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1. 发明申请

WO2008005565A2 ANTIVIRAL PHOSPHINATE COMPOUNDS 审中-公开
标题翻译：抗磷酸化合物
公开(公告)号：WO2008005565A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015664
申请日：2007-07-06
申请人： GILEAD SCIENCES, INC. , CASAREZ, Anthony , CHAUDHARY, Kleem , CHO, Aesop , CLARKE, Michael , DOERFFLER, Edward , FARDIS, Maria , KIM, Choung, U. , PYUN, Hyungjung , SHENG, Xiaoning, C. , WANG, Jianying
发明人： CASAREZ, Anthony , CHAUDHARY, Kleem , CHO, Aesop , CLARKE, Michael , DOERFFLER, Edward , FARDIS, Maria , KIM, Choung, U. , PYUN, Hyungjung , SHENG, Xiaoning, C. , WANG, Jianying
IPC分类号： A61K31/662 , A61P31/12 , C07F9/572 , C07F9/6558
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

2. 发明申请

WO2007002912A3 ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗增生化合物，组合物及其使用方法
公开(公告)号：WO2007002912A3
公开(公告)日：2007-06-28
申请号：PCT/US2006025726
申请日：2006-06-29
申请人： GILEAD SCIENCES INC , CHENG XIAOQIN , COOK GARY P , DESAI MANOJ C , DOERFFLER EDWARD , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , ROHLOFF JOHN C , WANG JIANYING , YANG ZHENG-YU
发明人： CHENG XIAOQIN , COOK GARY P , DESAI MANOJ C , DOERFFLER EDWARD , HE GONG-XIN , KIM CHOUNG U , LEE WILLIAM A , ROHLOFF JOHN C , WANG JIANYING , YANG ZHENG-YU
IPC分类号： C07F9/6561 , A61K31/66 , A61K31/675 , A61P31/12
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y 1A and Y 1B are independently Y 1 ; R X1 is R X ; R X2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y 1 is = O, -O(R X ), =S, -N(R X ), -N(O)(R X ), -N(OR X ), -N(O)(OR X ), or -N(N(R X )(R X )); R X is independently R 1 , R 2 , R 4 , W 3 , or a protecting group; R 1 is independently -H or alkyl of 1 to 18 carbon atoms; R 2 is independently R 3 or R 4 wherein each R 4 is independently substituted with 0 to 3 R 3 groups or taken together at a carbon atom, two R 2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R 3 groups; R 3 is R 3a , R 3b , R 3c or R 3d , provided that when R 3 is bound to a heteroatom, then R 3 is R 3c or R 3d ; R 3a is -H, -F, -Cl, -Br, -I, -CF 3 , -CN, N 3 , -NO 2 