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1. 发明申请

WO2017112617A1 4-AMINO-2-(1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL)-6-OXO-6,7-DIHYDRO-5H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THE RESPECTIVE (1H-INDAZOL-3-YL) DERIVATIVES AS CGMP MODULATORS FOR TREATING CARDIOVASCULAR DISEASES 审中-公开
标题翻译： 4-氨基-2-（1H-吡唑并[3,4-b]吡啶-3-基）-6-氧代-6,7-二氢-5H-吡咯并[2,3-d]嘧啶衍生物和其相应的（ 1H-INDAZOL-3-YL）衍生物作为用于治疗心血管疾病的CGMP调节剂
公开(公告)号：WO2017112617A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067654
申请日：2016-12-20
申请人： MERCK SHARP & DOHME CORP. , BERGER, Raphelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKLE, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron, J. , STELMACH, John , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
发明人： BERGER, Raphelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKLE, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron, J. , STELMACH, John , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R 1 , R 2 , R 4 , R a , and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance, such as cardiovascular disease, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary hypertension (WHO groups I, II, III, IV), angina pectoris, thrombosis, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hypertonia, erectile dysfunction, asthma, acute respiratory distress syndrome (ARDS), chronic kidney disease, cystic fibrosis, sickle cell anemia, scleroderma, Raynaud's Syndrome, diabetes, diabetic retinopathy, cirrhosis of the liver, chronic obstructive pulmonary disease (COPD), acute lung injury, pulmonary fibrosis or interstitial lung disease. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to the compounds or their pharmaceutically acceptable salts for use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
摘要翻译：本发明提供式（I）的化合物或其药学上可接受的盐，其中X，Y，Z，R 1，R 2， R 4，R a和下标m，p和q如本文所述。所述化合物或其药学上可接受的盐可调节身体产生环鸟苷单磷酸（“cGMP”），并且通常适用于治疗和预防与干扰的cGMP平衡有关的疾病，例如心血管疾病，内皮功能障碍，心脏衰竭，肺动脉高压（WHO组I，II，III，IV），心绞痛，血栓形成，再狭窄，心肌梗塞，中风，心功能不全，纤维化，肺高血压，勃起功能障碍，哮喘，急性呼吸窘迫综合征（ARDS），慢性肾病，囊性纤维化，镰状细胞贫血，硬皮病，雷诺氏综合征，糖尿病，糖尿病视网膜病变，肝硬化，慢性阻塞性肺病（COPD），急性肺损伤，肺纤维化或间质肺部疾病。本发明还提供了包含式（I）化合物或其药学上可接受的盐的药物组合物。本发明还涉及用于治疗和预防上述疾病以及为此目的制备药物的化合物或其药学上可接受的盐。

2. 发明申请

WO2015088886A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
标题翻译：可溶性冠状动脉激素
公开(公告)号：WO2015088886A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/068689
申请日：2014-12-05
申请人： MERCK SHARP & DOHME CORP. , HAN, Xiaoqing , WHITEHEAD, Alan , RAGHAVAN, Subharekha , CERNAK, Timothy, A. , DREHER, Spencer , GROEPER, Jonathan , GUO, Jian , ZHANG, Yong
发明人： HAN, Xiaoqing , WHITEHEAD, Alan , RAGHAVAN, Subharekha , CERNAK, Timothy, A. , DREHER, Spencer , GROEPER, Jonathan , GUO, Jian , ZHANG, Yong
IPC分类号： A61K31/519 , A61K31/52 , C07D473/00
CPC分类号： C07D519/00 , A61K31/519 , A61K31/52 , A61K45/06 , C07B2200/05 , A61K2300/00
摘要： A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (" cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceuticall acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula I or a pharmaceutically acceptable salt thereof.
摘要翻译：式I化合物或其药学上可接受的盐能够调节身体产生环鸟苷酸（“cGMP”），并且通常适用于治疗和预防与受干扰的cGMP平衡有关的疾病。本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于此目的的药物以及包含式I化合物的药物制剂或其药学上可接受的盐。

