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1. 发明申请

US20210330227A1 TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING 有权
公开(公告)号：US20210330227A1
公开(公告)日：2021-10-28
申请号：US17163851
申请日：2021-02-01
申请人： Seventh Sense Biosystems, Inc.
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie , Mark Michelman
IPC分类号： A61B5/15 , A61B5/151 , A61B5/145 , A61B5/00 , A61B5/157
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

2. 发明申请

US20210022681A1 SAMPLING DEVICE INTERFACES 有权
公开(公告)号：US20210022681A1
公开(公告)日：2021-01-28
申请号：US16806426
申请日：2020-03-02
申请人： Seventh Sense Biosystems, Inc.
发明人： Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie , Howard Bernstein , Douglas A. Levinson
IPC分类号： A61B5/00 , A61B5/15 , A61B5/151 , A61B5/157 , A61B5/145
摘要： The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, in some cases, may be interfaced with external equipment to determine an analyte contained within a fluid contained within or collected by the device. For example, the device may be mounted or engaged on an external holder, the device may include a port for transporting fluid out of the device, the device may include a window for interrogating a fluid contained within the device, or the like. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

3. 发明授权

US09730624B2 Delivering and/or receiving fluids 有权
公开(公告)号：US09730624B2
公开(公告)日：2017-08-15
申请号：US14328892
申请日：2014-07-11
申请人： Seventh Sense Biosystems, Inc.
发明人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
IPC分类号： A61B5/00 , A61B5/15 , A61B5/151 , A61B10/00 , A61M37/00 , A61B5/154 , G06F19/00 , A61B5/145 , A61B5/1459 , A61B5/1486
CPC分类号： A61B5/150374 , A61B5/1411 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/150984 , A61B5/151 , A61B5/15113 , A61B5/15117 , A61B5/15144 , A61B5/154 , A61B5/411 , A61B5/685 , A61B10/0045 , A61B10/0051 , A61B10/007 , A61B2010/008 , A61M37/0015 , G06F19/00 , G16H10/40
摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

4. 发明申请

US20170215790A1 SYSTEMS AND TECHNIQUES FOR MONITORING SUBJECTS 审中-公开
公开(公告)号：US20170215790A1
公开(公告)日：2017-08-03
申请号：US15290217
申请日：2016-10-11
申请人： Seventh Sense Biosystems, Inc.
发明人： Douglas A. Levinson , Howard Bernstein
IPC分类号： A61B5/00 , A61B5/11 , A61B5/15 , G06F19/00 , A61B5/145
CPC分类号： A61B5/4833 , A61B5/1112 , A61B5/145 , A61B5/14503 , A61B5/14514 , A61B5/14546 , A61B5/150022 , A61B5/150099 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150809 , A61B5/150824 , A61B5/150854 , A61B5/150862 , A61B5/150969 , A61B5/150984 , A61B5/15113 , A61B5/15125 , A61B5/15142 , A61B5/154 , A61B5/157 , A61B5/4839 , A61B5/4848 , A61B5/6824 , A61B10/0045 , A61B2010/0009 , A61B2010/008 , A61M5/1723 , A61M37/0015 , A61M2037/0023 , G06F19/3418 , G06F19/3456 , G06F19/3468 , G06Q20/10 , G06Q30/02 , G06Q30/0207 , G06Q50/22 , G16H40/63 , Y02A90/22 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.

5. 发明申请

US20170154164A9 MONITORING OR FEEDBACK SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170154164A9
公开(公告)日：2017-06-01
申请号：US14682478
申请日：2015-04-09
申请人： Seventh Sense Biosystems, Inc.
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/00 , Y02A90/26
摘要： The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.

6. 发明申请

US20150057510A1 PATIENT-ENACTED SAMPLING TECHNIQUE 审中-公开
标题翻译：患者采集采样技术
公开(公告)号：US20150057510A1
公开(公告)日：2015-02-26
申请号：US14513327
申请日：2014-10-14
申请人： Seventh Sense Biosystems, Inc.
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie
IPC分类号： A61B5/15 , A61B10/00 , A61B5/00 , A61B5/157
CPC分类号： A61B5/150984 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150221 , A61B5/150229 , A61B5/150297 , A61B5/150305 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150977 , A61B5/15105 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15125 , A61B5/15144 , A61B5/15186 , A61B5/157 , A61B5/74 , A61B10/0045 , A61B2010/008
摘要： The present invention is generally directed to systems and methods for sampling fluids from subjects. The fluid may be any suitable bodily fluid, e.g., blood or interstitial fluid. In some cases, the subject is a patient. The subject may have a device that can be applied to the skin of the subject (e.g., by the subject, or another person), and the device is able to obtain a sample of fluid. The fluid may be stored within a reservoir in the device, and the fluid may be obtained from the subject at any convenient time, e.g., at home, away from a healthcare setting, etc. In some embodiments, the device, or a portion thereof, may be returned to a clinical and/or laboratory setting to analyze the fluid stored within the device.
摘要翻译：本发明总体上涉及用于从主体取样流体的系统和方法。流体可以是任何合适的体液，例如血液或间质液。在某些情况下，受试者是患者。受试者可以具有可以应用于受试者的皮肤（例如受试者或其他人）的装置，并且该装置能够获得流体样本。流体可以存储在装置中的储存器中，并且可以在任何方便的时间（例如在家中，远离保健设置等）从受试者获得流体。在一些实施例中，装置或其一部分，可以返回到临床和/或实验室设置以分析存储在装置内的流体。