or -OR 4 ; R 3b is = O, -O(R 4 ), =S, -N(R 4 ), -N(O)(R 4 ), -N(OR 4 ), -N(O)(OR 4 ), or -N(N(R 4 )(R 4 )); 3c is -R 4 , -N(R 4 )(R 4 ), -SR 4 , -S(O)R 4 , -S(O) 2 R 4 , -S(O)(OR 4 ), -S(O) 2 (OR 4 ), -OC(R 3b )R 4 , -OC(R 3b )OR 4 , -OC(R 3b )(N(R 4 )(R 4 )), -SC(R 3b )R 4 , -SC(R 3b )OR 4 , -SC(R 3b )(N(R 4 )(R 4 )), -N(R 4 )C(R 3b )R 4 , -N(R 4 )C(R 3b )OR 4 , -N(R 4 )C(R 3b )(N(R 4 )(R 4 )), W 3 or -R 5 W 3 ; R 3d is -C(R 3b )R 4 , -C(R 3b )OR 4 , -C(R 3b )W 3 , -C(R 3b )OW 3 or -C(R 3b )(N(R 4 )(R 4 )); R 4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R 5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W 3 is W 4 or W 5 ; W 4 is R 6 , -C(R 3b )R 6 , -C(R 3b )W 5 , -SO M2 R 6 , or -SO M2 W 5 , wherein R 6 is R 4 wherein each R 4 is substituted with O to 3 R 3 groups; W 5 is carbocycle or heterocycle wherein W 5 is independently substituted with O to 3 R 2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.
摘要翻译：描述了式I的化合物和组合物，其可用作抗增殖剂，特别是抗HPV，其中：Y 1A和Y 1B独立地为Y， 1 ; R X1是R X; R 2 X 2是2至18个碳原子的链烯基或2至18个碳原子的炔基; Y 1是= O，-O（R X），= S，-N（R X）X - ， - N（O）（ N（O，X），-N（O）（OR X）或-N（N（R' SUP> X ）（R ^{X ））; R X独立地为R 1，R 2，R 4，W 3，，或保护基团; R 1独立地是-H或1至18个碳原子的烷基; R 2独立地是R 3或R 4，其中每个R 4独立地被0至3个R 3取代， SUP> 3个或3个碳原子一起取代，2个R 2基团形成3〜8个碳环，该环可以被0〜3个R 3 组 R 3是R 3a，R 3b，R 3c或R i，R 3，条件是当R 3与杂原子结合时，R 3是R 3c或R 3d; R 3a是-H，-F，-Cl，-Br，-I，-CF 3，-CN，N 3 - ， - NO 2或-OR 4; R 3是= O，-O（R 4），= S，-N（R 4）， - N（O）（（OR 4），-N（OR 4）， - N（O）（OR 4）或-N（N（R' SUP> 4 ）（R ^{4 ））; （S 4），-S（R 4），-SR 4，-S（R 4） 4，-S（O）R 4，-S（O）2 R 4，-S（O）（或（S）4），-S（O）2（OR 4），-OC（R 3b）R -OC（R 3b）或OR 4，-OC（R 3b）（N（R 3）（R 4）），-SC（R 3b）R 4，-SC（R SUP）（R 3）（R 4）（R 4）（R 4） /（S）S），-N（R 4）S（R 3b）R 4，-N（R 4） C（R 3b）或者4，-N（R 4）C（R 3））（N（R 4）（R 4）），W 3或-R 5 W > 3 ; R 3 d 3是-C（R 3b）R 4，-C（R 3b）或 - -C（R 3b）W 3，-C（R 3b）OW 3 O， >或-C（R 3b）（N（R 4））（R 4））; R 4是-H或1至18个碳原子的烷基，2至18个碳原子的烯基或2至18个碳原子的炔基; R 5是1至18个碳原子的亚烷基，2至18个碳原子的亚烯基或2至18个碳原子的亚炔基; W 3或W 5是W 4或W 5; R 4是R 6，-C（R 3b）R 6，-C（R'），或3个或更多个，其中，R 1，R 2，R 3，R 5，其中R 6是R 4，其中每个R 4被0至3个R 3取代， / SUP>组 W 5是碳环或杂环，其中W 5独立地被O至3个R 2基团取代; M2为0,1或2; 或其药学上可接受的盐。}}