3. 发明申请

WO2013068328A1 BICYCLO [2.2.2] OCTAN-1-YLCARBOXYLIC ACID COMPOUNDS AS DGAT-1 INHIBITORS 审中-公开
标题翻译： BICYCLO [2.2.2] OCT-1-YLCARBOXYLIC ACID化合物作为DGAT-1抑制剂
公开(公告)号：WO2013068328A1
公开(公告)日：2013-05-16
申请号：PCT/EP2012/071894
申请日：2012-11-06
申请人： INTERVET INTERNATIONAL B.V. , CERNAK, Timothy, A. , DE VITA, Robert, J. , YU, Yang , WU, Zhicai , DYKSTRA, Kevin, D. , VERRAS, Andreas , BALKOVEC, James M. , WHITEHEAD, Alan
发明人： CERNAK, Timothy, A. , DE VITA, Robert, J. , YU, Yang , WU, Zhicai , DYKSTRA, Kevin, D. , VERRAS, Andreas , BALKOVEC, James M. , WHITEHEAD, Alan
IPC分类号： C07D403/04 , C07D471/04 , C07D491/04 , C07D498/04 , A61K31/4184 , A61K31/444 , A61K31/437 , A61P3/04 , A61P3/06 , A61P3/10
CPC分类号： C07D498/04 , C07D403/04 , C07D471/04 , C07D491/04
摘要： Described herein are compounds of formula (I). The compounds of formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：本文描述的是式（I）的化合物。式（I）化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。

4. 发明申请

WO2011149921A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS 审中-公开
标题翻译：可溶性葡萄糖循环激活剂
公开(公告)号：WO2011149921A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/037718
申请日：2011-05-24
申请人： MERCK SHARP & DOHME CORP. , RAGHAVAN, Subharekha , STELMACH, John, E. , SMITH, Cameron, J. , LI, Hong , WHITEHEAD, Alan , WADDELL, Sherman, T. , CHEN, Yi-Heng , MIAO, Shouwu , ORNOSKI, Olga, A. , GARFUNKLE, Joie , LIAO, Xibin , CHANG, Jiang , HAN, Xiaoqing , GUO, Jian , GROEPER, Jonathan, A. , BROCKUNIER, Linda, L. , ROSAUER, Keith , PARMEE, Emma, R.
发明人： RAGHAVAN, Subharekha , STELMACH, John, E. , SMITH, Cameron, J. , LI, Hong , WHITEHEAD, Alan , WADDELL, Sherman, T. , CHEN, Yi-Heng , MIAO, Shouwu , ORNOSKI, Olga, A. , GARFUNKLE, Joie , LIAO, Xibin , CHANG, Jiang , HAN, Xiaoqing , GUO, Jian , GROEPER, Jonathan, A. , BROCKUNIER, Linda, L. , ROSAUER, Keith , PARMEE, Emma, R.
IPC分类号： A01N43/90 , A61K31/519
CPC分类号： C07D487/04 , A61K31/519 , C07D519/00
摘要： A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate ("cGMP") and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的化合物或其药学上可接受的盐能够调节身体的环磷酸鸟苷（“cGMP”）的产生，并且通常适用于治疗和预防与受干扰的cGMP平衡相关的疾病。本发明还涉及用于制备式I化合物或其药学上可接受的盐的方法，用于治疗和预防上述疾病和用于制备用于此目的的药物以及包含式（III）化合物的药物制剂 I）或其药学上可接受的盐。

5. 发明申请

WO1983002283A1 PROCESS FOR THE RECOVERY OF OIL FROM SHALE 审中-公开
标题翻译：从鲨鱼中恢复油的过程
公开(公告)号：WO1983002283A1
公开(公告)日：1983-07-07
申请号：PCT/AU1982000162
申请日：1982-09-30
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , CSR LIMITED , McCARTHY, David, John , MANDELSON, John , SITNAI, Oto , WHITEHEAD, Alan, Balmforth
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ... , CSR LIMITED
IPC分类号： C10B53/06
CPC分类号： C10B49/16 , C10G1/02
摘要： A continuous process for recovery of oil and energy from oil shale. Particulate oil shale (1) is mixed with hot particulate heat carrier (2) containing free lime and retorted at conventional retorting temperatures in the presence of a purge gas (3). The purge gas comprises compounds which can react with the free lime. The mixture of spent shale and heat carrier solids (5) is separated from the product gas and vapours (4) and the solids are combusted in air (6), (7) with the optional addition of materials (8) to control the free lime content of the ash product from combustion. A stream of particles (12), extracted from the combustor is separated into a larger portion of coarser hot shale ash which is recirculated to the retorting zone as heat carrier. A smaller stream (15) is disposed of as waste after separating the energy (17) therefrom. The sensible and chemical heat from the waste solids and the sensible heat from the gases leaving the combustion zone, is recovered (J).
摘要翻译：从油页岩回收油和能源的连续过程。颗粒油页岩（1）与含有游离石灰的热颗粒热载体（2）混合，并在常规蒸煮温度下在吹扫气体（3）的存在下进行蒸馏。净化气体包括可以与游离石灰反应的化合物。将废页岩和热载体固体（5）的混合物与产物气体和蒸气（4）分离，固体在空气（6），（7）中燃烧，并且可选地添加材料（8）以控制游离来自燃烧的灰分产品的石灰含量。从燃烧器提取的颗粒物流（12）被分离成大部分较粗的热页岩灰，其作为热载体再循环到蒸煮区。在从其中分离能量（17）之后，将较小的流（15）作为废物进行处置。回收来自废固体的敏感和化学热以及离开燃烧区的气体的显热（J）。

