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1. 发明申请

WO2014014933A1 HIV TREATMENT WITH AMIDO-SUBSTITUTED PYRIMIDINONE DERIVATIVES 审中-公开
标题翻译：用氨基取代的嘧啶酮衍生物进行艾滋病毒治疗
公开(公告)号：WO2014014933A1
公开(公告)日：2014-01-23
申请号：PCT/US2013/050715
申请日：2013-07-16
申请人： MERCK SHARP & DOHME CORP. , COLEMAN, Paul, J. , WALJI, Abbas , DANG, Qun , BENNETT, David, J. , CLAS, Sophie, D. , WAI, John , BALSELLS-PADROS, Jaume , WU, Henry, Y. , SMITH, Ronald, L. , NOFSINGER, Rebecca , SANCHEZ, Rosa, I.
发明人： COLEMAN, Paul, J. , WALJI, Abbas , DANG, Qun , BENNETT, David, J. , CLAS, Sophie, D. , WAI, John , BALSELLS-PADROS, Jaume , WU, Henry, Y. , SMITH, Ronald, L. , NOFSINGER, Rebecca , SANCHEZ, Rosa, I.
IPC分类号： C07D413/12 , A61P31/18 , A61K31/506
CPC分类号： C07D413/12 , A61K31/427 , A61K31/513 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： The present invention relates to Amido-Substituted Pyrimidinone Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Pyrimidinone Derivative, and methods of using the Amido-Substituted Pyrimidinone Derivatives for treating or preventing HIV infection in a subject.
摘要翻译：本发明涉及式（I）的酰胺取代的嘧啶酮衍生物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。本发明还涉及包含至少一种酰胺取代的嘧啶酮衍生物的组合物，以及使用酰胺取代的嘧啶酮衍生物来治疗或预防受试者中HIV感染的方法。

2. 发明申请

WO2007139772A3 ROLLING BAGGAGE WHEELS AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：滚动包车轮及其制造方法
公开(公告)号：WO2007139772A3
公开(公告)日：2008-07-17
申请号：PCT/US2007012140
申请日：2007-05-22
申请人： GEARGUARD SPORTS LLC , REED RONALD WAYNE , YEAROUS JEFFREY BLAINE , SHAW DAVID , SHAW RONNIE JIM LU , SHAW AHON , WU HENRY
发明人： REED RONALD WAYNE , YEAROUS JEFFREY BLAINE , SHAW DAVID , SHAW RONNIE JIM LU , SHAW AHON , WU HENRY
IPC分类号： B60C7/00
CPC分类号： A45C5/14 , A45C2003/007
摘要： A wheel for rolling bags and associated assembly methods are provided. The wheel includes a non-inflatable outer tire, a plurality of segments positioned inside the tire concentrically about an axis of the tire and supporting an inner surface of the tire, and first and second rims capping first and second openings in the tire, respectively, and supporting the plurality of segments.
摘要翻译：提供了一种用于滚动袋和相关组装方法的轮子。车轮包括不可充气的外轮胎，多个分段位于轮胎内同心圆周内并支撑轮胎的内表面，第一和第二轮圈分别在轮胎中封盖第一和第二开口，并支持多个段。

3. 发明申请

WO2007047529A3 ACCOMMODATING INTRAOCULAR LENS SYSTEM UTILIZING DIRECT FORCE TRANSFER FROM ZONULES AND METHOD OF USE 审中-公开
标题翻译：使用区域直接转移的住院镜片系统及其使用方法
公开(公告)号：WO2007047529A3
公开(公告)日：2007-10-04
申请号：PCT/US2006040252
申请日：2006-10-12
申请人： POWERVISION INC , ESCH VICTOR , SMILEY TERRY , CHESKIN BARRY , MYALL PATRICK , EVANS BILL , WU HENRY , SCHOLL JOHN
发明人： ESCH VICTOR , SMILEY TERRY , CHESKIN BARRY , MYALL PATRICK , EVANS BILL , WU HENRY , SCHOLL JOHN
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/1635 , A61F2002/1682 , A61F2002/1699
摘要： An accommodating intraocular lens is provided having optical parameters that are altered in-situ, wherein an optic portion of the lens includes a lens piston that alters the shape of a lens element of the lens to alter the optical power of the lens, responsive to forces applied to a haptic portion to the lens by contraction of the ciliary muscles. Forces applied to the haptic portion are transferred hydraulically to cause the lens to become more or less accommodated. The haptic portion is retained in a fixed unaccommodated state during an initial healing period following implantation to facilitate affixation of the haptic portion to the capsule.
摘要翻译：提供一种适应性的眼内透镜，其具有原位改变的光学参数，其中透镜的光学部分包括透镜活塞，该透镜活塞改变透镜的透镜元件的形状以响应于力而改变透镜的光焦度通过睫状肌的收缩应用于透镜的触觉部分。施加到触觉部分的力被液压地转移以使得透镜变得或多或少地被容纳。在植入之后的初始愈合期间，触觉部分被保持在固定的未调节状态，以便于将触觉部分固定在胶囊上。