7. 发明授权

US10799166B2 Delivering and/or receiving fluids 有权
公开(公告)号：US10799166B2
公开(公告)日：2020-10-13
申请号：US15634354
申请日：2017-06-27
申请人： Seventh Sense Biosystems, Inc.
发明人： Javier Gonzalez-Zugasti , A. David Boccuti , Donald E. Chickering, III , Mark Michelman , Ramin Haghgooie , Shawn Davis , Scott James , Maisam Dadgar , Greg Fisher , Richard L. Miller , Christopher J. Morse , Howard Bernstein , Douglas A. Levinson
IPC分类号： A61B5/00 , A61B5/15 , A61B5/151 , A61B10/00 , A61B5/145 , A61M37/00 , G16H10/40 , G06F19/00 , A61B5/154 , A61B5/1459 , A61B5/1486
摘要： The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

8. 发明申请

US20190209820A1 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
公开(公告)号：US20190209820A1
公开(公告)日：2019-07-11
申请号：US16048722
申请日：2018-07-30
申请人： Seventh Sense Biosystems, Inc.
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61M37/00 , A61B5/15 , A61B5/145 , A61B5/00 , A61M5/142 , A61N1/32 , A61B90/96 , A61B90/98
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

9. 发明申请

US20170127991A1 SYSTEMS AND METHODS FOR COLLECTION AND/OR MANIPULATION OF BLOOD SPOTS OR OTHER BODILY FLUIDS 审中-公开
公开(公告)号：US20170127991A1
公开(公告)日：2017-05-11
申请号：US15156386
申请日：2016-05-17
申请人： Seventh Sense Biosystems, Inc.
发明人： Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ping Gong , Kristin Horton , Scott James
IPC分类号： A61B5/15 , B01L3/00 , A61B5/151
CPC分类号： A61B5/150099 , A61B5/1411 , A61B5/1438 , A61B5/14514 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1455 , A61B5/1486 , A61B5/150022 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150343 , A61B5/150358 , A61B5/150412 , A61B5/150419 , A61B5/150503 , A61B5/150755 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15105 , A61B5/15142 , A61B5/154 , A61B10/0045 , A61B2562/0295 , A61M1/34 , A61M1/3486 , A61M1/3687 , A61M2202/0415 , A61M2205/3334 , B01L3/502753 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N33/18 , G01N33/1826
摘要： The present invention generally relates to systems and methods for receiving blood (or other bodily fluids) from a subject, e.g., from or beneath the skin of a subject. In some cases, the blood (or other bodily fluids) may be deposited on a membrane or other substrate. For example, blood may be absorbed in a substrate, and dried in some cases to produce a dried blood spot. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and directing the blood on a substrate, e.g., for absorbing blood. The substrate, in some embodiments, may comprise filter paper or cotton-based paper. After absorption of some blood onto the substrate, the substrate may be removed from the device and shipped or analyzed. In some cases, the device itself may be shipped or analyzed. For example, in some embodiments, a portion of the device may be sealed such that the substrate is contained within an airtight portion of the device, optionally containing desiccant. Other aspects are generally directed at other devices for receiving blood (or other bodily fluids), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

10. 发明申请

US20170127990A1 TECHNIQUES AND DEVICES ASSOCIATED WITH BLOOD SAMPLING 审中-公开
公开(公告)号：US20170127990A1
公开(公告)日：2017-05-11
申请号：US15387459
申请日：2016-12-21
申请人： Seventh Sense Biosystems, Inc.
发明人： Douglas A. Levinson , Howard Bernstein , Donald E. Chickering, III , Shawn Davis , Ramin Haghgooie , Mark Michelman
IPC分类号： A61B5/15 , A61B5/145
CPC分类号： A61B5/150099 , A61B5/0013 , A61B5/0022 , A61B5/0077 , A61B5/1438 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/1459 , A61B5/14865 , A61B5/150022 , A61B5/150221 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150969 , A61B5/150984 , A61B5/151 , A61B5/15125 , A61B5/157 , A61B5/411 , A61B5/4839 , A61B5/4845 , A61B5/486 , A61B5/685 , A61B5/6898 , A61B5/743
摘要： The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

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