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1. 发明申请

WO2006007303A2 APPARATUS AND METHOD FOR IMPLANTING INTRAOCULAR LENS THROUGH A SMALL INCISION 审中-公开
标题翻译：通过小切口植入眼内晶状体的装置和方法
公开(公告)号：WO2006007303A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/019918
申请日：2005-06-07
申请人： MEDENNIUM, INC. , WU, Henry , WILCOX, Christopher, D. , DIEP, Loi
发明人： WU, Henry , WILCOX, Christopher, D. , DIEP, Loi
IPC分类号： A61F2/16
CPC分类号： A61F2/1664 , A61F2/1616 , A61F2210/0023
摘要： Apparatus and method for implantation of intraocular lenses (IOLs) with various designs, particularly a full-size IOL, into the eye through small incisions are disclosed. A full-size intraocular lens mimics the natural human crystalline lens in size and volume. The SMART TM IOL, a full-size design, utilizes the thermodynamic properties of a crystalline polymeric material composition. The insertion apparatus and method of the present invention allow the full-size SMART TM IOL to be inserted through a small incision (about 4 mm or less) by deforming it with a crimping device into a solid rod and delivering the rod into the eye with a temperature-controlled injector equipped with a temperature control device. Once the solid rod is located in the desired position inside the eye, human body temperature softens the rod and allows it to reform back into the original lens geometry with defined optical properties.
摘要翻译：公开了用于通过小切口将具有各种设计，特别是全尺寸IOL的人工晶状体（IOL）植入眼内的设备和方法。全尺寸人工晶状体在尺寸和体积上模仿天然人体晶状体。全尺寸设计的SMART TM TM IOL利用了结晶聚合物材料组合物的热力学性质。本发明的插入设备和方法允许全尺寸的SMART TM人工晶状体通过小的切口（约4mm或更小）插入，通过使用卷边装置将其变形成实心杆，并且用装有温度控制装置的温度控制注射器将杆送入眼内。一旦固体棒位于眼睛内部的理想位置，人体温度就会软化棒，并允许它重新形成具有确定光学特性的原始晶状体几何形状。

2. 发明申请

WO2006002189A1 PHOTOCHROMIC INTRAOCULAR LENSES AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：光致内窥镜及其制造方法
公开(公告)号：WO2006002189A1
公开(公告)日：2006-01-05
申请号：PCT/US2005/021967
申请日：2005-06-16
申请人： MEDENNIUM, INC. , ZHOU, Stephen, Q. , WILCOX, Christopher, D. , LIAU, Christine
发明人： ZHOU, Stephen, Q. , WILCOX, Christopher, D. , LIAU, Christine
IPC分类号： A61F2/16
CPC分类号： B29D11/023 , A61F2/1659 , A61F2002/16965 , A61F2240/001
摘要： Intraocular lenses containing a photochromic agent having its maximum absorption peak in the wavelength range of about 400-500 nm, are disclosed. Methods for making these intraocular lenses are also taught.
摘要翻译：公开了含有在约400-500nm的波长范围内具有最大吸收峰的光致变色剂的人造眼镜。还教导制造这些眼内透镜的方法。

3. 发明申请

WO2016149304A1 IMPROVED SELF-CENTERING PHAKIC REFRACTIVE LENSES WITH PARACHUTE DESIGN 审中-公开
标题翻译：改进的自放置PHAKIC折射镜与PARACHUTE设计
公开(公告)号：WO2016149304A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022545
申请日：2016-03-16
申请人： MEDENNIUM, INC.
发明人： WILCOX, Christopher, D. , DEMENTIEV, Dimitrii , FELDMAN, Jacob , ABADIA, Julian
IPC分类号： A61F2/16
CPC分类号： A61F2/1601 , A61F2/161 , A61F2002/1683 , A61F2002/1689 , A61F2009/00863
摘要： An improved self-centering phakic refractive lens is disclosed. The lens floats freely in the posterior chamber of the eye and corrects vision of the patient but also prevents buildup of intraocular pressure, cataract induction and iris pigment dispersion. The lens comprises an optical body, haptic members which extend outward from the optical body, and a small hole in the approximate center of the optical body for the purpose of allowing aqueous humor to flow through that hole. The lens is designed such that its posterior surface conforms to the shape of the anterior surface of the patient's natural crystalline lens.
摘要翻译：公开了一种改进的自定心晶状体折射透镜。透镜在眼后房自由浮动，矫正患者的视力，同时也可防止眼内压，白内障诱导和虹膜色素分散。透镜包括光学体，从光学体向外延伸的触觉构件，以及在光学体的大致中心处的小孔，用于允许房水流过该孔。透镜被设计成使得其后表面符合患者天然晶状体的前表面的形状。