4. 发明申请

WO2007047530A2 ACCOMMODATING INTRAOCULAR LENS HAVING PERIPHERALLY ACTUATED DEFLECTABLE SURFACE AND METHOD 审中-公开
标题翻译：具有外部致动表面和方法的内窥镜镜片
公开(公告)号：WO2007047530A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040258
申请日：2006-10-12
申请人： POWERVISION INC , ESCH VICTOR , SCHOLL JOHN , SMILEY TERRY , MYALL PATRICK , EVANS BILL , CHESKIN BARRY , WU HENRY
发明人： ESCH VICTOR , SCHOLL JOHN , SMILEY TERRY , MYALL PATRICK , EVANS BILL , CHESKIN BARRY , WU HENRY
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1613 , A61F2/1648 , A61F2002/1682 , A61F2250/0053
摘要： An accommodating intraocular lens is provided in which a deflectable lens element is anchored to a substrate along its optical axis to define a fluid filled space. Fluid-filled haptics disposed in fluid communication with the space vary the fluid volume in the space responsive to forces applied by the ciliary muscles, thereby causing the periphery of the lens element to deflect relative to the substrate and changing the optical power of the intraocular lens.
摘要翻译：提供了一种适应性眼内透镜，其中可偏转透镜元件沿其光轴锚定到基底以限定流体填充空间。与空间流体连通地设置的流体填充的触觉件响应于由睫状肌施加的力而改变空间中的流体体积，从而导致透镜元件的周边相对于基底偏转并改变眼内透镜的光焦度。

5. 发明申请

WO2006011891A1 SYSTEM AND METHODS OF AUTOMATIC VIEW RECOGNITION OF ECHOCARDIOGRAM VIDEOS USING PARTS-BASED REPRESENTATION 审中-公开
标题翻译：使用基于部件表示的自动视频识别系统和方法
公开(公告)号：WO2006011891A1
公开(公告)日：2006-02-02
申请号：PCT/US2004/028722
申请日：2004-08-26
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , EBADOLLAHI, Shahram , CHANG, Shih-Fu , WU, Henry
发明人： EBADOLLAHI, Shahram , CHANG, Shih-Fu , WU, Henry
IPC分类号： G06K9/62
CPC分类号： G06T7/00 , G06K9/469 , G06K9/6892 , G06K2209/05 , G06T7/74 , G06T7/77 , G06T2207/10016 , G06T2207/10132 , G06T2207/20072 , G06T2207/30048
摘要： A system and methods (Figure 4) for the automatic identification of a test image, such as images from an echocardiogram video, is disclosed herein. The structure of the image is represented by the constellation (Fig. 4, 60) of its parts (e.g., chambers of the hear) under the different labels (e.g., different views). The statistical variations of the parts in the constellation and their spatial relationships are modeled using a generative model, such as Markov Random Field models. A discriminative method is then used for view recognition which fuses the assessments of a test image by all the view-models (fig. 4, M1 62, M2 64, Mk, 68).
摘要翻译：本文公开了用于自动识别测试图像（例如来自超声心动图视频的图像）的系统和方法（图4）。图像的结构由不同标签（例如，不同视图）的其部分（例如，听觉室）的星座（图4，60）表示。使用生成模型（如马尔可夫随机场模型）对星座中各部分及其空间关系的统计变化进行建模。然后将辨别方法用于视觉识别，该视觉识别通过所有视图模型（图4，M1 62，M2 64，Mk，68）融合测试图像的评估。

