会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明申请
    • SULFONAMIDE COMPOUNDS HAVING 5-HT RECEPTOR ACTIVITY
    • 具有5-HT受体活性的磺酰胺化合物
    • WO1998029411A1
    • 1998-07-09
    • PCT/EP1997007034
    • 1997-12-15
    • KNOLL AKTIENGESELLSCHAFTWISHART, NeilBIRCH, Alan, Martin
    • KNOLL AKTIENGESELLSCHAFT
    • C07D405/06
    • C07D405/06C07D405/12C07D405/14C07D413/14C07D493/04
    • Compounds of formula (I) and pharmaceutically acceptable salts thereof in which A is methylene or -O-; B is methylene or -O-; g is 0, 1, 2, 3 or 4; U is an alkylene chain optionally substituted by one or more alkyl; Q represents a divalent group containing nitrogen atoms; and T represents an aryl or heteroaryl group, have utility in the treatment of central nervous system disorders, for example depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, Parkinson's disease, obesity, hypertension, Tourette's syndrome, sexual dysfunction, drug addiction, drug abuse, cognitive disorders, Alzheimer's disease, senile dementia, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders and anorexia, cardiovascular and cerebrovascular disorders, non-insulin dependent diabetes mellitus, hyperglycaemia, constipation, arrhythmia, disorders of the neuroendocrine system, stress and spasticity.
    • 式(I)化合物及其药学上可接受的盐,其中A是亚甲基或-O-; B是亚甲基或-O-; g为0,1,2,3或4; U是任选被一个或多个烷基取代的亚烷基链; Q表示含有氮原子的二价基团; 和T代表芳基或杂芳基,可用于治疗中枢神经系统疾病,例如抑郁症,焦虑症,精神病(例如精神分裂症),迟发性运动障碍,帕金森病,肥胖症,高血压,图雷特综合征,性功能障碍,药物 成瘾,药物滥用,认知障碍,阿尔茨海默病,老年痴呆,强迫症,恐慌发作,社交恐怖症,进食障碍和厌食症,心血管和脑血管疾病,非胰岛素依赖性糖尿病,高血糖症,便秘,心律失常, 神经内分泌系统,压力和痉挛状态。