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1. 发明申请

WO2004083448A2 MOLECULAR DIFFERENCES BETWEEN SPECIES OF THE M.TUBERCULOSIS COMPLEX 审中-公开
标题翻译： M.TUBERCULOSIS复合物种之间的分子差异
公开(公告)号：WO2004083448A2
公开(公告)日：2004-09-30
申请号：PCT/US2004007668
申请日：2004-03-11
申请人： UNIV LELAND STANFORD JUNIOR , STATENS SERUMINSTITUT , BEHR MARCEL , SMALL PETER , WILSON MICHAEL A , SCHOOLNIK GARY , AAGAARD CLAUS , ROSENKRANDS IDA , WELDINGH KARIN , ANDERSON PETER
发明人： BEHR MARCEL , SMALL PETER , WILSON MICHAEL A , SCHOOLNIK GARY , AAGAARD CLAUS , ROSENKRANDS IDA , WELDINGH KARIN , ANDERSON PETER
IPC分类号： C07K14/35 , C07K16/12 , C12Q20060101 , C12Q1/68 , C12Q
CPC分类号： C07K14/35 , C07K16/1289 , C12Q1/689
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tbThe genetic markers can be used for diagnosis of M. tb. infection. One or more antigens provided from the genetic markers can be used in diagnostic assays, e.g. a serological assay.
摘要翻译：在分枝杆菌分离株中鉴定出特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异以及BCG中存在的许多缺失与M.tb相比。遗传标记可用于诊断M.bb。感染。从遗传标记提供的一种或多种抗原可用于诊断测定，例如血清学检测。

2. 发明申请

WO0179274A8 TUBERCULOSIS ANTIGENS AND METHODS OF USE THEREOF 审中-公开
标题翻译：结核菌抗原及其使用方法
公开(公告)号：WO0179274A8
公开(公告)日：2004-04-29
申请号：PCT/DK0100276
申请日：2001-04-19
申请人： STATENS SERUMINSTITUT , AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
发明人： AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/35 , C12N1/12
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/523 , A61K2039/53 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides.
摘要翻译：本发明基于鉴定和表征许多新型结核分枝杆菌来源的蛋白质和蛋白质片段。本发明涉及多肽及其免疫活性片段，编码它们的基因，免疫组合物如疫苗和含有多肽的皮肤试验试剂。

3. 发明申请

WO0179274B1 TUBERCULOSIS ANTIGENS AND METHODS OF USE THEREOF 审中-公开
标题翻译：结核菌抗原及其使用方法
公开(公告)号：WO0179274B1
公开(公告)日：2002-08-08
申请号：PCT/DK0100276
申请日：2001-04-19
申请人： STATENS SERUMINSTITUT , AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
发明人： AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/35 , C12N1/12
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/523 , A61K2039/53 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides.
摘要翻译：本发明基于鉴定和表征许多新型结核分枝杆菌来源的蛋白质和蛋白质片段。本发明涉及多肽及其免疫活性片段，编码它们的基因，免疫组合物如疫苗和含有多肽的皮肤试验试剂。

4. 发明申请

WO0179274A2 M. TUBERCULOSIS ANTIGENS 审中-公开
标题翻译： M. TUBERCULOSIS抗原
公开(公告)号：WO0179274A2
公开(公告)日：2001-10-25
申请号：PCT/DK0100276
申请日：2001-04-19
申请人： STATENS SERUMINSTITUT , AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
发明人： AGGER ELSE MARIE , ANDERSEN PETER , OKKELS LI MEI MENG , WELDINGH KARIN
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/35 , C07K14/195
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/523 , A61K2039/53 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides.
摘要翻译：本发明基于鉴定和表征许多新型结核分枝杆菌来源的蛋白质和蛋白质片段。本发明涉及多肽及其免疫活性片段，编码它们的基因，免疫组合物如疫苗和含有多肽的皮肤试验试剂。

