of gastric constriction of the gastric constriction device and a pulse generator to control delivery of electrical stimulation to the patient. The control unit and pulse generator are enclosed within a housing implanted within the patient. By enclosing the control unit and pulse generator within a common housing, the trauma experienced by the patient during the implantation procedure may be substantially reduced. Additionally, the cost of the controller may be less than the cost of purchasing a control unit and a pulse generator separately.
摘要翻译：本公开描述了一种可植入医疗装置，其将患者的电刺激与患者的食物的限制摄取结合到条约肥胖。可植入医疗装置包括胃收缩装置，例如具有一体形成在其上的多个电极的液压或机械胃束带。控制器包括控制单元，用于控制胃收缩装置的胃收缩程度和脉冲发生器，以控制对患者的电刺激递送。控制单元和脉冲发生器被封装在植入患者体内的壳体内。通过将控制单元和脉冲发生器包围在公共壳体内，患者在植入手术过程中经历的创伤可能会大大降低。此外，控制器的成本可能小于单独购买控制单元和脉冲发生器的成本。

3. 发明申请

US20070203531A9 Heart rate variability control of gastric electrical stimulator 审中-公开
标题翻译：胃电刺激器的心率变异性控制
公开(公告)号：US20070203531A9
公开(公告)日：2007-08-30
申请号：US10836354
申请日：2004-04-30
申请人： Warren Starkebaum
发明人： Warren Starkebaum
IPC分类号： A61N1/18
CPC分类号： A61B5/02405 , A61B5/04014 , A61B5/4035 , A61B5/42 , A61N1/05 , A61N1/36007 , A61N1/36114
摘要： Methods and systems for stimulating a gastrointestinal system and for modifying a stimulation signal based on an indicator of autonomic nervous system function are described. One indicator of autonomic nervous system described is cardiac activity, including heart rate variability. Methods for selecting candidate patients for gastrointestinal stimulation therapy based on an indicator of autonomic nervous system function and methods of treating patients at risk of or suffering from gastrointestinal disorders by modifying therapy based on an indicator of autonomic function are also discussed.
摘要翻译：描述了基于自主神经系统功能指标刺激胃肠系统和修改刺激信号的方法和系统。描述的自主神经系统的一个指标是心脏活动，包括心率变异性。还讨论了基于自主神经系统功能的指标选择候选患者的候选患者的方法以及通过基于自主功能的指标进行修改治疗来治疗患有胃肠疾病的患者或患有胃肠疾病的患者的方法。

4. 发明申请

US20070123954A1 Techniques for positioning therapy delivery elements within a spinal cord or brain 有权
标题翻译：在脊髓或脑中定位治疗递送元件的技术
公开(公告)号：US20070123954A1
公开(公告)日：2007-05-31
申请号：US11669758
申请日：2007-01-31
申请人： Frans Gielen , Gary King , Daryle Petersen , Mark Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary King , Daryle Petersen , Mark Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。此后可以用位置控制机构和/或位置控制器原位调整治疗递送元件，以改善期望的治疗，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

5. 发明申请

US20060247768A1 Bulking of upper esophageal sphincter for treatment of obesity 失效
标题翻译：膨胀上食管括约肌治疗肥胖
公开(公告)号：US20060247768A1
公开(公告)日：2006-11-02
申请号：US11117060
申请日：2005-04-28
申请人： Warren Starkebaum
发明人： Warren Starkebaum
IPC分类号： A61F2/02
CPC分类号： A61B17/12
摘要： A method for treatment of obesity involves implantation of bulking devices within the upper esophageal sphincter (UES) to inhibit swallowing, thereby limiting food intake and treating obesity. One or more bulking devices are implanted within or near the UES to create a partial obstruction, partially impair UES muscle function, or both. The bulking devices make swallowing difficult, limiting the rate of food intake by a patient, and discouraging the patient from quickly consuming an excessive amount of food at one time.
摘要翻译：用于治疗肥胖症的方法包括在上食管括约肌（UES）内植入膨胀装置以抑制吞咽，从而限制食物摄取和治疗肥胖。在UES内或附近植入一个或多个膨胀装置以产生部分阻塞，部分损害UES肌肉功能或两者。膨胀装置使吞食困难，限制了患者的食物摄取速率，并且阻止患者一次快速消耗过量的食物。

