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1. 发明申请

WO2011028450A2 ELECTRON CAPTURE DISSOCIATION APPARATUS AND RELATED METHODS 审中-公开
标题翻译：电子捕获装置及相关方法
公开(公告)号：WO2011028450A2
公开(公告)日：2011-03-10
申请号：PCT/US2010046201
申请日：2010-08-20
申请人： VARIAN INC , WELLS GREGORY J
发明人： WELLS GREGORY J
IPC分类号： H01J49/26 , H01J49/08
CPC分类号： H01J49/0054
摘要： An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction.
摘要翻译：电子捕获离解装置包括离子导向电极，电子发射体和电子控制装置。离子导向电极沿着中心轴线布置并且沿圆周方向间隔开以围绕沿着中心轴线延伸的内部空间。电子发射器设置在内部空间的外部。电子控制装置被构造成沿着两个离子导向电极之间的径向电子束方向将来自电子发射体的电子束朝向中心轴聚焦，并且用于在可调电压电位定向的DC减速场中减速电子束沿着电子束方向。

2. 发明申请

WO2009079222A2 CHARGE CONTROL FOR IONIC CHARGE ACCUMULATION DEVICES 审中-公开
标题翻译：离子充电累积装置的充电控制
公开(公告)号：WO2009079222A2
公开(公告)日：2009-06-25
申请号：PCT/US2008/085576
申请日：2008-12-04
申请人： VARIAN, INC , WELLS, Gregory, J.
发明人： WELLS, Gregory, J.
IPC分类号： H01J49/10 , H01J49/26 , H01J49/02 , G01N27/62
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/067
摘要： A method for controlling charge flux into a charge accumulation device includes determining a charge accumulation time during which charges are to be accumulated in the charge accumulation device, measuring a charge flux of a first ion beam produced from an ion source, determining a target number of charges to be accumulated in the charge accumulation device during the charge accumulation time based on the measured charge flux and, based on the determined target number of charges, modulating a second ion beam produced from the ion source to cause the target number of charges from the second ion beam to be accumulated in the charge accumulation device during the charge accumulation time. An ion processing device is configured for controlling the charge flux. An ion beam modulator modulates the ion beam.
摘要翻译：一种用于控制电荷累积装置的电荷通量的方法包括：确定在电荷累积装置中积累电荷的电荷累积时间，测量从离子源产生的第一离子束的电荷通量，基于测量的电荷通量在电荷累积时间期间积累在电荷累积装置中的电荷，并且基于确定的电荷的目标数量，调制由离子源产生的第二离子束，以使来自第二离子束在电荷累积时间期间积聚在电荷累积装置中。离子处理装置被配置为用于控制电荷通量。离子束调制器调制离子束。

3. 发明申请

WO2005119738A3 LINEAR ION TRAP APPARATUS AND METHOD UTILIZING AN ASYMMETRICAL TRAPPING FIELD 审中-公开
标题翻译：线性离子阱装置和利用不对称捕获场的方法
公开(公告)号：WO2005119738A3
公开(公告)日：2006-12-07
申请号：PCT/US2005017549
申请日：2005-05-19
申请人： VARIAN INC , WELLS GREGORY J
发明人： WELLS GREGORY J
IPC分类号： H01J49/42
CPC分类号： H01J49/423
摘要： A linear ion trap includes four electrodes and operates with an asymmetrical trapping field in which the center of the trapping field is displaced from a geometrical center of the trap structure. The asymmetrical trapping field can include a main AC potential providing a quadrupole component and an additional AC potential. The main AC potential is applied between opposing pairs of electrodes and the additional AC potential is applied across one pair of electrodes. The additional AC potential can add a dipole component for rendering the trapping field asymmetrical. The additional AC potential can also add a hexapole component used for nonlinear resonance. A supplementary AC potential can be applied across the same pair of electrodes as the additional AC potential to enhance resonant excitation. The operating point for ejection can be set such that a pure resonance condition can be used to increase the amplitude of ion oscillation preferentially in one direction. Ions trapped in the composite field can be mass-selectively ejected in a single direction to an aperture in one of the electrodes.
摘要翻译：线性离子阱包括四个电极，并且以非对称捕获场操作，其中俘获场的中心从陷阱结构的几何中心位移。不对称捕获场可以包括提供四极组件和附加AC电位的主AC电势。主交流电势被施加在相对的电极对之间，并且附加的交流电位被施加在一对电极之间。附加的交流电位可以添加偶极子分量，以使捕获场不对称。附加的交流电位还可以添加用于非线性共振的六极分量。辅助交流电位可以作为额外的交流电位施加在同一对电极上，以增强谐振激励。可以设置喷射的工作点，使得可以使用纯共振条件来优先在一个方向上增加离子振动的振幅。捕获在复合场中的离子可以沿单个方向质量选择性地喷射到一个电极中的孔。

