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1. 发明申请

WO2005074417A3 MULTIPLE ANTIGEN DETECTION ASSAYS AND REAGENTS 审中-公开
标题翻译：多种抗原检测试剂和试剂
公开(公告)号：WO2005074417A3
公开(公告)日：2006-04-06
申请号：PCT/US2004028939
申请日：2004-09-03
申请人： SALK INST FOR BIOLOGICAL STUDI , KOLMAN JOHN L , WAHL GEOFFREY M
发明人： KOLMAN JOHN L , WAHL GEOFFREY M
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6804 , C12Q2531/113 , C12Q2563/179
摘要： Provided herein are multiple antigen detection (MAD) assays and reagents for performing such assays. MAD assay embodiments are useful for identifying proximal antigens in a sample (e.g., antigens existing in a complex), and are performed by contacting a sample with two or more hybrids, where each hybrid comprises a nucleic acid and a binding partner that specifically binds to an antigen. In these embodiments, the hybrid nucleic acids hybridize to one another when the hybrids bind to proximal antigens, and the hybridization product then is detected, often by a polymerase chain reaction (PCR) process or a nucleic acid binding agent comprising a detectable label MAD assays and reagents are applicable to antigen detection in situ, chromatin immunoprecipitation and genomic sequencing, detection of proximal intramolecular regions in an antigen, detecting antigen multimerization, diagnostics and therapeutics. Also provided are kits for conducting MAD applications.
摘要翻译：本文提供了用于进行这种测定的多重抗原检测（MAD）测定和试剂。 MAD测定实施方案可用于鉴定样品中的近端抗原（例如存在于复合物中的抗原），并且通过使样品与两个或更多个杂交体接触来进行，其中每个杂合物包含核酸和特异性结合于抗原。在这些实施方案中，当杂交体与近端抗原结合时，杂交核酸彼此杂交，然后通常通过聚合酶链式反应（PCR）方法或包含可检测标记MAD测定法的核酸结合剂检测杂交产物并且试剂适用于原位抗原检测，染色质免疫沉淀和基因组测序，检测抗原中的近端分子内区域，检测抗原多聚化，诊断和治疗。还提供了用于进行MAD应用的套件。

2. 发明申请

WO2010111422A3 INDUCED PLURIPOTENT STEM CELL GENERATION USING TWO FACTORS AND P53 INACTIVATION 审中-公开
标题翻译：使用两个因子和P53失活诱导的PLUIPOTETI干细胞生成
公开(公告)号：WO2010111422A3
公开(公告)日：2011-03-24
申请号：PCT/US2010028541
申请日：2010-03-24
申请人： SALK INST FOR BIOLOGICAL STUDI , KAWAMURA TERUHISA , SUZUKI JOTARO , WANG YUNYUAN V , RAYA ANGEL , WAHL GEOFFREY M , IZPISUA BELMONTE JUAN CARLOS
发明人： KAWAMURA TERUHISA , SUZUKI JOTARO , WANG YUNYUAN V , RAYA ANGEL , WAHL GEOFFREY M , IZPISUA BELMONTE JUAN CARLOS
IPC分类号： C12N5/074 , C12N5/10 , C12N15/12
CPC分类号： C12N5/0696 , C12N2501/40 , C12N2501/602 , C12N2501/603 , C12N2501/998 , C12N2510/00
摘要： Methods and compositions are provided for, inter alia, the generation of induced pluripotent stem cells. Induced pluripotent stem cells may be generated by reprogramming and inhibition of p53. Further, useful intermediates for the generation of induced pluripotent stem cells are also provided.
摘要翻译：提供方法和组合物，尤其是诱导多能干细胞的产生。诱导的多能干细胞可通过重编程和抑制p53产生。此外，还提供了用于产生诱导多能干细胞的有用中间体。

