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1. 发明申请

WO2011156698A3 NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS 审中-公开
标题翻译：新型吡咯并[3,4-d]吡嗪化合物
公开(公告)号：WO2011156698A3
公开(公告)日：2012-02-09
申请号：PCT/US2011039958
申请日：2011-06-10
申请人： ABBOTT LAB , WOLLER KEVIN R , CURTIN MICHAEL L , FRANK KRISTINE E , JOSEPHSOHN NATHAN S , LI BIQIN C , WISHART NEIL
发明人： WOLLER KEVIN R , CURTIN MICHAEL L , FRANK KRISTINE E , JOSEPHSOHN NATHAN S , LI BIQIN C , WISHART NEIL
IPC分类号： A01N43/38 , A61K31/40
CPC分类号： C07D487/04
摘要： The present disclosure is directed to novel compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are as defined herein. The compounds of Formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, Crohn's disease, psoriasis and asthma.
摘要翻译：本公开涉及新的式（I）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。式（I）的化合物可用作激酶抑制剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如类风湿性关节炎，系统性红斑狼疮，多发性硬化症，克罗恩病疾病，牛皮癣和哮喘。

2. 发明申请

WO2011068881A1 NOVEL TRICYCLIC COMPOUNDS 审中-公开
标题翻译：新型三聚体化合物
公开(公告)号：WO2011068881A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058572
申请日：2010-12-01
申请人： ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
发明人： WISHART, Neil , ARGIRIADI, Maria, A. , CALDERWOOD, David, J. , ERICSSON, Anna, M. , FIAMENGO, Bryan, A. , FRANK, Kristine, E. , FRIEDMAN, Michael , GEORGE, Dawn, M. , GOEDKEN, Eric, R. , JOSEPHSOHN, Nathan, S. , LI, Biqin, C. , MORYTKO, Michael, J. , STEWART, Kent, D. , VOSS, Jeffrey, W. , WALLACE, Grier, A. , WANG, Lu , WOLLER, Kevin, R.
IPC分类号： A01N43/58
CPC分类号： C07D487/14 , A61K31/437 , A61K31/4985 , A61K45/06 , C07D471/14 , C07D498/14 , C07D513/14
摘要： The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

3. 发明申请

WO2008060766A3 HISTAMINE H4 RECEPTOR LIGANDS FOR USE IN PAIN TREATMENT 审中-公开
标题翻译： HISTAMINE H4受体配体用于治疗疼痛
公开(公告)号：WO2008060766A3
公开(公告)日：2009-02-19
申请号：PCT/US2007080132
申请日：2007-10-02
申请人： ABBOTT LAB , COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D
发明人： COWART MARLON D , ALTENBACH ROBERT J , LIU HUAQING , DRIZIN IRENE , WISHART NEIL , BABINSKI DAVID J , GREGG ROBERT J , ESBENSHADE TIMOTHY A , HSIEH GIN C , BRIONI JORGE D , HONORE MARIE P , BLACK LAWRENCE A , ZHAO CHEN , WAKEFIELD BRIAN D , HANCOCK ARTHUR A
IPC分类号： A61K31/417 , A61K31/496 , A61K31/506 , A61K45/06 , A61P29/00
CPC分类号： A61K31/506 , A61K31/417 , A61K31/496 , A61K45/06
摘要： This invention discloses histamine H4 receptor ligands for use in a method of treating pain
摘要翻译：本发明公开了用于治疗疼痛的方法中的组胺H 4受体配体

4. 发明申请

WO2013043826A1 TRICYCLIC COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：三分子化合物作为蛋白激酶抑制剂有用
公开(公告)号：WO2013043826A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/056266
申请日：2012-09-20
申请人： ABBVIE INC. , WISHART, Neil , BONAFOUX, Dominique F. , FRANK, Kristine E. , HOBSON, Adrian D. , KONOPACKI, Donald B, , MARTINEZ, Gloria Y. , WANG, Lu
发明人： WISHART, Neil , BONAFOUX, Dominique F. , FRANK, Kristine E. , HOBSON, Adrian D. , KONOPACKI, Donald B, , MARTINEZ, Gloria Y. , WANG, Lu
IPC分类号： C07D471/14 , C07D487/14 , A61K31/4985 , A61K31/437 , A61P35/00 , A61P37/00
CPC分类号： C07D487/14 , C07D471/14
摘要： The invention provides compounds of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫和肿瘤病症。

5. 发明申请

WO2011079105A1 NOVEL THIENOPYRROLE COMPOUNDS 审中-公开
标题翻译：新型三硝基化合物
公开(公告)号：WO2011079105A1
公开(公告)日：2011-06-30
申请号：PCT/US2010/061475
申请日：2010-12-21
申请人： ABBOTT LABORATORIES , ERICSSON, Anna M. , EDMUNDS, Jeremy J. , HOBSON, Adrian D. , STEWART, Kent D. , WISHART, Neil , WANG, Lei , IHLE, David C. , FERENZ, Catherine R. , DUNSTAN, Theresa A. , WANG, Lu
发明人： ERICSSON, Anna M. , EDMUNDS, Jeremy J. , HOBSON, Adrian D. , STEWART, Kent D. , WISHART, Neil , WANG, Lei , IHLE, David C. , FERENZ, Catherine R. , DUNSTAN, Theresa A. , WANG, Lu
IPC分类号： C07D265/00
CPC分类号： C07D487/04 , C07D487/08 , C07D495/04 , C07D498/04
摘要： The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

