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1. 发明申请

WO2005072710A2 DRUGS AND GENE CARRIER PARTICLES THAT RAPIDLY MOVE THROUGH MUCOUS BARRIERS 审中-公开
标题翻译：药物和基因携带者粒子快速移动通过MUCOUS障碍
公开(公告)号：WO2005072710A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002556
申请日：2005-01-28
申请人： JOHNS HOPKINS UNIVERSITY , HANES, Justin , DAWSON, Michelle, Rose , WIRTZ, Denis , FU, Jie , KRAULAND, Eric, Mark
发明人： HANES, Justin , DAWSON, Michelle, Rose , WIRTZ, Denis , FU, Jie , KRAULAND, Eric, Mark
IPC分类号： A61K9/51
CPC分类号： A61K9/5153 , A61K9/0073 , A61K9/167 , A61K9/5031 , A61K9/5123 , A61K9/5146 , A61K47/543 , A61K47/6935 , A61K47/6937 , A61K48/0033 , A61K48/0041 , B82Y5/00
摘要： The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
摘要翻译：本发明一般涉及适合于通过粘膜屏障传递生物活性剂的聚合物颗粒。本发明还涉及制备和使用这些聚合物颗粒的方法。

2. 发明申请

WO02060377A3 THE SEPARATION, IDENTIFICATION AND QUANTITATION OF PROTEIN MIXTURES 审中-公开
标题翻译：蛋白质混合物的分离，鉴定和定量
公开(公告)号：WO02060377A3
公开(公告)日：2003-01-03
申请号：PCT/US0147754
申请日：2001-12-14
申请人： UNIV JOHNS HOPKINS , KATZ JOSEPH L , WIRTZ DENIS
发明人： KATZ JOSEPH L , WIRTZ DENIS
IPC分类号： B01J19/00 , G01N33/543 , G01N33/553 , G01N33/53 , G01N33/537
CPC分类号： B01J19/0093 , B01J2219/00864 , B01J2219/00952 , G01N33/54326
摘要： A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.
摘要翻译：用于蛋白质混合物中蛋白质的快速分离，鉴定，分类和定量的重复分类程序（RCP）利用通常基序抗体，其通常结合具有共同基序或同系物的混合物中的多种蛋白质一些尊重通过重复使用一般基序抗体或使用一般基序抗体与特异性抗体结合，可以产生唯一识别感兴趣蛋白质的结合模式。通过使用固定的一般基序抗体来实现分离，样品中蛋白质的鉴定，分类和定量可用于表征疾病状态的蛋白质合成模式。可以基于磁场中具有结合蛋白质的非常小的珠粒的移动来确定样品中的蛋白质的定量，其中较大量的结合蛋白质导致珠粒行进相对较小的距离或以相对较慢的速率行进。

3. 发明申请

WO2002060377A2 THE SEPARATION, IDENTIFICATION AND QUANTITATION OF PROTEIN MIXTURES 审中-公开
标题翻译：蛋白质混合物的分离，鉴定和定量
公开(公告)号：WO2002060377A2
公开(公告)日：2002-08-08
申请号：PCT/US2001/047754
申请日：2001-12-14
申请人： THE JOHNS HOPKINS UNIVERSITY , KATZ, Joseph, L. , WIRTZ, Denis
发明人： KATZ, Joseph, L. , WIRTZ, Denis
IPC分类号： A61K
CPC分类号： B01J19/0093 , B01J2219/00864 , B01J2219/00952 , G01N33/54326
摘要： A Repeated Classification Procedure (RCP) for the rapid separation, identification, classification, and quantitation of proteins in a mixture of proteins utilizes general-motif antibodies which typically bind to a plurality of proteins in a mixture which have a common motif or are homologs in some respect. By repeatedly using general-motif antibodies or using general-motif antibodies in conjunction with specific antibodies, a pattern of binding can be produced which uniquely identifies proteins of interest. By using immobilized general-motif antibodies to effect separation, the identification, classification, and quantitation of proteins in a sample can be use to characterize the protein synthesis pattern of disease states. Quantitation of protein in a sample can be determined based on the movement of very small beads with bound protein in a magnetic field, wherein larger quantities of bound protein causes the beads to travel relatively smaller distances or at relatively slower rates.
摘要翻译：用于蛋白质混合物中蛋白质的快速分离，鉴定，分类和定量的重复分类程序（RCP）利用通常基序抗体，其通常结合具有共同基序或同系物的混合物中的多种蛋白质一些尊重通过重复使用一般基序抗体或使用一般基序抗体与特异性抗体结合，可以产生唯一识别感兴趣蛋白质的结合模式。通过使用固定的一般基序抗体来实现分离，样品中蛋白质的鉴定，分类和定量可用于表征疾病状态的蛋白质合成模式。可以基于磁场中具有结合蛋白质的非常小的珠粒的移动来确定样品中的蛋白质的定量，其中较大量的结合蛋白质导致珠粒行进相对较小的距离或以相对较慢的速率行进。

4. 发明申请

WO2005072710A3 DRUGS AND GENE CARRIER PARTICLES THAT RAPIDLY MOVE THROUGH MUCOUS BARRIERS 审中-公开
标题翻译：药物和基因携带者粒子快速移动通过MUCOUS障碍
公开(公告)号：WO2005072710A3
公开(公告)日：2006-08-03
申请号：PCT/US2005002556
申请日：2005-01-28
申请人： UNIV JOHNS HOPKINS , HANES JUSTIN , DAWSON MICHELLE ROSE , WIRTZ DENIS , FU JIE , KRAULAND ERIC MARK
发明人： HANES JUSTIN , DAWSON MICHELLE ROSE , WIRTZ DENIS , FU JIE , KRAULAND ERIC MARK
IPC分类号： A61K49/12 , A61K9/00 , A61K9/16 , A61K9/50 , A61K9/51 , A61K47/48 , A61K48/00
CPC分类号： A61K9/5153 , A61K9/0073 , A61K9/167 , A61K9/5031 , A61K9/5123 , A61K9/5146 , A61K47/543 , A61K47/6935 , A61K47/6937 , A61K48/0033 , A61K48/0041 , B82Y5/00
摘要： The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.
摘要翻译：本发明一般涉及适合于通过粘膜屏障传递生物活性剂的聚合物颗粒。本发明还涉及制备和使用这些聚合物颗粒的方法。

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