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1. 发明申请

WO2005110410A2 KINASE INHIBITORS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：激酶抑制剂作为治疗药物
公开(公告)号：WO2005110410A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/016903
申请日：2005-05-13
申请人： ABBOTT LABORATORIES , CUSACK, Kevin , SALMERON-GARCIA, Jose-Andres , GORDON, Thomas D. , BARBERIS, Claude E. , ALLEN, Hamish J. , BISCHOFF, Agniezka K. , ERICSSON, Anna M. , FRIEDMAN, Michael M. , GEORGE, Dawn M. , ROTH, Gregory P. , TALANIAN, Robert V. , THOMAS, Christine , WALLACE, Grier A. , WISHART, Neil , YU, Zhengtian
发明人： CUSACK, Kevin , SALMERON-GARCIA, Jose-Andres , GORDON, Thomas D. , BARBERIS, Claude E. , ALLEN, Hamish J. , BISCHOFF, Agniezka K. , ERICSSON, Anna M. , FRIEDMAN, Michael M. , GEORGE, Dawn M. , ROTH, Gregory P. , TALANIAN, Robert V. , THOMAS, Christine , WALLACE, Grier A. , WISHART, Neil , YU, Zhengtian
IPC分类号： A61K31/4743
CPC分类号： C07D471/04 , A61K31/4743 , C07D487/04 , C07D491/04 , C07D495/04 , Y02A50/481
摘要： A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译：式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

2. 发明申请

WO2011163478A3 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2011163478A3
公开(公告)日：2012-05-03
申请号：PCT/US2011041633
申请日：2011-06-23
申请人： ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
发明人： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
IPC分类号： A61K39/395 , C07K16/00 , C12P21/02
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

3. 发明申请

WO2011163478A2 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
公开(公告)号：WO2011163478A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041633
申请日：2011-06-23
申请人： ABBOTT LABORATORIES , GHAYUR, Tariq , LIU, Junjian , JAKWAY, James, J. , TALANIAN, Robert, V. , BENATUIL, Lorenzo
发明人： GHAYUR, Tariq , LIU, Junjian , JAKWAY, James, J. , TALANIAN, Robert, V. , BENATUIL, Lorenzo
IPC分类号： A61K39/395 , C07K16/24 , C12N9/96 , C07H21/00 , C12N15/63 , C12P21/00 , G01N33/566 , C12N5/10 , C12N1/21 , C12N1/15 , C12N1/00 , A61P29/00 , A61P35/00
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

4. 发明申请

WO2009128931A1 IN VITRO ESTIMATION OF IN VIVO HALF-LIFE BINDING PROTEINS 审中-公开
标题翻译：估计的
公开(公告)号：WO2009128931A1
公开(公告)日：2009-10-22
申请号：PCT/US2009/002384
申请日：2009-04-16
申请人： ABBOTT LABORATORIES , TALANIAN, Robert, V.
发明人： TALANIAN, Robert, V.
IPC分类号： C12Q1/34
CPC分类号： C12Q1/37
摘要： The present invention discloses methods used to estimate the in vivo half-life of a binding protein of interest. The disclosed methods involve (a) determining for a binding protein of interest and for each of at least two different reference binding proteins an in vitro half-life using an in vitro protease reaction assay, wherein said reference binding proteins have known different in vivo half-lives, (b) determining the correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of each of the reference binding proteins, and (c) estimating from said correlation between the known in vivo half-lives and the in vitro proteolytic half-lives of the reference binding proteins the in vivo half-life of the binding protein of interest that correlates with the in vitro proteolytic half-life of the binding protein of interest.
摘要翻译：本发明涉及一种用于估计一个有趣的结合蛋白的体内半衰期的方法。所公开的方法包括（a）确定的目标结合蛋白的体外半衰期的步骤和各使用蛋白酶反应的体外测定在至少两个不同参照结合蛋白的，所述参照结合蛋白具有不同的半衰期体内已知的，（b）确定在每个所述参考的已知的体外半衰期在体内和蛋白水解半衰期之间的相关性结合蛋白，和（c 从已知的半衰期在体内和半衰期之间的所述相关）蛋白水解估计体外参照结合蛋白有趣的结合蛋白的体内半衰期，其与半衰期相关蛋白在体外结合蛋白有趣。

5. 发明申请

WO2007117465A3 INDAZOLE COMPOUNDS 审中-公开
标题翻译： INDAZOLE化合物
公开(公告)号：WO2007117465A3
公开(公告)日：2008-08-28
申请号：PCT/US2007008307
申请日：2007-04-02
申请人： ABBOTT LAB , ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
发明人： ERICSSON ANNA M , BURCHAT ANDREW , FRANK KRISTINE E , CALDERWOOD DAVID J , ABBOTT LILY K , ARGIRIADI MARIA A , BORHANI DAVID W , CUSACK KEVIN P , DIXON RICHARD W , GORDON THOMAS D , MULLEN KELLY D , TALANIAN ROBERT V , WU XIAOYUN , ZHANG XIAOLEI , WANG LU X , LI BIQIN , BARBERIS CLAUDE E , WISHART NEIL
IPC分类号： A61K31/5377
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