4. 发明申请

WO2004029675A1 METHOD OF MANUFACTURING OPHTHALMIC LENSES MADE FROM HYDROPHOBIC ACRYLIC POLYMERS 审中-公开
标题翻译：从疏水性丙烯酸聚合物制造眼镜的方法
公开(公告)号：WO2004029675A1
公开(公告)日：2004-04-08
申请号：PCT/US2003/027811
申请日：2003-09-04
申请人： MEDENNIUM, INC.
发明人： LIAO, Xiugao , WILCOX, Christopher, D.
IPC分类号： G02B1/04
CPC分类号： B29D11/023
摘要： A method of forming an ophthalmic lens, such as an intraocular lens, from a hydrophobic acrylic polymer is disclosed. In this method, a pre-polymer gel is formed form the hydrophobic acrylic polymer, at least the optical portion of the lens is formed from the gel using a fused silica mold, and the lens is solvent extracted such that it remains transparent and substantially without glistenings in an aqueous medium.
摘要翻译：公开了从疏水性丙烯酸类聚合物形成眼用透镜的方法，例如眼内透镜。在该方法中，由疏水性丙烯酸类聚合物形成预聚物凝胶，至少透镜的光学部分使用熔融石英模具由凝胶形成，并且透镜被溶剂萃取使得其保持透明并且基本上不含水性介质中的闪光。

5. 发明授权

EP1289740B1 CRYSTALLINE POLYMERIC COMPOSITIONS FOR OPHTHALMIC DEVICES 有权
标题翻译：液晶聚合物组合物眼科器械
公开(公告)号：EP1289740B1
公开(公告)日：2005-08-10
申请号：EP01916703.0
申请日：2001-03-16
申请人： Medennium, Inc.
发明人： ZHOU, Stephen, Q. , WILCOX, Christopher, D. , LIAU, Christine , VALYUNIN, Igor
IPC分类号： B29D11/02 , A61F2/16 , B29C61/06 , A61L27/16
CPC分类号： A61F2/16 , A61F2/145 , A61F2002/1681 , A61L27/16 , A61L2430/16 , Y10S623/907 , C08L33/10
摘要： Ophthalmic devices suitable for implantation into the eye through small incisions are disclosed. These devices are made from a composition comprising crystalline or semi-crystalline polymeric materials which have a glass transition temperature (Tg) of from about -100° C. to about 20° C., a melting point temperature (Tm) of from about 0° C. to about 37° C., and wherein Tg for the material is lower than Tm for the composition. Disclosed devices include intraocular lenses, corneal inlays, ocular drug delivery devices and implants for reducing intraocular pressure in glaucoma patients; intraocular lenses are preferred.

6. 发明授权

EP1305061B1 OCULAR PLUG FOR PUNCTAL AND INTRACANALICULAR IMPLANTS 有权
标题翻译： OKULARPFROPF眼泪和点INTRAKANALIKULÄRES植入
公开(公告)号：EP1305061B1
公开(公告)日：2004-11-03
申请号：EP00991677.6
申请日：2000-08-04
申请人： Medennium, Inc.
发明人： ZHOU, Stephen, Q. , WILCOX, Christopher, D. , ABADIA, Julian
IPC分类号： A61L31/04 , A61L27/50 , A61L31/06 , A61L31/14
CPC分类号： A61L31/14 , A61L31/048 , A61L31/06 , A61L2430/16 , C08L33/08 , C08L33/12 , C08L83/08
摘要： An ocular plug design and method of insertion is described for the treatment of dry eye. This ocular plug is a narrow rod-like cylinder of appropriate diameter, which is tapered at one end, for insertion into an ocular channel. The plug is prepared from either (or both) of two specific classes of polymeric materials having both viscous and elastic properties. The first class of polymeric materials have a glass transition temperature (Tg) at or below human body temperature (37 °C). The second class of polymeric materials have a melting temperature (Tm) at or below human body temperature (37 °C). The plug is stored in a frozen, rigid, elongated state prior to insertion into an ocular channel. Once inserted into an ocular channel, the smart plug responds to an increase in temperature, due to the surrounding physiochemical environment, whereby it becomes soft and the plug subsequently expands to adapt to the size and shape of the patient's punctum or canaliculum. Once the plug expands to the size of the particular ocular channel, the plug is met with a resistance from the surrounding tissue. At this point, expansion of the plug ceases and the plug can effectively block tear drainage through either ocular channel.

7. 发明公开

EP3270822A1 IMPROVED SELF-CENTERING PHAKIC REFRACTIVE LENSES WITH PARACHUTE DESIGN 有权
标题翻译：采用PARACHUTE设计的改进的自定心PHAKIC REFRACTIVE LENSES
公开(公告)号：EP3270822A1
公开(公告)日：2018-01-24
申请号：EP16714645.5
申请日：2016-03-16
申请人： Medennium, Inc.
发明人： WILCOX, Christopher, D. , DEMENTIEV, Dimitrii , FELDMAN, Jacob , ABADIA, Julian
IPC分类号： A61F2/16
CPC分类号： A61F2/1601 , A61F2/161 , A61F2002/1683 , A61F2002/1689 , A61F2009/00863
摘要： An improved self-centering phakic refractive lens is disclosed. The lens floats freely in the posterior chamber of the eye and corrects vision of the patient but also prevents buildup of intraocular pressure, cataract induction and iris pigment dispersion. The lens comprises an optical body, haptic members which extend outward from the optical body, and a small hole in the approximate center of the optical body for the purpose of allowing aqueous humor to flow through that hole. The lens is designed such that its posterior surface conforms to the shape of the anterior surface of the patient's natural crystalline lens.