3. 发明申请

WO2007002912A2 ANTI-PROLIFERATIVE COMPOUNDS, COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗增殖化合物，组合物及其使用方法
公开(公告)号：WO2007002912A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025726
申请日：2006-06-29
申请人： GILEAD SCIENCES, INC. , CHENG, Xiaoqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
发明人： CHENG, Xiaoqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
IPC分类号： C07F9/6561 , A61P31/12 , A61K31/66
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula I are described, useful as anti-proliferative agents, and in particular anti-HPV, wherein: Y 1A and Y 1B are independently Y 1 ; R X1 is R X ; R X2 is alkenyl of 2 to 18 carbon atoms or alkynyl of 2 to 18 carbon atoms; Y 1 is = O, -O(R X ), =S, -N(R X ), -N(O)(R X ), -N(OR X ), -N(O)(OR X ), or -N(N(R X )(R X )); R X is independently R 1 , R 2 , R 4 , W 3 , or a protecting group; R 1 is independently -H or alkyl of 1 to 18 carbon atoms; R 2 is independently R 3 or R 4 wherein each R 4 is independently substituted with 0 to 3 R 3 groups or taken together at a carbon atom, two R 2 groups form a ring of 3 to 8 carbons and the ring may be substituted with 0 to 3 R 3 groups; R 3 is R 3a , R 3b , R 3c or R 3d , provided that when R 3 is bound to a heteroatom, then R 3 is R 3c or R 3d ; R 3a is -H, -F, -Cl, -Br, -I, -CF 3 , -CN, N 3 , -NO 2 or -OR 4 ; R 3b is = O, -O(R 4 ), =S, -N(R 4 ), -N(O)(R 4 ), -N(OR 4 ), -N(O)(OR 4 ), or -N(N(R 4 )(R 4 )); 3c is -R 4 , -N(R 4 )(R 4 ), -SR 4 , -S(O)R 4 , -S(O) 2 R 4 , -S(O)(OR 4 ), -S(O) 2 (OR 4 ), -OC(R 3b )R 4 , -OC(R 3b )OR 4 , -OC(R 3b )(N(R 4 )(R 4 )), -SC(R 3b )R 4 , -SC(R 3b )OR 4 , -SC(R 3b )(N(R 4 )(R 4 )), -N(R 4 )C(R 3b )R 4 , -N(R 4 )C(R 3b )OR 4 , -N(R 4 )C(R 3b )(N(R 4 )(R 4 )), W 3 or -R 5 W 3 ; R 3d is -C(R 3b )R 4 , -C(R 3b )OR 4 , -C(R 3b )W 3 , -C(R 3b )OW 3 or -C(R 3b )(N(R 4 )(R 4 )); R 4 is -H, or an alkyl of 1 to 18 carbon atoms, alkenyl of 2 to 18 carbon atoms, or alkynyl of 2 to 18 carbon atoms; R 5 is alkylene of 1 to 18 carbon atoms, alkenylene of 2 to 18 carbon atoms, or alkynylene of 2 to 18 carbon atoms; W 3 is W 4 or W 5 ; W 4 is R 6 , -C(R 3b )R 6 , -C(R 3b )W 5 , -SO M2 R 6 , or -SO M2 W 5 , wherein R 6 is R 4 wherein each R 4 is substituted with O to 3 R 3 groups; W 5 is carbocycle or heterocycle wherein W 5 is independently substituted with O to 3 R 2 groups; and M2 is 0, 1 or 2; or pharmaceutically acceptable salts thereof.
摘要翻译：描述了式I的化合物和组合物，其可用作抗增殖剂，特别是抗HPV，其中：Y 1A和Y 1B表示抗体， sup独立地是Y ^{1 ; R X1是R X; R X2是2至18个碳原子的链烯基或2至18个碳原子的炔基; Y 1 = O，-O（R X），= S，-N（R X）， - N（O）（ -N（OR X），-N（O）（OR X）或-N（N（R X） SUP> X ）（R ^{X ））; R X独立地为R 1，R 2，R 4，W 3，R 4，R 4，R 4，，或保护基团; R 1独立地为-H或1-18个碳原子的烷基; R 2独立地为R 3或R 4，其中每个R 4独立地被0至3个R 4取代，两个R 2基团形成3至8个碳原子的环并且该环可以被0至3个R 3取代组; R 3是R 3a，R 3b，R 3c或R 3d，其中R 3a，条件是当R 3 3与一个杂原子结合时，则R 3是R 3c或R 3d; R 3a是-H，-F，-Cl，-Br，-I，-CF 3，-CN，N 3， - NO <2>或-OR <4>; （R 4）， - N（R 4）， - N（O）（ -N（OR 4）， - N（O）（OR 4）或-N（N（R 4） SUP> 4 ）（R ^{4 ））; 3c是-R 4，-N（R 4）（R 4），-SR 5，（O）R 4，-S（O）2 R 4，-S（O）（ OR 4），-S（O）2（OR 4），-OC（R 3b）R （R（R 3）4，-OC（R 3b）OR 4，-OC（R 3b）（R 4）），-SC（R 3b）R 4，-SC（R sup）（R（R 4））（R 4）（R 4）R 4（R 4） -N（R 4）C（R 3b）R 4，-N（R 4）（R 3b）OR 4，-N（R 4）C（R 3b））（N（R 4）（R 4））），W 3或-R 5 W ^{3 ; R 3d为-C（R 3b）R 4，-C（R 3b）OR， 4 -C（R 3b）W 3，-C（R 3b）OW 3-sup （R（R 4））或-C（R 3b）（N（R 4）（R 4））; R 4是-H，或1至18个碳原子的烷基，2至18个碳原子的烯基或2至18个碳原子的炔基; R 5是1-18个碳原子的亚烷基，2-18个碳原子的亚烯基或2-18个碳原子的亚炔基; W ^{3 是W 或W ^{5 ; W 4是R 6，-C（R 3b）R 6，-C（R 5） 3b）W 5，-SO 2 R 6或-SO 2 M W ^{组; W 5是碳环或杂环，其中W 5独立地被O至3个R 2基团取代; M2是0,1或2; 或其药学上可接受的盐。}}}}}}}