6. 发明申请

WO2006007303A2 APPARATUS AND METHOD FOR IMPLANTING INTRAOCULAR LENS THROUGH A SMALL INCISION 审中-公开
标题翻译：通过小切口植入眼内晶状体的装置和方法
公开(公告)号：WO2006007303A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/019918
申请日：2005-06-07
申请人： MEDENNIUM, INC. , WU, Henry , WILCOX, Christopher, D. , DIEP, Loi
发明人： WU, Henry , WILCOX, Christopher, D. , DIEP, Loi
IPC分类号： A61F2/16
CPC分类号： A61F2/1664 , A61F2/1616 , A61F2210/0023
摘要： Apparatus and method for implantation of intraocular lenses (IOLs) with various designs, particularly a full-size IOL, into the eye through small incisions are disclosed. A full-size intraocular lens mimics the natural human crystalline lens in size and volume. The SMART TM IOL, a full-size design, utilizes the thermodynamic properties of a crystalline polymeric material composition. The insertion apparatus and method of the present invention allow the full-size SMART TM IOL to be inserted through a small incision (about 4 mm or less) by deforming it with a crimping device into a solid rod and delivering the rod into the eye with a temperature-controlled injector equipped with a temperature control device. Once the solid rod is located in the desired position inside the eye, human body temperature softens the rod and allows it to reform back into the original lens geometry with defined optical properties.
摘要翻译：公开了用于通过小切口将具有各种设计，特别是全尺寸IOL的人工晶状体（IOL）植入眼内的设备和方法。全尺寸人工晶状体在尺寸和体积上模仿天然人体晶状体。全尺寸设计的SMART TM TM IOL利用了结晶聚合物材料组合物的热力学性质。本发明的插入设备和方法允许全尺寸的SMART TM人工晶状体通过小的切口（约4mm或更小）插入，通过使用卷边装置将其变形成实心杆，并且用装有温度控制装置的温度控制注射器将杆送入眼内。一旦固体棒位于眼睛内部的理想位置，人体温度就会软化棒，并允许它重新形成具有确定光学特性的原始晶状体几何形状。

7. 发明申请

WO2009015226A2 ACCOMMODATING INTRAOCULAR LENSES AND METHODS OF USE 审中-公开
标题翻译：容纳内窥镜和使用方法
公开(公告)号：WO2009015226A2
公开(公告)日：2009-01-29
申请号：PCT/US2008/070918
申请日：2008-07-23
申请人： POWERVISION, INC. , SMILEY, Terah, Whiting , SMITH, David, John , CHOI, Steven , SCHOLL, John, A. , WU, Henry , BURNS, Denise, H.
发明人： SMILEY, Terah, Whiting , SMITH, David, John , CHOI, Steven , SCHOLL, John, A. , WU, Henry , BURNS, Denise, H.
IPC分类号： A61F2/16
CPC分类号： A61F2/1635 , A61F2/1601 , A61F2/1613 , A61F2/1624 , A61F2/1648 , A61F2002/1682 , A61F2002/1683 , A61F2002/1689 , A61F2250/0053
摘要： Accommodating intraocular lenses containing a flowable media and their methods of accommodation.
摘要翻译：容纳含有可流动介质的人工晶状体及其调节方法。

8. 发明申请

WO2011091160A1 CUSTOM-FORMULATED PHOSPHOLIPID MICROBUBBLES AND METHODS AND USES THEREOF 审中-公开
标题翻译：自制配方磷石微生物及其用途及方法
公开(公告)号：WO2011091160A1
公开(公告)日：2011-07-28
申请号：PCT/US2011/021915
申请日：2011-01-20
申请人： WU, Henry
发明人： WU, Henry
IPC分类号： A61M37/00
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K31/20 , A61K31/202 , A61K41/0028
摘要： A phospholipid microbubble comprising a shell which comprises a plurality of polyunsaturated fatty acid ("PUFA")-containing phospholipids, and a core of inert gas surrounded by the shell comprising the plurality of PUFA-containing phospholipids. The present invention also provides methods of delivering a prophylactically or therapeutically effective amount of PUFA to an area of disease or injury in a subject. The present invention also provides methods of preventing or treating a disease in a subject using a prophylactically or therapeutically effective amount of the aforementioned phospholipid microbubbles.
摘要翻译：一种包含壳的磷脂微泡，其包含多个多不饱和脂肪酸（“PUFA”）的磷脂，以及由壳包围的包含多种含PUFA的磷脂的惰性气体芯。本发明还提供将预防或治疗有效量的PUFA递送到受试者的疾病或损伤区域的方法。本发明还提供使用预防或治疗有效量的上述磷脂微泡来预防或治疗受试者的疾病的方法。