8. 发明授权

EP1758521B1 PHOTOCHROMIC INTRAOCULAR LENSES AND METHODS OF MAKING THE SAME 有权
标题翻译： PHOTO铬人工晶体及其制造方法
公开(公告)号：EP1758521B1
公开(公告)日：2012-02-08
申请号：EP05771578.1
申请日：2005-06-16
申请人： Medennium, Inc.
发明人： ZHOU, Stephen, Q. , WILCOX, Christopher, D. , LIAU, Christine
IPC分类号： A61F2/16
CPC分类号： B29D11/023 , A61F2/1659 , A61F2002/16965 , A61F2240/001
摘要： Intraocular lenses containing a photochromic agent having its maximum absorption peak in the wavelength range of about 400-500 nm, are disclosed. Methods for making these intraocular lenses are also taught.

9. 发明公开

EP1543356A1 METHOD OF MANUFACTURING OPHTHALMIC LENSES MADE FROM HYDROPHOBIC ACRYLIC POLYMERS 审中-公开
标题翻译：用于生产疏水POLYACRALATEN眼镜片
公开(公告)号：EP1543356A1
公开(公告)日：2005-06-22
申请号：EP03754446.7
申请日：2003-09-04
申请人： Medennium, Inc.
发明人： LIAO, Xiugao , WILCOX, Christopher, D.
IPC分类号： G02B1/04 , A61L27/16 , A61F2/16
CPC分类号： B29D11/023
摘要： A method of forming an ophthalmic lens, such as an intraocular lens, from a hydrophobic acrylic polymer is disclosed. In this method, a pre-polymer gel is formed form the hydrophobic acrylic polymer, at least the optical portion of the lens is formed from the gel using a fused silica mold, and the lens is solvent extracted such that it remains transparent and substantially without glistenings in an aqueous medium.

10. 发明公开

EP1305061A1 OCULAR PLUG FOR PUNCTAL AND INTRACANALICULAR IMPLANTS 有权
标题翻译：用于P骨和跖骨植入物的眼球塞
公开(公告)号：EP1305061A1
公开(公告)日：2003-05-02
申请号：EP00991677.6
申请日：2000-08-04
申请人： Medennium, Inc.
发明人： ZHOU, Stephen, Q. , WILCOX, Christopher, D. , ABADIA, Julian
IPC分类号： A61L31/04 , A61L27/50 , A61L31/06 , A61L31/14
CPC分类号： A61L31/14 , A61L31/048 , A61L31/06 , A61L2430/16 , C08L33/08 , C08L33/12 , C08L83/08
摘要： An ocular plug design and method of insertion is described for the treatment of dry eye. This ocular plug is a narrow rod-like cylinder of appropriate diameter, which is tapered at one end, for insertion into an ocular channel. The plug is prepared from either (or both) of two specific classes of polymeric materials having both viscous and elastic properties. The first class of polymeric materials have a glass transition temperature (Tg) at or below human body temperature (37 °C). The second class of polymeric materials have a melting temperature (Tm) at or below human body temperature (37 °C). The plug is stored in a frozen, rigid, elongated state prior to insertion into an ocular channel. Once inserted into an ocular channel, the smart plug responds to an increase in temperature, due to the surrounding physiochemical environment, whereby it becomes soft and the plug subsequently expands to adapt to the size and shape of the patient's punctum or canaliculum. Once the plug expands to the size of the particular ocular channel, the plug is met with a resistance from the surrounding tissue. At this point, expansion of the plug ceases and the plug can effectively block tear drainage through either ocular channel.
摘要翻译：描述了用于治疗干眼症的眼插塞设计和插入方法。该眼球塞是一个适当直径的窄杆状圆柱体，其一端渐缩，用于插入眼睛通道。塞由两种具有粘性和弹性的聚合物材料中的一种（或两种）制备。第一类聚合物材料具有等于或低于人体温度（37℃）的玻璃化转变温度（Tg）。第二类聚合物材料具有等于或低于人体温度（37℃）的熔化温度（Tm）。在插入眼部通道之前，塞子以冷冻，刚性，拉长状态储存。一旦插入眼通道中，由于周围的生理化学环境，智能插头响应于温度的升高，从而其变得柔软并且插头随后扩展以适应患者的泪点或小管的尺寸和形状。一旦塞子膨胀至特定眼通道的大小，塞子就会受到来自周围组织的阻力。此时，塞子的膨胀停止，并且塞子可以有效地阻止通过任一眼部通道的泪液排出。

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