4. 发明申请

WO2011028450A3 ELECTRON CAPTURE DISSOCIATION APPARATUS AND RELATED METHODS 审中-公开
公开(公告)号：WO2011028450A3
公开(公告)日：2011-03-10
申请号：PCT/US2010/046201
申请日：2010-08-20
申请人： VARIAN, INC , WELLS, Gregory, J.
发明人： WELLS, Gregory, J.
IPC分类号： H01J49/26 , H01J49/08
摘要： An electron capture dissociation apparatus comprises ion guide electrodes, an electron emitter, and an electron control device. The ion guide electrodes are arranged along a central axis and spaced circumferentially to circumscribe an interior space extending along the central axis. The electron emitter is disposed outside the interior space. The electron control device is configured for focusing an electron beam from the electron emitter toward the central axis, along a radial electron beam direction between two of the ion guide electrodes, and for decelerating the electron beam in a DC decelerating field of adjustable voltage potential directed along the electron beam direction.

5. 发明申请

WO2007149451B1 CYCLOALKANOPYRROLOCARBAZOLE DERIVATIVES AND THE USE THEREOF AS PARP, VEGFR2 AND MLK3 INHIBITORS 审中-公开
标题翻译：环丙卡洛吡唑酮衍生物及其作为PARP，VEGFR2和MLK3抑制剂的用途
公开(公告)号：WO2007149451B1
公开(公告)日：2008-04-10
申请号：PCT/US2007014300
申请日：2007-06-19
申请人： CEPHALON INC , CHATTERJEE SANKAR , DIEBOLD JAMES L , DUNN DEREK , HUDKINS ROBERT L , DANDU REDDEPPAREDDY , WELLS GREGORY J , ZULLI ALLISON L
发明人： CHATTERJEE SANKAR , DIEBOLD JAMES L , DUNN DEREK , HUDKINS ROBERT L , DANDU REDDEPPAREDDY , WELLS GREGORY J , ZULLI ALLISON L
IPC分类号： A61K31/437 , A61K31/407 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/4412 , A61K31/4439 , A61K31/4453 , A61K31/497 , A61K31/501 , A61K31/5377 , A61P3/10 , A61P9/10 , A61P15/00 , A61P17/06 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D471/14 , C07D487/04 , C07D491/04 , C07D491/14 , C07D495/04 , C07D519/00
CPC分类号： C07D491/14 , C07D471/14 , C07D487/04 , C07D491/04 , C07D495/04 , C07D519/00
摘要： The present invention is directed to novel multicyclic molecules of Formula (IIIIa)* that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of PARP3 VEGFR2, and MLK3 enzymes, including, for example, neurodegenerative diseases, inflammation, ischemia, and cancer.
摘要翻译：本发明涉及介导酶活性的式（IIIa）*的新型多环分子。特别地，这些化合物可有效治疗与PARP3 VEGFR2和MLK3酶的活性相关的疾病或疾病状态，包括例如神经变性疾病，炎症，局部缺血和癌症。