9. 发明申请

WO2009015226A3 ACCOMMODATING INTRAOCULAR LENSES AND METHODS OF USE 审中-公开
标题翻译：容纳内窥镜和使用方法
公开(公告)号：WO2009015226A3
公开(公告)日：2009-03-12
申请号：PCT/US2008070918
申请日：2008-07-23
申请人： POWERVISION INC , SMILEY TERAH WHITING , SMITH DAVID JOHN , CHOI STEVEN , SCHOLL JOHN A , WU HENRY , BURNS DENISE H
发明人： SMILEY TERAH WHITING , SMITH DAVID JOHN , CHOI STEVEN , SCHOLL JOHN A , WU HENRY , BURNS DENISE H
IPC分类号： A61F2/16
CPC分类号： A61F2/1648 , A61F2/1601 , A61F2/1635 , A61F2002/1682
摘要： An accommodating intraocular lens IOL (10) including a peripheral non-optic portion comprising haptics (12) and (14). The IOL also includes an optic portion including anterior lens element (16), intermediate layer (18) which comprises actuator (20), and substrate, or posterior element (22). ' Anterior element (16) is bonded to intermediate layer (18) at its periphery. The anterior element, may also be bonded to actuator (20). The intermediate layer is also bonded to posterior element (22). The inner surface of haptics (12) and (14) define interior volumes (24) which are in fluid communication with active channel (26) defind by posterior element (22) and intermediate layer (18). As shown, actuator (20) is integral with intermediate layer (18). Posterior element (22) is molded with buttresses (11) which include a buttress bore (13) therethrough. The haptics have a haptic attachment element (15) which is sized and shaped to fit within buttless bore (13).
摘要翻译：包括包括触觉件（12）和（14）的外围非光学部分的适应性眼内透镜IOL（10）。 IOL还包括光学部分，其包括前透镜元件（16），包括致动器（20）的中间层（18）和基底或后部元件（22）。 '前部元件（16）在其周边结合到中间层（18）。前部元件也可以结合到致动器（20）。中间层也结合到后部元件（22）。触觉件（12）和（14）的内表面限定内部容积（24），其与由后部元件（22）和中间层（18）确定的活动通道（26）流体连通。如图所示，致动器（20）与中间层（18）成一体。后部元件（22）由支撑件（11）模制，其中包括穿过其中的支撑孔（13）。触觉件具有触觉附接元件（15），其尺寸和形状适于安装在无孔孔（13）内。

10. 发明申请

WO2007139772A2 ROLLING BAGGAGE WHEELS AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：滚动行李轮及其制造方法
公开(公告)号：WO2007139772A2
公开(公告)日：2007-12-06
申请号：PCT/US2007/012140
申请日：2007-05-22
申请人： GEARGUARD SPORTS LLC , REED, Ronald, Wayne , YEAROUS, Jeffrey, Blaine , SHAW, David , SHAW, Ronnie, Jim Lu , SHAW, Ahon , WU, Henry
发明人： REED, Ronald, Wayne , YEAROUS, Jeffrey, Blaine , SHAW, David , SHAW, Ronnie, Jim Lu , SHAW, Ahon , WU, Henry
IPC分类号： B60B15/02
CPC分类号： A45C5/14 , A45C2003/007
摘要： A wheel for rolling bags and associated assembly methods are provided. The wheel includes a non-inflatable outer tire, a plurality of segments positioned inside the tire concentrically about an axis of the tire and supporting an inner surface of the tire, and first and second rims capping first and second openings in the tire, respectively, and supporting the plurality of segments.
摘要翻译：提供一种用于滚动袋和相关组装方法的轮子。车轮包括不可充气的外轮胎，多个分段，其位于轮胎内部同心圆周内并支撑轮胎的内表面，第一和第二轮圈分别在轮胎中封盖第一和第二开口，并支持多个段。

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