5. 发明申请

WO2004099771A1 A NEW SPECIFIC EPITOPE BASED IMMUNOLOGICAL DIAGNOSIS OF TUBERCULOSIS 审中-公开
标题翻译：基于新的特异性抗原决定基的免疫组织化学诊断
公开(公告)号：WO2004099771A1
公开(公告)日：2004-11-18
申请号：PCT/DK2004/000314
申请日：2004-05-06
申请人： STATENS SERUM INSTITUT , ANDERSEN, Peter , BROCK, Inger , WELDINGH, Karin
发明人： ANDERSEN, Peter , BROCK, Inger , WELDINGH, Karin
IPC分类号： G01N33/50
CPC分类号： G01N33/6812 , C07K14/35 , G01N33/505 , G01N33/5695
摘要： The current used method for immunological diagnosis of tuberculosis infection, the tuberculin skin test, is problematic for a number of reasons; it has low specificity in BCG vaccinated individuals, a high interobserver variance and requires skill to be read and interpreted. Furthermore it requires an extra visit to the clinic to have the test read. Both people vaccinated with BCG and those exposed to non-tuberculosis mycobacteria give a positive skin test result similar to that seen in a TB infected individual. This also applies for purified protein derivative (PPD) when used in a blood cell based test. The present invention disclosed the development of an immunological TB diagnostic tool based on a combination of epitopes from proteins encoded by regions of the M. Tuberculosisi (M. tub) genome, that are not present in the BCG vaccine strain or in the most common non-tuberculosis mycobacteria. Four recently characterized proteins with this diagnostic potential were selected. Peptides from these proteins were tested one by one with peripheral blood mononuclear cells from microscopy or culture confirmed TB patients as well as from healthy BCG vaccinated controls. Some combinations of peptides showed a sensitivity level comparable to the level seen with these peptides combined with ESAT 6 and CFP 10 gave a sensitivity of 93% representing a raise in sensitivity of about 26-33% compared to using ESAT6 or CFP10 alone. The results from a panel of TB patients, using a collection of the new specific epitopes clearly demonstrates, the addition of other specific epitopes to the already known specific antigens, increases the sensitivity of a diagnostic assay based on cell mediated immune response.
摘要翻译：目前使用的结核菌感染免疫诊断方法，结核菌素皮肤试验，有其原因有问题; 它在BCG接种个体中具有低特异性，具有高的观察者间差异，并且需要阅读和解释技能。此外，还需要额外访问诊所以进行测试。接种BCG的人和暴露于非结核分枝杆菌的两个人都能获得与TB感染个体相似的阳性皮肤试验结果。当用于基于血细胞的试验中时，这也适用于纯化的蛋白质衍生物（PPD）。本发明公开了免疫结核病诊断工具的开发，该工具基于由结核分枝杆菌（M.Buberculosisi，M.Bob）的基因组区域编码的蛋白质的表位的组合，其不存在于BCG疫苗株或最常见的非 - 结核分枝杆菌。选择了具有该诊断潜力的四种最近鉴定的蛋白质。使用来自显微镜或培养物确认的TB患者以及来自健康的BCG接种对照的外周血单核细胞逐个测试来自这些蛋白质的肽。肽的一些组合显示出与这些肽结合ESAT 6所观察到的水平相当的灵敏度水平，与单独使用ESAT6或CFP10相比，CFP 10具有93％的敏感性，表示灵敏度升高约26-33％。使用新的特异性表位的一组结核病患者的结果清楚地表明，已经已知的特异性抗原的其他特异性表位的添加增加了基于细胞介导的免疫应答的诊断测定的灵敏度。

6. 发明申请

WO2004083448A3 MOLECULAR DIFFERENCES BETWEEN SPECIES OF THE M.TUBERCULOSIS COMPLEX 审中-公开
公开(公告)号：WO2004083448A3
公开(公告)日：2004-09-30
申请号：PCT/US2004/007668
申请日：2004-03-11
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , STATENS SERUM INSTITUT , BEHR, Marcel , SMALL, Peter , WILSON, Michael, A. , SCHOOLNIK, Gary , AAGAARD, Claus , ROSENKRANDS, Ida , WELDINGH, Karin , ANDERSON, Peter
发明人： BEHR, Marcel , SMALL, Peter , WILSON, Michael, A. , SCHOOLNIK, Gary , AAGAARD, Claus , ROSENKRANDS, Ida , WELDINGH, Karin , ANDERSON, Peter
IPC分类号： C07K14/35
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb The genetic markers can be used for diagnosis of M. tb. infection. One or more antigens provided from the genetic markers can be used in diagnostic assays, e.g. a serological assay.

7. 发明申请

WO0021983A3 TUBERCULOSIS VACCINE AND DIAGNOSTIC REAGENTS BASED ON ANTIGENS FROM THE MYCOBACTERIUM TUBERCULOSIS CELL 审中-公开
标题翻译：基于来自MYCOBACTERIUM TUBERCULOSIS 细胞的抗原的流感疫苗和诊断试剂
公开(公告)号：WO0021983A3
公开(公告)日：2000-11-23
申请号：PCT/DK9900538
申请日：1999-10-08
申请人： STATENS SERUMINSTITUT , ANDERSEN PETER , WELDINGH KARIN , HANSEN CHRISTINA VEGGERBY , FLORIO WALTER , OKKELS LI MEI MENG , SKJOET RIKKE LOUISE VINTHER , ROSENKRANDS IDA
发明人： ANDERSEN PETER , WELDINGH KARIN , HANSEN CHRISTINA VEGGERBY , FLORIO WALTER , OKKELS LI MEI MENG , SKJOET RIKKE LOUISE VINTHER , ROSENKRANDS IDA
IPC分类号： A61K39/00 , C07K14/35 , A61K39/04 , G01N33/569
CPC分类号： C07K14/35 , A61K39/00
摘要： The present invention relates to substantially pure polypeptides, which has a sequence identity of at least 80 % to an amino acid sequence disclosed, or which is a subsequence of at least 6 amino acids thereof, preferably a B- or T-cell epitope of the polypeptides disclosed. The polypeptide or the subsequence thereof has at least one of nine properties. The use of the disclosed polypeptides in medicine is disclosed, preferably as vaccine or diagnostic agents relating to virulent Mycobacterium . The invention further relates to the nucleotide sequences disclosed and the nucleotide sequences encoding the disclosed polypeptides. Medical and non-medical use of the nucleotide sequences is disclosed.
摘要翻译：本发明涉及基本上纯的多肽，其与所公开的氨基酸序列具有至少80％的序列同一性，或者是其至少6个氨基酸，优选B细胞或T-细胞表位的亚序列多肽披露。多肽或其亚序列具有九个性质中的至少一个。公开了所公开的多肽在药物中的用途，优选作为与毒性分枝杆菌有关的疫苗或诊断剂。本发明还涉及所公开的核苷酸序列和编码公开的多肽的核苷酸序列。披露了核苷酸序列的医学和非医学用途。

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