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1. 发明授权

US07570125B2 Crystal oscillator 有权
标题翻译：水晶振荡器
公开(公告)号：US07570125B2
公开(公告)日：2009-08-04
申请号：US10553321
申请日：2004-04-14
申请人： Victor Petrovich Ostanin , Alexander Sleptsov
发明人： Victor Petrovich Ostanin , Alexander Sleptsov
IPC分类号： H03B5/32
CPC分类号： G01N29/036 , G01N2291/0256 , H03B5/368 , H03B21/00 , H03L5/00
摘要： An ocscillator circuit having: a) a piezoelectric crystal connected to a surface; b) a variable frequency generator for generating a driving signal which is supplied to the crystal to cause the crystal to oscillate, thereby causing the surface to oscillate; and, c) an analyser for monitoring the phase shift between the voltage across the crystal and the current flowing through it and, in response generating an adjustment signal which relates to the difference between the oscillation frequency and a resonant frequency of the crystal, the variable frequency generator being responsive to the adjustment signal to vary the frequency of the driving signal to cause the crystal to oscillate at the resonant frequency.
摘要翻译：一种振荡器电路，具有：a）连接到表面的压电晶体; b）可变频率发生器，用于产生提供给晶体以使晶体振荡的驱动信号，从而使表面振荡; 以及c）用于监测晶体两端的电压与流经晶体的电流之间的相移的分析器，并且响应于产生与晶体的振荡频率和谐振频率之间的差异相关的调整信号，频率发生器响应于调节信号来改变驱动信号的频率，以使晶体以共振频率振荡。

2. 发明授权

US07195909B2 Measurement and use of molecular interactions 有权
标题翻译：测量和使用分子相互作用
公开(公告)号：US07195909B2
公开(公告)日：2007-03-27
申请号：US10350892
申请日：2003-01-24
申请人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev
发明人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev
IPC分类号： C12M3/00
CPC分类号： G01N33/54373 , G01N33/5438 , Y10S435/808 , Y10S436/805
摘要： The subject invention pertains to a method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of: (i) contacting the binding partners, one of which is immobilised on a surface; (ii) oscillating the surface at increasing amplitude; and (iii) detecting a dissociation event. An analogous method can be used to separate a target analyte from a composition. The subject invention also pertains to an apparatus for determining the affinity between binding partners, and comprises: a surface (10) having one binding partner (16) immobilised thereon; means for oscillating the surface at increasing amplitude; and means (14, 15) for detecting a dissociation event.
摘要翻译：本发明涉及用于确定结合配偶体之间的亲和力的方法，或者是依赖于亲和力的一种结合配偶体的性质，其包括步骤

3. 发明授权

US06589727B1 Measurement and use of molecular interactions 有权
标题翻译：测量和使用分子相互作用
公开(公告)号：US06589727B1
公开(公告)日：2003-07-08
申请号：US09700485
申请日：2000-11-15
申请人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev
发明人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev
IPC分类号： C12Q300
CPC分类号： G01N33/54373 , G01N33/5438 , Y10S435/808 , Y10S436/805
摘要： A method for determining the affinity between binding partners, or a property of one of the binding partners dependent on the affinity, comprising the steps of: (i) contacting the binding partners, one of which is immobilised on a surface; (ii) oscillating the surface at increasing amplitude; and (iii) detecting a dissociation event. An analogous method can be used to separate a target analyte from a composition. The subject invention also pertains to an apparatus for determining the affinity between binding partners, and comprises: a surface (10) having one binding partner (16) immobilised thereon; means for oscillating the surface at increasing amplitude; and a device (14, 15) for detecting a dissociation event.
摘要翻译：用于确定结合配偶体之间的亲和力或依赖于亲和力的结合配偶体之一的性质的方法，包括以下步骤：（i）使结合伴侣（其中一个固定在表面上）;（ii）表面增大振幅; 和（iii）检测解离事件。可以使用类似的方法从组合物中分离靶分析物。本发明还涉及用于确定结合配偶体之间的亲和力的装置，并且包括：具有固定在其上的一个结合配偶体（16）的表面（10）用于以增加的振幅振荡表面的装置; 以及用于检测解离事件的装置（14,15）。

4. 发明授权

US07763475B2 Measurement and use of molecular interactions 有权
标题翻译：测量和使用分子相互作用
公开(公告)号：US07763475B2
公开(公告)日：2010-07-27
申请号：US11706654
申请日：2007-02-13
申请人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev , Matthew Cooper
发明人： David Klenerman , Victor Petrovich Ostanin , Fedor Nikolaievich Dultsev , Matthew Cooper
IPC分类号： G01N33/551 , G01N33/552
CPC分类号： C07K1/14
摘要： The present invention is based on the realization that the bonds between a target molecule, or a target molecule attached to a particle, and a surface, can be ruptured by mechanically oscillating the surface at increasing amplitude, leading to detachment of the target molecule or particle from the surface. The required acceleration, and hence force, will depend on a variety of factors, including the mass of the molecule or particle, the nature of the bond to the surface and the geometric shape or size of the target molecule or particle. The present invention may therefore be used to separate or to size different target molecules, or to detect their presence.
摘要翻译：本发明基于通过以增加的幅度机械振荡表面而导致目标分子或附着于颗粒的靶分子与表面之间的键可能破裂，导致靶分子或颗粒的分离从表面。所需的加速度，因而力将取决于多种因素，包括分子或颗粒的质量，与表面的键的性质以及靶分子或颗粒的几何形状或尺寸。因此，本发明可以用于分离或调整不同的靶分子或检测其存在。

5. 发明授权

US07543476B2 Rupture event sensors 失效
标题翻译：破裂事件传感器
公开(公告)号：US07543476B2
公开(公告)日：2009-06-09
申请号：US10553471
申请日：2004-04-14
申请人： Victor Petrovich Ostanin
发明人： Victor Petrovich Ostanin
IPC分类号： G01N15/06
CPC分类号： G01N29/036 , G01N2291/0256 , H03B5/368 , H03B21/00 , H03L5/00
摘要： An apparatus for separating an analyte from a mixture or for detecting an analyte or for determining the affinity, or a property related to affinity, between binding partners includes: a) a surface having the analyte or one of the binding partners immobilized thereon, in use; b) a transducer for oscillating the surface; c) a controller connected to the transducer for varying the amplitude and/or frequency of the oscillation to cause a dissociation event; and, d) an analyzer connected to the transducer for detecting an oscillation of the transducer due to the dissociation event. The controller includes an oscillator connected in a resonant circuit with the transducer such that the transducer oscillates at two frequencies simultaneously, one of these causing the transducer to oscillate the surface and the other being supplied as an output to the analyzer.
摘要翻译：用于从混合物中分离分析物或用于检测分析物或用于确定结合伴侣之间的亲和力或与亲和力相关的性质的装置包括：a）在使用中具有分析物或其中一个结合对象的表面固定在其上的表面 ; b）用于振荡表面的换能器; c）连接到换能器的控制器，用于改变振荡的振幅和/或频率以引起解离事件; 以及d）连接到所述换能器的分析器，用于检测由于解离事件引起的所述换能器的振荡。控制器包括与谐振电路连接的振荡器，使得换能器同时以两个频率振荡，这些振荡器中的一个使得换能器振荡表面，另一个作为输出被提供给分析器。

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