6. 发明申请

WO2009079222A3 CHARGE CONTROL FOR IONIC CHARGE ACCUMULATION DEVICES 审中-公开
标题翻译：离子电荷积累装置的电荷控制
公开(公告)号：WO2009079222A3
公开(公告)日：2009-09-24
申请号：PCT/US2008085576
申请日：2008-12-04
申请人： VARIAN INC , WELLS GREGORY J
发明人： WELLS GREGORY J
IPC分类号： H01J49/10 , G01N27/62 , H01J49/02 , H01J49/26
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/067
摘要： A method for controlling charge flux into a charge accumulation device includes determining a charge accumulation time during which charges are to be accumulated in the charge accumulation device, measuring a charge flux of a first ion beam produced from an ion source, determining a target number of charges to be accumulated in the charge accumulation device during the charge accumulation time based on the measured charge flux and, based on the determined target number of charges, modulating a second ion beam produced from the ion source to cause the target number of charges from the second ion beam to be accumulated in the charge accumulation device during the charge accumulation time. An ion processing device is configured for controlling the charge flux. An ion beam modulator modulates the ion beam.
摘要翻译：一种用于控制进入电荷积累装置的电荷通量的方法包括：确定电荷积聚时间，在该时间期间电荷将被积聚在电荷积累装置中;测量由离子源产生的第一离子束的电荷通量; 基于所测量的电荷通量在电荷积累时间期间累积在电荷积累装置中的电荷，并且基于所确定的目标电荷数量，调制从离子源产生的第二离子束以使来自第二离子束在电荷积累时间期间积聚在电荷积累装置中。离子处理装置被配置用于控制电荷通量。离子束调制器调制离子束。

7. 发明申请

WO2007070500A3 ELECTRON SOURCE FOR IONIZATION WITH LEAKAGE CURRENT SUPPRESSION 审中-公开
标题翻译：用于泄漏电流抑制的电子源
公开(公告)号：WO2007070500A3
公开(公告)日：2008-04-17
申请号：PCT/US2006047342
申请日：2006-12-12
申请人： VARIAN INC , WELLS GREGORY J , MARQUETTE EDWARD G
发明人： WELLS GREGORY J , MARQUETTE EDWARD G
IPC分类号： H01J49/14 , H01J3/02 , H01J49/08
CPC分类号： H01J49/14 , H01J3/024 , H01J49/08
摘要： An electron source includes a first electrode, a second electrode, a thermionic element interposed between and electrically isolated from the first electrode and the second electrode, and a guard electrode interposed between and electrically isolated from the first electrode and the second electrode. The thermionic element and the guard electrode may be at substantially the same voltage. Another electron source includes a first electrode, a second electrode, a thermionic element interposed between and electrically isolated from the first electrode and the second electrode, and a thermal expansion component interposed between and electrically isolated from the first electrode and the second electrode. The thermal expansion component may be heated to cause expansion. The heating may be cycled to cause alternating expansion and contraction.
摘要翻译：电子源包括插入在第一电极和第二电极之间并且与第一电极和第二电极电绝缘的第一电极，第二电极和热电离元件，以及插入在第一电极和第二电极之间并与之电隔离的保护电极。热离子元件和保护电极可以处于基本上相同的电压。另一个电子源包括介于第一电极和第二电极之间并与之电绝缘的第一电极，第二电极和热电离元件，以及介于第一电极和第二电极之间并与之电隔离的热膨胀组件。热膨胀部件可能被加热以引起膨胀。可以循环加热以引起交替的膨胀和收缩。

8. 发明申请

WO2005119738A2 LINEAR ION TRAP APPARATUS AND METHOD UTILIZING AN ASYMMETRICAL TRAPPING FIELD 审中-公开
标题翻译：线性离子阱装置和利用不对称捕获场的方法
公开(公告)号：WO2005119738A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/017549
申请日：2005-05-19
申请人： VARIAN, INC. , WELLS, Gregory, J.
发明人： WELLS, Gregory, J.
IPC分类号： H01J49/42
CPC分类号： H01J49/423
摘要： A linear ion trap includes four electrodes and operates with an asymmetrical trapping field in which the center of the trapping field is displaced from a geometrical center of the trap structure. The asymmetrical trapping field can include a main AC potential providing a quadrupole component and an additional AC potential. The main AC potential is applied between opposing pairs of electrodes and the additional AC potential is applied across one pair of electrodes. The additional AC potential can add a dipole component for rendering the trapping field asymmetrical. The additional AC potential can also add a hexapole component used for nonlinear resonance. A supplementary AC potential can be applied across the same pair of electrodes as the additional AC potential to enhance resonant excitation. The operating point for ejection can be set such that a pure resonance condition can be used to increase the amplitude of ion oscillation preferentially in one direction. Ions trapped in the composite field can be mass-selectively ejected in a single direction to an aperture in one of the electrodes.
摘要翻译：线性离子阱包括四个电极，并且以非对称捕获场操作，其中俘获场的中心从陷阱结构的几何中心位移。不对称捕获场可以包括提供四极组件和附加AC电位的主AC电势。主交流电位被施加在相对的电极对之间，并且附加的交流电位被施加在一对电极之间。附加的交流电位可以增加偶极子分量，以使捕获场不对称。附加的交流电势也可以添加用于非线性共振的六极分量。辅助交流电位可以跨越同一对电极施加，作为附加的交流电位，以增强谐振激励。可以设置喷射的工作点，使得可以使用纯共振条件来优先在一个方向上增加离子振动的振幅。捕获在复合场中的离子可以沿单个方向质量选择性地喷射到一个电极中的孔。