3. 发明申请

WO2010111422A2 INDUCED PLURIPOTENT STEM CELL GENERATION USING TWO FACTORS AND P53 INACTIVATION 审中-公开
标题翻译：使用两个因子和P53失活诱导的PLUIPOTETI干细胞生成
公开(公告)号：WO2010111422A2
公开(公告)日：2010-09-30
申请号：PCT/US2010/028541
申请日：2010-03-24
申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES , KAWAMURA, Teruhisa , SUZUKI, Jotaro , WANG, Yunyuan, V. , RAYA, Angel , WAHL, Geoffrey, M. , IZPISUA BELMONTE, Juan Carlos
发明人： KAWAMURA, Teruhisa , SUZUKI, Jotaro , WANG, Yunyuan, V. , RAYA, Angel , WAHL, Geoffrey, M. , IZPISUA BELMONTE, Juan Carlos
IPC分类号： C12N5/074 , C12N15/12 , C12N5/10
CPC分类号： C12N5/0696 , C12N2501/40 , C12N2501/602 , C12N2501/603 , C12N2501/998 , C12N2510/00
摘要： Methods and compositions are provided for, inter alia , the generation of induced pluripotent stem cells. Induced pluripotent stem cells may be generated by reprogramming and inhibition of p53. Further, useful intermediates for the generation of induced pluripotent stem cells are also provided.
摘要翻译：提供方法和组合物，尤其是诱导多能干细胞的产生。诱导的多能干细胞可通过重编程和抑制p53产生。此外，还提供了用于产生诱导多能干细胞的有用中间体。

4. 发明申请

WO2005074417A2 MULTIPLE ANTIGEN DETECTION ASSAYS AND REAGENTS 审中-公开
标题翻译：多种抗原检测试剂和试剂
公开(公告)号：WO2005074417A2
公开(公告)日：2005-08-18
申请号：PCT/US2004/028939
申请日：2004-09-03
申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES , KOLMAN, John, L. , WAHL, Geoffrey, M.
发明人： KOLMAN, John, L. , WAHL, Geoffrey, M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2531/113 , C12Q2563/179
摘要： Provided herein are multiple antigen detection (MAD) assays and reagents for performing such assays. MAD assay embodiments are useful for identifying proximal antigens in a sample ( e.g ., antigens existing in a complex), and are performed by contacting a sample with two or more hybrids, where each hybrid comprises a nucleic acid and a binding partner that specifically binds to an antigen. In these embodiments, the hybrid nucleic acids hybridize to one another when the hybrids bind to proximal antigens, and the hybridization product then is detected, often by a polymerase chain reaction (PCR) process or a nucleic acid binding agent comprising a detectable label MAD assays and reagents are applicable to antigen detection in situ, chromatin immunoprecipitation and genomic sequencing, detection of proximal intramolecular regions in an antigen, detecting antigen multimerization, diagnostics and therapeutics. Also provided are kits for conducting MAD applications.
摘要翻译：本文提供了用于进行这种测定的多重抗原检测（MAD）测定和试剂。 MAD测定实施方案可用于鉴定样品中的近端抗原（例如存在于复合物中的抗原），并且通过使样品与两个或更多个杂交体接触来进行，其中每个杂合物包含核酸和特异性结合于抗原。在这些实施方案中，当杂交体结合近端抗原时，杂交核酸彼此杂交，然后通常通过聚合酶链式反应（PCR）方法或包含可检测标记MAD测定法的核酸结合剂检测杂交产物并且试剂适用于原位抗原检测，染色质免疫沉淀和基因组测序，检测抗原中近端分子内区域，检测抗原多聚化，诊断和治疗。还提供了用于进行MAD应用的套件。

5. 发明申请

WO0220823A3 METHODS AND COMPOSITIONS FOR VISUALIZING AND INTERFERING WITH CHROMOSOMAL TETHERING OF EXTRACHROMOSOMAL MOLECULES 审中-公开
标题翻译：用于观察和干扰超声波分子的染色体鉴定的方法和组合物
公开(公告)号：WO0220823A3
公开(公告)日：2002-05-16
申请号：PCT/US0128130
申请日：2001-09-07
申请人： SALK INST FOR BIOLOGICAL STUDI , KANDA TERU , WAHL GEOFFREY M , FASEL OTTER MICHELE
发明人： KANDA TERU , WAHL GEOFFREY M , FASEL-OTTER MICHELE
IPC分类号： C07K14/03 , C07K14/05 , C12N5/22 , C12N15/86 , C12N15/869 , G01N33/50 , C07H19/00 , C12N5/10 , C12Q1/00 , C12Q1/04 , C12Q1/06
CPC分类号： G01N33/502 , C07K14/005 , C12N15/86 , C12N2710/16222 , C12N2710/16243 , C12N2800/108 , C12N2810/6081 , C12N2830/46 , C12Q1/6841 , C12Q1/6886 , C12Q1/701 , G01N33/5008 , G01N33/5011 , G01N33/5091 , C12Q2563/125 , C12Q2522/101
摘要： The invention provides methods and compositions for visualizing and interfering with chromosomal tethering and segregation of extrachromosomal molecules.
摘要翻译：本发明提供了用于显现和干扰染色体束缚和分离染色体外分子的方法和组合物。

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