6. 发明申请

US20060247720A1 Intra-luminal device for gastrointestinal stimulation 有权
标题翻译：用于胃肠道刺激的腔内装置
公开(公告)号：US20060247720A1
公开(公告)日：2006-11-02
申请号：US11118629
申请日：2005-04-29
申请人： Warren Starkebaum
发明人： Warren Starkebaum
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61B5/42 , A61B5/6882
摘要： A stimulation device for electrical stimulation of a target location of a gastrointestinal tract of a patient that includes a device housing sized for introduction into a gastrointestinal tract, wherein the device housing is configured to attach to a connector, an electrical pulse generator, mounted within the device housing, to generate an electrical stimulation waveform, one or more electrodes electrically coupled to the electrical pulse generator and mounted to the device housing to deliver the electrical stimulation waveform to the gastrointestinal tract, and a fixation structure to attach the device housing to the target location of the gastrointestinal tract, wherein the stimulation device is configured to be tethered to an area around the target location using the connector. A method for attaching a stimulation device of the invention to a wall of a gastrointestinal tract is also included
摘要翻译：一种用于电刺激患者的胃肠道的目标位置的刺激装置，其包括尺寸适于引入胃肠道的装置壳体，其中所述装置壳体被配置为附接到连接器，电脉冲发生器，其安装在以产生电刺激波形，一个或多个电极，其电耦合到所述电脉冲发生器并且安装到所述装置壳体以将所述电刺激波形传送到所述胃肠道;以及固定结构，以将所述装置壳体附接到所述靶胃肠道的位置，其中使用连接器将刺激装置配置成系在目标位置周围的区域。还包括将本发明的刺激装置附着到胃肠道的壁的方法

7. 发明授权

US06853862B1 Gastroelectric stimulation for influencing pancreatic secretions 失效
标题翻译：胃电刺激影响胰腺分泌物
公开(公告)号：US06853862B1
公开(公告)日：2005-02-08
申请号：US09537070
申请日：2000-03-28
申请人： Benoit Marchal , Warren Starkebaum
发明人： Benoit Marchal , Warren Starkebaum
IPC分类号： A61N1/32 , A61N1/36 , A61N1/08
CPC分类号： A61N1/36007 , A61N1/36114
摘要： A gastroelectric stimulator comprises a neurostimulator for producing a stimulation signal, at least one electrical lead, and at least two electrical contacts. The electrical lead has a proximal end and a distal end, the proximal end being connected to the neurostimulator and the distal end positionable in a lead position within the patient's abdomen. The electrodes are carried near the electrical lead distal end. The electrodes are electrically connected through the electrical lead to the neurostimulator to receive the stimulation signal and convey this signal to an electrode position within the patient's digestive system. The stimulation signal is adapted to influence pancreatic secretions.
摘要翻译：胃电刺激器包括用于产生刺激信号的神经刺激器，至少一个电引线和至少两个电触点。电引线具有近端和远端，近端连接到神经刺激器，远端可定位在患者腹部内的引导位置。电极被放置在电引线远端附近。电极通过电导线电连接到神经刺激器以接收刺激信号并将该信号传送到患者消化系统内的电极位置。刺激信号适用于影响胰腺分泌物。