9. 发明申请

WO2010071885A1 PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS 审中-公开
标题翻译：作为ALK和JAK2抑制剂的PYRROOTRIAZINES
公开(公告)号：WO2010071885A1
公开(公告)日：2010-06-24
申请号：PCT/US2009/069006
申请日：2009-12-21
申请人： CEPHALON, INC. , BRESLIN, Henry J. , CHATTERJEE, Sankar , DIEBOLD, James L. , DORSEY, Bruce D. , DUNN, Derek , GINGRICH, Diane E. , HOSTETLER, Greg A. , HUDKINS, Robert L. , HUNTER, Rachael , JOSEF, Kurt , LISKO, Joseph , MESAROS, Eugen F. , MILKIEWICZ, Karen L. , OTT, Gregory R. , SUNDAR, Babu G. , THEROFF, Jay P. , THIEU, Tho , TRIPATHY, Rabindranath , UNDERINER, Theodore L. , WEINBERG, Linda , WELLS, Gregory J. , ZIFICSAK, Craig A.
发明人： BRESLIN, Henry J. , CHATTERJEE, Sankar , DIEBOLD, James L. , DORSEY, Bruce D. , DUNN, Derek , GINGRICH, Diane E. , HOSTETLER, Greg A. , HUDKINS, Robert L. , HUNTER, Rachael , JOSEF, Kurt , LISKO, Joseph , MESAROS, Eugen F. , MILKIEWICZ, Karen L. , OTT, Gregory R. , SUNDAR, Babu G. , THEROFF, Jay P. , THIEU, Tho , TRIPATHY, Rabindranath , UNDERINER, Theodore L. , WEINBERG, Linda , WELLS, Gregory J. , ZIFICSAK, Craig A.
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides a compound of formula (I) or a salt form thereof, wherein Q 1 , Q 2 , Q 3 , and Q 4 are as defined herein. The compound of formula (I) has ALK and/or JAK2 inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式（I）化合物或其盐形式，其中Q1，Q2，Q3和Q4如本文所定义。式（I）化合物具有ALK和/或JAK2抑制活性，可用于治疗增殖性疾病。

10. 发明申请

WO2008051547A1 FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS 审中-公开
标题翻译： 2,4-二氨基嘧啶作为ALK和C-MET抑制剂的熔融双相衍生物
公开(公告)号：WO2008051547A1
公开(公告)日：2008-05-02
申请号：PCT/US2007/022496
申请日：2007-10-23
申请人： CEPHALON, INC. , PHARMACOPEIA DRUG DISCOVERY, INC. , AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
发明人： AHMED, Gulzar , BOHNSTEDT, Adolph , BRESLIN, Henry, Joseph , BURKE, Jason , CURRY, Matthew, A. , DIEBOLD, James, L. , DORSEY, Bruce , DUGAN, Benjamin, J. , FENG, Daming , GINGRICH, Diane, E. , GUO, Tao , HO, Koc-Kan , LEARN, Keith, S. , LISKO, Joseph, G. , LIU, Rong-Qiang , MESAROS, Eugen, F. , MILKIEWICZ, Karen , OTT, Gregory, R. , PARRISH, Jonathan , THEROFF, Jay, P. , THIEU, Tho, V. , TRIPATHY, Rabindranath , UNDERINER, Theodore, L. , WAGNER, Jason, C. , WEINBERG, Linda , WELLS, Gregory, J. , YOU, Ming , ZIFICSAK, Craig, A.
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/495 , A61P35/00
CPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , A 1 , A 2 , A 3 , A 4 , and A 5 , are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
摘要翻译：本发明提供式I或II化合物或其药学上可接受的盐形式，其中R 1，R 2，R 3， R 4，R 5，A 1，A 2，A 3， A 4 S 4和A 5 5如本文所定义。式I或II的化合物具有ALK和/或c-Met抑制活性，可用于治疗增殖性疾病。

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