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1. 发明申请

WO2005074417A3 MULTIPLE ANTIGEN DETECTION ASSAYS AND REAGENTS 审中-公开
标题翻译：多种抗原检测试剂和试剂
公开(公告)号：WO2005074417A3
公开(公告)日：2006-04-06
申请号：PCT/US2004028939
申请日：2004-09-03
申请人： SALK INST FOR BIOLOGICAL STUDI , KOLMAN JOHN L , WAHL GEOFFREY M
发明人： KOLMAN JOHN L , WAHL GEOFFREY M
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6804 , C12Q2531/113 , C12Q2563/179
摘要： Provided herein are multiple antigen detection (MAD) assays and reagents for performing such assays. MAD assay embodiments are useful for identifying proximal antigens in a sample (e.g., antigens existing in a complex), and are performed by contacting a sample with two or more hybrids, where each hybrid comprises a nucleic acid and a binding partner that specifically binds to an antigen. In these embodiments, the hybrid nucleic acids hybridize to one another when the hybrids bind to proximal antigens, and the hybridization product then is detected, often by a polymerase chain reaction (PCR) process or a nucleic acid binding agent comprising a detectable label MAD assays and reagents are applicable to antigen detection in situ, chromatin immunoprecipitation and genomic sequencing, detection of proximal intramolecular regions in an antigen, detecting antigen multimerization, diagnostics and therapeutics. Also provided are kits for conducting MAD applications.
摘要翻译：本文提供了用于进行这种测定的多重抗原检测（MAD）测定和试剂。 MAD测定实施方案可用于鉴定样品中的近端抗原（例如存在于复合物中的抗原），并且通过使样品与两个或更多个杂交体接触来进行，其中每个杂合物包含核酸和特异性结合于抗原。在这些实施方案中，当杂交体与近端抗原结合时，杂交核酸彼此杂交，然后通常通过聚合酶链式反应（PCR）方法或包含可检测标记MAD测定法的核酸结合剂检测杂交产物并且试剂适用于原位抗原检测，染色质免疫沉淀和基因组测序，检测抗原中的近端分子内区域，检测抗原多聚化，诊断和治疗。还提供了用于进行MAD应用的套件。

2. 发明申请

WO2005074417A2 MULTIPLE ANTIGEN DETECTION ASSAYS AND REAGENTS 审中-公开
标题翻译：多种抗原检测试剂和试剂
公开(公告)号：WO2005074417A2
公开(公告)日：2005-08-18
申请号：PCT/US2004/028939
申请日：2004-09-03
申请人： SALK INSTITUTE FOR BIOLOGICAL STUDIES , KOLMAN, John, L. , WAHL, Geoffrey, M.
发明人： KOLMAN, John, L. , WAHL, Geoffrey, M.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q2531/113 , C12Q2563/179
摘要： Provided herein are multiple antigen detection (MAD) assays and reagents for performing such assays. MAD assay embodiments are useful for identifying proximal antigens in a sample ( e.g ., antigens existing in a complex), and are performed by contacting a sample with two or more hybrids, where each hybrid comprises a nucleic acid and a binding partner that specifically binds to an antigen. In these embodiments, the hybrid nucleic acids hybridize to one another when the hybrids bind to proximal antigens, and the hybridization product then is detected, often by a polymerase chain reaction (PCR) process or a nucleic acid binding agent comprising a detectable label MAD assays and reagents are applicable to antigen detection in situ, chromatin immunoprecipitation and genomic sequencing, detection of proximal intramolecular regions in an antigen, detecting antigen multimerization, diagnostics and therapeutics. Also provided are kits for conducting MAD applications.
摘要翻译：本文提供了用于进行这种测定的多重抗原检测（MAD）测定和试剂。 MAD测定实施方案可用于鉴定样品中的近端抗原（例如存在于复合物中的抗原），并且通过使样品与两个或更多个杂交体接触来进行，其中每个杂合物包含核酸和特异性结合于抗原。在这些实施方案中，当杂交体结合近端抗原时，杂交核酸彼此杂交，然后通常通过聚合酶链式反应（PCR）方法或包含可检测标记MAD测定法的核酸结合剂检测杂交产物并且试剂适用于原位抗原检测，染色质免疫沉淀和基因组测序，检测抗原中近端分子内区域，检测抗原多聚化，诊断和治疗。还提供了用于进行MAD应用的套件。

3. 发明专利

DE2221950A1 未知
公开(公告)号：DE2221950A1
公开(公告)日：1972-12-21
申请号：DE2221950
申请日：1972-04-27
申请人： KOLMAN JOHN L
发明人： L KOLMAN JOHN
IPC分类号： A61F2/64 , A61F2/68
摘要： A knee structure for a prosthetic limb, which allows the shin portion to pivot with respect to the thigh portion about an axle and has a brake band around the axle with novel means for causing the brake band to tighten around the axle, when the wearer places weight on the limb, to allow the knee to lock at any angular position. The brake automatically releases when the weight is lifted off the limb.

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