8. 发明授权

US06795737B2 Techniques for positioning therapy delivery elements within a spinal cord or a brain 失效
标题翻译：将治疗递送元件定位在脊髓或脑内的技术
公开(公告)号：US06795737B2
公开(公告)日：2004-09-21
申请号：US09934001
申请日：2001-08-21
申请人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
发明人： Frans Gielen , Gary W. King , Daryle Petersen , Mark T. Rise , Michael Schendel , Warren Starkebaum
IPC分类号： A61N118
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2209/045 , A61M2210/0693 , A61M2210/1003 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/0553 , A61N1/0558 , A61N1/056 , A61N1/36071
摘要： Apparatus and techniques to address the problems associated with lead migration, patient movement or position, histological changes, neural plasticity or disease progression. Disclosed are techniques for implanting a lead having therapy delivery elements, such as electrodes or drug delivery ports, within a vertebral or cranial bone so as to maintain these elements in a fixed position relative to a desired treatment site. The therapy delivery elements may thereafter be adjusted in situ with a position control mechanism and/or a position controller to improve the desired treatment therapy, such as electrical stimulation and/or drug infusion to a precise target. The therapy delivery elements may be positioned laterally in any direction relative to the targeted treatment site or toward or away from the targeted treatment site. A control system maybe provided for open- or closed-loop feedback control of the position of the therapy delivery elements as well as other aspects of the treatment therapy.
摘要翻译：用于解决与铅迁移，患者运动或位置，组织学变化，神经可塑性或疾病进展相关的问题的装置和技术。公开了用于在椎骨或颅骨内植入具有治疗递送元件（例如电极或药物递送端口）的引线以将这些元件相对于期望的治疗部位保持在固定位置的技术。治疗递送元件此后可以用位置控制机构和/或位置控制器原位调整以改善期望的治疗疗法，例如电刺激和/或药物输注到精确靶。治疗递送元件可以相对于目标治疗部位或朝向或远离目标治疗部位的任何方向横向定位。可以提供控制系统用于开放或闭环反馈控制治疗递送元件的位置以及治疗疗法的其它方面。

9. 发明申请

US20060265021A1 Intra-Luminal Device for Gastrointestinal Electrical Stimulation 审中-公开
标题翻译：用于肠胃电刺激的腔内装置
公开(公告)号：US20060265021A1
公开(公告)日：2006-11-23
申请号：US11379911
申请日：2006-04-24
申请人： Timothy Herbert , Warren Starkebaum
发明人： Timothy Herbert , Warren Starkebaum
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0517 , A61N1/372 , A61N1/37205 , A61N1/3756 , Y02A90/26
摘要： An intra-luminal device for gastrointestinal electrical stimulation is self-powered and self-contained within a capsule-like housing, and is capable of non-surgical implantation within the patient. The device includes an implantable pulse generator and one or more electrodes mounted within a common device housing. The device housing is capable of endoscopic introduction to a desired location within the gastrointestinal tract, such as the stomach, via the esophagus. The device may be appropriate for short-term, mid-term or trial stimulation applications.
摘要翻译：用于胃肠电刺激的腔内装置是自动供电的并且自包含在胶囊状壳体内，并且能够在患者体内非手术植入。该装置包括可植入脉冲发生器和安装在公共装置外壳内的一个或多个电极。装置外壳能够通过食道内窥镜引入胃肠道内的所需位置，例如胃。该装置可适用于短期，中期或试验刺激应用。

10. 发明申请

US20060247718A1 Dual mode electrical stimulation to treat obesity 审中-公开
标题翻译：双重电刺激治疗肥胖
公开(公告)号：US20060247718A1
公开(公告)日：2006-11-02
申请号：US11117061
申请日：2005-04-28
申请人： Warren Starkebaum
发明人： Warren Starkebaum
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61N1/372
摘要： The disclosure describes techniques for electrical stimulation to regulate the caloric intake of a patient and thereby alleviate obesity. A first set of stimulation pulses is delivered to the stomach to suppress appetite and limit food intake, and a second set of stimulation pulses is delivered to the small intestine to accelerate food transit and reduce caloric absorption. In this manner, the electrical stimulation limits food intake and caloric absorption, providing a two-pronged therapy for obesity. In a sense, the electrical stimulation electrically mimics the physiological effects of the Roux-en-Y gastric bypass procedure without the need for surgery.
摘要翻译：本公开描述了用于电刺激以调节患者的热量摄入并由此减轻肥胖症的技术。将第一组刺激脉冲输送到胃以抑制食欲并限制食物摄入，并且将第二组刺激脉冲输送到小肠以加速食物转运并降低热量吸收。以这种方式，电刺激限制食物摄取和热量吸收，为肥胖提供双管齐下的疗法。在某种意义上，电刺激电动模拟Roux-en-Y胃旁路手术的生理作用，而不需要手术。

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