6. 发明申请

WO2007117465A2 INDAZOLE COMPOUNDS 审中-公开
标题翻译： INDAZOLE化合物
公开(公告)号：WO2007117465A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008307
申请日：2007-04-02
申请人： ABBOTT LABORATORIES , ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
发明人： ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
IPC分类号： A61K31/5377
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

7. 发明申请

WO2005110410A3 KINASE INHIBITORS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：激酶抑制剂作为治疗剂
公开(公告)号：WO2005110410A3
公开(公告)日：2007-03-29
申请号：PCT/US2005016903
申请日：2005-05-13
申请人： ABBOTT LAB , CUSACK KEVIN , SALMERON-GARCIA JOSE-ANDRES , GORDON THOMAS D , BARBERIS CLAUDE E , ALLEN HAMISH J , BISCHOFF AGNIESZKA K , ERICSSON ANNA M , FRIEDMAN MICHAEL M , GEORGE DAWN M , ROTH GREGORY P , TALANIAN ROBERT V , THOMAS CHRISTINE , WALLACE GRIER A , WISHART NEIL , YU ZHENGTIAN
发明人： CUSACK KEVIN , SALMERON-GARCIA JOSE-ANDRES , GORDON THOMAS D , BARBERIS CLAUDE E , ALLEN HAMISH J , BISCHOFF AGNIESZKA K , ERICSSON ANNA M , FRIEDMAN MICHAEL M , GEORGE DAWN M , ROTH GREGORY P , TALANIAN ROBERT V , THOMAS CHRISTINE , WALLACE GRIER A , WISHART NEIL , YU ZHENGTIAN
IPC分类号： C07D471/02 , A61K31/4743 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/02
CPC分类号： C07D471/04 , A61K31/4743 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译：式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

8. 发明申请

WO1998029411A1 SULFONAMIDE COMPOUNDS HAVING 5-HT RECEPTOR ACTIVITY 审中-公开
标题翻译：具有5-HT受体活性的磺酰胺化合物
公开(公告)号：WO1998029411A1
公开(公告)日：1998-07-09
申请号：PCT/EP1997007034
申请日：1997-12-15
申请人： KNOLL AKTIENGESELLSCHAFT , WISHART, Neil , BIRCH, Alan, Martin
发明人： KNOLL AKTIENGESELLSCHAFT
IPC分类号： C07D405/06
CPC分类号： C07D405/06 , C07D405/12 , C07D405/14 , C07D413/14 , C07D493/04
摘要： Compounds of formula (I) and pharmaceutically acceptable salts thereof in which A is methylene or -O-; B is methylene or -O-; g is 0, 1, 2, 3 or 4; U is an alkylene chain optionally substituted by one or more alkyl; Q represents a divalent group containing nitrogen atoms; and T represents an aryl or heteroaryl group, have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendocrine system, stress and spasticity.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中A是亚甲基或-O-; B是亚甲基或-O-; g为0,1,2,3或4; U是任选被一个或多个烷基取代的亚烷基链; Q表示含有氮原子的二价基团; 和T代表芳基或杂芳基，可用于治疗中枢神经系统疾病，例如抑郁症，焦虑症，精神病（例如精神分裂症），迟发性运动障碍，帕金森病，肥胖症，高血压，图雷特综合征，性功能障碍，药物成瘾，药物滥用，认知障碍，阿尔茨海默病，老年痴呆，强迫症，恐慌发作，社交恐怖症，进食障碍和厌食症，心血管和脑血管疾病，非胰岛素依赖性糖尿病，高血糖症，便秘，心律失常，神经内分泌系统，压力和痉挛状态。

9. 发明申请

WO2011068899A1 NOVEL TRICYCLIC COMPOUNDS 审中-公开
标题翻译：新型三聚体化合物
公开(公告)号：WO2011068899A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/058598
申请日：2010-12-01
申请人： ABBOTT LABORATORIES , WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
发明人： WISHART, Neil , ARGIRIADI, Maria A. , BREINLINGER, Eric C. , CALDERWOOD, David J. , ERICSSON, Anna M. , FIAMENGO, Bryan A. , FRANK, Kristine E. , FRIEDMAN, Michael , GEORGE, Dawn M. , GOEDKEN, Eric R. , JOSEPHSOHN, Nathan S. , LI, Biqin C. , MORYTKO, Michael J. , MULLEN, Kelly D. , SOMAL, Gagandeep , STEWART, Kent D. , VOSS, Jeffrey W. , WALLACE, Grier A. , WANG, Lu , WOLLER, Kevin R.
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07F9/06 , C07D471/14 , C07D487/14 , C07D498/14 , C07D513/14
摘要： The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
摘要翻译：本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik），或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。本发明的化合物可用于治疗免疫学和肿瘤学病症。

10. 发明申请

WO2008060767A3 MACROCYCLIC BENZOFUSED PYRIMIDINE DERIVATIVES 审中-公开
公开(公告)号：WO2008060767A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/080133
申请日：2007-10-02
申请人： ABBOTT LABORATORIES , ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , COWART, Marlon D , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D.
发明人： ALTENBACH, Robert J , LIU, Huaqing , DRIZIN, Irene , COWART, Marlon D , WISHART, Neil , BABINSKI, David J , GREGG, Robert J , ESBENSHADE, Timothy A , HSIEH, Gin C , BRIONI, Jorge D , HONORE, Marie P , BLACK, Lawrence A , ZHAO, Chen , WAKEFIELD, Brian D.
IPC分类号： C07D491/04 , C07D493/04 , C07H17/04
摘要： Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

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