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1. 发明申请

WO2011109372A1 ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 审中-公开
标题翻译：使用双重检测方法进行超声检测分子
公开(公告)号：WO2011109372A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/026657
申请日：2011-03-01
申请人： QUANTERIX CORPORATION , DUFFY, David, C. , RISSIN, David, M. , WALT, David, R. , SONG, Linan , CHANG, Lei
发明人： DUFFY, David, C. , RISSIN, David, M. , WALT, David, R. , SONG, Linan , CHANG, Lei
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/5306
摘要： Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.
摘要翻译：本文描述了用于检测和/或确定流体样品中分析物分子或颗粒的浓度的测量的系统和方法。在某些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。本发明的某些方法包括将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体相关联，并将分析物分子空间分离成表面上的多个位置。可以通过确定第一类型的结合配体和第二类型的结合配体的存在来确定在位置处或位置处的分析物分子的存在。

2. 发明申请

WO2009029073A1 METHODS FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN SOLUTION. 审中-公开
标题翻译：用于确定溶液中分析物浓度的方法。
公开(公告)号：WO2009029073A1
公开(公告)日：2009-03-05
申请号：PCT/US2007/019184
申请日：2007-08-30
申请人： THE TRUSTEES OF TUFTS COLLEGE , WALT, David, R. , RISSIN, David, M.
发明人： WALT, David, R. , RISSIN, David, M.
IPC分类号： G01N33/543 , G01N33/50 , G01N33/53
CPC分类号： C12Q1/40 , G01N33/54366 , G01N33/6854 , G01N2333/522 , G01N2333/938
摘要： Disclosed is a method for measuring the concentration of an analyte or analytes in a solution. Although the methods can be conducted using a number of different assay formats, in one embodiment, the assays are conducted in reaction vessels defined, at least in part, by the distal ends of fiber optic strands.
摘要翻译：公开了一种用于测量溶液中分析物或分析物的浓度的方法。尽管可以使用许多不同测定形式进行该方法，但是在一个实施方案中，测定在至少部分由纤维光纤束的远端限定的反应容器中进行。

3. 发明申请

WO2008048698A3 CHEMICAL SWITCHES FOR DETECTING REACTIVE CHEMICAL AGENTS 审中-公开
标题翻译：用于检测反应性化学试剂的化学开关
公开(公告)号：WO2008048698A3
公开(公告)日：2008-07-24
申请号：PCT/US2007062568
申请日：2007-02-22
申请人： TUFTS COLLEGE , WALT DAVID R , BENCIC-NAGALE SANDRA
发明人： WALT DAVID R , BENCIC-NAGALE SANDRA
IPC分类号： G01N21/64
CPC分类号： G01N33/0057 , C07D219/06 , G01N21/643 , Y10T436/16 , Y10T436/163333
摘要： Certain embodiments of the present invention relate to the preparation of microbeads that exhibit a "turn on" fluorescence response within seconds of exposure to an analyte vapor (e.g., a chemical warfare agent or a reactive stimulant). This sensing approach is modeled after the mechanism for inhibition of acetylcholinesterase enzyme activity, and utilizes a specific and irreversible reaction between phosphonyl halides and a fluorescent indicator. The present invention also relates to a sensor and a method for sensing an analyte through detection of changes in the fluorescing properties of the inventive microbeads.
摘要翻译：本发明的某些实施方案涉及在暴露于分析物蒸汽（例如化学战剂或反应兴奋剂）的几秒钟内显示出“开启”荧光响应的微珠的制备。该感测方法在抑制乙酰胆碱酯酶活性的机制之后被建模，并利用膦酰卤与荧光指示剂之间的特异性和不可逆反应。本发明还涉及通过检测本发明微珠的荧光特性变化来检测分析物的传感器和方法。