6. 发明申请

WO2007117465A2 INDAZOLE COMPOUNDS 审中-公开
标题翻译： INDAZOLE化合物
公开(公告)号：WO2007117465A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/008307
申请日：2007-04-02
申请人： ABBOTT LABORATORIES , ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
发明人： ERICSSON, Anna M. , BURCHAT, Andrew , FRANK, Kristine E. , CALDERWOOD, David J. , ABBOTT, Lily K. , ARGIRIADI, Maria A. , BORHANI, David W. , CUSACK, Kevin P. , DIXON, Richard W. , GORDON, Thomas D. , MULLEN, Kelly D. , TALANIAN, Robert V. , WU, Xiaoyun , ZHANG, Xiaolei , WANG, Lu X. , LI, Biqin , BARBERIS, Claude E. , WISHART, Neil
IPC分类号： A61K31/5377
CPC分类号： C07D487/04 , C07D403/12 , C07D403/14 , C07D409/04 , C07D409/14
摘要： Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.
摘要翻译：式（I）的新型化合物或其药学上可接受的盐，前体药物和式（I）的生物活性代谢物，其中取代基如本文所定义，其可用作治疗剂。

7. 发明申请

WO2005110410A3 KINASE INHIBITORS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：激酶抑制剂作为治疗剂
公开(公告)号：WO2005110410A3
公开(公告)日：2007-03-29
申请号：PCT/US2005016903
申请日：2005-05-13
申请人： ABBOTT LAB , CUSACK KEVIN , SALMERON-GARCIA JOSE-ANDRES , GORDON THOMAS D , BARBERIS CLAUDE E , ALLEN HAMISH J , BISCHOFF AGNIESZKA K , ERICSSON ANNA M , FRIEDMAN MICHAEL M , GEORGE DAWN M , ROTH GREGORY P , TALANIAN ROBERT V , THOMAS CHRISTINE , WALLACE GRIER A , WISHART NEIL , YU ZHENGTIAN
发明人： CUSACK KEVIN , SALMERON-GARCIA JOSE-ANDRES , GORDON THOMAS D , BARBERIS CLAUDE E , ALLEN HAMISH J , BISCHOFF AGNIESZKA K , ERICSSON ANNA M , FRIEDMAN MICHAEL M , GEORGE DAWN M , ROTH GREGORY P , TALANIAN ROBERT V , THOMAS CHRISTINE , WALLACE GRIER A , WISHART NEIL , YU ZHENGTIAN
IPC分类号： C07D471/02 , A61K31/4743 , C07D471/04 , C07D491/04 , C07D495/04 , C07D498/02
CPC分类号： C07D471/04 , A61K31/4743 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译：式（I）的化合物或其药学上可接受的盐，其中取代基如本文所定义，其可用作激酶抑制剂。

8. 发明申请

WO2011163478A4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开
标题翻译：双变量域免疫球蛋白及其用途
公开(公告)号：WO2011163478A4
公开(公告)日：2012-07-05
申请号：PCT/US2011041633
申请日：2011-06-23
申请人： ABBOTT LAB , GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
发明人： GHAYUR TARIQ , LIU JUNJIAN , JAKWAY JAMES J , TALANIAN ROBERT V , BENATUIL LORENZO
IPC分类号： A61K39/395 , C07K16/00 , C12P21/02
CPC分类号： C07K16/2875 , C07K16/241 , C07K16/468 , C07K2317/31 , C07K2317/64
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译：本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。

9. 发明申请

WO1996026280A1 NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1'beta' CONVERTING ENZYME 审中-公开
标题翻译：与白细胞介素-1转化酶相关的新型CYSTEINE蛋白
公开(公告)号：WO1996026280A1
公开(公告)日：1996-08-29
申请号：PCT/US1996002418
申请日：1996-02-21
申请人： BASF AKTIENGESELLSCHAFT , KAMENS, Joanne , ALLEN, Hamish , PASKIND, Michael , MANKOVICH, John, A. , TALANIAN, Robert, V. , GHAYUR, Tariq
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C12N15/57
CPC分类号： C12N9/6475 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： A novel human cysteine protease (referred to as Ich-2 or Bih-3) related to interleukin-1 beta converting enzyme (ICE) but having an amino acid sequence that differs by 47 % from that of ICE is disclosed. The Ich-2 protein of the invention exhibits proteolytic activity and can induce apoptosis in cells. The invention provides isolated nucleic acid molecules encoding Ich-2 (including proteolytic cleavage products, subunits, fusion proteins and non-naturally occurring homologs thereof), as well as recombinant expression vectors containing these nucleic acid molecules, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying an Ich-2-encoding nucleic acid. The invention further provides isolated Ich-2 proteins (including proteolytic cleavage products, subunits, fusion proteins and non-naturally occurring homologs thereof), as well as anti-Ich-2 antibodies. The invention still further provides methods for identifying modulators of Ich-2 protease activity (e.g., inhibitors and activators) and methods for modulating apoptisis in cells.
摘要翻译：公开了与白细胞介素-1β转换酶（ICE）相关但具有与ICE不同的氨基酸序列47％的新型人半胱氨酸蛋白酶（称为Ich-2或Bih-3）。本发明的Ich-2蛋白质表现出蛋白水解活性，可诱导细胞凋亡。本发明提供编码Ich-2（包括蛋白水解切割产物，亚基，融合蛋白和非天然存在的同系物）的分离的核酸分子，以及含有这些核酸分子的重组表达载体，表达载体具有的宿主细胞和携带编码Ich-2的核酸的非人转基因动物。本发明还提供了分离的Ich-2蛋白（包括蛋白水解切割产物，亚基，融合蛋白和非天然存在的同系物）以及抗-Ich-2抗体。本发明还提供了鉴定Ich-2蛋白酶活性调节剂的方法（例如抑制剂和激活剂）以及调节细胞凋亡的方法。

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