6. 发明申请

WO2019236396A1 TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
公开(公告)号：WO2019236396A1
公开(公告)日：2019-12-12
申请号：PCT/US2019/034783
申请日：2019-05-31
申请人： MERCK SHARP & DOHME CORP. , YU, Tao , WHITEHEAD, Alan , CHEN, Yili , SUN, Chunrui , HU, Zhiyong , ZHAO, Kake , KIM, Ronald, M. , MCCAULEY, John, A.
发明人： YU, Tao , WHITEHEAD, Alan , CHEN, Yili , SUN, Chunrui , HU, Zhiyong , ZHAO, Kake , KIM, Ronald, M. , MCCAULEY, John, A.
IPC分类号： A61K31/53 , A61P31/12 , C07D471/16
摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

7. 发明申请

WO2019209667A1 TRICYCLIC HETEROCYCLE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS 审中-公开
公开(公告)号：WO2019209667A1
公开(公告)日：2019-10-31
申请号：PCT/US2019/028432
申请日：2019-04-22
申请人： MERCK SHARP & DOHME CORP. , YU, Tao , APGAR, James, M. , WHITEHEAD, Alan , ZHANG, Yonglian , HU, Zhiyong , SHURTLEFF, Valerie, W. , MCCAULEY, John, A. , RAHEEM, Izzat, T.
发明人： YU, Tao , APGAR, James, M. , WHITEHEAD, Alan , ZHANG, Yonglian , HU, Zhiyong , SHURTLEFF, Valerie, W. , MCCAULEY, John, A. , RAHEEM, Izzat, T.
IPC分类号： A61K31/4985 , C07D487/16
摘要： The present invention relates to Tricyclic Heterocycle Compounds of Formula (I): (I) and pharmaceutically acceptable salts or prodrug thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are as defined herein. The present invention also relates to compositions comprising at least one Tricyclic Heterocycle Compound, and methods of using the Tricyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

8. 发明申请

WO2017107052A1 SOLUBLE GUANYLATE CYCLASE STIMULATORS 审中-公开
标题翻译：可溶性鸟苷酸环化酶促进剂
公开(公告)号：WO2017107052A1
公开(公告)日：2017-06-29
申请号：PCT/CN2015/098251
申请日：2015-12-22
申请人： MERCK SHARP & DOHME CORP. , BERGER, Raphaelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKEL, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron J. , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
发明人： BERGER, Raphaelle , CHEN, Yi-Heng , LI, Guoqing , GARFUNKEL, Joie , LI, Hong , MIAO, Shouwu , RAGHAVAN, Subharekha , SMITH, Cameron J. , WHITEHEAD, Alan , ZHANG, Rui , ZHANG, Yong , FU, Jianmin , JI, Gang , JIANG, Falong
IPC分类号： C07D487/04 , A61K31/519 , A61P9/00 , A61P3/10
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R 1 , R 2 , R 4 , R a , and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate ("cGMP"), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose.
摘要翻译：本发明提供式（I）的化合物或其药学上可接受的盐，其中X，Y，Z，R 1，R 2， R 4，R a和下标m，p和q如本文所述。所述化合物或其药学上可接受的盐可调节身体产生环鸟苷单磷酸（“cGMP”），并且通常适用于治疗和预防与扰乱的cGMP平衡有关的疾病。本发明还提供了包含式（I）化合物或其药学上可接受的盐的药物组合物。本发明还涉及这些化合物或其药学上可接受的盐在治疗和预防上述疾病以及为此目的制备药物中的用途。