4. 发明申请

WO2006047038A1 APPARATUS AND METHOD FOR CELL MIGRATION ASSAYS 审中-公开
标题翻译：细胞迁移测定的装置和方法
公开(公告)号：WO2006047038A1
公开(公告)日：2006-05-04
申请号：PCT/US2005/034627
申请日：2005-09-28
申请人： TRUSTEES OF TUFTS COLLEGE , WALT, David, R. , DI CESARE, Christopher, J.
发明人： WALT, David, R. , DI CESARE, Christopher, J.
IPC分类号： C12M1/34 , G01N21/64 , G01N33/543
CPC分类号： G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N2015/0065
摘要： The present invention is directed to a method and apparatus for detecting and analyzing cell migration. More specifically, the present invention is directed to novel technology for analyzing cellular movement, including whole cell migration and subcellular component movement. Cells are distributed onto a substrate and monitored for migration or movement. According to one embodiment, when a labelled cell or portion of a cell passes over one of the delineations between detection units, such as individual fibers in a fiber optic bundle, the label causes a large intensity increase, which stays for a given "residence time" until the cell departs from the detection unit. Each cell is disposed over at least one detection unit.
摘要翻译：本发明涉及一种用于检测和分析细胞迁移的方法和装置。更具体地，本发明涉及用于分析细胞运动的新技术，包括全细胞迁移和亚细胞组分运动。细胞分布在基质上并监测迁移或运动。根据一个实施例，当标记的细胞或细胞的一部分经过诸如光纤束中的单个纤维的检测单元之间的描绘中的一个时，标签引起大的强度增加，其停留在给定的“停留时间 “直到细胞离开检测单元。每个单元被设置在至少一个检测单元上。

5. 发明申请

WO0169245A3 CROSS-REACTIVE SENSORS 审中-公开
标题翻译：交叉传感器
公开(公告)号：WO0169245A3
公开(公告)日：2002-05-02
申请号：PCT/US0108126
申请日：2001-03-14
申请人： TUFTS COLLEGE , WALT DAVID R , SCHAUER CAROLINE L , STEEMERS FRANK J
发明人： WALT DAVID R , SCHAUER CAROLINE L , STEEMERS FRANK J
IPC分类号： C12Q1/37 , C12Q1/44 , G01N33/50 , C12Q1/00 , C12Q1/68 , G01N33/543 , G01N33/566
CPC分类号： C12Q1/44 , C12Q1/37
摘要： The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements reacts in a different manner with each of said one or more species of liquid analytes of interest to produce a detectable agent of each analyte of interest, whereby said detectable agent is analyzed and the information is processed for data acquisition and interpretation. In certain preferred embodiments, the detectable agent and/or change is detected directly, while in certain other preferred embodiments, the detectable agent and/or change is detected with the help of a transducing agent capable of relaying information about each detectable agent generated for each of said species of liquid analyte of interest, whereby said information is processed for data acquisition and interpretation. The present invention also provides method for the analysis of analytes comprising contacting one or more analytes with the inventive system described above.
摘要翻译：本发明提供一种利用交叉反应识别元件的新型交互反应传感器系统。在本发明的系统中，所述一个或多个交叉反应性识别元件中的每一个能够与多于一种的感兴趣的液体分析物相互作用，由此所述一个或多个交叉反应性识别元件中的每一个以不同的方式与每个的所述一种或多种感兴趣的液体分析物种类以产生感兴趣的每种分析物的可检测试剂，由此分析所述可检测试剂，并且对所述信息进行处理以进行数据采集和解释。在某些优选的实施方案中，直接检测可检测的试剂和/或变化，而在某些其它优选的实施方案中，可以借助于能够中继关于每个可产生的每个可检测试剂的信息的转导剂来检测可检测的试剂和/或变化的所述物质的感兴趣的液体分析物，由此所述信息被处理用于数据采集和解释。本发明还提供了用于分析分析物的方法，包括使一种或多种分析物与上述本发明的系统接触。

6. 发明申请

WO0228530A2 SELF-ENCODING SENSOR WITH MICROSPHERES 审中-公开
标题翻译：具有微结构的自编码传感器
公开(公告)号：WO0228530A2
公开(公告)日：2002-04-11
申请号：PCT/US0131581
申请日：2001-10-09
申请人： TUFTS COLLEGE , WALT DAVID R
发明人： WALT DAVID R
IPC分类号： C40B60/14 , G01N21/77 , B01L
CPC分类号： G01N21/7703 , B01J2219/00317 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , C40B60/14
摘要： A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
摘要翻译：公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置使用光学可询问编码方案的传感器阵列中的这种传感器的数量。还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。

7. 发明申请

WO2013040216A3 DIGITAL BRIDGE PCR 审中-公开
公开(公告)号：WO2013040216A3
公开(公告)日：2013-03-21
申请号：PCT/US2012/055174
申请日：2012-09-13
申请人： TUFTS UNIVERSITY , TWIN LIGHTS BIOSCIENCE, INC. , WALT, David, R. , DUFFY, David, C.
发明人： WALT, David, R. , DUFFY, David, C.
IPC分类号： C12Q1/68 , C12N15/11
摘要： The present disclosure, among other things, provides methodologies for quantifying targets of interest in samples by 1) capturing single target entities on individual solid phase particles in a manner that permits that those particles that contain captured targets to be optically distinguished from those that do not, and 2) optically analyzing the particles so that those with captured target entities are "counted". In some embodiments, provided methods and compositions in the present application comprise a population of particles including one or more sub-populations distinguishable from one another.