4. 发明申请

WO2005064008A1 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2005064008A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/042991
申请日：2004-12-22
申请人： Gilead Sciences, Inc. , ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
发明人： ARIMILLI, Murty N. , BECKER, Mark M. , BIRKUS, Gabriel , BRYANT, Clifford , CHEN, James M. , CHEN, Xiaowu , CIHLAR, Tomas , DASTGAH, Azar , EISENBERG, Eugene J. , FARDIS, Maria , HATADA, Marcos , HE, Gong-Xin , JIN, Haolun , KIM, Choung U. , LEE, William A. , LEE, Christopher P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard L. , MCDERMOTT, Martin J. , MITCHELL, Michael L. , NELSON, Peter H. , PYUN, Hyung-Jung , ROWE, Tanisha D. , SPARACINO, Mark , SWAMINATHAN, Sundaramoorthi , TARIO, James D. , WANG, Jianying , WILLIAMS, Matthew A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard H. , ZHANG, Jiancun , ZHANG, Lijun
IPC分类号： C12Q1/44
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译：提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以任选地使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

5. 发明申请

WO2009100110A1 ALPHA 5 - BETA 1 ANTIBODIES AND THEIR USES 审中-公开
标题翻译： ALPHA 5 - BETA 1抗体及其用途
公开(公告)号：WO2009100110A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/033042
申请日：2009-02-04
申请人： MEDAREX, INC. , PFIZER INC. , BENDER, Steven, Lee , CASPERSON, Gerald, Fries , HU-LOWE, Dana, Dan , JIANG, Xin , LI, Gang , NORTH, Michael, Aidan , WANG, Jianying , WICKMAN, Grant , BRAMS, Peter , HUANG, Haichun , DEVAUX, Brigitte , CHEN, Haibin , TANAMACHI, Dawn, M. , TOY, Kristopher , YANG, Lan , SPROUL, Tim, W. , YAMANAKA, Mark
发明人： BENDER, Steven, Lee , CASPERSON, Gerald, Fries , HU-LOWE, Dana, Dan , JIANG, Xin , LI, Gang , NORTH, Michael, Aidan , WANG, Jianying , WICKMAN, Grant , BRAMS, Peter , HUANG, Haichun , DEVAUX, Brigitte , CHEN, Haibin , TANAMACHI, Dawn, M. , TOY, Kristopher , YANG, Lan , SPROUL, Tim, W. , YAMANAKA, Mark
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/2842 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5βl antibodies or antigen binding portions thereof described herein.
摘要翻译：本公开提供了以高亲和力特异性结合整联蛋白a5β1的分离的单克隆抗体，特别是人单克隆抗体或其抗原结合部分。还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。还提供了免疫偶联物，双特异性分子和包含抗体或其抗原结合部分的药物组合物。本公开还提供了使用本文所述的抗α5β1抗体或其抗原结合部分治疗各种癌症的方法。