9. 发明申请

WO2015124657A1 NETWORK ELEMENTS, WIRELESS COMMUNICATION SYSTEM AND METHODS THEREFOR 审中-公开
标题翻译：网络元件，无线通信系统及其方法
公开(公告)号：WO2015124657A1
公开(公告)日：2015-08-27
申请号：PCT/EP2015/053473
申请日：2015-02-19
申请人： IP.ACCESS LIMITED , KILGOUR, Christopher Edward John , JOHNSON, Nicholas Dougall , PIERCY, Neil Philip , HARROW, James Edward Brereton , WHITEHEAD, Alan , BROCK, David Charles
发明人： KILGOUR, Christopher Edward John , JOHNSON, Nicholas Dougall , PIERCY, Neil Philip , HARROW, James Edward Brereton , WHITEHEAD, Alan , BROCK, David Charles
IPC分类号： H04W48/12 , H04W36/00
CPC分类号： H04W36/0066 , H04W36/0061 , H04W48/12 , H04W88/02 , H04W88/08
摘要： A method and apparatus for redirecting a wireless communication unit (113) from a LTE cell to a neighbouring 3G or 2G cell for the purposes of performing a procedure which is available in the 2G or 3G cell but not available in the LTE cell includes the provision of an additional LTE access point (109) within the coverage area of an LTE macrocell. The additional LTE access point (109) is arranged to capture a wireless communication unit (113) which is camped onto the LTE macrocell and redirect it to a 3G/2G cell irrespective of whether or not a better service may be provided in the 2G/3G cell.. The invention has application to presence detection where collection of wireless communication units' and subscribers' IDs for such a purpose is possible in 3G and 2G cells but not in LTE cells.
摘要翻译：为了执行在2G或3G小区中可用的但在LTE小区中不可用的过程的目的，将无线通信单元（113）从LTE小区重定向到相邻的3G或2G小区的方法和装置包括：在LTE宏小区的覆盖区域内的另外的LTE接入点（109）。附加LTE接入点（109）被配置为捕获驻留在LTE宏小区上的无线通信单元（113），并将其重定向到3G / 2G小区，而不管是否可以在2G / 3G小区。本发明适用于存在检测，其中针对这样的目的的无线通信单元和用户ID的集合在3G和2G小区中是可能的，而在LTE小区中是可能的。

10. 发明申请

WO2009156345A1 METHOD AND APPARATUS FOR PROVISIONING OF INFORMATION IN A CELLULAR COMMUNICATION NETWORK 审中-公开
标题翻译：在细胞通信网络中提供信息的方法和装置
公开(公告)号：WO2009156345A1
公开(公告)日：2009-12-30
申请号：PCT/EP2009/057669
申请日：2009-06-19
申请人： IP.ACCESS LIMITED , MCPHERSON, Ian , NEIL, David , WHITEHEAD, Alan , CISCO TECHNOLOGIES, INC , LITTLEFIELD, Joshua , OKMYANSKIY, Anton , HENSLEY, Archie , HAYES, Edward
发明人： MCPHERSON, Ian , NEIL, David , WHITEHEAD, Alan , LITTLEFIELD, Joshua , OKMYANSKIY, Anton , HENSLEY, Archie , HAYES, Edward
IPC分类号： H04W24/04 , H04W88/08 , H04W88/12 , H04W88/18 , H04W84/04 , H04W16/32
CPC分类号： H04L63/10 , H04L2463/121 , H04W12/08 , H04W16/32 , H04W24/04 , H04W84/045 , H04W88/08 , H04W88/12 , H04W88/18
摘要： A network management system (240) for managing communications in a cellular communication network comprising an access point (215) operably coupled to an access controller (235). The network management system (240) comprises an access controller configuration logic (255) arranged to configure the access controller (235) with configuration information. The network management system (240) further comprises an access point configuration logic (245) arranged to configure the access point (215) with configuration information comprising, at least in part, configuration information intended for the access controller (235).
摘要翻译：一种用于管理蜂窝通信网络中的通信的网络管理系统（240），包括可操作地耦合到接入控制器（235）的接入点（215）。网络管理系统（240）包括访问控制器配置逻辑（255），其配置为配置访问控制器（235）配置信息。网络管理系统（240）还包括接入点配置逻辑（245），其被配置为配置所述接入点（215），所述配置信息至少部分地包括用于所述接入控制器（235）的配置信息。

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