8. 发明申请

WO2011109364A2 ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS 审中-公开
标题翻译：使用珠子或其他捕获物体对分子或颗粒进行超敏感检测
公开(公告)号：WO2011109364A2
公开(公告)日：2011-09-09
申请号：PCT/US2011026645
申请日：2011-03-01
申请人： QUANTERIX CORP , DUFFY DAVID C , RISSIN DAVID M , WALT DAVID R , FOURNIER DAVID , KAN CHEUK
发明人： DUFFY DAVID C , RISSIN DAVID M , WALT DAVID R , FOURNIER DAVID , KAN CHEUK
IPC分类号： G01N33/50 , C12Q1/68
CPC分类号： G01N33/54393 , G01N33/54306 , G01N33/54313
摘要： The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.
摘要翻译：本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。多个捕获对象的至少一部分可以在空间上分离成多个位置。可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

9. 发明申请

WO2011053788A3 RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：适用于皮肤的相对小的装置，模块化系统及其使用方法
公开(公告)号：WO2011053788A3
公开(公告)日：2011-07-28
申请号：PCT/US2010054725
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS INC , BERNSTEIN HOWARD , CHICKERING DONALD E , LEVINSON DOUGLAS A , WALT DAVID R , DAVIS SHAWN , HAGHGOOIE RAMIN
发明人： BERNSTEIN HOWARD , CHICKERING DONALD E , LEVINSON DOUGLAS A , WALT DAVID R , DAVIS SHAWN , HAGHGOOIE RAMIN
IPC分类号： A61M5/32 , A61B5/151 , A61B5/157
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.
摘要翻译：本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。在一些方面，设备被构造和布置成具有多个模块。例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体受试者的皮肤。在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周等等，或不超过约一小时，不超过约10分钟等

10. 发明申请

WO2011053787A2 SYSTEMS AND METHODS FOR APPLICATION TO SKIN AND CONTROL OF ACTUATION, DELIVERY AND/OR PERCEPTION THEREOF 审中-公开
标题翻译：用于皮肤应用的系统和方法及其致动，传递和/或认知的控制
公开(公告)号：WO2011053787A2
公开(公告)日：2011-05-05
申请号：PCT/US2010/054723
申请日：2010-10-29
申请人： SEVENTH SENSE BIOSYSTEMS, INC. , CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
发明人： CHICKERING, Donald, E. , LEVINSON, Douglas, A. , DAVIS, Shawn , HAGHOOIE, Ramin , BERNSTEIN, Howard , WALT, David, R.
IPC分类号： A61M5/32 , A61B5/155 , A61B5/151
CPC分类号： A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150122 , A61B5/150129 , A61B5/150137 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150893 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/15105 , A61B5/15109 , A61B5/15113 , A61B5/15117 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/685 , A61B2560/0412 , A61B2560/0443 , A61M5/425 , A61M35/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/588
摘要： The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.
摘要翻译：本发明在某些方面一般涉及用于皮肤的系统和方法，以及对其致动，传递和/或感知的控制。例如，本发明的某些方面通常涉及用于递送到和/或从流体或从受试者递送到皮肤和/或从皮肤下方的装置。在一个方面，流体的递送和/或排出至少部分地模糊。例如，遮蔽可以是时间，和/或通过感觉遮蔽（例如，通过提供触觉，嗅觉，听觉和/或视觉感觉）。本发明的某些方面通常涉及能够在活化后自动递送至皮肤和/或皮下的流体的装置，例如在流体被输送和/或取出而不需要任何额外干预的情况下。可以通过任何合适的技术来激活装置。在其他方面，装置可以包含在包装中，并且当从包装中取出时，可以构造和布置该装置，以便当该装置应用于皮肤时能够输送和/或抽出流体，并且在某些情况下，自动地和/或没有受试者或另一个人的进一步干预。

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