6. 发明申请

WO2008005565A9 ANTIVIRAL PHOSPHINATE COMPOUNDS 审中-公开
标题翻译：抗磷酸化合物
公开(公告)号：WO2008005565A9
公开(公告)日：2009-01-29
申请号：PCT/US2007015664
申请日：2007-07-06
申请人： GILEAD SCIENCES INC , CASAREZ ANTHONY , CHAUDHARY KLEEM , CHO AESOP , CLARKE MICHAEL , DOERFFLER EDWARD , FARDIS MARIA , KIM CHOUNG U , PYUN HYUNGJUNG , SHENG XIAONING C , WANG JIANYING
发明人： CASAREZ ANTHONY , CHAUDHARY KLEEM , CHO AESOP , CLARKE MICHAEL , DOERFFLER EDWARD , FARDIS MARIA , KIM CHOUNG U , PYUN HYUNGJUNG , SHENG XIAONING C , WANG JIANYING
IPC分类号： A61K31/662 , A61P31/12 , C07F9/572 , C07F9/6558
CPC分类号： C07F9/65583
摘要： The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
摘要翻译：本发明涉及抗病毒次膦酸盐化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

7. 发明申请

WO2005066189A1 PHOSPHONATES, MONOPHOSPHONAMIDATES, BISPHOSPHONAMIDATES FOR THE TREATMENT OF VIRAL DISEASES 审中-公开
标题翻译：磷酸盐，单磷酰胺，治疗病毒性疾病的双磷酰胺
公开(公告)号：WO2005066189A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/043969
申请日：2004-12-29
申请人： GILEAD SCIENCES, INC. , CHENG, Xiaqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
发明人： CHENG, Xiaqin , COOK, Gary, P. , DESAI, Manoj, C. , DOERFFLER, Edward , HE, Gong-Xin , KIM, Choung, U. , LEE, William, A. , ROHLOFF, John, C. , WANG, Jianying , YANG, Zheng-Yu
IPC分类号： C07F9/44
CPC分类号： C07F9/65616 , Y02P20/55
摘要： Compounds and compositions of Formula (I) are described, useful as anti-proliferative agents, and in particular anti-HPV.
摘要翻译：描述了式（I）的化合物和组合物，其可用作抗增殖剂，特别是抗HPV。

8. 发明申请

WO2005064008A9 METHOD AND COMPOSITIONS FOR IDENTIFYING ANTI-HIV THERAPEUTIC COMPOUNDS 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：WO2005064008A9
公开(公告)日：2006-09-28
申请号：PCT/US2004042991
申请日：2004-12-22
申请人： GILEAD SCIENCES INC , ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
发明人： ARIMILLI MURTY N , BECKER MARK M , BIRKUS GABRIEL , BRYANT CLIFFORD , CHEN JAMES M , CHEN XIAOWU , CIHLAR TOMAS , DASTGAH AZAR , EISENBERG EUGENE J , FARDIS MARIA , HATADA MARCOS , HE GONG-XIN , JIN HAOLUN , KIM CHOUNG U , LEE WILLIAM A , LEE CHRISTOPHER P , LIN KUEI-YING , LIU HONGTAO , MACKMAN RICHARD L , MCDERMOTT MARTIN J , MITCHELL MICHAEL L , NELSON PETER H , PYUN HYUNG-JUNG , ROWE TANISHA D , SPARACINO MARK , SWAMINATHAN SUNDARAMOORTHI , TARIO JAMES D , WANG JIANYING , WILLIAMS MATTHEW A , XU LIANHONG , YANG ZHENG-YU , YU RICHARD H , ZHANG JIANCUN , ZHANG LIJUN
IPC分类号： C12N9/99 , C12Q1/44 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译：提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

9. 发明申请

WO2013010064A1 CROP RESISTANCE TO NEMATODES 审中-公开
标题翻译：对抗性的抗性
公开(公告)号：WO2013010064A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046631
申请日：2012-07-13
申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI , CORNELL UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE , MITCHUM, Melissa, G. , REPLOGLE, Amy , WANG, Jianying , WANG, Xiaohong , CHEN, Shiyan , LANG, Ping
发明人： MITCHUM, Melissa, G. , REPLOGLE, Amy , WANG, Jianying , WANG, Xiaohong , CHEN, Shiyan , LANG, Ping
IPC分类号： C12N15/82 , A01H5/00 , C12N5/04 , C12N5/10
CPC分类号： C12N15/8285 , C12N15/8218 , C12N15/8239 , Y02A40/164
摘要： Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLE peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
摘要翻译：提供了抑制植物寄生线虫的方法，获得用于抑制这种线虫的转基因植物的方法，以及通过抑制植物线虫CLE肽受体基因对植物寄生线虫具有抗性的转基因植物。还提供了用植物线虫CLE肽受体基因启动子在植物寄生线虫饲养位点表达基因的方法，以及可用于在线虫饲养位点以及转基因植物和线虫抗性转基因植物中表达基因的线虫CLE肽受体基因启动子包括启动子。

10. 发明申请

WO2012018489A3 NEMATODE RESISTANT CROPS 审中-公开
标题翻译：抗线虫作物
公开(公告)号：WO2012018489A3
公开(公告)日：2012-05-31
申请号：PCT/US2011043882
申请日：2011-07-13
申请人： UNIV MISSOURI , CORNELL RES FOUNDATION INC , UNIV NORTH CAROLINA STATE , UNIV IOWA STATE RES FOUND INC , UNIV GEORGIA , MITCHUM MELISSA G , REPLOGLE AMY , WANG JIANYING , WANG XIAOHONG , CHEN SHIYAN , LANG PING , DAVIS ERIC L , BAUM THOMAS J , HUSSEY RICHARD S
发明人： MITCHUM MELISSA G , REPLOGLE AMY , WANG JIANYING , WANG XIAOHONG , CHEN SHIYAN , LANG PING , DAVIS ERIC L , BAUM THOMAS J , HUSSEY RICHARD S
IPC分类号： A01H5/00 , A01H3/00 , C12N15/82
CPC分类号： A01D91/00 , C07K14/415 , C12N15/8285 , Y02A40/164
摘要： Methods of inhibiting plant parasitic nematodes, methods of obtaining transgenic plants useful for inhibiting such nematodes, and transgenic plants that are resistant to plant parasitic nematodes through inhibition of plant nematode CLE peptide receptor genes are provided. Methods for expressing genes at plant parasitic nematode feeding sites with plant nematode CLE peptide receptor gene promoters are also provided, along with nematode CLE peptide receptor gene promoters that are useful for expressing genes in nematode feeding sites as well as transgenic plants and nematode resistant transgenic plants comprising the promoters.
摘要翻译：提供了抑制植物寄生线虫的方法，获得用于抑制此类线虫的转基因植物的方法，以及通过抑制植物线虫CLE肽受体基因对植物寄生线虫产生抗性的转基因植物。还提供了用植物线虫CLE肽受体基因启动子在植物寄生线虫摄食部位表达基因的方法，以及线虫CLE肽受体基因启动子，其可用于在线虫摄食部位以及转基因植物和线虫抗性转基因植物中表达基因包含启动子。

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